정신분열증환자에서 Haloperidol과 Reduced Haloperidol 사이의 상호변환에 있어 Haloperidol Reductase에 관한 연구

김민정,정은기,오동열,김이영,양병환 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5

Haloperidol is metabolized through reductation by the enzyme haloperidol reductase at the benzylic ketone to form an alcohol metabolite, known as reduced haloperidol. The basic and clinical pharmacology of reduced haloperidol and also haloperidol reductase is the main subject of haloperidol study, as the reduced metabolite can be converted back to the parent drug which has some neuroleptic effect. This study was undertaken to investigate correlations between haloperiol reductase activity in RBC and reduced haloperidol formation, also the difference of haloperidol reductase activity between responding and nonresponding schizophrenic patient. The results were as follows : 1) The haloperidol reductase activity of schizophrenic patients in RBC at 2 weeks was 12.8±4.3ng/30 min/200ul RBC, 16.0±11.9 at 4 weeks and 22.3±71 in control group. There was statistically significant difference of haloperidol reductase activity in RBC between schizophrenic patient and control group at 2 weeks but no difference at 4 weeks. 2) We divided the patient into responding and nonresponding group by the percentage of improvement in total BPRS score as more or less than 31% respectively and there was no significant difference of haloperidol reductase activity in RBC among two groups. 3)) There was no significant relationship between haloperidol dose of administration and haloperidol reductase activity in RBC. Considering the above results, haloperidol reductase activity in schizophrenic patients showed different results according to the duration of drug administration, so the study which deal with the factors, influencing the activity of haloperidol reductase, should be undertaken in the future.

측두엽 간질의 선택적인 후대뇌동맥 Sodium Amytal 검사 2예

이경열,김옥준,서범천,이병인,김원주 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

생활체육활동 참가유형 및 정도와 건강관리 특성의 관계

김환섭,이은석,유병열 한국레크리에이션 교육학회 1999 한국여가학회지 Vol.1 No.1

The purpose of this study was to analyze the relationships among participation degree and pattern on leisure sports and the characteristics of health care. The subject of the study was selected by multi-stage stratified cluster random sampling among the sports center and sports club to participate sports program whose age were 20-60 year old among inhanitant the Seoul metropolitan area. The data were collected through a questionnaire adapted from Payne and Hahn's (1986) ‘Understanding Your Health-A personal profile; Evaluating Your Health’. The pilot test was executed after the questionnaire was translated into Korean. The statistics employed the study were validity and reliability test, χ2 verification, frequency, ANOVA, multiple classification analysis, ANCOVA and Multiple Regression Analysis. The results that were derived form these processes were as follows. 1. There is partial difference according to the participation patterns of Leisure Sports. There were differences according to stress managent, physical fitness, social relationship, nutrition, drinking, smoking, drug use care, health comsummersion. 2. There is a partial difference according to the dimensions of Leisure Sports. There were differences according to physical fitness, social relationship, nutrition, drinking, smoking, drug use care, heredity.

항정신병약물로 유발된 추체외로증상에 대한 Amantadine과 Benztropine의 효과비교

오동열,양병환,김상욱 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

Clinically anticholinergic antiparkinsonian drugs are the most commonly used medication in drug induced extraphramidal symptoms treatment, and amantadine, a drug developed as an antiviral agent, also is known to be effective in drug induced extrapyramidal symptoms. A double blind cross-over study was performed to compare the effect between amantadine and benztropine on drug induced exptrapyramidal symptoms. The subjects was 32 female schizophrenic patients who developed exprapyramidal symptoms after discontinuing antiparkinsonian drug medication. The procedure was proceeded for a period of 5 weeks using KiMascio extrapyramidal symptom rating scale and Simpson & Angus extrspyramidal symptom rating scale. The results are as followings; 1) Both amantadine and benztropine had significant effect on exprapyramidal symptoms na dno difference in effectiveness was found between the two drugs. 2) Amantadine and Benztropine were effective in extrapyramidal symptoms from the 1st and 3rd day except for dystonia. 3) Both drug were effective in dystonia, but did not show the significant effect on dystonia as far as duration of use is concerned.

DSM-Ⅲ-R 성격장애 진단의 내용타당도

양병환,조연규,김창현,황순택,오동열 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.2

The purpose of this study was to examine the content validity of DSM-Ⅲ-R personality disorder(PDs). A 3-point rating scale of 150 preliminary diagnostic criteria including 95 DSM-Ⅲ-R PD diagnostic criteria was sent to psychiatrists. Each item in this scale was rated by psychiatrists(n=101) in term of prototypicality to every DSM-Ⅲ-R PD. The results show that each PD criteria set of DSM-Ⅲ-R was registered high level of interrater consistency and items listed in the DSM-Ⅲ-R were, for the most part, rated as very prototypical to their DSM-Ⅲ-R diagnosis. Some criteria were, however, not rated to characteristic features to their DSM-Ⅲ-R diagnosis. 11 items of DSM-Ⅲ-R diagnostic criteria scored high not only to their DSM-Ⅲ-R diagnosis but also other diagnosis. 16 items rated as high prototypicality item of other diagnosis. Another 16 items seemed not to be appropriate to any of DSM-Ⅲ-R PD diagnosis. These results suggest that the content validity of the DSM-Ⅲ-R personality disorder is not so high.

말초혈액 내 백혈구수와 대사증후군과의 연관성

황상태,김범수,황상준,서정열,김병진,이원영,성기철,강진호,김선우,이만호,박정로 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

교육대학 학생을 위한 초등학교 성교육 지도자료 개발

송광용,김지자,유병일 서울敎育大學校 學生生活硏究所 2003 學生生活硏究 Vol.28 No.-

본 연구는 교육대학의 성교육에 대한 이론적 기초를 확립하여 예비교사들로 하여금 성에 대한 바람직한 이해와 전인적인 성장이 가능하도록 도울 수 있는 체계적 성교육의 틀을 제시하기 위한 목적으로 이루어지게 되었다. 이를 위해서 성에 대한 다양한 이론적 배경 고찰, 국내외 초등학교에서의 성교육 실시 사례 분석, 교육대학생을 위한 성교육 지도자료 및 구체적 성교육 내용 등을 중심으로 연구가 수행되었으며, 주요 결과들을 요약하면 다음과 같다. 우리나라 초등학교 성교육은 주로 보건교사들이 담당함으로써, 시수의 확보에서나 일반 학생지도에서 통합적으로 이루어지지는 못하고 있으나 성교육 지도의 전문성이 확보된다는 면에서 장점을 지니고 있다. 그러나, 현실적으로 일선 초등학교에서 한 명의 보건교사가 학교 전체 학생들을 대상으로 성교육을 하기에는 무리가 따르므로, 담임교사가 성교육 연간 시수의 일부 시간을 분담, 의뢰받아서 성교육을 담당하고 있는 것으로 나타났다. 그러므로, 초등학교에서 성교육을 제대로 실행하기 위해서는 먼저 모든 교사들이 그 지도내용과 수업운영에 대해 충분히 숙지할 수 있도록 해야 된다고 보여진다. 미국의 성교육은 주에 따라서 또는 학교에 따라서 다양하며 1988년부터 국가에서 AIDS 확산과 10대 임신을 방지하기 위해서 기존의 교육과정에 성교육을 통합적으로 가르치도록 교육기관에 기술적, 재정적 지원을 해오고 있다. 캘리포니아 주의 학교 성교육을 살펴보면, 학교에 배치된 간호사와 주 소속 보건통계의 교육훈련 연구팀에 의하여 실시되었으나, 최근 들어 교육 예산의 절감으로 여러 개의 학교를 한사람이 담당하게 되는 학교 구 담당 간호사들이 학교를 방문하여 보건교육과 더불어 성교육을 실시하고 있다. 성교육 시행 횟수는 한 학기에 1회 이상을 목표로 하되 대상을 학년별로 또는 남녀학생을 별도로 하여 실시한다. 한편, 학교 성교육 실시에 대한 미국 사회의 분위기는 대체로 보수적이어서 학생들의 학교 성교육 시간에 참여 가능 여부를 사전에 학부모에게 통보하여 동의서를 받아오는 학생에 한하여 교육을 받도록 하고 있다. 일본의 성교육은 원조교제의 저연령화와 어린이 성폭행 사건의 증가 등의 사회적 문제로 인하여, 1999년부터 일본 문부성이 제작한 "성교육의 사고와 진행방식"이라는 지도자료를 중심으로 유치원, 초, 중, 고등학교에서 조직적으로 실시할 수 있도록 장려하고 있다. 대부분의 초등학교에서는 성의 생리학적, 심리적, 사회적 측면을 포함하는 폭 넓은 인간교육을 지향하는 성교육 부독본을 교재로 채택하고 있으며, 6년간 교육과정에서 약 12시간 정도를 성교육 시간으로 할애하고 있다. 일부 학교에서는, 저학년과 여아 아이들을 대상으로 하는 첫 월경교육의 경우 부모들이 수업참관을 실시하여 그 반응을 참고로 성교육의 충실성을 도모하기도 한다. 국내외 초등학교 성교육 실시 사례들을 종합해 볼 때, 성교육의 내실을 다지기 위한 학교와 학부모간의 협력체제 구축 노력 뿐만 아니라 국가적 차원에서의 중요성 인식과 더불어 성교육 과정 및 프로그램 개발, 성교육 관련 연구 등에 국가차원에서의 적극적인 지원이 일부 이루어지고 있음을 볼 수 있다. 우리나라의 초등학교 성교육이 보다 내실있게 이루어지기 위해서도 이와 같이 성교육 교육과정과 성교육 프로그램 및 자료들이 충분히 개발되고 검증될 수 있도록 보다 적극적이고도 지속적인 지원 노력이 요구된다고 보여진다. 끝으로, 본 연구에서는 남녀의 신체적, 심리적 특성을 이해함으로써 긍정적인 자아개념의 형성과 원만한 사회 생활 영위, 양성 평등의 성역할을 이해함으로써 책임있는 성행동을 하도록 한다는 교육인적자원부의 성교육 목표를 기초로 하여, 초등학교 성교육의 영역과 내용 및 성교육 지도 프로그램의 실제 등을 구체적으로 제시함으로써 예비교사들의 성교육 내용에 대한 보다 체계적이고도 심회된 이해를 도모하고자 하였다 As the problems of sexual harassment among teenagers have increased rapidly, the school has focused on developing prevention program. As a result, many publications related on sexual harassment that can use on class is appearing. Like a most social problem, the sexual harassment have an emphasis on prevention than after treatment. Now, we have to emphasize on systematic sexual education for every class of school. The purpose of this study is to develop the basic theoretical sexual education at the university of education, therefore future teachers comprehend about well organized sexual education. Due t this purpose. We researched various factors such as different theoretical inquiry, domestic and foreign sexual education that have been taken place, teaching material of sexual education for the students of university of education and content of core sexual education. The summary of significant result is following sentences. The domestic sexual education in elementary school is not based on the teacher who is on charge of class, the teacher of preservation of health is taking care of sexual education, it ensures the professional teaching method for students. however, it is difficult to manage the time schedule for all the elementary school. In a reality, it is difficult to apply on count of lack of professional teacher of preservation of health. In accordance, school teachers are teaching classes some part of annual time schedule. For those reasons, the school teachers hsould educate themselves familiarity on the subject. In the United States, sexual education has been practiced in variety way in compliance with States or school. The nation has supported sexual education to prevent spread of AIDS and teenager pregnancy. According to the California State's sexual education system, there is not a cast that teachers are teaching sexual education for their classes. The sexual education was taught by professional teacher from preservation of health. However, the system is changed to one professional teacher taking care of several school since the cutback of State budget. The number of classes will be more than on time per semester. The education class will be divided to grade or sex. The atmosphere of society toward sexual education taking place in school is conservative therefore the school teaches only students who have permission from their parents about sexual education. In Japan, there are numerous social problems related with increasing sexual harassment such as prostitution of teenagers. In addition, the government encourages organized education in kindergarten, primary, middle, and high school with a text book which is produced by Education department of japan, called "Cognition and Process of Sexual Education". A large percent of primary school takes a supportive moral human nature supplementary reader that include biological, psychological, and social sexual education. It takes 12 hours of 6 years curriculum, some portion of primary school may make class subject to lower grade and female student teach women period. They also invite students' parents to accommodate the devotion if education. In summary, not only to make an effort to unite parents of students and school is important but also government's effort to support the development of programs and research of sexual education is important. The domestic elementary school needs advanced research, program, and textbook of sexual education to make our education more efficient. In order to achieve this, we need more supportive government policy. This study is based on the Education department of Republic of Korea's policy that makes young generation to understand the difference between male and female physically and psychologically so that they can be adaptive and responsible to society. This study was designed to help students of university of education to understand systematically about the content and domain of elementary sexual education. An on the job teachers, parents, and the school administrators are concerned with the essential of sexual education in elementary. However, there are actual issues fromm misunderstanding among the teachers that cause the narrow knowledge on sexual education to students. The domestic sexual education need continuous support to improve program that an on the job teachers and future teachers can use it for real.

정신분열장애환자의 할로페리돌혈청농도와 임상반응에 관한 연구

오동열,양병환,김광일,정하승 漢陽大學校 精神健康硏究 1989 精神健康硏究 Vol.8 No.-

주요우울증에서 우울과 불안 증상의 심각도에 따른 뇌파 A1,A2, Percent 비대칭 지표들의 특성 연구

이준석,양병환,오동열,김기성 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objectives : In this study we investigated characteristics of asymmetry pattern of EEG in patients with major depressive disor-der according to the severity of depression and anxiety symptoms, employing A1, A2, and Percent (PCT) asymmetry indices. Methods : Subjects involved in this study were 11 healthy controls and 11 patients with major depressive disorder who have taken no medicines for four weeks just before the study. These subjects were selected so that the two groups can have no difference in gender and age. Beck Depression Inventory (BDI), 17-item Hamilton Depression Rating Scale (HDRS), Zung's Self-Rating Depression Scale (SDS) and Spielberger's State-Trait Anxiety Inventory (STAI) were used to evaluate depression and anxiety symptoms, respectively. Resting EEG was recorded &om F3, F4, C3, C4, T7, T8, 01 and 02 electrode sites. Results : The temporal region showed a difference in A1, A2, and PCT asymmetry indices between the depression group and the control group. Frontal (F3, F4) and temporal (T7, T8) regions showed correlation between STAI-T score and A1, A2, and PCT asymmetry indices. Conclusion : The results of this study showed that EEG A1, A2, and PCT asymmetry indices can be used as useful indices for depression. Also, it was found that trait anxiety had influence on A1, A2, and PCT asymmetry indices.

광주 근교산 붕어의 아미노산 및 지질성분의 분석

李蓮玉,朴貞淑,金忠模,李炳燮,李明烈 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

광주 근교산 붕어의 일반성분, total amino acid 및 free amino arid를 HPLC로 분석 그리고 유리지질과 결합지질을 추출하고 이를 각각 column chromatography에 의하여 중성지질, 당지질 및 인지질로 분획한 다음 이를 각 지질의 구성 지질을 TLC scanner, GC 등으로 분리 정량한 결과는 다음과 같다. 1. 붕어의 조단백질은 5.6%, 조지방은 5.4% 이었다. 2. 총 아미노산 및 유리아미노산은 17종이였으며, 총아미노산은 glycine이 많고 유리아미노산은 arginine이 많이 함유되어 있으며, 필수아미노산량은 총아미노산량의 약 28%를 차지하였다. 3. 총지질 중 유리지질이 5.2% 및 결합지질이 0.2%가 함유 되었으며 유리지질을 구성하는 지질의 함량을 중성지질 81.2%, 인지질 25.5%, 당지질 1.3%로 구성 되였으며 결합지질에는 중성지질 25.5, 인지질 70.0%, 당지길 4.5%로 구성되었다. 4. 유리 및 결합지길 중의 중성지질로는 monoglyceride, diglyceride, free sterol, fatly acid, triglyceride, esterified sterol 등이 분리 동정 되었으며 이중 triglyceride가 유리지질에 82.8%결합지질에 46.1%로 가장 많이 함유되었다. 5. 유리지질과 결합지질을 구성하는 인지질로는 phosphatidyl choline, lecithin, phosphatidylglycerol, phosphatidyl serine, steryl glycoside+phosphatidyl ethanolamine 등이 분리동정 되었으며 유리지질의 경우 phosphatidy1 choline이 2.8%, 결합지질에는 lecithin이 43.5%가 함유되었다. 6. 총지질을 구성하는 주된 지방산은 C_16, _OC18 1의 함량이 가장 많았으며 중성지질은 C_18 2의 함량이 높았으며, 당지질은 유리지질이 C_14 1, C_20 1이 다량 함유되어 있으며 결합지질은 C_20 4,C_18 1이 다량 함유되어 있다. 인지질의 지방산 조성은 C^19_0이 다량 함유되어 있으며 특히 결합지질에는 C_22 6이 다량 함유되어 있다. Approximate compositions, total amino acids and free amino acid, and the isolation and identification of fatty acids in Carassius auratus were analyzed by high performance liquid chromatography, thin layer chromatography and gas chromatography. The results are; Carassius auratus contained 73.8% water, 5.6% crude protein and 5.4% crude fat. 17 kinds of total and free amino acids were analyzed, respectively, glycin is the richest in total amino acids and arginine in free amino acids and total amounts of the essential amino acid were about 28% of total amino acids. Total lipid was contained 5.2% free lipid and 0.2% bound lipid. Free forms and bound forms were mostly consisted of neutral lipids(81.2%) and phospholipid(70.0%), respectively.