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무증상 역류성 식도염의 자연 경과 -건진검진자를 대상으로 한 후향적 연구-
한성혁 ( S. H. Han ),김재준 ( J. J. Kim ),손희정 ( H. J. Son ),김영호 ( Y. H. Kim ),백승운 ( S. W. Paik ),이종철 ( J. C. Rhee ),최규완 ( K. W. Choi ),김지은 ( J. E. Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 역류성 식도염은 서구에서 전 인구의 3-4%의 유병률을 보이는 흔한 질환이며 국내 에서도 건강 검진자를 대상으로 한 몇몇 연구에서 유병률이 2%정도로 보고하고 있다. 전형적인 증상이 있는 역류성 식도염에서 치료의 필요성에 대해서는 논란의 여지가 없지만 증상이 없이 우연히 상부 위장관 내시경을 시행하여 역류성 식도염으로 진단된 경우 자연경과에 대해서는 알려져 있지 않아 치료방침에 대한 기준이 없는 실정이다. 이에 연구자들은 무증상 역류성 식도염
대장직장암과 선종에서의 Cyclooxygenase-2 발현
김정욱,도재혁,정규,장세경,한성혁,정현주 대한소화기학회 2000 대한소화기학회지 Vol.35 No.4
Backgound/Aims: Several epidemiological and animal studies suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and sulindac, decreases the risk of colorectal cancer and adenoma. A likely mechanism by NSAIDs is a cyclooxygenase-2 (Cox-2) related inhibition of cell proliferation. The aim of our study was to evaluate the incidence of Cox-2 expression in colorectal carcinoma, as well as adenoma, and its clinicopathologic significance. Methods: We investigated the expression of Cox-1 and Cox-2 in 20 colorectal adenomas, 21 colorectal carcinomas and paired normal tissues of large intestine. The levels of Cox-1 and Cox-2 mRNA were determined by reverse transcription-polymerase chain reaction and Digoxigenin-labelled probe. Results: Cox-1 mRNA was expressed in all examined tissues including the adenomas, carcinomas and paired normal tissues. On the other hand, Cox-2 mRNA was expressed in some colorectal carcinomas (33.3%, 7/21) and adenomas (15.0%, 3/20), but not in paired normal tissues. Cox-2 expression rates in colorectal carcinomas and adenomas were lower in this study than in other previous studies. Conclusions: The expression rate of Cox-2 mRNA was higher in colorectal adenocarcinoma than in the adenoma and normal mucosa.
김정욱,김상진,박중원,김재규,장세경,박실무,유병철,한성혁,정규,장인택,김미경 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Angiomyolipoma is a mesenchymal hamartoma composed of blood vessels, smooth muscle, adipose tissue, and supporting connective tissue. It is occasionally associated with tuberous sclerosis. Most of angiomyolipoma arises in the kidney and gastrointestinal angiomyolipoma is very rare. We experienced a case of symptomatic ileal angiomyolipoma, which was the first documented case. A 60-year-old female was admitted to our hospital because of intermittent periumbilical pain. In the physical examination, slightly painful abdominal mass was palpated. Abdominal ultrasonography and computed tomography suggested intussusception. The patient underwent a segmental resectioin of the ileum. Postoperative gross finding showed 4×4×3 cm mass having yellowish resection plane without hemorrhage and necrosis in the terminal ielum. Microscopic fingings of the mass revealed intermixed adipose tissue, blood vessels, and smooth muscle bundles. Immunohistochemically, the proliferating smooth muscle cells were positive for vimentin. Phologic findings confirmed the diagnosis of angiomyolipoma of ileum.
비알코올성 지방간 환자에서 지방간염의 병리학적 심화도를 예측할 수 있는 임상적 지표들
유병철,김상진,박중원,김미경,김재규,박실무,김형준,홍요한,한성혁 대한소화기학회 2000 대한소화기학회지 Vol.36 No.6
Background/Aims: Nonalcoholic steatohepatitis (NASH) may progress to advanced liver disease. The aims of our study were to examine clinical factors distinguishing NASH from simple steatosis in patients with nonalcoholic fatty liver and to identify clinical predictors reflecting the pathologic severity in patients with NASH. Methods: For thirty-nine patients with fatty liver, medical history, body mass index (BMI), and the results of serological test and ultrasonography of liver, were reviewed retrospectively. Then, the clinical and biochemical data of nonalcoholic steatosis (NAS) and NASH was compared. Results: NAS was observed in fifteen patients (median age: 32.7, M:F=13:2) and NASH was observed in twenty-four patients (median age: 32.8, M:F=17:7). Only body mass index (BMI) showed the significant difference between NASH (28.4±3.4) and NAS (25.8±2.8) (p$lt;0.03). The incidence of NASH was high in patients with BMI over 28.9. Serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio was reveely correlated with the degree of steatosis (p$lt;0.01). Multivariate analysis showed the correlation between BMI and the degree of fibrosis (p$lt;0.01) and the reverse-relation between serum ALT value and the degree of fibrosis (p$lt;0.01). Coclusions: BMI helps identify NASH in patients with nonalcoholic fatty liver. In patients with NASH, high BMI accompanied with low ALT value and severe fatty change on ultrasonography could suggest severe fibrosis. Thus, these patients need a close follow-up including a liver biopsy.
무증상 역류성 식도염의 자연 경과 -건강 검진자를 대상으로 한 후향적 연구-
손주익 ( Ju Ik Son ),김재준 ( Jae J. Kim ),박문경 ( Moon Kyung Park ),한성혁 ( Seong Hyeock Han ),김지은 ( Jee Eun Kim ),이재욱 ( Jae Wook Lee ),심상군 ( Sang Goon Shim ),이준행 ( Jun Haeng Lee ),손희정 ( Hee Jung Son ),김영호 ( Y 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.2
목적: 건강 검진이 늘어나면서 무증상이면서 내시경 검사상 역류성 식도염 소견을 보이는 환자들도 증가하고 있다. 그러나 아직까지 증상을 동반하지 않은 식도염의 자연 경과나 치료방침에 대해서는 체계적인 연구가 없는 실정이다. 이에 저자 등은 건강 검진자를 대상으로 시행한 상부소화관내시경 검사상 우연히 발견된 무증상 역류성 식도염 환자들의 의무 기록을 후향적으로 검토하여 자연 경과 및 경과에 영향을 미치는 인자들을 알아보고자 하였다. 대상 및 방법: 1994 Background/Aims: The natural history of endoscopically proven reflux esophagitis without any gastrointestinal symptom is not clear. The aim of the present study was to evaluate the natural course of asymptomatic reflux esophagitis without any specific tre