복귀돌연변이시험을 이용한 이온화에너지 처리 우유 및 아이스크림의 유전독성학적 평가

유지숙, 한선경, 신명수, 구본철, 최지현, 이주운, 조철훈, 함준상, 이완규 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.1

본문참고

전류응력이 고탄소강의 미세조직에 미치는 영향

지주현,이태근 서울産業大學校 2005 논문집 Vol.54 No.1

잔류응력은 재료에 부하되는 응력 패턴에 따라 구조물에 상이한 영향을 미친다. 특히 쇼트피닝 처리는 압축잔류응력에 많은 영향을 받고 있다. 이러한 잔류응력을 정확히 모니터링 할 수 있다면 실기 부품의 안전성 유지와 보수기간 및 잔존수명 예측에 유용하게 사용할 수 있다. 본 논문은 쇼트피닝에 의한 잔류응력과 미세조직 변화를 실험적으로 관찰하였다. 쇼트피닝 투사속도가 증가함에 따라 변형층의 두께가 증가하였다. 경도 및 압축잔류응력은 표면에서 깊이 방향으로 증가하였고, 내부에 형성된 압축 잔류응력의 깊이와 유사하게 감소하였다. 투사속도가 증가함에 따라 압축 잔류응력과 을력분포는 증가하게 되고, 입자 크기는 미세화 하였고 침상의 Bainite 조직이 발달 함에 따라 경도값도 증가하였다. Residual stress gives different impact on the microstructures according to the stress pattern loaded to materials, and it is useful for the prediction of safety maintenance, maintenance period and residual life of parts for practical training. This paper studied the changes of the residual stress and microstructure of SK-5M high carbon steel by applying shot peening. As shot ball speed of shot peening increases, the thickness of deformation layer has increased. Hardness and compressive residual stress increased vertically from surface. As compressive residual stress and its distribution increased, grain size became refined and Bainite structure of bed increased hardness.

치근단 미완성 치아의 자가치아이식

정지숙,박호원,이주현,서현우 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

자가치아이식이란 자신의 치아를 구강 내의 한 위치에서 다른 발치와나 외과적으로 형성된 치조와로 이동시키는 술식이다. 통상적으로 이 술식은 상실되거나 보존하기 힘든 제1대구치를 다른 치아로 대체하거나, 매복된 견치를 악궁의 정상 위치로 이동시키거나, 전치부와 같이 심미적으로 중요한 부위의 상실된 치아를 소구치로 대체하는 경우에 많이 사용된다. 자가치아이식을 성공적으로 수행하기 위해서는 세심한 수술 기법과 더불어 적절한 증례 선택이 중요한데, 이식할 치아는 치근 발육이 1/2~3/4 정도 이루어진 미성숙 치아가 유리하고 근단공이 넓을수록 치수 재혈관화의 가능성도 높아져 이후의 근관 치료의 필요성도 줄일 수 있다. 본 증례들은 소아에서 치근단 미완성 치아의 자가치아이식을 통해 임상적, 방사선학적으로 양호한 치유 결과를 얻었고, 별도의 근관 치료 없이 양호한 치수 치유 결과를 보였기에 보고하는 바이다. Autogenous tooth transplantation can be defined as the surgical movement of a tooth from one position in the mouth to another in the same individual. The most common reasons for tooth transplantation include replacement of a missing first molar, transplantation of impacted canines to their normal positions in the arch, and transplantation of premolars in areas of missing teeth, especially in the anterior area of the mouth. The key to successful tooth transplantation is proper selection of graft with adequate root development as well as the design of surgical operation. Root development stage with half to three-quarter-developed roots increase the success rate of autotransplantation. We report the cases of successful autotransplantation which resulted in ideal healing of periodontal ligament, gingiva and alveolar bone. All transplanted teeth presented immature root formation at the moment of the procedure. After surgical procedure, we can observe good healing pattern without endodontic problem.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

습식크리닝에 의한 지류문화재의 물성변화

천주현,장은지 국립중앙박물관 2005 박물관보존과학 Vol.6 No.-

지류문화재의 보존처리과정에서 실시되는 습식크리닝의 영향을 알아보기 위해 습식크리닝 전과 후의 물성변화를 관찰하였다. 조사방법으로 고지와 현대지 7종을 각각 습식크리닝 전과 후의 구조적, 광학적, 강도적 성질의 변화를 측정하였다. 그 결과 습식크리닝은 지류문화재의 물성변화를 일으키고 특히 안료, 먹, 염료 등의 구성성분을 약화시킬 수 있음을 확인할 수 있었다. To understand the influence of wet cleaning performed in the course of preserving paper items, the change of matter properties by before and after wet cleaning was observed. Specifically, structural and optical qualities and strength were measured. The result showed that wet cleaning caused a substance change in the paper items and particularly weakened the structure material of pigments, Chinese ink, dyes, etc.

프롤린 함량 증가 및 내건성 강화 관련 새로운 RING-Type E3 유비퀴틴 리가아제 애기장대 atrzf1 돌연변이체의 생리적 기능 연구

주현우,민지희,정문수,김철수 전남대학교 농업과학기술연구소 2021 농업생명과학연구동향 Vol.59 No.-

The covalent attachment of ubiquitin to proteins plays a fundamental role in the regulation of cellular function through biological events involving abiotic of biotic stress responses, immune responses, and apoptosis, Here, we characterize the biological function of the Arabidopsis thaliana RING Zinc Finger 1 (AtRZF1) in dehydration response. AtRZF1 was significantly reduced by drought stress. The atrzf1 mutant was less sensitive to osmotic stress than the wild-type during early seedling development, wheareas transgenic pants overexpressing AtRZF1 were hypersensitive, indicating that AtRZF1 megatively regulates drought-mediated control of early seedling developmeng. Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitiv parameters including proline content, water loss, membrance ion leakage and the expression of dehy-dration stress-relat genes. ARZF1 is a functional E3 ubiquitin ligase, and its conserved C3H2C3-type RING domain is likely important for the biological function of AtRZF1 in drought response. Together, these results suggest that the E3 ligase AtRZF1 is an important regulator of water deficit stress during early seedling development.

층상구조 산화물 Na_(x)Ni_(x/2)Ti_(1-x/2)O₂의 합성과 구조적 특성

신유주,곽지현 가톨릭대학교 자연과학연구소 1998 자연과학논문집 Vol.19 No.-

층상구조 산화물 Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤X≤1.0)이 고상합성법에 의해 Ar 분위기하에서 950℃-1100℃로 가열하여 합성되었다. 단일상 영역은 0.75≤x≤1.0에서 rhombohedral(O3), 0.60≤x≤0.75에서는 primitive hexagonal 상(P2)으로 결정되었고, x<0.60은 층상구조와 함께 pruderite 구조상이 공존하는 혼합상 영역이었다. 격자상수 a는 x가 감소함에 따라 단순감소 하였고 c는 반대로 증가하는 것이 관측되었는데 이는 Ni^(2+)와 Ti^(4+) 이온 반경의 차, (Ni/Ti)O₂ 층간의 정전기적 반발력, (Ni/Ti)O_(6) 정팔면체의 trigonal distortion 정도와 관련지어 논의되었다. O3에서 P2로의 구조전이 과정은 (Ni/Ti)-O와 Na-O간 경쟁적인 공유-이온 결합성의 변화에 기인하는 것으로 이해되었다. Na_(0.67)Ni_(0.33)Ti_(0.67)O₂의 경우 Rietvelt 분석법을 이용하여 그 결정구조를 결정하였다. Layer-type oxides Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤x≤1) have been prepared for the first time by solid-state reaction by heating the appropriate mixtures of starting materials at 950℃-1100℃ under Ar ambience. Two consecutive single phases were observed, rhombohedral(03) phase for 0.75≤x≤1.0 and hexagonal one(p2) for 0.60≤x<0.75, and a mixed-phase appeared including pruderite phase with x<0.60. Lattice parameter a decrease with x, while c increases as x diminishes. Such behaviors have been discussed on the basis of the difference of ionie radii between Ni^(2+) and Ti^(4+), the electrostatic repulsion of (Ni/Ti)0₂ slabs and the evolution of trigonal distortion of (Ni/Ti)0_(6) octahedra. Structural transition from 03 to P2 has been understood due to the competitive iono-covalency between (Ni/Ti)-0 and Na-0 bonds. As for Na_(0.67)Ni_(0.33)Ti_(0.67)O, the crystal structure has been determined by the Rietveld profile-analysis method.

Systemic Lupus Erythematosus를 동반한 Multiple sclerosis

이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.

우울 증상을 수반한 만성 정신분열병 입원환자에서의 Paroxetine 효과 : 이중맹검 위약대조 연구

한평주,백영석,오상우,전현태,김지영 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 우울 증상이 있는 만성 정신분열병 환자를 대상으로 항정신병약물과 항우울제인 paroxetine 20mg을 병합 투여하여 우울 증상, 양성 증상, 음성 증상 및 일반적인 정신병리의 호전 여부를 밝히고자 하였다. 방법: DSM-IV 기준상 정신분열병으로 진단된 입원환자 중 우울 증상이 있는 49명을 대상으로 parox-etine과 위약을 이중맹검을 대조한 전향적 임상 연구로서 Hamilton Rating Scale for Depression (HRSD), Brief Psychiatric Rating Scale(BPRS), Positive and Negative Syndrome Scale (PANSS), Extrapyramidal Symptom Rating Scale(ESRS), UKU side effect rating scale(UKU), Clinical Global Impression(CGI)을 기저선과 1주, 2주, 4주, 6주의 시점에서 다섯 번 반복 측정하여 비교 검토하였다. 결과: 36명의 환자가 6주간의 실험을 마쳤다. Paroxetine군과 위약군을 비교해볼 때 HRSD 총점은 양군에서 의미있게 감소되어(p<.01) 우울 증상이 호전되었으나, 두 군간에 통계적으로 의미있는 차이는 없었다. 시간경과에 따라 항우울 효과는 paroxetine 군에서는 2주, 위약군에서는 4주 후부터 관찰되었다. 그리고 paroxetine군과 위약군 모두 PANSS 총점(p<.01)과 CGI 점수(p<.05)가 감소되어 전반적인 정신병리의 감소와 전체적인 임상적 호전을 보였으나, 두 군에서 양성 증상, 음성 증상, 일반적인 정신병리 그리고 약물 부작용은 유의미한 차이가 없었다. Paroxetine군에서 반응군고 비반응군으로 나누어 비교했을 때, 반응군이 비반응군보다 HRSD의 총점(p<.01)과 우울한 기분, 자살, 정신적 불안, 죄채감의 세부 항목에서 유의한 호전을 보였고(p</01),일과 활동, 초기 불면증, 건강염려증의 세부 항목이 호전되어(p<.05) 현저한 우울 증상의 호전을 보였다. 또한 반응군이 비반응군보다 BPRS 총점(p</01)과 PANSS의 일반적인 정신병리 점수(p<.05)가 낮게 나와, 일반 정신병리의 호전을 보였다. 결론: Paroxetine군과 위약군 모두에서 우울 증상의 감소가 있었지만, paroxetine군에서 항우울 효과가 빠르게 나타났다. 두 군간에 양성 증상, 음성 증상, 일반적인 정신병리와 부작용에 대한 차이는 없었다. Paroxetine군에서 반응군은 비반응군보다 우을 증상과 일반적인 정신병리에서 유의한 호전을 보였다. 즉 우울한 기분, 자살, 정신적 불안, 죄책감, 일과 활동, 초기 불면증, 건강염려증이 심한 정신분열병 환자에게 우울 증상을 회복시키는데 paroxetine 20mg의 병용 투여가 효과가 있었다. Objectives: This double-blind placebo-controlled study was conducted to demonstrate the improvement of depressive, positive and negative symptoms, and general psychopatholgy in depressed chronic schizophrenic inpatients with adjunctive paroxetine 20mg therapy in the morning. Methods: Forty nine chronic schizophrenic inpatients with depressive symptoms were randomly received adjunctive paroxetine of placebo for 6 week study period. Therapeutic effect and side dffects were evaluated by means of the Hamiltom Rating Scale for Depression(HRSD),The Brief Psychiatric Rating Scale(BPRS), the Positive and Negative Syndrome Scale(PANSS), the Extrapyramidal Symptom Rating Scale(ESRS), the UKU side effect rating scale(UKU), and the Clinical Global Impression(CGI) at baseline, first, second, forth, and sixth week of treatment in a controlled double-blind design. Results: 18 patients completed six weeks of paroxetine therapy, and 18 patients placebo therapy. 1) Comparison between paroxetine and placebo groups: (1) HRSD total scores in both groups were significantly decreased(p<.01) but there was no statistically significant difference between 2 groups. This study showed that significant effect in paroxetine group appeared at 2nd week of treatment(p<.01), while in placebo group at 4th week of treatment(p<.01). (2) PANSS, BPRS< CGI, ESRS, and UKU : In both groups, PANSS total scores and CGI scores were significantly decreased respectively(p<.01, p<.05) and thus indicated th im-provement of global psychopathology and entire effects. There were no significant differences between 2 groups in positive, negative symptoms, general psychopathology, and drug side effects. 2) Comparison between responding and nonresponding groups in paroxetine adjunctive therapy : (1) Compared with nonresponding group, responding group had significant decrease in HRSD total score(p<.01), in HRSD subitems such as depressed mood, suicide, psychic anxiety, and feelings of guilt(p<.01), and in other subitems such as work and activity, early insomnia, and hypochondriasis(p<.05). (2) Compared with nonresponding group, responding group had significantly decrease in BPRS total score(p<.01) and in general subscale of PANSS(p<.05). Conclusion: The results suggest that both paroxetine and placebo groups were improved in depressive symptoms, but paroxetine group had more rapid improvement than placebo group. There were no significant differences in positive symptoms, negative symptoms, general psychopathology, and drug side effects between two groups. Compared with nonresponding group in paroxetine adjunctive therapy, responding group had significant improvement in depressive symptoms and general psychopathology.

무선 ATM에서의 동적 슬롯 할당 알고리즘

이지현,유소영,서주하 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

In recent years, the predominant part in telecommunications is mobile communications. The next generation network is extending today's voice-only mobile networks to multi-service networks. ATM Network is possible to carry such multi-media traffic and it will be expect to use wireless ATM for the future mobile access network. One of manly important aspects for the performance of wireless ATM is the Medium Access Control (MAC) protocol. The MAC protocol must be able to satisfyingly handle the different ATM services (CBR, VBR, ABR and UBR) with their radically different performance requirements. Additionally, the MAC protocol must be able to cope with the complex radio environment where fading, multi-path propagation interference and burst-errors further complicate the situation. In this paper, a dynamic slot allocation algorithm in wireless ATM is proposed for an efficient channel sharing/media access at the MAC layer. We use equivalent capacity in the allocation of slots for VBR traffic which is variable along the time. It is simple and effective slot allocation method for VBR service. In particular, we consider the slot allocation of a session consisted of several connections for requirement of multimedia traffic. Simulation shows that the cell loss ratio is reduced by re-allocation of extra slots in Mobile Terminal (MT).