입원한 알코올 의존 환자의 임상적 특성 및 Aldehyde Dehydrogenase II와 Arylsulfatase A 유전자 다형성

정인원(In-Won Chung),홍주봉(Joo-Bong Hong),이상익(Sang-Ick Lee),김 헌(Heon Kim),손정우(Jung-Woo Son) 한국중독정신의학회 2000 중독정신의학 Vol.4 No.2

Aldehyde dehydrogenase II (ALDH2) and arylsulfatase A (ASA) gene polymorphisms were explored for the association of alcohol dependence and/or its clinical characteristics. Polymerase chain reaction and restriction fragment length polymorphism were used to determine the genotypic and allelic frequencies of 128 male hospitalized alcoholic patients who met DSM-IV criteria for alcohol dependence and 128 agematched healthy male control subjects. The ALDH2 genotypic frequencies in alcoholic patients were 0.992 (NN), 0.008 (ND), and 0.000 (DD), which were significantly different from those of control subjects (0.484, 0.430, and 0.086, respectively). The ASA genotypic frequencies at the pseudodeficient Nglycosylation and polyadenylation sites showed grossly no differences between alcoholic patients and control subjects. There was no association between genotypic distributions of ALDH2 and ASA and clinical characteristics of alcohol dependence. These results suggested that the D allele of ALDH2 gene has a protective role against alcohol dependence. The further extensive researches for the relationship between alcohol dependence and the pseudodeficient ASA gene polymorphisms are required.

20대 한국 직장인의 음주 심각도에 대한 직무 스트레스와 BDNF 유전자 다형성의 역할

김보아,이상익,김시경,신철진,손정우,홍주봉,남영우,주가원,Kim, Bo-Ah,Lee, Sang-Ick,Kim, Sie-Kyeong,Shin, Chul-Jin,Son, Jung-Woo,Hong, Joo-Bong,Nam, Yeong-Woo,Ju, Ga-Won 대한생물정신의학회 2012 생물정신의학 Vol.19 No.2

Objectives : The aim of this study was to examine the effects of brain-derived neurotrophic factor (BDNF) genetic polymorphism and job stress on the severity of alcohol drinking. It was hypothesized that individuals with the Met/Met BDNF genotype would be more vulnerable than those carrying the Val allele. Methods : Participants were 133 healthy Korean adults (mean age $28.2{\pm}1.1$). Job stress and the severity index of drinking were investigated through self-reported questionnaires. BDNF (rs6265) gene was genotyped. Results : There was no significant association between job stress and the severity of alcohol drinking. Although the severity of alcohol drinking was not associated with BDNF genetic polymorphism, there was a significant difference in men according to genotype and job stress. Men with homozygous BDNF Met allele were more severe in alcohol drinking when job stress was high, less severe in alcohol drinking when job stress was low than those carrying the Val allele (F = 4.47, p = 0.038). Also higher level of job stress was correlated with higher severity of alcohol drinking in men homozygous for BDNF Met allele (rs = 0.620, p = 0.005). Conclusions : These findings suggest the possibility that Met allele could have differential susceptibility, with men homozygous for BDNF Met allele being more susceptible to both more adverse and less adverse environmental influences.

입원 중인 알코올 의존 환자의 자아주체성

송양순(Yang Soon Song),안병은(Byong-Eun An),지경환(Kyung-Whan Chi),홍주봉(Joo-Bong Hong),황상종(Sang-Jong Hwang) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.1

Objective:The purpose of this study was to investigate the difference between alcoholic patients and normal controls on ego identity, depression, anxiety. Methods:We compared 72 alcoholic patients who were admitted to Gongju National Mental Hospital and Daejeon Hanmaum Hospital with 74 controls. All subjects are assessed by Dignan’s ego identity scale and Zung’s self rating anxiety scale and Depression scale and only controls are assessed by CAGE. Results:Results were as follows 1) In comparisons with controls, alcohol dependent patients showed significant lower scores in the total scores of Dignan’s ego identity scale and the items of stability, interpersonal relationship, self acceptance, self assertion, and sense of self. 2) Alcohol dependent patients had significant higher scores in Zung’s self rating Anxiety scale and Zung’s self rating Depression scale than controls 3) Ego identity had negative correlations with anxiety and depression. Anxiety had positive correlations with depression. 4) In alcohol dependent patients, ego identity did not developed to age and stagnated. Conclusion:As described in about study results, alcohol dependent patients had lower ego identity and unstable self-concept and sense of self. Therefore, while psychosocial treatments of alcohol dependent patients have been practiced, intervention about both ego identity and depression and anxiety is needed to improve treatment outcome of such patients.

정신과 외래 우울증 환자에서 분노 경험

안병훈(Byung-Hoon Ahn),지익성(Ik-Seung Chee),왕성근(Seong-Keun Wang),홍주봉(Joo-Bong Hong),박권수(Kwon-Soo Park),김영란(Young-Lan Kim),김정란(Jeong-Lan Kim) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: This study was conducted to evaluate the degree and type of anger experienced by patients with depressive disorders and to determine which type of anger is correlated with symptom severity. Methods: One hundred-six psychiatric outpatients with depressive disorders and ninety normal control subjects completed the Korean version of Aggression Questionnaire(AQ) and Korean version of Depression, Anxiety, and Stress Scale (DASS). Comparison between two groups was conducted to evaluate which type of anger are prominent in the depressed group. Therefore, correlation and partial correlation between the scores of 4 subscales(Anger, Hostility, Verbal aggression, and Physical aggression) of AQ and the scores of 3 subscales(Depression, Anxiety, and Stress) of DASS were assessed. A multiple regression analysis was performed to determine which type of anger predicted symptom severity. Results: Total AQ score, hostility, anger and physical aggression scores were significantly higher in patients with depressive disorders. After the score of Stress and Anxiety subscale of DASS were controlled; the depression score was significantly correlated with total AQ score, physical aggression and hostility score. The Hostility score was a major predictor of the depressive symptom severity. In addition, the Anger score was a major predictor of the anxiety and stress symptom severity. Conclusion: Anger is frequently found symptom in patients with depressive disorders. Therefore, it is important that clinicians routinely evaluate the degree and type of anger in patients with depressive disorders.

초발정신분열병

홍주봉,정인원 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.2

초발(first episode)정신분열병에 대한 연구는 다음과 같은 장점을 가지고 있다. 1) 정신분열병의 질병경과에 의해 생긴 문제나 약물치료에 의해 생기는 교란효과를 최소화 할 수 있으며, 2) 발병시기에 질병의 원인이나 정신병리학적으로 중요한 역할을 하는 생물학적 또는 심리적 요인을 찾아낼 가능성이 높으며, 3) 원인, 경과, 예후에 대한 전향성 연구를 할 기회를 가질 수 있다 그래서 이런 장점들 때문에 초발정신분열병에 대한 연구가 활발해지고 있다. 저자들은 이 초발정신분열병에 대해 연구한 결과들을 정리해 정신분열병을 좀더 이해하는데 도움이 되고자 하였다. 이 소고에서는 만성정신분열병과 비교하여 초발정신분열병의 자연적 경과, 뇌의 형태와 기능, 예후를 알아보았다. Study of first episode schizophrenia has several advantages; 1) the confounding effects of chronicity and pharmacotherapy can be minimized, 2) the biological or psychological fators that are etiologically or pathophysiologically significant may be detected more at illness onset, 3) the opportunity to carry out prospective studies of biology, course, and outcome can be increased. The natural course, brain dysfunction, and outcome in first episode schizophrenia were reviewed in comparison with multiple treated schizophrenia.

알코올 의존과 후보 유전자들간의 연관성 연구

정인원,김헌,홍주봉,지경환,이규영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 알코올 대사와 중추신경계내의 알코올 작용부위와 관련한 일부 후보유전자들이 알코올 의존과 관련이 있는지를 확인하고자 하였다. 방 법 : DSM-IV로 진단된 알코올 의존 환자 128명과 정상 대조군 128명을 대상으로 후보 유전자들의 다형성을 중합효소 연쇄반응과 제한효소처리법을 이용하여 동정하였다. 여기서 분리된 대립유전자와 유전자형에 따른 빈도의 차이를 유전자별로 각각 비교하였으며, 알코올 의존에 작용하는 서로 다른 유전자들에 의한 영향력을 배제하기 위하여 logistic regression 분석을 적용하였다. 결 과 : 알코올 의존군에서는 ALDH_2 유전자의 NN(wild type)형이 정상대조군에 비하여 유의하게 많았다(chi-square test, p<0.001). logistic regression analysis를 통하여 다른 유전자들에 의한 영향을 보정한 상태에서 ALDH_2가 NN(wild type)인 경우 다른 아형에 비하여 알코올 의존에 대한 odds ratio는 130.312이며 그 신뢰구간은 (17.22, 986.43)이었다. 한편, ASA는 N-glycosylation 부위에 변이형 대립유전자를 갖고 있는 경우(AG or GG)는 wild type에 비하여 알코올 의존에 대한 위험도는 2.344배이며 그 95% 신뢰구간은 (1.128, 4.871)이었다. 결 론 : 알코올 의존과 ALDH_2 유전자간에는 밀접한 연관성이 확인되었다. 또한 다른 유전자들은 개별 연관분석에서 의미있는 연관성이 관찰되지는 않았지만 logistic regression analysis를 통하여 N-glycosylation 부위에 다형성이 있는 ASA 유전자가 알코올 의존과 관련이 있음을 시사하였다. Objectives : This study was to explore the association between alcohol dependence and five candidate genes related to the metabolism of alcohol and the enzymes of the suspected sites in CNS. Methods : The genotype and allele frequencies of five candidate genes in 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 age-matched healthy male control subjects using polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was applied in order to exclude the reciprocal interactions among five candidate genes. Results : The NN genotype frequency of the ALDH_2 gene was significantly higher in alcoholic patients than in control subjects(chi-square test, p<0.001). No difference in frequency was found in the other four genes. In a logistic regression analysis, the odds ratio for alcohol dependence in the NN genotype of the ALDH_2 gene and AG or GG genotypes of the N glycosylation site on the ASA gene were 130.312(95% confidence interval, 17.22-986.43) and 2.344(95% confidence interval. 1.128-4.871), respectively. Conclusion : The result reiterates the association of the ALDH_2 gene polyporphism and the alcohol dependence. Logistic regression analysis additionally suggested that the N-glycosylation site on the ASA gene was associated with alcohol dependence.