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양파(Allium cepa L.) 추출물이 Tyrosinase 유전자 발현에 미치는 효과
조남철,윤연희,이혜진,손현정,김양경,최근희,나명석,조영권,이황희,진종언 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.3
Melanin 생성에 관여하는 tyrosinase 유전자의 발현을 억제하는 물질을 탐색하고자 tyrosinase promoter를 지닌 Bl6 mouse melanoma cell해 앙파 methanol 추출물을 처리한 바 양파 methanol 추풀물은 10.0㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml의 농도에서 대조군에 비해서 약 15%, 23% 57%의 억제효과를 나타냈으며 세포생존율은 1.0 ㎍/ml, 10.0 ㎍/ml, I00.0 ㎍/ml, 1.0㎎/ml의 농도에서 약 126 %, 92%. 85%, 64%로서 세포독성이 낮게 나타났다. Ethyl acetate, butyl alcohol, 그리고 물 용매 분획물은 tyrosinase 유전자의 발현물 억제하는 효과가 없었지만 methylene chloride 용해 분획물은 10.0 ㎍/ml과 100.0 ㎍/ml의 농도에서 약 37%와 35%의 발현율을 나타냄으로서 대조군에 비해 크게 억제하였다. Onion(Allium cepa L,) extract by methanol repressed the expression of tyrosinase gene of B16 mouse melanoma cell containing tyrosinase promoter. 10.0 ㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml of the extract repressed expression of tyrosinase gene about 15%, 23%, and 57%, respectively, compared with control. In the MTT assay, the same extract exhibited low cytotoxicity at 1.0 ㎍/ml, 10.0 ㎍/ml, 100.0 ㎍/ml, and 1.0 ㎎/ml, respectively. The fractions of ethyl acetate, butyl alcohol, and water did not showed the repressive effect on the expression of tyrosinase gene, but the fraction of methylene chloride repressed highly at 10.0 ㎍/ml and 100.0 ㎍/ml.
민경원,진호일,최성범,조현순 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-
이 연구는 상동광산 주변에 적치되어 있는 폐석과 폐재 자원을 부가가치가 높은 건설자재와 새로운 건설소재 및 첨단산업소재로 활용하기 위하여 폐석 및 폐재에 대한 암석학적 및 물리적·화학적 특성을 규명하고자 하였다. 상동광산 주변의 폐석은 주로 석회암과 셰일, 호온펠스 등이며, 폐재적치장에 쌓여 있는 폐재는 주로 석영과 정장석, 각섬석, 백운모 등의 광물로서, 구폐재 적치장의 폐재가 신폐재 적치장의 폐재보다 약간 더 조립질이고 알카리성을 나타내었다. 폐재의 주성분 원소중 MgO 함량은 신폐재에서, P₂O5는 구폐재에서 각각 뚜렷하게 더 높은 값을 보여 주었으며, 질산과 과염소산의 혼합산에 의한 부분분해에 의해 Al₂O₃, Fe₂O₃(T), MnO, MgO, K₂O, Na₂O 등은 비교적 많은 함량이 추출되었으나, TiO₂, CaO, P₂O5 등은 거의 부분 추출되지 않았다. 폐재의 pH가 증가할수록 Fe₂O₃(T)는 감소하는 경향을 나타내었고, 작열감량(L.O.I.)은 CaO와는 높은 양의 상관관계, SiO₂와는 높은 음의 상관관계를 보여 주었다. The purpose of this study is to determine the petrographic, physical and chemical characteristics of waste rock and sludges around Sangdong mine in order to utilize them as new and high quality construction materials. The waste rocks piled around Sangdong mine are mainly composed of limestone, shale and hornfels, and the sludges in sludge-piles are mainly composed of quartz, orthoclase, amphiboles and muscovite. The sludges in old sludge-piles show a tendency of coarse grains and alkaline than those in new sludge-piles. The sludges of new sludge-piles contain significantly higher abundances of MgO, and those of old sludge-piles show significantly higher content of P₂O5. In consideration of total extraction contents for sludges, the partially extracted contents of Al₂O₃, Fe₂O₃(T), MnO, MgO, K₂O and Na₂O by mixing acid of nitric and perchloric acid, are relatively high, and those of TiO₂, CaO and P₂O5 are very low. According as pH increases, abundance of Fe₂O₃(T) in the sludges of Sangdong mine decreases. L.O.I.(loss on ignition) shows highly positive and negative correlations with CaO, and SiO₃, respectively.
CHO, Hyun-chong,HADJIISKI, Lubomir,SAHINER, Berkman,CHAN, Heang-Ping,PARAMAGUL, Chintana,HELVIE, Mark,V. NEES, Alexis,CHO, Hyun Chin INSTITUTE OF ELECTRONICS, INFORMATION & 2016 IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS E SE Vol.99e.d No.6
<P>To study the similarity between queries and retrieved masses, we design an interactive CBIR ( Content-based Image Retrieval) CADx ( Computer-aided Diagnosis) system using relevance feedback for the characterization of breast masses in ultrasound ( US) images based on radiologists' visual similarity assessment. The CADx system retrieves masses that are similar to query masses from a reference library based on six computer-extracted features that describe the texture, width-to-height, and posterior shadowing of the mass. The k-NN retrieval with Euclidean distance similarity measure and the Rocchio relevance feedback algorithm ( RRF) are used. To train the RRF parameters, the similarities of 1891 image pairs from 62 ( 31 malignant and 31 benign) masses are rated by 3 MQSA ( Mammography Quality Standards Act) radiologists using a 9-point scale ( 9= most similar). The best RRF parameters are chosen based on 3 observer experiments. For testing, 100 independent query masses ( 49 malignant and 51 benign) and 121 reference masses on 230 ( 79 malignant and 151 benign) images were collected. Three radiologists rated the similarity between the query masses and the computer-retrieved masses. Average similarity ratings without and with RRF were 5.39 and 5.64 for the training set and 5.78 and 6.02 for the test set, respectively. Average AUC values without and with RRF were, respectively, 0.86+/- 0.03 and 0.87+/- 0.03 for the training set and 0.91+/- 0.03 and 0.90+/- 0.03 for the test set. On average, masses retrieved using the CBIR system were moderately similar to the query masses based on radiologists' similarity assessments. RRF improved the similarity of the retrieved masses.</P>
( Hyun Chin Cho ),( Yu Jin Kim ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Byung Chul Yoo ),( Seung Woon Paik ) 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.2
Background/Aims: The aim of this study was to evaluate the seroconversion rate of a hepatitis A virus (HAV) vaccination in patients with hepatitis B virus (HBV)-related chronic liver disease (CLD). Methods: Analyses were conducted using clinical records from 94 patients with chronic HBV infection who were seronegative for IgG anti-HAV antibodies between September 2008 and June 2009. Two doses of an HAV vaccine were administered 24 weeks apart. A third vaccine dose was administered only for patients seronegative for anti-HAV antibodies at week 48. Results: The seroconversion rate of anti-HAV following the two-dose vaccination was 86.17%. The seroconversion rate of anti-HAV was not signifi cantly different according to age or status of liver disease. The rate was higher in female than in male patients. A third HAV vaccine dose was administered to 13 patients seronegative for anti-HAV after the two-dose regimen, and 84.62% of these patients showed seroconversion at week 72. Conclusions: HAV vaccination is effective in most Korean patients with HBV-related CLD, and it might be necessary to evaluate three-dose vaccination approach for non-responders to the conventional regimen to maximize the success of an HAV vaccination program. (Gut Liver 2011;5:217-220)
( Hyun Chin Cho ),( Geum Youn Gwak ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Byung Chul Yoo ),( Seung Woon Paik ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: Pegylated interferon (peginterferon) and ribavirin is the current standard therapy for chronic hepatitis C. The aims of this study were to evaluate the efficacy of peginterferon and ribavirin and to identify predictors of a sustained virological response (SVR) to the retreatment of chronic hepatitis C in Korea. Methods: The clinical records of 91 patients with chronic hepatitis C who were retreated with peginterferon and ribavirin were retrospectively analyzed. None of the patients had previously attained a SVR, and the patients were categorized according to their previous re-sponses (nonresponder, relapser, or inadequate treatment) to conventional interferon/ribavirin. Results: The overall SVR rate was 54.9%. Independent predictors of a SVR were genotypes 2 and 3, relapse, an adherence to peginterferon of over 80%, and an early virological response (EVR). For genotype 1 patients, an adherence to peginterferon of over 80% was an independent predictor of a SVR. Conclusions: Peginterferon and ribavirin therapy is effective for the retreat-ment of Korean chronic hepatitis C patients who have failed interferon/ribavirin, especially in patients with genotypes 2 and 3, relapse, an adherence to peginterferon over 80%, and an EVR. For genotype 1 patients, retreatment was effective in patients with an adherence to peginterferon over 80%. (Gut Liver 2013;7:585-593)
( Hyun Chin Cho ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( In Gyu Bae ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.1
Several cases of Polygonum multiflorum Thunb-induced hepatitis have been reported worldwide. Anthraquinone is an active ingredient of P. multiflorum Thunb. that has been thought to play a role in its hepatotoxicity. Here we report the case of a 34-year-old Korean man who had P. multiflorum Thunb-induced hepatitis and reactivation of pulmonary tuberculosis caused by bone marrow suppression, which developed simultaneously. He was admitted to our hospital with recently developed fatigue and aggravated jaundice. He was a previously healthy man except for the sequelae of pulmonary tuberculosis seen on chest X-ray. He had a 30-day history of ingesting the root of P. multiflorum as a form of liquor and tea. The patient was diagnosed with P. multiflorum Thunb-induced hepatitis after excluding all other potential causes of acute hepatitis. Liver function gradually improved following the total cessation of the consumption of the material. However, he suffered from spiking fever with progressive pancytopenia during the hospital stay. A bone marrow biopsy showed markedly hypocellular marrow, suggesting transient bone marrow suppression, which was probably caused by extrinsic factors such as drugs, toxins, and viral infection. Although he began to complain of a dry cough, repeated sputum investigations revealed positive acid-fast bacillus staining. The fever subsided and pancytopenia improved after treatment for pulmonary tuberculosis. These observations suggest that P. multiflorum Thunb induces both bone marrow suppression and hepatotoxicity. (Gut and Liver 2009;3:52-56)