자궁경부 세포도말 검사에시 미세침윤성 편평세포암종의 세포학적 분석

최현주,박인애,Choi, Hyun-Joo,Park, In-Ae 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Whlie cytologic characteristics of squamous dysplasia, carcinoma in situ, and invasive squamous cell carcinoma of the uterine cervix are well documented, relatively few studios have dealt with the cellular features of microinvasive carcinoma. In order to describe the cellular characteristics of microinvasive squamous cell carcinoma, we retrospectively reviewed 45 cervovaginal smears(15 carcinoma in situ, 15 microinvasive cancer, 15 invasive cancer) which were confirmed by histologic examination of specimens obtained by hysterectomy at the Seoul National University Hospital during S years from 1995 to 1999. The cytologic features about tumor diathesis, inflammatory background, ceil arrangement, anisonucleosis, nuclear membrane irregularity, nuclear chromatin pattern, and nucleoli were observed. The cytologlc characteristics of microinvasive squamous cell carcinoma of the uterine cervix are syncytial pattern, mild tumor diathesis, the irregularity of nuclear membrane, irregularly distributed nuclear chromatin, and occurrence of micronucleoli. But, correlation between the depth of Invasion and the cytologic feature had limited value.

타액선의 다형성 선종에서 발견한 암종의 세침흡인 세포학적 소견 -5 예 보고-

최현주,김활웅,함의근,박인애,Choi, Hyun-Joo,Kim, Hwal-Woong,Ham, Eui-Keun,Park, In-Ae 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2

Carcinoma ex pleomorphic adenoma(CXPA) is a rare malignant tumor of the salivary gland, fine needle aspiration cytology(FNAC) of which are rarely reported. We retrospectively reviewed FNAC of five cases of histologically proven CXPA of the salivary glands diagnosed in Seoul National University Hospital to evaluate their cytologic characteristics. Histologically, the carcinoma components were low-grade in three cases and high-grade in two cases. The cytologic diagnosis were malignancy in two cases(40%), suspicious for malignancy in one(20%), and benign(pleomorphic adenoma) in two(40%). All of the high-grade carcinomas were correctly diagnosed by FNAC, however, 2 cases of low-grade carcinomas were diagnosed as benign by FNAC. The low sensitivity in cytologic diagnosis is due to interpretative difficulties in low-grade tumors. The characteristic cytologic features of CXPA were high cellularity, necrotic, bloody, and inflammatory background, marked nuclear overlapping, coarsely granular chromatin, prominent macronucleoli, and atypical mitosis in epithelial component in addition to the typical biphasic pattern of pleomorphic adenoma consisting of epithelial cells admired with spindle-shaped cells and chondromyxoid stroma. Even though low-grade tumors show mild pleomorphism, the cytologic findings of necrotic background, moderate to high cellularity, and nuclear overlapping could lead to an accurate cytodiagnosis of CXPA.

집합 결합과 신경망을 이용한 복합질환의 예측

최현주,김승현,위규범,Choi, Hyun-Joo,Kim, Seung-Hyun,Wee, Kyu-Bum 한국정보처리학회 2008 정보처리학회논문지B Vol.15 No.4

복합질환은 다수의 유전자들이 상호작용하여 유발되는 질병으로서, 여러 유전자들이 관여한다는 복잡성 때문에 전통적인 분석 방법을 적용하는데 한계가 있다. 최근에는 기계학습 기법을 이용한 새로운 분석 방법들이 제안되고 있다. 신경망은 이처럼 복잡한 데이터에서 일정한 패턴을 찾아 이를 분류하는데 적합한 모델이다. 그러나 다량의 데이터가 입력으로 들어오는 경우에 학습에 오랜 시간이 걸리고 패턴을 찾기가 어려워지는 단점이 있다. 본 연구에서는 다량의 SNP 데이터로부터 질병에 연관된 소수의 중요 SNP을 찾기 위한 통계학적인 방법인 집합결합(set association)과 신경망을 결합한 모델을 제시한다. 이 모델을 천식 관련 SNP 데이터에 적용하여 천식 발병 여부를 예측한 결과, 신경망만 사용했을 때보다 실행 시간도 빠르고 예측 정확도도 높았다. 이 모델은 다른 복합질환의 예측에도 효과적으로 사용할 수 있을 것으로 기대한다. Since complex diseases are caused by interactions of multiple genes, traditional statistical methods are limited in its power to predict the onset of a complex disease. Recently new approaches using machine learning techniques are introduced. Neural nets are a suitable model to find patterns in complex data. When large amount of data are fed into a neural net, however, it takes a long time for learning and finding patterns. In this study we suggest a new model that combines the set association, which is a statistical technique to find important SNPs associated with complex diseases, and neural network. We experiment with SNP data related to asthma to test the effectiveness of our model. Our model shows higher prediction accuracy and shorter execution time than neural net only. We expect our model can be used effectively to predict the onset of other complex diseases.

지루 피부염 환자의 피지 조성에 관한 연구

최현주,임성빈,이승헌 ( Hyun Joo Choi,Sung Bin Lim,Seung Hun Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6

N/A We attempted to examine the compositions of seborrheic lipids from the scalp of the human adult males and the patints who have the seborrheic dermatitis by the ?hin layer chromatography(TLC) and the photodensitometer. The human skin surface lipids are composed of the seborrheic lipids from the sebaceous glands and epidermal lipids from the ediermis. The sebaceous lipids were known that they played the role to protect the skin and they had the pathophysiologic role in the seborrheic dermatitis and the ance. We observed that the sebacous lipids were composed of squalene, ??olestrol ester, wax ester, triglyceride, free fatty acid, and saturated hydrocabon in both the control group and the patient group. In the mean values of the ratio of the seborrheic lipids composition, the ratio of squalene and cholesterol eater were higher, and the ratio of free fatty acid and triglyceride were lower in the patient group than in the control group, and the ratio of wax ??ster which was originated from sebaceous glands was no difference between two groups. Thus, n?the seborrheic dermatitis, there was no change in the sebum secertion rate, but the lipid compositions were changed.

유방의 침윤성 미세유두암종의 세침흡인 세포검사

최현주,정지한,신정하,민기옥,강석진,이교영,유진영,Choi, Hyun-Joo,Jung, Ji-Han,Shin, Jung-Ha,Min, Ki-Ouk,Kang, Seok-Jin,Lee, Kyo-Young,Yoo, Jin-Young 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1

Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.

자궁경부 Adenoma Malignum의 세포학적 소견 - 1예 보고 -

최현주,김영신,이교영,강창석,심상인,Choi, Hyun-Joo,Kim, Young-Shin,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Adenoma malignum is an extremely well-differentiated variant of cervical adenocarcinoma in which the cells composing the tumor lack the typical cytological features of malignancy. The prognosis of this rare tumor is poor in spite of high degree of differentiation. The cytologic characteristics are extremely bland so frequently make a confusion of adenoma mailgnum with endocervical glandular hyperplasia. We report a case of adenoma malignum in a 35-year-old woman who complained of mucoid vaginal discharge and vaginal bleeding. The cervicovaginal smear showed endocervical cells exhibiting a spectrum of atypical chances. The cells were arranged in multilayered strips and monolayered sheets. Individual cells ranged from cuboidal to columnar; typically the columnar cells had abundant lacy or vacuolated cytoplasm. The smear showed the majority of only atypical cells and small numbers of frankly malignant cells.

국가로망스로서의 이병주의 『지리산』

최현주 ( Hyun Joo Choi ) 현대문학이론학회 2013 現代文學理論硏究 Vol.0 No.55

이병주의 『지리산』은 1930년대 식민지 시기부터 1940년대 해방 공간을 거쳐 한국 전쟁 종전까지의 한국 근현대사를 소재로 한 대하장편소설이다. 이 작품은 새로운 근대국가 형성의 과정과 모순을 구체적으로 제시했다는 점에서 국가 창건 서사 혹은 국가 로망스라 명명해볼 수 있는 것이다. 작품에서 제시된 공간으로서의 지리산은 화원의 사상의 공간이면서 민족국가의 기원으로서의 국토라는 개념을 포획해내고 있다. 또한 주인공 박태영을 비롯한 서사주체들은 진정한 근대 민족국가의 국민되기를 위해 고통스러운 기투를 감행하지만 허망한 정열로 귀결되고 만다. 결국 그것은 여전히 한반도에 진정한 의미의 탈식민과 탈이념이 관철되지 못했기 때문일 것이다. 『지리산』은 많은 업둥이들의 기투와 열정에도 결국은 실패로 돌아간 근대국가 건설의 양상을 제대로 보여준 국가로망스이다. 작가 이병주는 아버지로 인한 상처를 극복하기 위해 새로운 아버지를 찾아 진정한 가족을 재구성하려고 했던 가족로망스의 업둥이처럼 실패한 근대국가 건설의 트라우마를 극복하고 진정한 근대국가 형성을 지향하는 국가로망스를 창작한 셈이다. 그는 민중들이 지향하는 정치학과 그들에게 친숙한 대중미학화의 방식을 결합시킴으로서 그만의 정치 서사를 구축해냈으며, 『지리산』이라는 대하 역사소설을 통하여 근대국가 형성과정에 대한 민중들의 열정과 좌절의 국가로망스를 제시해낸 것이다. Lee Byung-Ju`s 『The Mountain Jiri』 is a proper text of National Romance. It realistically depicts the Japanese colonial domination, and the effort of intellectuals and students for establishing a national state after the liberation. This work reveals the Mountain Jiri as a national territory of origin of modern ethic groups. The main character of the work, Park Tae-Young, tries to become a subject of a modern national state. But his hard efforts suffer a setback because of imperialism still remaining in the Korean peninsula. Lee Byung-Ju`s 『The Mountain Jiri』can be claimed to be a National Romance because it presents people`s hard efforts and failures of establishing a national state after the liberation Just like a person who tries to overcome his childhood trauma from his father and establish his own genuine family, the writer Lee Byung-Ju creates a Natioanl Romance which tries to overcome a trauma of failure of modern nation building and looks forward to establishing a genuine modern nation.

고령자의 담화 이해 능력과 구어 작업기억 및 언어기억과의 상관

최현주(Hyun joo Choi) 한국언어청각임상학회 2014 Communication Sciences and Disorders Vol.19 No.4

배경 및 목적: 고령자의 담화 이해 능력은 실제적인 의사소통 능력을 반영하며, 다양한 인지기능과 관련을 가진다. 본 연구는 이야기를 듣고 질문에 답하는 담화 이해 과제를 사용하여 고령자의 성별, 연령, 교육년수 및 K-MMSE 점수가 담화 이해 능력에 미치는 영향을 살펴보고, 구어 작업기억 및 언어기억과 담화 이해 능력의 상관을 알아보는 것을 목적으로 하였다. 방법: 본 연구는 일반 고령자 60명(남성 30명, 여성 30명)을 대상으로 하였다. 담화 이해 과제는 청각적으로 제시되는 이야기를 듣고 질문에 답하도록 하는 이야기 이해 과제를 사용하였다. 구어 작업기억 과제로 숫자 외우기(Digit Span Test)를, 언어기억 과제로 서울언어학습검사(SVLT)를 사용하였다. 결과: 첫째, 성별, 연령, 교육년수 및 K-MMSE점수는 고령자의 담화 이해 능력에 영향을 미치지 않는 것으로 나타났다. 둘째, 상관분석 결과 담화 이해 점수는 구어 작업기억 중 숫자 거꾸로 따라 외우기와 SVLT의 모든 항목과 유의한 상관을 보였다. 셋째, 중다회귀분석 결과 숫자 거꾸로 따라 외우기와 SVLT점수가 담화 이해 능력을 유의하게 설명하는 것으로 나타났다. 논의 및 결론: 이와 같은 결과로부터 담화 이해 능력은 다양한 기억 능력과 관련이 있음을 알 수 있다. 또한, 본 연구의 결과는 다양한 신경언어장애군의 담화 이해 평가 및 치료를 위한 기초 자료로 활용할 수 있다. Objectives: Comprehension of spoken discourse is an important component of functional communication in the elderly and is related to various cognitive processes. The purpose of the present study was to identify the characteristics of discourse comprehension in healthy elderly adults and see how discourse comprehension is influenced by both verbal working memory and verbal memory. Methods: Sixty healthy elderly adults (male 30, female 30) participated in this study. They took part in discourse comprehension tasks using two different stories, a verbal working memory test (Digit Span Test: Forward/Backward) and a verbal memory test (Seoul Verbal Learning Test [SVLT]). Results: The results were as follows. First, discourse comprehension ability did not vary with gender, age, educational level or Korean Mini-Mental State Examination score. Second, there was a significant correlation between the discourse comprehension score and performance on the Backward Digit Span Test and all sections of the SVLT. Third, regression analysis indicated that verbal working memory and verbal memory were significant predictors for discourse comprehension ability in healthy elderly. Conclusion: These results suggest that discourse comprehension ability is a complex skill that depends largely on different aspects of verbal memory. These finding have clinical implications for evaluation and intervention in discourse comprehension for elderly patients with neurogenic communication disorders.

주름측정법을 이용한 전이된 CVD 그래핀의 분석

최현주(Hyun-Ju Choi),김재현(Jae-Hyun Kim),김상민(Sang-Min Kim),이승모(Seung-Mo Lee),이학주(Hak-Joo Lee),최병익(Byung-Ik Choi) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

전시방문자의 정보매체선택과 만족, 행동의도간의 영향 연구

최현주 ( Hyun Joo Choi ) 한국이벤트컨벤션학회 2008 이벤트 컨벤션 연구 Vol.4 No.2

The study examines the different types of information media used to advertize or inform potential visitors about trade show. We analyze the different media selection with respect to the purpose of visit specifics of the trade show and to their impact on the potential visitors considering satisfaction and behavioral intention of the target visitors. We tried to identify the best advertising methods and the best advertising strategy which we feel shall be tailored to the potential visitors to a given trade show. As a result of our study we found out that generally visitors tend to prefer broadcast (TV, Radio) & internet medias than printed advertisement(news papers, brochures, newsletters, leaflets, DM, exhibition journals) or outdoor advertisements & transportation advertisement, and printed media showed significant differences according to the purpose of visit. Second, printed media showed significant differences by various purpose of the trade show visitors. Third, it was analyzed that Trade Show visitor`s satisfaction highly influenced their behavioral intention. The results of our analysis implied that managers of a trade show shall carefully examine the purpose of visit, consider the timing of the trade show before setting their advertising strategy and determining effective advertising methods.