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우리나라 주택의 외관형태의 다양성에 관한 연구 : 1980년대 이후 건축가가 설계한 주택을 중심으로
홍숙경,한기정,손세관 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5
The purposes of this study are to analyse the varieties of external shapes of detached houses in Korea after 1980s and to arrange the characteristics of those. For these purposes, 152 houses designed by architects have been selected. And the general form, the relationship of external form factors, the intermediate spaces in each form, the arrangement of internal spaces, especially livingroom and master bed room, and the roof styles of those were analysed by typological method. The results of analysis are as follows; Firstly, the general form of houses in Korea after 1980s is ㄱ-shape. Secondly, the external forms of houses are composed with complex form factors, and these form factors are annexed, adjoined, and crossed at right angles. Thirdly, the separated form factors are connected with hallway or staircase. Fourthly, the arrangement of a living room and a master bed room are identified by adjoined each other on the first floor. Fifthly, the representative roof style of architect-designed houses in Korea is even roof.
인유두종 바이러스의 감염 또는 감염되지 않은 자궁 경부 이형성증에서 p53 및 Ki-67의 발현
최숙경 ( Sook Kyung Choi ),김태전 ( Tai Jeon Kim ),홍승복 ( Seung Bok Hong ),이훈택 ( Hun Taeck Lee ) 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2
This research focuses on the overall evaluation of tumor protein (p53) and cell growth marker (Ki-67) in their functions as carcinogenic factors in both a HPV-infected group and in a HPV-noninfected group with the precancerous dysplasia of uterine cervix. Histological grades were determined by the H&E staining and the expression level of p53 and Ki-67 were tested by the immunohistochemistry method. The results were as follows. Among the total of 66 cases, p53 (+) was observed in 19 cases (29.0%) from the mild grade group, 22 cases (33.0%) from the moderate grade group, and 19 cases (29.0%) from the severe grade group. The values correlate with the increase of dysplasia intensity in HPV-noninfected group and showed significant correlation (p<0.05), but there were no significant difference from the HPV-infected group. Among a total of 66 cases, the mitotic index of Ki-67 (+) were observed in 19 cases (29.0%) from the mild grade group, 22 cases (33.0%) from the moderate grade group, and 19 cases (29.0%) from the severe grade group. The values were significantly different against dysplasia intensity (p<0.05), but showed no significant difference from HPV infection. After cross comparing the statistical parameters of p53 and ki-67 in their significance, p53 was shown to be statistically significant with Ki-67 while there was no statistically significant difference with Ki-67 (p<0.05). Taken together, tumor protein (p53) and an index of Ki-67 observed in cervical dysplasia and in HPV related dysplasia of cervix uterine did not have any notable significance with HPV infection. The incidence rate of p53, however, had some significant correlation with dysplasia while Ki-67 had no particular statistical significance. As a result, p53 and Ki-67 can be considered as effective diagnostic markers in predicting the disease progression of dysplasia to cervical cancer.
최선하,도숙경,정지윤,이신엽,최진은,홍미정,강효경,석양기,이응배,유승수,이재희,차승익,김창호,박재용 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with nonsmall cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T[A and rs4658G[C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T[A was associated with significantly better OS (adjusted hazard ratio [aHR]=0.57, 95% confidence interval [CI]=0.34-0.94, P=0.03, under dominant model), and rs4658G[C was associated with significantly worse OS (aHR=1.91, 95% CI=1.09-3.33, P=0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend=4 9 10-3). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.
최선하,이신엽,홍미정,최진은,강효경,도숙경,장혁,유승수,이응배,석양기,조석기,전상훈,이재희,차승익,김창호,박재용 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0
Background: Genome-wide association studies have indicated that most of the currently identified disease and trait-associated single nucleotide polymorphisms(SNPs) are intronic or intergenic. RegulomeDB is a recently developed database that provides functional annotations for regulatory features of SNPs located in non-coding regions. We evaluated the potential regulatory SNPs in the EGFR gene region using RegulomeDB and their associations with prognosis after surgery in non-small cell lung cancer (NSCLC) patients. Methods: A total of 698 patients with surgically resected NSCLC were enrolled and seven SNPs were selected based on the RegulomeDB database. All SNPs were genotyped using SEQUENOM MassARRAY iPLEX assay. Results: Among the seven SNPs evaluated, rs9642391 (EGFR ivs19+2851C>G) was significantly associated with survival outcome (adjusted hazard ratio [HR] for overall survival=0.70, 95% confidence interval [CI] 0.56-0.87, P=0.001; adjusted HR for disease-free survival=0.82, 95% CI 0.70-0.97, P=0.02; under a codominant model). According to RegulomeDB, rs9642391C>G, which is located in intron 19 of EGFR, was predicted to influence the expression of GBAS but not EGFR. As predicted, rs9642391C>G was associated with GBAS (P=0.024) but not EGFR messenger RNA expression in tumor tissues. Conclusion: In conclusion, our study provides evidence that rs9642391C>G in the intron of EGFR is associated with GBAS expression and survival outcomes of patients with surgically resected early-stage NSCLC.
비파열성 난관임신에 대한 Methotrexate의 비수술적 치료
윤성도,김종인,임춘근,양숙경,류호충,홍원표 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.1
저자들은 계명대학교 동산의료원 산부인과에서 초음파 및 beta-hCG로 최종 확정된 비파열성 난관임신중 착상부위의 크기가 18 mm이하, 복강내 혈액량이 소량(100 cc), 난관벽이 안정되어 있고 복통과 같은 심한 증상이 없으며, 혈압 및 맥박이 안정된 비파열성 난관임신 3명에 대한 4회의 methotrexate(1mg/kg/day)와 4회의 citrovorum factor(0.1mg/kg/day) 투여하여, 아무런 부작용 및 특별한 수술적 조작없이 치유를 경험하여, 문헌고찰과 함께 보고하는 바이다. Nonsurgical management of the unruptured tubal pregnancy with methotrexate is suggessted as an alternative to surgery in the management of early unruptured tubal pregnancy. Entry criteria required that the ectopic focus be tubal pregnanpy, no greater than 18 mm in diameter by USG, no active bleeding and no abnormal fluid collection in Cul de sac. The diagnosis was established in all three cases by sonography, serum beta-subunit of human chorionic gonadotropin. Three unreptured tubal pregnancies were treated with four doses methotrexate (1.0 mg/kg/day) followed by four doses of citrovorum fator(0.1 mg/kg/day). The treatment was based upon the level of beta-hCG, size of gestational sac on follow up USG, improvement of clinical symptoms with MTX/CF given to subjects. In all three subjects, the ectopic pregnancies were resoluted without further surgical intervention. Our experience suggests that the nonsurgical conservative management of the methotrexate may become a new, effective & safe treatment modality for the unruptured tubal pregnancy.