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조경민,김범석,하혜림,김미소,정재우,송우정,김태민,전윤경,강혜련,김동완,김철우,허대석 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.4
Background/Aims: This study was to evaluate the clinical significance of infusion- related reaction (IRR) of rituximab in diffuse large B-cell lymphoma (DLBCL) patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) as a first-line chemotherapy. Methods: The medical records of 326 patients diagnosed with DLBCL were re trospectively analyzed. Both doctor’s progress records and nursing records were reviewed. IRR was graded according to the National Cancer Institute Common Terminology Criteria. Results: IRR was not associated with overall survival (OS) or progression-free survival (PFS) of DLBCL patients as compared to those who did not have IRR (OS: median 78.0 months vs. 69.0 months, p = 0.700; PFS: median 65.4 months vs. 64.0 months, p = 0.901). IRR grade did not affect OS or PFS. B symptoms was independently associated with IRR (hazard ratio [HR], 1.850; 95% confidence interval [CI], 1.041 to 3.290; p = 0.036). Further, bone marrow involvement was independently associated with re-IRR (HR, 4.904; 95% CI, 0.767 to 3.118; p = 0.029). Conclusions: Our study shows that IRR of rituximab is not associated with OS or PFS of DLBCL patients who received R-CHOP. Furthermore, our study suggests a need for more careful observation for IRR in patients with B symptoms or bone marrow involvement.
조경민 영미어문학회 2016 영미어문학연구 Vol.32 No.1
The purpose of this study is to investigate the frequency of personal pronouns in the collected data from TED Talks which are videos from expert speakers on various areas with subtitles, and to explore the possibilities of the TED Talks as a personal pronoun learning material in English education. In the analyzed data, the personal pronouns accounted for 11% of all tokens(38,583/ 362,123). Of all the 31 types of personal pronouns, 8 personal pronouns represent 80% of the frequency. In addition, when TED Talks were classified into and analyzed in two features such as Studies and Most Viewed, the frequency of personal pronouns was different from that of the whole TED Talks. This suggests that although TED Talks are a good resource for learning the cohesion of a text and the pragmatic nature of discourse, teachers should first grasp the attributes of each talk and then provide appropriate materials based on the goal of a lesson.