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Nicotine에 의한 자발성고혈압백서(自發性高血壓白鼠)의 혈장 Cholesterol 농도의 변동
류호충,고상돈,신홍기,김기순,Yoo, Ho-Choong,Koh, Sang-Don,Shin, Hong-Kee,Kim, Kee-Soon 대한생리학회 1982 대한생리학회지 Vol.16 No.2
The present study was undertaken to find out fasting total plasma cholesterol levels of SHR at different phases(labile, established and malignant) in the course of hypertension development and also to investigate effect of nicotine on plasma cholesterol levels of these animals. In nicotine administered group, 2.18 mg/kg nicotine was given daily for six weeks. The results obtained are as follows; 1) Mean total plasma cholesterol levels of SHR at labile, established and malignant phases were $104.6{\pm}3.1\;mg/dl$, $120.8{\pm}2.6\;mg/dl$ and $136.6{\pm}2.5\;mg/dl$ respectively. The total plasma cholesterol level generally increased with age of experimental animals. 2) After administration of nicotine (2.18 mg/kg/day) for six weeks, mean total plasma cholesterol levels of SHR at labile, established and malignant phases were $130.2{\pm}3.1\;mg/dl$, $150.4{\pm}3.3\;mg/dl$ and $166.6{\pm}3.2\;mg/dl$, respectively. The result of present study strongly suggests that nicotine has a positive relationship with plasma cholesterol levels in SHR.
비파열성 난관임신에 대한 Methotrexate의 비수술적 치료
윤성도,김종인,임춘근,양숙경,류호충,홍원표 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.1
저자들은 계명대학교 동산의료원 산부인과에서 초음파 및 beta-hCG로 최종 확정된 비파열성 난관임신중 착상부위의 크기가 18 mm이하, 복강내 혈액량이 소량(100 cc), 난관벽이 안정되어 있고 복통과 같은 심한 증상이 없으며, 혈압 및 맥박이 안정된 비파열성 난관임신 3명에 대한 4회의 methotrexate(1mg/kg/day)와 4회의 citrovorum factor(0.1mg/kg/day) 투여하여, 아무런 부작용 및 특별한 수술적 조작없이 치유를 경험하여, 문헌고찰과 함께 보고하는 바이다. Nonsurgical management of the unruptured tubal pregnancy with methotrexate is suggessted as an alternative to surgery in the management of early unruptured tubal pregnancy. Entry criteria required that the ectopic focus be tubal pregnanpy, no greater than 18 mm in diameter by USG, no active bleeding and no abnormal fluid collection in Cul de sac. The diagnosis was established in all three cases by sonography, serum beta-subunit of human chorionic gonadotropin. Three unreptured tubal pregnancies were treated with four doses methotrexate (1.0 mg/kg/day) followed by four doses of citrovorum fator(0.1 mg/kg/day). The treatment was based upon the level of beta-hCG, size of gestational sac on follow up USG, improvement of clinical symptoms with MTX/CF given to subjects. In all three subjects, the ectopic pregnancies were resoluted without further surgical intervention. Our experience suggests that the nonsurgical conservative management of the methotrexate may become a new, effective & safe treatment modality for the unruptured tubal pregnancy.