에스트로겐과 활성형 비타민 D의 병합투여가 요추 골밀도에 미치는 영향

조석신,이재억,유중배,황윤영,조수현,문형 대한폐경학회 1996 대한폐경학회지 Vol.2 No.1

Administration of estrogen or vitamin D has been shown to increase bone mineral density in postmenopausal women. To evaluate any added beneficial effects of estrogen combined with vitamine D, 101 postmenopausal attending menopause clinic were allocated into two treatment group; group l,estrogen + progestin(n=72); group 2,estrogen + progestin + 1a-hydroxyvitamin D3 0.5ug/day(n=29). After 1 year of treatment, spinal bone mineral density(BMD) were increased 3.3% in all women. The percent increament of spinal BMD is higher in group 2 than in group 1(244±6.7 vs 5.7±9.8, p$lt; 0.05) and higher in women with osteopenia than normal BMD before treatment(3.4±2.4 vs 8.4±11.2, p$lt;0.05).The percent increasment of spinal BMD correlated with age(group 1; r=0.27, p=0.02, group 2;r=0.41, p=0.02) and menopausal duration in group 2(r=0.45, p=0.01). From the above results, it might be suggested that conbined therapy is more effective in postmenopausal women with osteopenia.

양수내의 Testosteron 대 Follicle Stimulating Hormone 비율에 관한 연구

조석신 대한핵의학회 1982 핵의학 분자영상 Vol.16 No.2

To evaluate fetal sex-hormonal status before delivery, testosterone and follicle stimulating hormone(FSH)levels were measured in 64 amniotic fluid samples at midgestation by radioimmunoassay method. The mean concentration of testosterone in amniotic fluid of 37 cases carrying male fetus was 90.7pg/ml and 27 cases carrying female fetus was 62.3pg/ml. The mean amniotic fluid FSH concentration of male fetus was 1.15 mIU/ml and of female fetus was 11.98 mIU/ml. The amniotic fluid testoserone and FSH' concentrations had statistical difference between male and female fetuses. The ratio of testosterone over FSH in the amniotic fluid was 231.2 in female, 9.8 in female respetively and very significant difference was noticed. The levels of testosterone/FSH greater than 25 were found over 92% of male fetus and lesser than 25 were found over 92% female fetus. Measurement of testosterone and FSH especially testosterone/FSH ratio in amniotic fluid in midgestation may be an adjunct to other method of fetal sex determination.

韓國人 乳房癌患者의 S. H. B. G. 에 關한 硏究

조석신 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1

Recent studies have confirmed that the breast cancer was classified as two groups by their bormone dependency, namely, Estrogen Receptor Positive and Estrogen Korea till now in spite of its clinical importance. Some authors reported the plasma S. H. B. G. and E. R. in breast cancer had close correlation by their hormonal responses. As a preliminary study of estrogen receptor assay in Korean breast cancer, plasmal S. H. B. G. capacity was checked and compared with normal control and breast cancer patients. In normal control, the plasma S. H. B. G. capacity showed no significant difference between premenopausal and postmenopausal group of follicular and luteal phase of menstrual cycles. In 53 cases of breast can cer patients, the plasma S. H. B. G. capacity showed significantly increase in luteal phase comparing with same phase of control group and also showed increasing tendency in postmenoause group. Among the 23 cases of luteal phase breast cancer Patients, 13 cases showed above the upper limit of 99% confidence interval in normal control and among 11 cases of postmenopause breast cancer patients group, 7 cases showed also above the same upper limit in postmenopause control.

한국 여성의 평균 요추 골 밀도와 요추 골절 환자에서 추정되는 골절역치에 관하여

조석신 대한폐경학회 1996 대한폐경학회지 Vol.2 No.2

Purpose: To examine the normal range of bone mineral density(BMD) of lumbar spine and suggest the suspected fracture threshold of lumbar spine in Korean women. Materiale and Method: Measurement of lumbar BMD was done with Gd-153 dual photon absorptiometry in 628 normal Korean women and 74 patients with asymptornatic lumbar spine fracture respectively. The normal group was divided into premenopausal, menopausal and postrnenopoausal group and changes of BMD with aging was analized and suspected fracture threshold was calculated from BMD of patients with lumbar spine fractrure. Resutle: 1. The mean BMD of lumbar spine in Korean women was 1.03 g/cm2, significantly declined with aging, with 0.017g/cm2yr of bone loss, and more rapid bone loss was during postmenopausal stage. 2. The mean BMD in patients with lumbar spine fracture was 0.72g/cm2, which is significnatly decreased comparing the normal group(P$lt;0.01). 3. Suspected frature threshold was 0.913g/cm2, which is 90 percentile value of BMD in patients with lumbar spine fracture. Condusion: mean BMD is significantly declined with aging especially after menopause, and decreased BMD is important cause of lumabr spine fracture, and careful observation if recommended in Korean women with BMD less than 0.913g/cm2

동위원소 주사로 확인된 복수의 이동에 의한 수흉

조석신,강종명,서흥석 대한핵의학회 1987 핵의학 분자영상 Vol.21 No.1

핵의학적 검사로 관찰된 기정맥계

조석신,강종명 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.2

Azygos system, one of the main collateral vessels which communicates superior vena cava with inferior vena cava, is well visualized by X-ray angiography. This systern is rarely demonstrated by radioisotope study. We report a case whose azygos system was shown during (99m)^Tc-DTPA renal scanning.

극저주파 영역에서의 개인 노출량 평가에 관한 실험 연구

김윤신,조용성,조석신 漢陽大學校 環境 및 産業醫學硏究所 1997 環境과 産業醫學 Vol.6 No.1

The purpose of this study was to investigate of the EMFs exposures of personal environment, 60Hz magnetic fields. Subjects were randomly assigned to two groups. Each 35 subjects in occupational and non-occupational group measured personal 24-h continual exposure, using EMDEX Ⅱ (for 40-800Hz, Enertech Consultant, Inc), from May 1996 to April 1997. The mean personal exposure levels of occupational group were 0.195μT, whereas non-occupational group were 0.135μT. Occupational group were exposed more highly while at work. Finally, this study would provide significant data for furture study of exposure assessment of magnetic fields. A large scale study concerning more detailed exposure assessment should provide important information on health risk assessment of MFs.

紙狀兒를 同伴한 雙胎妊娠

趙石臣,金明子,金善元,金聖心 大韓産婦人科學會 1968 大韓産婦人科學會雜誌 Vol.11 No.8

임산부의 임상통계적 관찰

조석신(SS Cho) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.11

A clinical and statistical study on 2.028 women and their 1,880 newborn babies has been carried out with specific reference to groups of women who had reeived and not received antenatal cares. These 2,028 women had been admitted and delivered their babies at the Seoul National University Hospital during the period from April 1,1966 to March 31, 1968. Among the observed pregnant women 552 received regular antenatal care at the Out Patient Clinic, Department of Obstetrics and Gynecology, Seoul National Hopital and the rest 1,476 did not. The above-mentione 1,880 now born infants are sum of 547 infants of the ante- natallu cared group and 1,33 infants of the non-cared group. The following conclusion could be obtained by deviding the patients into primipara and multipara group and the antenatally cared and non-cared group respecively. The average number of admitted pregnant women was 84.2 per month and only 27,2% of them had received regular antenatal care. The obstetrical history,excluding the pregnancy at the time of admission, reveaked that average frequency of their previous pregnancy was 1.60. 759 primipara occupied 37.7% of the observed pregnant women and the rest 62.3% (1,269) multipara. In the observed patients 93.2% (1,889) never experienced premature delivery. No history of abortion was noted in 73.7% (1,491) of the total pregnant women. The average frequency of abortion wxperienced by the patients was 0.48 and there was some difference of the frequency between the antenatally cared group and non-cared group, that was 0.28 in the cared group and 0.55 in the non-cared group. The average number of living babies was and 52.1% (1,055) of the observed patients had no baby. The average duration of hospitalization in the admitted patients was 4.38 days. Showing the relativly short hospitalization in the antenatally cared group, average duration in the cared group was 3.98 days and 4.71 days in the non-cared group. The average homoglobin value at the time of delivery was 10.5gm/d (10.73gm/d in the cared group and 10.47gm/d in the non-caredgroup), and the hematocrit value was 33.4% (33.38% in the cared group and 32.59% in the non-cared group). The normal delivery was possible in 75.7% of the observed pregnant women (82.7% of the cared group and 72.8% of the non-cared group). Cestrean section was performed in 8.7% of the patients(4.6% of cared group and 10.4% of non-cared group). The manual expulsion of the placenta was done in 3.2% of the cared group and 10.2% of the non-cared group. Average amount of blood-loss during delivery was 304m (283m in the cared group and 310m in the non-caredngroup). Obstetrical complications were observed in 89 patients (16.5%) of the 538 antenatally cared patients and the total frequency of the complications was 149 times. In the non-cared group with total number of 1,312, 31.4% showed the obstetrical complication and their total freque- ncy was 699 times. The perinatal mortality was 70.81(27.4 in cared group and 83.42 in the non-cared group). The secondary sex ratio of the newborn infants was 106:100 and the average body weight of the newborn infants was 3.345gm (3.354gm in male and 3.335gm in female).

二重 流出路를 가진 左心室 : 部分的 大脈管轉位症을 同伴한 先天性 心畸形의 1剖檢例 An Autopsy case Report of a Congenital Heart Anomaly with a Partial Transposition of Great Vessels

趙石臣,金明子,金善元,鄭佐九,池堤根,李尙國 大韓産婦人科學會 1968 大韓産婦人科學會雜誌 Vol.11 No.1