위암의 (胃癌) 통계학적 관찰과 병리조직학적 (病理組織學的) 분류의 문제점에 대하여

홍숙희(Sook Hee Hong),석동수(Dong soo Suk),주종은(Jong Eun Joo),임인숙(In Sook Lim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Total 211 lesions of stomach cancer were collected from the pathology department of the Pusan Paik Hospital during 1979 and 1985. Statistical analysis was carried out showing the following findings; 1) Among the total 211 cancers, male 139 and female 72. The male-female ratio is 2:1. 2) Average age is 52 years, male 54.7 and female 47.5 years old. These figures are 7 years lower than Japanese, and 4 years lower than Americans, clearly suggesting higher carcinogenic agents present in the Korean environment (food). 3) The size of the gastric cancer is 2-5 cm in diameter in the majority of the cases. Those of female are 0.6 cm larger in the average diameter than those of male. 4) The site of the cancer is antrum in half of all cases, the next is body and pylorus. 5) Depth of cancer invasion into the gastric wall shows the serosa the most frequent, 37.4%, the next is subserosa, 28.4%. There was the Early Gastric Cancer in 11% among all cancers of the stomach. 6) Metastasis of the regional lymph nodes was found in 66.8%. The frequency of the metastasis is increasing proportionally with the size of the cancer and the depth of the cancer invasion in the gastric wall. 7) Histopathology of the stomach cancer shows in the following order; poorly differentiated(38.4 %), moderately differentiated(22.7%) and well differentiated(18.5%). Together of these three types consist of 80% of total lesions. There is a distinct difference between male and female on the histological types, for there are 52% in undifferentiated and 48% in differentiated types among male while 72% and 28% among female groups. In average, they are 60% and 40%, respectively. 8) Prominent infiltration of lymphocytes in the stroma is found 2-5% of the cancers. Promenent proliferation of fibrous connective tissue of the stroma is found in 3-9% of the cancers. 9) The distinct difference in female group such as lower age group and more frequent association with undifferentiated form, will be elucidated by genetic disposition, and should be tested by tissue typing. 10) The histopathological classification should be as those of the traditional detailed description of the histopathological types. It will be much benefitcial having a standard classicfication adopted by all institutes of Korea such as the currently adopted method of japanese institutes

증례 : 혈액종양 ; 비인두암 환자 중 동시항암화학방사선요법 후 발생한 단순 헤르페스 뇌염

최혜진 ( Hye Jin Choi ),이지은 ( Ji Eun Lee ),홍숙희 ( Suk Hee Hong ),전은경 ( Eun Kyung Jeon ),이시원 ( Sea Won Lee ),김연실 ( Yeon Shil Kim ),강진형 ( Jin Hyoung Kang ) 대한내과학회 2015 대한내과학회지 Vol.88 No.5

동시항암화학방사선요법 또는 전뇌방사선 치료 등을 시행하는 환자의 경우 면역 반응의 저하로 인하여 HSE가 발병할 확률이 증가하며 임상증상 및 검사 소견이 비특이적이다. 따라서 발열 및 의식 변화가 나타나는 환자에서는 HSE를 감별진단 중 하나로 고려해야 한다. 본 증례에서는 즉각적인 항바이러스 치료에 좋은 반응을 보였으며 비교적 양호한 임상경과를 보인, 동시항암화학방사선요법 시행 중에 병발한 HSE를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. Herpes simplex encephalitis (HSE) is a rare viral encephalitis in adults. A high (70%) mortality rate with serious complications has been reported even after active, appropriate management. The association between HSE and immune suppression is unclear, but there are case reports of cancer patients in which HSE concomitantly developed after whole brain radiation or high-dose steroid treatment. The clinical manifestations and laboratory findings of these patients are atypical compared to the general population. Although brain magnetic resonance images reveal typical HSE findings, cerebrospinal fluid (CSF) analysis might be normal in cancer patients. We report a case of HSE in a 48-year-old male diagnosed with nasopharyngeal cancer and treated with concurrent chemoradiation. This patient had a normal cell count in CSF, but HSE was finally diagnosed from positive polymerase chain reaction test results. After administration of acyclovir and systemic steroid treatment, the patient had a good clinical course with few neurologic sequelae. (Korean J Med 2015;88:602-607)

복막투석 환자에서 gadolinium 사용 후 발생한 콩팥성 전신성 섬유증 1예

구태형 ( Tae Hyoung Koo ),이동현 ( Dong Hyun Lee ),백희경 ( Hee Kyung Baek ),김도경 ( Do Kyong Kim ),김보경 ( Bo Kyung Kim ),홍숙희 ( Suk Hee Hong ),안원석 ( Won Suk An ) 대한내과학회 2010 대한내과학회지 Vol.78 No.4

콩팥성 전신성 섬유증은 급성 또는 만성 신부전 환자에서 gadolinium조영제를 사용하였을 경우에 생기는 질환으로 상하지 말단의 부종 후 딱딱해짐, 관절운동 장애 및 전신증상을 일으키는 질환으로 전세계적으로 증례들이 보고되고 있다. 저자들은 복막투석 환자에서 gadolinium을 사용한 자기 공명영상 촬영 후 하지부종 및 통증을 동반한 nephrogenic systemic fibrosis 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Nephrogenic systemic fibrosis is a systemic illness that only affects patients with kidney failure. Exposure to gadolinium-based contrast agents has been associated with the subsequent development of nephrogenic systemic fibrosis in patients with decreased renal function. Nephrogenic systemic fibrosis is characterized by skin induration after swelling and limited joint movement through a loss in flexibility that preferentially affects the extremities. A 58-year-old man in peritoneal dialysis developed swelling and stiffness of the lower limbs following gadolinium exposure for brain magnetic resonance imaging. This patient was diagnosed with nephrogenic systemic fibrosis by CD34 immunoreactivity of subcutaneous fibroblasts in a skin biopsy. We report, for the first time in Korea, that nephrogenic systemic fibrosis developed after gadolinium exposure in a peritoneal dialysis patient. (Korean J Med 78:507-511, 2010)

소장에 발생한 장관포상기종 ( 보고 )

성영환(Young Haun Seong),이진용(Jin Yong Lee),홍숙희(Suk Hee Hong) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

Pneumatosis cystoides intestinalis, which was first reported by DuVernoy in 1730 from the path- ologic finding at autopsy, is a relatively rare condition characterized by multiple intramural pockets of gas involving any portion of the gastrointestinal tract and occasionally the mesenteric attach- ments. The mean age is 56.6 years old, predominantly in male, involves small bowel frequently and combined with other gastrointestinal lesions in 85g of cases. Treatment is conservative for the symptoms of combined gastrointestinal lesion and chronic obstructive pulmonary disease because of spontaneous regression, but surgery is indicated for the development of complications such as intussusception, volvulus, obstruction, bleeding and perforation. Pneumatosis in adults frequently has a benign course and prognosis, depending upon associated diseases of the gastrointestinal or pulmonary organs. Infantile pneumatosis intestina]is associated with necrotizing enteritis, however, is a more serious condition and has a high mortality rate. Authors report a case of the Pneurnatosis cystoides intestinalis which was treated surgically due to duodenal ulcer with pyloric obstruction and review the recent literature.

류마티스 관절염 환자에서 빈뇨로 발현된 방광의 유전분증 2예

이창재 ( Chang Jae Lee ),최세웅 ( Se Woong Choi ),문승환 ( Seung Hwan Mun ),허정훈 ( Jung Hoon Huh ),김경태 ( Kyoung Tae Kim ),원종진 ( Jong Jin Won ),안원석 ( Won Suk An ),윤성국 ( Sung Kuk Yun ),홍숙희 ( Sook Hee Hong ),이성원 ( 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3

Secondary amyloidosis is characterized by accumulation of an amorphous proteinous material in the various tissue and organs with infectious disease or inflammatory disease. Symptoms of the amyloidosis are variable according to the involved organs. Reactive amyloidosis of bladder in rheumatoid arthritis (RA) is a rare condition with hematuria in the most cases. However, we report two cases of patients with RA, who have frequency due to secondary amyloidosis of bladder without hematuria. Therefore secondary amyloidosis of urinary bladder should be considered as a possible cause of frequency in patients with long-term RA.

甚한 淋巴球浸潤과 多核性巨大細胞를 同伴한 胃癌의 1例

석동수,홍숙희,윤혜경,강현진 대한병리학회 1986 Journal of Pathology and Translational Medicine Vol.20 No.1

위의 염증성 섬유양용종 - 1례 보고 -

윤혜경,석동수,홍숙희 인제대학교 1986 仁濟醫學 Vol.7 No.1

A relatively large inflammatory fibroid polyp of stomach in a twenty-four year old female is reported with its histopathology and the current theory of the etiology.

소아 사시 수술 후 발생하는 오심 및 구토에 대한 Propofol과 Enflurane의 영향

곽상현,정성수,정창영,윤명하,홍숙희 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.1

Introduction : Nausea & vomiting are one of the most distressful events after strabismus surgery in pediatric patients. Propofol is known to reduce the incidence of postoperative emesis. The aim of this study was to compare the influence of propofol to that of enflurane on the postoperative nausea & vomiting after pediatric strabismus surgery. Methods : Forty children scheduled for strabismus surgery were randomly assigned into two groups according to the induction agent and main anesthetics. Propofol group (n=20) received propofol, Enflurane gruop (n=20) thiopental as an induction agent and anesthesia were maintained either propofol- O2-air or enflurane-O2-air. The incidence of postoperative nausea & vomiting was assessed at awakening period, in the recovery room and at the 1st, 2nd day after operation. Operation time, awakening time and the incidence of oculocardiac reflex were evaluated. Results : The operation time was not different between two groups, and the awakening time was shorter in Propofol group than in Enflurane group. Although oculocardiac reflexes were more frequently seen in Propofol group, no cases of postoperative nausea & vomiting were seen in Propofol group. The incidence of postoperative nausea & vomiting was not significantly different between two groups except at the 1st day after operation. At that time, the incidence of nausea was greater in Enflurane group than in Propofol group. Conclusion : These findings indicated that propofol resulted in a more rapid recovery and less postoperative nausea & vomiting than enflurane, but more oculocardiac reflexes were seen in propofol. (Korean J Anesthesiol 1998; 35: 151∼155)

실험동물에서 Lipopolysaccharide와 Thalidomide에 의한 Vascular Endothelial Growth Factor와 Tumor Necrosis Factor-α 발현의 변화

최동락,조창호,정진숙,홍숙희,윤길숙 대한대장항문학회 2004 Annals of Coloproctolgy Vol.20 No.3

성상신경절차단후 진단한 재발성 다발성 연골염

곽상현,정성수,정창영,임웅모,정성욱,홍숙희 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.36 No.6

Relapsing polychondritis (RP) is an uncommon disorder of unknown etiology characterized by inflammation and destruction of the cartilaginous structures of many organs, including the tracheobronchial tree. We experienced a rare case of RP diagnosed after stellate ganglion block. A 56-year-old female has been treated under impression of rheumatoid arthritis and bronchial asthma for several years, but her symptoms were not markedly relieved. We performed right stellate ganglion block with 8 mL of 1% mepivacaine for the relief of the right shoulder pain. About 5 minutes later, she complained severe dyspnea and became cyanotic. Bronchoscopic finding was diffuse bronchoconstriction during expiration. We confirmed the diagnosis of relapsing polychondritis by bronchoscopic biopsy finding. Unfortunately, she died 3 months later due to recurrent pneumonia and acute respiratory distress syndrome. (Korean J Anesthesiol 1999; 36: 1087∼1090)