혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

저체중 출생이 학동기 및 청소년기 소아 천식의 중증도에 미치는 영향에 대한 고찰

정훈 ( Hoon Jeung ),김형대 ( Heung Dae Kim ),이윤진 ( Yun Jin Lee ),이균우 ( Kyun Woo Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2006 소아알레르기 및 호흡기학회지 Vol.16 No.1

목 적 : 본 연구는 저출생 체중아로 출생한 소아에 있어서 학동기 및 청소년기 소아 천식의 중증도에 미치는 영향에 관해서 후향적으로 검토하였다. 방 법 : 대동병원 소아과와 호흡기내과에 통원 중에 있거나 부산 동래구 및 연제구 소재 개인의원에서 대동병원으로 전원 된 천식 환자 중에서 8세 이상 18세 이하의 소아 및 청소년을 대상으로 출생체중을 기준으로 1,500 g 이상 2,500 g 미만인 15명을 추출하여 연구군으로 하고 출생체중 2,500 g 이상이며 연구군의 나이에 일치하는 순서대로 2명씩 추출하여 이 30명을 대조군으로 하였다. 결 과 : 양군을 비교한 결과 천식 중증도는 연구군에서 유의하게 높았다.(P=0.015) 또 흡입 스테로이드 약의 사용 빈도(증례군 13명/15명, 대조군 4명/30명 : P=0.0001)와 사용 기간에 있어서도 연구군에서 유의하게 높게 나왔다.(P= 0.009) 혈중 총 IgE치와 아토피피부염의 유병률은 대조군에서 높았다.(각각 P=0.007, P=0.0001) 폐기능 검사와 PC(20), 특이 IgE 항체는 두 군 사이에 유의한 결과를 볼 수가 없었다.(P>0.05) 결 론 : 천식의 중증도와 흡입 스테로이드 사용의 빈도와 기간 등으로 미루어 볼 때 저출생 체중은 소아 천식의 중증도를 증가시키는 요인 일 수 있음을 시사한다. Purpose : Over the past several decades, the survival rates of low birth weight(LBW; birth weight <2,500 g) infants have been improving. Many of these infants have had bronchial asthma(BA) at childhood and aldolescence. The aim of this study is to investigate whether LBW influenced the severity of BA in prealdolescent children and aldolescence by a retrospective case control study. Methods : 15 LBW children(1,500 g<birth weight<2,500 g) between 8 year-old and 18 year-old with BA visiting Dae-dong hospital as the case group were compared with 2 BA children to each case as the control group(total 30 children) on the basis of following criteria : the same age, he/she attended Dae-Dong hospital or local medical center after 8 years old, birth weight was more than 2,500 g. Asthma severity was modified from 2003 Guideline for management of childhood asthma at The Korean Academy of Pediatric Allergy and Respiratory Disease. PFT(Pulmonary function test) were measured using a portable spirometer. The value are expressed as percentage predicted using standard reference values. Total IgE and specific IgE Ab. were assessed by the PRIST method and MAST Allergy Test. Methacholine challenge test and PC20 was assessed by the Masterlab. Results : LBW group had : a significantly more severe symptoms between 8 year-old and 18 year-old than control group.(P=0.015) A significantly more used to ICSs(Inhaled corticosteroids) and add-on therapy than control group.(P=0.009)(P=0.0001) There were no significant differences in the PFT and PC(20) and specific IgE Ab. between LBW group and control group. But, total IgE level is higher in the control group than in the LBW group. Conclusion : These results suggest that LBW is a risk factor for the severity of BA. We suggest that infants with birth weight of less than 2,500 g have a more severe risk of asthma during prealdolescent children and aldolescence than who were birth weight of more than 2,500 g. [Pediatr Allergy Respir Dis(Korea) 2006;16:38-46]

서초동(서울시 서초구)의 거미상

김주필(Joo Pil Kim),정혜리(Hye ri Jeong),김대희(Dae Hee Kim),박동우(Dong Woo Park),서재웅(Jae Woong Seo),이현우(Hyun woo Lee) 한국거미연구소 2017 한국거미 Vol.33 No.1

2016년 3월 31일부터 7월 31일까지 서울특별시 서초구 서초동에 위치한 서울고등학교 교정 일대를 서울고등학교 환경생물부 부원들이 채집 조사한 결과 20과 43속 53종의 거미가 조사 연구되어 이에 보고하는 바이다. From March 31st to July 31st in 2016, members of an environmental biology club at Seoul High School located in Seocho-gu, Seoul, Dae-Hee Kim, Dong-Woo Park, Jae-Woong Seo and Hyun-woo Lee, collected 20 families 43 genera 53 species of spiders and report the result of the study here.

한국인에서 혈소판 당단백 Ⅱb/Ⅲa 유전자 다형성과 관동맥 성형술 후 재 협착과의 관계

이민수,이정우,김보영,임대승,강정아,김정희,김윤철,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Platelet aggregation is the final pathway of acute coronary syndrome such as acute myocardial infarction and unstable angina. Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and yon Willebrand factor and it plays an important role in platelet aggregation and in the pathogenesis of acute coronary syndrome. It is known that polymorphism of the gene that encoding platelet glycoprotein IIb/IIIa(PI^A1/A2) is strongly related to acute coronary syndrome in Caucasian, but not in Koreans. We investigated relationship between platelet glycoprotein llb/Illa gene polymorphism and restenosis of coronary artery after angioplasty in Koreans. Total 371 patients(M=251. F=120) were enrolled. Angioplasty group comprised 143 patients who underwent coronary angioplasty, and in the angioplasty group, restenosis group comprised with the 65 patients who had restenotic lesion over 50% of luminal diameter in follow-up coronary angiography. Normal group comprised 153 patients who had no significant angiographic lesion and variant angina group comprised 75 patients who were positive in ergonovine test. Genomic DNA was extracted from peripheral arterial blood. To determine the frequency of P1^A1/A2 genotype, polymerase chain reaction(PCR) was done and the product was restricted with Mspl. 3%. agarrose gel electrophoresis showed restriction fragment length polymorphism. Clinical profile and risk factor were also reviewed. Among all 371 patients of study group, genotype of only one patients in restenosis group if is proven to be PI^A1/A2 heterozygote. All patients of normal study group, no restenosis group, and the other patients in restenosis group have an PI^A1 homozygote genotype. In our study, platelet glycoprotein IIb/Illa polymorphism has no relationship with restenosis of the coronary artery after angioplasty in Koreans. But the genotypic frequency of platelet glycoprotein IIb/IIIa gene polymorphism in Koreans is concordant with that of previous studies.

심근 세포내 칼슘이온 활동도에 미치는 Vanadate의 효과

이정렬,김우겸,엄대용 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.3

The effects of vanadate on the isometric contraction, membrane potenrial and intracellular calcium ion activities of rabbit myocardial cells were investigated, using calcium selective microelectrode, filled with neutral calcium ion carrier, ETH-1001. The resting tension, the membrane potenrial and the intracellular calcium ion activities were recorded in normal Tyrode solution and compared with those in the contracture induced by 10 mM vanadate. The following results were obtained: 1. The dose-response reationship between the concentration of vanadate and twitch tension showed near-maximum response in 5mM with no corresponding changes in action potential. 2. The resting tension increased up to the amplitude of a control twitch in 10mM vanadate with resting membrane potential, hyperpolarized. 3. Increase in intracellular calcium ion activities preceded the contracture by 10mM vanadate which were restored to the control level in accordance with a decrease of intracellular calcium ion activities. 4. The amplitude of contractures by 10mM vancadate were 90∼120% fo the control twitch thesion in which the intracellular calcium ion activities were increased about 70 times from pCa, 7.1 in the control to pCa, 5.3 in the contractures.

만성 간질환에서 혈청 Type Ⅳ Collagen 측정의 의의

이헌영,김성걸,정현용,구선회,박종우,강대영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To evaluate the clinical significance of serum type N collagen levels in patients with various liver diseases, serum type IV collagen levels were measured by one-step sandwich enzyme immunoassay using monoclonal antibodies in 80 patients from December 1993 to December 1994 at Chung Nam National University Hospital. The results were as follows : 1. Mean age of patients was 45 years. Men was 2.1 times more than women. 2. Compared to 15 normal controls(159.9±34.0 ng/ml), serum type IV collagens were significantly elevated in patients with chronic hepatitis (254.5±158.0 ng/ml), liver cirrhosis(281.0±195.7 ng/ml) and hepatocellular carcinoma(420.5±241.4 ng/ml) (p<0.005). 3. Serum type IV collagen levels were increased without significance in patients with alcholic liver cirrhosis(331.6±244.5 ng/ml) compared to non-alcholic cirrhosis(230.4±117.8 ng/ml. p>0.05). 4. The serum levels of type IV collagen were not correlated with the levels of alanine amino-trnasferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase(ALP). The results suggest that the serum type IV collagen levels correlate well with the degree of progression of chronic liver diseases. Therefore the measurement of serum type IV collagen is relatively simple and useful method to reflect the progression of chronic liver diseases.

상추種子 活力의 生化學的 評價硏究 : Ⅰ. Ethylene生成 Ⅰ. Ethylene Evolution

禹永澮,朴大榮,李政明 경희대학교 부설 식량자원개발연구소 1992 硏究論文集 Vol.13 No.-

Studies were conducted to find out relationship between the vigor of lettuce and the production of ethylene from germinating seeds of i5 cultivars and lines at 3 different temperatures. The effect of red light illumination and the effect of ACC (1-aminocyclopropane-1-carboxylic acid) and red light on seed germination and ethylene production were also investigated. major results can be summarized a s follows. 1. The lettuce seeds with greater ability of producing ethylene germinated better at high temperatures (25 and 30℃). Highly significant, positive correlations were found between the ethylene evolution and the germination rate at both tested temperatures. 2. Red light treatment significantly increased ethylene evolution and the seed germination rate at 25℃. Treatment of ACC in addition to the red light illumination further increased the germination rate as compared to the red light treatment alone. 3. Red light treatment a t high temperatures was found to be effective in releasing the thermodormancy induced by high temperatures, but the effectiveness varied considerably depending upon the cultivars.

Isozyme Polymorphism에 의한 무 品種 標識 鑑別 硏究

禹永澮,朴大榮,李政明 경희대학교 부설 식량자원개발연구소 1991 硏究論文集 Vol.12 No.-

Identification of radish (Raphanus sativus) has been principally based on the phenotypes including flowering habit. As new cultivars are constantly being develped, the need for advanced and more reliable means of cultivar identification has been growing, particularly for the purpose of varietal protection and ensuring breeder's rights. This study was conducted to gather infomation on distinguishing cultivars using isozyme polymorphism by polyacrylamide gel electrophoresis(PAGE). PAGE performance was markedly affected by various factors such as gel concentration, slab gel thickness, glass plate size, running time, frequency of electrode buffer use, duration of sample storage, and others. AcPH, EST(1ow pH buffer system) and PGM isozyme could be used for testing the purity of a given hybrid but were not suitable for the precise cultivar identification. Among the 11 isozymes investigated, esterase(EST, high pH buffer system) isozyme gave clear differences in banding pattern depending upon cultivars but not between individual plants within a same cultivar.

가구디자인에 있어서 3D MODELLING DATA BANK 연구

이대우 瑞逸大學 1999 論文集 Vol.17 No.-