http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
윤명하,최남열,이치환 전력전자학회 2002 전력전자학회 논문지 Vol.7 No.5
This paper proposed a feed-forward adaptive position controller that is robust for variable inertia. The control system consists of PI Position controller, feed-forward and model reference adaptive control. A parameter g(t) of the feed-forward adaptive position controller is adapted by using both the reference model speed and position error. So it improves the transient response and reduces the settling time. And normalization function is used to make linear adaptation time. The validity of the feed-forward adaptive controller is confirmed by simulation results. 본 연구는 관성의 변화에 견실한 피드포워드 적응 위치제어기를 제안한다. 제안된 피드포워드 적응 위치제어기는 PI 위치제어기에 피드포워드와 기준모델 적응제어기를 추가한 구조를 가진다. 제어기의 특징은 과도상태에서 적응제어기가 위치오차와 기준모델의 속도 정보를 이용하여 피드포워드 이득을 조정한다. 이것은 과도응답 특성을 향상시키고, 정상상태의 수렴 시간을 개선시킨다. 위치 오차에 속도의 정보를 받아들여 기존의 PI 위치제어 및 기준모델 적응제어에 비하여 속응성이 우수하다. 그리고, 적응제어기에 규준화 함수를 사용하여 입력크기에 대해 출력신호가 일정한 응답특성을 가지도록 하였다. 시뮬레이션을 통하여 제안된 피드포워드 적응 위치제어기 동작의 타당성을 보였다.
Isoflurane의 최소폐포농도에 관한 척수강 칼슘통로 차단제의 효과
윤명하,최정일,정성욱 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.5
Background: Much evidence suggests that the spinal cord may be an important anesthetic action site. Volatile anesthetics have been shown to inhibit neurotranmitter release by inhibition of intracellular calcium entry. Many types of calcium channels (L, N, P, Q, T) were demonstrated in the dorsal horn of the spinal cord. Therefore, the aim of this study was to determine whether intrathecal calcium channel antagonists may change the minimum alveolar concentration (MAC) of isoflurane in rats and examine the role of spinal calcium channels for anesthetic action of isoflurane. Methods: In Sprague-Dawley rats, the MAC of isoflurane was determined by the tail-clamp technique. First, control MAC was determined and then changes of control MAC were observed after intrathecal administration of calcium channel antagonists. Change of mean arterial pressure (MAP) and general behavior were also examined following intrathecal delivery of calcium antagonists. Results: Neither abnormal behavior nor change of MAP occured after intrathecal of all types of calcium channel antagonists. All drugs decreased the MAC of isoflurane. Conclusions: These results suggested that L, N, P, Q and T types of the calcium might play an important role in determining the MAC of isoflurane in the spinal cord. (Korean J Anesthesiol 2002; 43: 661~666)
Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
윤명하,박경덕,이형곤,김웅모,안태훈,김여옥,Lan Ji Huang,Cui Jin Hua 대한의학회 2008 Journal of Korean medical science Vol.23 No.6
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect of sildenafil was further investigated. Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. For induction of pain, 50 μL of 5% formalin solution was applied to the hindpaw. Isobolographic analysis was used for the evaluation of drug interaction between sildenafil and morphine. Furthermore, naloxone was intrathecally given to verify the involvement of the opioid receptor in the antinociception of sildenafil. Both sildenafil and morphine produced an antinociceptive effect during phase 1 and phase 2 in the formalin test. The isobolographic analysis revealed an additive interaction after intrathecal delivery of the sildenafil-morphine mixture in both phases. Intrathecal naloxone reversed the antinociception of sildenafil in both phases. These results suggest that sildenafil, morphine, and the mixture of the two drugs are effective against acute pain and facilitated pain state at the spinal level. Thus, the spinal combination of sildenafil with morphine may be useful in the management of the same state. Furthermore, the opioid receptor is contributable to the antinocieptive mechanism of sildenafil at the spinal level.
흰쥐의 신경병성 통증모델에서 척수강 내로 투여된 Ginsenosides가 기계적 이질통에 미치는 진통효과
윤명하 대한마취통증의학회 2008 Anesthesia and pain medicine Vol.3 No.3
Background: Traditionally, ginseng has been widely used to manage various types of diseases. In particular, the analgesic effect of ginsenosides has been reported for inflammatory pain. However, the effect of ginsenosides on neuropathic pain has not been determined. The aim of this study was to examine the effect of ginsenosides on neuropathic pain in the spinal cord. Methods: Neuropathic pain was induced by ligation of the lumbar 5, 6 spinal nerves in male Sprague-Dawley rats. Intrathecal catheters were placed into the subarachnoid space of rats that presented with mechanical allodynia. Mechanical allodynia was evaluated by measuring the withdrawal threshold to a von Frey filament applied to the plantar surface of rats. The analgesic effect of intrathecal ginsenosides was observed at 15, 30, 60, 90, 120, 150 and 180 min after delivery of the ginsenosides. Results: After nerve ligation, the paw withdrawal threshold was significantly decreased at the ligated site. At the doses used in this study, intrathecal ginsenosides did not alter the withdrawal threshold in the ligated paw during the entire observation period. However, a dose of intrathecal ginsenosides greater than 1,500μg caused motor impairment. Conclusions: These results suggest that ginsenosides may not have a direct modulatory role in the transmission of neuropathic pain at the spinal level.
생쥐의 골 암성통증 모형에서 ginsenosides의 효과
윤명하,이형곤,김웅모,주진,김여옥,최금화 대한마취통증의학회 2010 Anesthesia and pain medicine Vol.5 No.4
Background:Ginsenosides have been used for a long time as an oriental folk medicine. Although ginsenosides modulate the nociceptive transmission, the effect of ginsenosides on a bone cancer pain has not been elucidated. The authors examined the effect of ginsenosides in a mouse model of bone cancer pain. Methods:Bone cancer was induced by intramedullary injection of osteolytic sarcoma cells in to the femur in male C3H/HeJ mice. Mice showing mechanical allodynia after 14 days after cancer cells inoculation were included in this study. Mechanical allodynia was evaluated by measuring the withdrawal threshold to von Frey filament applying on the femoral cancer site. Effect of ginsenosides (30, 100, 300 mg/kg) was examined at 15, 30, 60, 90, 120 min after intraperitoneal administration of ginsenosides. Results:After cancer cells injection into the femur, bone cancer was developed in simple X-ray. A paw withdrawal threshold in a cancer site was significantly decreased. Intraperitoneal ginsenosides did not effectively alter the withdrawal threshold in the cancer site. Conclusions:Taken together, ginsenosides may not be effective to attenuate the bone cancer pain.