서울 백병원서의 절제위암의 (切除胃癌) 발생 연령에 관한 연구 : 중촌의 (中村) 공식으로 조사함

석동수(Dong soo Suk),고일향(Il Hyang Ko) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2

N/A A total of 329 cases of gastric cancer from the Seoul Paik Hospital (1974-1987) were anlyzed with the Nakamuras formula to estimate its starting age. (1) Average age at the time of diagnosis 50.9 years old (male 51.1, female 50.7). This figure is 7 years younger and 14 years younger than those of Japanese and Americans, respectively. The differences can be speculated to be the same on the age differences of the cancer clcvcloprnent. Among these three countries. Generally, stronger the carcinogen, the age will become younger. (2) The estimated starting age of stomach cacner shows the highest in 40s age group, 30.7%, followed by 30s (26.1%), and 50s (20.4%). From 31 to 60 years, the figure is 77.2%. Average starting age is 42.5 years in both sex. (3) Interval between the starting age and the diagnosis (latent period) is 8.4 years in average (male 8.6, female 8.2). For the 41 EGC out of 329 stomach cancer, this latent period is 4 years. Therefore, the above 8.4 years will become ever closer to 4 years as early gastric cancer will he detected more in Korea in the future. (4) In coniparison with the age of EGC of Japan (1,300 cases), there are strikingly high percentages in the lower age groups is while low percentages in the upper age groups in Korea. This finding will indicate that Korean environment (traditional food) may cause the cancer more strongly than that of Japan.

한국과 일본의 위암의 역학적 비교 검토

석동수 ( Dong Soo Suk ) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

서울白病院 胃癌 290例의 生物學的 成長樣式에 대한 檢索

石東壽(Dong Soo Suk),高一香(Il Hyang Ko) 대한외과학회 1989 Annals of Surgical Treatment and Research Vol.36 No.1

위암의 (胃癌) 통계학적 관찰과 병리조직학적 (病理組織學的) 분류의 문제점에 대하여

홍숙희(Sook Hee Hong),석동수(Dong soo Suk),주종은(Jong Eun Joo),임인숙(In Sook Lim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Total 211 lesions of stomach cancer were collected from the pathology department of the Pusan Paik Hospital during 1979 and 1985. Statistical analysis was carried out showing the following findings; 1) Among the total 211 cancers, male 139 and female 72. The male-female ratio is 2:1. 2) Average age is 52 years, male 54.7 and female 47.5 years old. These figures are 7 years lower than Japanese, and 4 years lower than Americans, clearly suggesting higher carcinogenic agents present in the Korean environment (food). 3) The size of the gastric cancer is 2-5 cm in diameter in the majority of the cases. Those of female are 0.6 cm larger in the average diameter than those of male. 4) The site of the cancer is antrum in half of all cases, the next is body and pylorus. 5) Depth of cancer invasion into the gastric wall shows the serosa the most frequent, 37.4%, the next is subserosa, 28.4%. There was the Early Gastric Cancer in 11% among all cancers of the stomach. 6) Metastasis of the regional lymph nodes was found in 66.8%. The frequency of the metastasis is increasing proportionally with the size of the cancer and the depth of the cancer invasion in the gastric wall. 7) Histopathology of the stomach cancer shows in the following order; poorly differentiated(38.4 %), moderately differentiated(22.7%) and well differentiated(18.5%). Together of these three types consist of 80% of total lesions. There is a distinct difference between male and female on the histological types, for there are 52% in undifferentiated and 48% in differentiated types among male while 72% and 28% among female groups. In average, they are 60% and 40%, respectively. 8) Prominent infiltration of lymphocytes in the stroma is found 2-5% of the cancers. Promenent proliferation of fibrous connective tissue of the stroma is found in 3-9% of the cancers. 9) The distinct difference in female group such as lower age group and more frequent association with undifferentiated form, will be elucidated by genetic disposition, and should be tested by tissue typing. 10) The histopathological classification should be as those of the traditional detailed description of the histopathological types. It will be much benefitcial having a standard classicfication adopted by all institutes of Korea such as the currently adopted method of japanese institutes

甚한 淋巴球浸潤과 多核性巨大細胞를 同伴한 胃癌의 1例

석동수,홍숙희,윤혜경,강현진 대한병리학회 1986 Journal of Pathology and Translational Medicine Vol.20 No.1

釜山白病院에서의 大腸癌의 統計 및 基質의 免疫 Globulin 生成細胞에 對한 硏究

石東壽,朱種銀 인제대학교 1987 仁濟醫學 Vol.8 No.3

부산백병원에서 수술절제한 대장암 총 74예를 병리학적 통계와 기질조직에서의 면역 Globulin 생성세포의 출현을 PAP법으로 검사하여 다음과 같은 결과를 얻었다. 1.가장 많은 연령층은 50대 (28.4%)과 60대 (27%)였다. 남녀 비율은 동일하였다. 2.40세 미만의 젊은층은 20%로서 일본이나 미국의 통계에 비해 고율이다. 3.발생 장소는 직장이 58.1%로 가장 많고, 상행결장이 다음으로 17.6%였다. 4.대장암의 크기는 직경 4cm대가 40.3%로 가장 많고, 5cm 미만이 60%가 된다. 5.암의 분화가 좋은 것이 전체의 81.1%를 차지하고 있다. 6.암이 대장의 장막까지 침범한 예가 74.3%로 많으며, 수술당시 임파절의 전이가 있는예가 발견되었다. 7.Ig생성세포의 양성율은 미약하였고, 대장암의 생물학적 태도와 밀접한 관계를 갖고 있는 것 같지 않았다. Total 74 cases of colon cancer (adenocarcinoma) were collected from the Pusan Paik hospital during the last 7 years. They were analysed according to the pathological findings and we concluded as followings; 1) The most prevalent age group is fifties (28.4%) and followed by 60s (27%),40s (20.3%). Ma1e-female ratio is 1.1:1, and the average age is 50.6 years. 2) Younger age group with less than 40 is consisted of 20.3% which is strikingly higher than those of Japan or America (6%) 3) Location of the colon cancer is most frequent in rectum (58.1%), followed by ascending (17.6%), transverse (10.8%), Sigmoid and cecum each 5.4%. Rectum and Sigmoid together, the distal region comprised in 63.5% 4) Size of the cancer (average diameter) is most prevalent in 4cm group (4-4.9cm) consisting 40.3%. Next is 6cm group which is 18.1%, then 5cm and 3cm groups (each 12.5%). Thus, less than 5cm tumor is consisted of 59.8% of the total colon cancers. 5) For the differentiation of the cancer, there is a great majority of better differentiated forms, for well differentiated, 71.5% and moderately differentiated, 9.5%. Mucinous form is 13.5% and poorly differentiated 5.4%. 6) There are Dukes B1 18.9%, Dukes B2, 27%, Dukes C1 6.8% and Dukes C2 47.3%, indicating that over half of the colon cancer are found having lymph node metastasis when they are initially diagnosed. 7) Between the size of the cancer, the degree of the invasion and the freuency of the regional lymph node metastasis, there is a parallel relationship during the stage of Dukes B,, but there is no more such relationship beyond that stage of the cancer advancment. 8) Stromal reaction of the cancer appears well related with the degree of the differentiation of the cancer, for better the differentiation, better stromal reaction is observed. 9) Ig-producing cells are few and only a few cases are positive (IgG 10.3%, IgM 23.1%, IgA 11.8%)suggesting that identification of each Ig-producing cells in colon cancer may not be so sensitive or important.

유방의 평 활근육종 -1예 보고-

임인숙,석동수 대한병리학회 1987 Journal of Pathology and Translational Medicine Vol.21 No.1

조직구 괴사성 림프절염 : A Clinicopathologic Study of 20 Cases

임인숙,석동수 인제대학교 1988 仁濟醫學 Vol.9 No.2

1979년 6월부터 1987년 12월까지 만 8년 7개월 동안 경험한 조직구 괴사성 림프절염 20예에 대한 임상 및 병리조직 표본을 검사하여 문헌 고찰과 함께 보고하는 바이다. The clinicopathological features of histiocytic necrotizing lymphadenitis in 20 patients are described. This disease occurs predominantly in third decade of life with a mean of 27 years, and is predominantly more common in female (F : M = 5.7 : 1). The most common symptom is multiple cervical lymphadenopathy in 18 of 20 patients(90%) and occasionally pain (35%) and fever (15%) are accompanied. Duration of cervical lymphadenopathy is 4 to 90 days with a mean of 27.4 days. Laboratory findings including viral and bacterial study are non-contributory except for leukopenia and raised erythrocyte sedimentation rate (ESR) in 52.9% and 87.5% in patients, respectively. Characteristic histological feature is multifocal, well-circumscribed, paracortical necrotizing lesions, and abundant karyorrhectic debris, a mixture of lymphocytes and histiocytes or macrophages with active phagocytosis of karyorrhectic nuclear debris and degenerating cells. Granulocyte and plasma cell infiltation is absent. The etiology of histiocytic necrotizing lymphadenitis is unknown. Histiocytic necrotizing lymphadenitis would be induced by the abnormal T cell-histiocyte response against some causative agents which induce a similar reaction of delayed hypersensitivity.

A Case of Human Gastric Anisakiasis in Korea

Jeong, Jin Sook,Suk, Dong-Soo 인제대학교 1984 仁濟醫學 Vol.5 No.3

28세된 부산 거주 회사원 남자가 심한 상복부 통증, 오심 고리고 구토를 주소로 부산 백병원에 입원하여 1983년 11월 10일 위궤양 진단하에 수술을 받던 중 우연히 궤양과 떨어진 곳에서 작은 육아종성 병변이 있음이 발견되었다. 병리조직학적으로, 이 병변은 점막에서 장막에까지 이르는 전 위벽에 한국성 염증을 일으키고 있었는데 심한 호산성 백혈구의 침윤이 있었다. 그리고 병변 중앙의 괴사성 육아병변에서 선충류의 절단면이 발견되었다. 이 절단면은 366×100㎛, 898×209㎛의 두 면을 보이나 그 위치상 한 선충류인 것으로 사료되며, 7-20㎛의 각피, Y자 모양의 측선, 다근육형 근층과 변성된 식도부가 관찰되었다. 그리고 아니사키스증을 가장 의심케하는 레너트 세포도 발견되었다. 이러한 병리조직학적 및 기생충학적 소견을 기초로 이 병변을 아니사키스과에 속하는 유충에 의한 병변으로 진단하였다. 이 증례는 바다생선을 먹은 일이 없었으며 특징적인 상복부 동통을 나타내었고, 절제된 위에서 과민성 아니사키스증으로서는 한국에서 첫번째로 기록되는 바이다. A case of human anisakiasis involving stomach was reported. This case was incidentally found in a 28-year-old Korean male during an operation for gastric ulcer. His chief complaints at admission were severe epigastric pain, nausea and vomitting. Histopathologically, the gastric wall was infiltrated extensively by eosinophils, neutrophils and plasma cells. Focal necrosis, with formation of several microabscesses, was seen. On section, disclosed a sectioned anisakis larva which was measured 898um in maximum dimension and was characterized by thick cuticle with thin hypodermis, focally degenerated muscle coat, Y-shaped lateral cords, possibly Renette cell and central degenerated esophagus.

원시성 신경외배엽 종양에 관한 병리학적 고찰- 5예 보고 -

이숙녀,주종은,석동수,김형동,김수휴,심재홍,지제근 대한병리학회 1989 Journal of Pathology and Translational Medicine Vol.23 No.3