2-Kilodalton Potato Proteinse Inhibitors의 세포 면역학적 방법을 이용한 존재 위치에 관한 연구

조준구(Jun-Koo Cho),정희돈(Hee-Don Chung),서상곤(Sang-Gon Suh) 한국원예학회 1993 한국원예학회 학술발표요지 Vol.11 No.1

간질환 환자의 갑상선 기능

이상인(Sang In Lee),조준구(Jun Koo Cho),전재윤(Chae Yoon Chon),함기백(Ki Baek Ham),정재복(Jae Bock Chung),최흥재(Heung Jai Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.3

N/A The liver has been recognized as an important site in the peripheral metabolism of thyroid homone, particularly in the mondeiodination of thyroxine to triiodothyronine. It is also the source of serum T, binding proteins. As is to be expected, disease of the liver has marked effects on serum thyroid hormone concentrations and bindings. In order to evaluate the change of thyroid hormones in various liver diseases and to elucidate the relationship between thyroid hormone status and severity of liver diseases, both thyroid hormones and liver functions were measured and analyzed in 110 patients with various liver diseases who were admitted to Yonsei University Severance Hospital during the period from April 1986 to October 1986. The results were as follows: 1) In various liver disease, acute hepatitis, fatty liver, chronic persistent hepatitis and chronic active hepatitis showed no significant difference in serum T3; T4, FT4, TSH and T3/T4 compared to normal controls. 2) The serum T3, T4 and FT4 of liver cirrhosis were signficantly lower than those of control group. but serum TSH, T3/T4 were within normal limits in liver cirrhosis. 3) The serum T3 and T4 and of hepatoma was significantly lower than those of control group, but mean serum FTTSH and T3/T4 showed no significant difference between hepatoma and control group. 4) The mean serum T3 level of seven patients with Child's class A was 100.73±25.44ng/dl, thirteen patients with class B 76.42±14.40ng/dl, and eighteen patients of class C 65.18±23.19ng/dl. There was a significant statistical difference among Child's class A, B and C. 5) There was no significant correlation between serum T3 and liver functions in Child's class A of liver cirrhosis. Serum T3 was significantly correlated with-total protein and albumin in Child's class B, with total protein, albumin and prothrombin time in Child class's C. 6) In liver cirrhosis, low serum T3 group (T3 <80 ng/dl) had a significant decrease in total protein, albumin and prolonged prothrombin time than normal serum T3 group (80 ng/dl < T3 < 220 ng/dl). 7) Serum T3 decreased significanlty in liver cirrhosis with ascites than in those without ascites. In conclusion, in liver cirrhosis and hepatoma, significant decrease in serum T3 and T4 level were observed and particularly serum T3 level may be useful in assessing the severity of hepato-cellular damage in liver cirrhosis.

다발성 원발성 악성종양

권혁문(Hyuck Moon Kwon),정재복(Jae Bock Chung),김주항(Joo Hang Kim),전상일(Sang Il Chun),조준구(Jun Koo Cho),박용준(Yong Jun Park),고은희(Eun Hee Koh),노재경(Jae Kyung Roh),서창옥(Chang Ok Suh),김귀언(Gwi Eon Kim),노준규(J . K . Loh) 대한내과학회 1987 대한내과학회지 Vol.33 No.1

N/A There is no acceptable evidence, either in this presentation of in the literature, that the patterns of occurance of multiple primary maligant neoplasms of different organs of tissues are governed by anything more than conincidence. The freqency of occurance of specific types of second primary cancers is probably largely determined by the age of the patient at the time of diagnosis of initial cancer and the expected longevity after treatment of the initial lesion. The absolute number of reported cases of multiple primary malignant tumors has increased in recent years and the freqency of occurance of this phenomenon has increased. There is no factual basis for assuming that the existence of any one malignant neoplasm influence or that it implies any susceptibility of any other organ or organ system to future cancer. But it becomes apparent that existence of one malignant neoplasm implies increased susceptibility to the development of a second lesion but also a malignant lesion in one organ may imply increased susceptibility of another organ to malignant neoplasm, particularly another organ in the same or an associated system. This report deals with the clincal analysis of 42 cases of multiple primary malignant tumors from tumor registry of Severance hospital and yonsei cancer center during 7 years from Jan 1979 to Dec. 1985 and review of the literatures, The following results were abtained. 1) The incidence of multiple primary malignant tumor was 0.26% of tumor registry (42/25, 863) and the mean age of 26 male patients at first cancer was 58.8 years old and 54.9 years old in 16 female patients. 2) The mean time interval between first and second cancer was 34.1 months in 12 metachronous tumors. 3) In male patients, the stomach cancer was the most common first cancer followed by lung cancer. In female patients, the cancer of uterine cervix was the most common first cancer. 4) The ratio between synchronous and metachronous multiple primary was 2.5:1 (30:12).

신증후군 환자에서 발생한 혈전증의 임상적 고찰

이호영(Ho Yung Lee),한승희(Seung Hee Han),정현철(Hyun Cheol Chung),황성철(Sung Chul Hwang),이영식(Young Sik Lee),조준구(Jun Koo Cho),한대석(Dae Suk Han) 대한내과학회 1988 대한내과학회지 Vol.34 No.2

N/A It is well known that thromboembolic complication can develop in patients with nephrotic syndrome. The precise mechanism for this complication is not clear yet, but several clotting disorders may be operable in combination to induce the hypercoagulable state espicially in nephrotic syndrome with predisposing factors. The authors reviewed 474 patients with nephrotic syndrome who admitted to Severance Hosipal from January 1980 to April 1987 and the following results were obtained. 1) The incidence of thromboembolism in patients with nephrotic syndrome was 3% with 14 cases among 474 cases of nephrotic syndrome. This complication developed most commonly in patients with membranous nephropathy with 13% among 46 cases. 2) Venous thrombosis were noted in 12 cases and aterial thrombosis in 2 cases of all 14 cases of these complications. Renal vein thrombosis was the most common type with 6 cases (43%). 3) The demonstrable precipitating conditions to this thromboembolic complication were membranous nephropathy in 6 cases (43%) and long-term use of diuretics in 4 cases (28.8%). 4) The clotting tests revealed increased fibrinogen level and decreased antithrombin III, but platelet counts, prothrombin time and partial thromboplastin time were within normal limits. 5) Almost all patients with this complication improved considerably with conservative treatment including anticoagulants but amputation in a patient with arterial thrombosis and nephrectomy in a patient with extensive renal vein thrombosis were needed and a patient died of massive pulmonary thromboembolism. In conclusion, although the incidence of acute massive thromboembolism is not so high in nephrotic syndrome it is necessary to give a full attention to detect this complication at early stage for the reduction of morbidity and mortality in the patients with nephrotic syndrome.

99mTc - phytate 간스캔을 이용한 간 경변증의 예후 평가

박성기(Sung Ki Park),변종훈(Jong Hoon Byun),양수현(Soo Hyun Yang),박봉철(Bong Chul Park),채동호(Dong Ho Che),조준구(Jun Koo Cho),송태원(Tae Won Song) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1

N/A To evaluate the prognostic significance of 99mTc-phytate liver scintigraphy in patients with cirrhosis, we measured the grade of extrahepatic uptake (EHU) of 99mTc-phytate, from 0 (absent EHU) to 5 (irnportant EHU), according to the relative distribution of the radiotracer among liver, spleen and bone marrow. The results were as follows: 1) EHU score was correlated to the Pugh score (r=0.64) and to survival. 2) The ROC curve on an observed status of death was superior for EHU score. In conclusion, 99mTc-phytate liver scintigraphy may be a useful prognostic method in patients with liver cirrhosis.

간장 및 담도 : 전격성간염의 사망예견 인자

최흥재(Heung Jai Choi),문영명(Young Myoung Moon),정재복(Jae Bock Chung),이상인(Sang In Lee),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon),김상애(Sang Ae Kim),조준구(Jun Koo Cho) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.2

N/A We assessed predicting factors of fafality in 42 patients with fulminant hepatitis such as age, sex, etiology, serurn levels of albumin, total bilirubin, SGOT, SGPT and alpha-fetoprotein, SGOT/SGPT ratio, plasma level of ammonia, prothrombin time, degree of encephalopathy and complication. Singificant differences were observed between the survivors (14 patients) and the non-survivors (28 patient.) by plasma level of ammonia and serum level of alpha-fetoprotein. Mortality tended to be increased by decreasing serum level of albumin and alpha-fetoprotein, prolonging prothrombin time, increasing plasma level of ammonia, a SGOT/SGPT ratio above than 1.0, deepening of encephalopathy and developing complication such as respiratory failure, cardiac dysfunction, cerebral edema or renal dysfunction. In patients with fulminant hepatitis B, the absence of HBsAg in serum had favorable prognostic value. In conclusion, the serum level of alpha-fetoprotein, plasma level of ammonia, prothrombin time, SGOT/SGPT ratio, degree of encephalopathy, and complication such as respiratorv failure, cardiac dysfunction. Cerebral edema and renal dysfunction may be used as predicting factors of fatality in fulminant hepatitis.

특발성 부갑상선기능저하증 1예

조준구,이현철,김현만,임승길,김경래,허갑범 최신의학사 1985 最新醫學 Vol.28 No.10

여러 질환에서의 Antinuclear Antibody(ANA) Test 에 관한 연구

조준구,김현숙,홍천수,조철호,권오현,김현만,이수곤,허갑범,전상일 대한내과학회 1987 대한내과학회지 Vol.32 No.2

Antinuclear antibodies are autoantibodies that are usually detected by indirect immunofluorescence and are directed against components of human and other mammalian cell nuclei. Between January 1982 and December 1984, we retrospectively reviewed the records of 238 patients with a positive ANA test. The following results were obtained from this review. 1) Among 238 ANA positive specimens, 98 (41.2%) were connective tissue disorders, 43 (18.0%) immune disorders and 97 (40.8%) other disorders. 2) Among 238 ANA positive specimens, 135 (57%) were low, 26 (11%) intermediate and 77 (32%) high titers. Sixty three of 98 (64.2%) sera from patients with connective tissue disorders and 44 of 53 (83%) sera from patients with SLE had ANA titers of 1:80 or more. Thirty two of 42 (74.4%) sera from patients with immune disorders and 68 of 97 (70.1%) sera from patients with other disorders had ANA titers of 1: 20. 3) Among 238 ANA positive specimens, immunofluorescent patterns showed that 105 (44%) were homogeneous, 102 (43%) speckled, 13 (5.5%) mixed, 12 (5%) peripheral and 6(2.5%) nucleolar pattern. 4) In 53 SLE patients, 41 (77%) were high titers in ANA test and homogeneous and speckled patterns were 26 (55.5%) and 20 (37.7%) respectively. Thirty of 37 (81%) SLE patients had positive anti-DNA test and 16cases (43%) were high titers. 5) Nineteen patients (13.6%) of 140 nonrheumatic disorders showed high ANA titers. Among nine patients with idipathic thrombocytopenic purpura, three patients showed high ANA titers (1:160 1). In conclusion ANA test was useful to diagnose various rheumatic disease. Some nonrheumatic patients also revealed positive ANA test. ANA titers were high in rheumatic disorders, but some non-rheumatic patients with high ANA titers should be followed to look for evolving rheumatic disorders.

Pasteurella Multocida 에 의한 패혈증 1 예

조준구,정윤섭,박인서,이동기,최흥재 대한내과학회 1987 대한내과학회지 Vol.32 No.1

This is a case of pasteurella multocida septicemia. A 50-year-old man was admitted to Severance Hospital, Yonsei University College of Medicine because of fever and dyspnea for 2 days. There was a past history of liver cirrhosis and hepatic coma 3 months ago. On examination, the patient had a temperature of 39.1℃, right side pleural effusion and ascites. Initial therapy with ampicillin and gentamicin was started after culture study. Pasteurella multocida was recovered from the blood culture. Patient improved under antibiotic therapy.

발작성 야간혈색소뇨증의 생존에 관한 연군

이영식,한지숙,이선주,조준구,안용정,고윤웅 大韓血液學會 1987 大韓血液學會誌 Vol.22 No.2