각종 간담도질환에 있어서의 혈청단백여지전기 영동분획상에 관한 연구

노순백(Soon Back Rho),정종훈(Jong Hoon Jung),채종구(Jong Koo Chae),정춘해(Choon Hai Jung),홍순표(Soon Pyo Hong),조건국(Kun Kook Cho) 대한내과학회 1986 대한내과학회지 Vol.30 No.6

N/A There are many reports on the changes of the protein fractions in healthy individuals and in the various disease states, but there are few published data on the relationship between each of the protein fractions and a specific disease entity. In order to investigate whether the changes of any of specific protein fractions in the serum A/G ratio and A/r ratio and A/r ratio have any value in differentiating each of hepatobiliary diseases, 165 patients with hepatobiliary diseases were examined by means of the Helena procedure(Tris- barbital-sodium, barbital buffer pH 8.8, ionic strength 0.067, Wartman No. 1 filter paper under 180 volt/cm and ponceau-s dye). Fifty normal Korean adults were served as the control group. The results were as follows: 1) In fifty normal subjects, the distributions of paper electrophoretically fractionated serum albumin, a1-, a2-, β-and γ-globulin were 54.72±4.52 %, 5.00±1.62%, 7.54±l.63%, 11.92±1.92%, 19.20±3.11% respectively. The albumin/globulin ratio was 1.42±0.31, and A/r ratio 3.17±0.58. 2) Generally, γ-globulin fraction was increased in patients with hepatobiliary diseases, and the markedly increased γ-globulin with markedly decreased albumin was the most outstanding feature with liver cirrhosis. 3) The pattern of abnormally decreased albumin, a2-and β-globulin with markedly increased γ-globulin was the characteristic feature in the cases with the advanced liver cirrhosis but not in the cases with early cirrhosis. 4) Serum albumin, a1-, a2- and β-globulins were progressively increasing as the disease progresses to the chronic state. 5) Alph 1-, a2-and β-globulin were increased in the patients with malignant hepatic diseases. 6) Alpha 1-and alpha 2-globulins were increased in the patients with liver abscess, cholecystitis or cholelithiasis.

비화농성 삼출성 복수를 동반하는 질환에서 복막 침생검의 진단적 의의

정종훈,서용태,오덕환,채종구,정춘해,조건국 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

Percutaneous needle biopsies of peritoneum with Abrams needle and Cope needle were done un 64 patients with non-purulent exudative ascites, who was admitted to the department of internal medicine, Chosun University hospital, from January 1978 to Deccmber 1983. The diagnostic significance and safety of the needle biopsy was estimated. The results were as follows. 1. Adequate peritoneal tissue for pathological diagnosis was obtained in 53 cases(82.8%) among 64 cases. (Abrams needle 84.8%, Cope needle 80.6%) 2. Definitive diagnosis was obtained in 31 cases among 53 cases (58.6%). (Tuberculosis 23 cases, malignancy 8 cases). 3. As compared final diagnosis with biopsy result, the rate of final diagnosis corresponding with biopsy diagnosis was 58.8% in tuberculosis and 26.3%, in malignancy, but the rate of biopsy diagnosis corresponding with final diagnosis was 100% in both tuberculosis and malignancy. 4. Cases of chronic non-specific inflammation which were diagnosed by biopsy were 13cases(24.5%)among 53 cases, and among these cases, tuberculosis was 69.2% and malignancy 30.8% on final diagnosis and among 53 cases, histologically normal was 9 cases(16.9%) of which 33.3% was tuberculosis and 66.7% was malignancy on final diagnosis. 5. Of the malignant cases on final diagnosis, Positive cytologic examination of ascitic fluid was 16.7% 6. Primary losions of cancerous peritonitis were stomach cancer (38.9%) hepatocellular cancer(22.2%) colon cancer (11.1%) ovarian cancer (11.1%) Pancreatic cancer (5.6%). 7. Complication of percutaneous peritoneal biopsy was local swelling with leakage of ascitic fluid and the accident rate were 36.4,% in Abraham needle and 3.2% in Cope needle.

재생 불량성 빈혈의 임상적 고찰

김만중,조승렬,노순백,채종구,정춘해,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

Clinical observation on 127 cases of aplastic anemia at diagnosed at Chosun University Hospital from January, 1976 to December, 1985 were reviewed. 1. The annual distribution of aplastic anemia showed no significant annual change during this Priod. The highest incidence were observed on second decade, 75 cases (59.1%) were observed below 30 years old and male to female sex ratio was 1.4 : 1. 2. Exposure to possible toxic agent were in 3o cases(27.6%), among which chloramphenicol was counted in 8 cases (6.3%), herb agent 6 cases (4.7%), analgesics 5 cases (3.9%), heavy metal 4 cases (3.1%), benzene 3 cases (2.4%), insecticides 3 cases (2.4%), parathion 3 cases (2.4%), and other various agents. The unknown causes are largely distributed 92 cases (72.4%). 3. Initial symptoms and signs on admission were anemia and pallor in 79 cases(62.2%), dizxness and weakness in 61 cases (48.0%), bleeding in 57 cases (44.9%), fever in 30 cases (23.6%), Petechia and ecchymosis in 22 cases (17.3%), hepatomegaly in 21 cases (16.5%), splenomegaly in 12 cases (9.5%), headache in 7 cases (0.5%) and other symptoms and signs in 13 casea (10.2%). 4. Among the laboratory findings, severe anemia with hemoglobin level of 5.0gm/㎗, or less were noted in 58 cases (45.7%). Neutrophil count of less than 2,000/㎣ found in 51 cases (10.2%) and platelet count of less than 50,000/㎣ in 68 cases (53.5%). Findings of bone marrow aspiration and biopsy were revealed hypercellularity in 4 cases (3.2%), normocellularity in 13 cases (10.2%), hypocellularty in 93 cases (73.2%) and dry tap in 17 cases (13.4%). 5. On the 95 cases which were follow-up for evaluation of prognosis, remission in 19 cases (15.0%), steady states in 58 cases (45.7%) and death in 18 cases (14.2%) were noted, So, Prognosis was not favorable in 32 cases (25.2,%). The causes of death of 18 cases by follow-up evaluation revealed infection in 7 cases (38.9%). bleeding in 5 cases (27.8%) and progressive anemia in 4 cases (22.2%), The unknown causes were counted in 2 cases (1.1%). 6. The treatment of aplaatic anemia consisted of blood transfusion, anabolic-androgenic steroid, adrenal corticosteroid hormone, and conservative or symptomatic management.

45,XI 46,XXr 핵형의 터너 증후군 1례

이기주,이봉규,정중화,이만재,전용준,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

A 16-years-old-girl was presented with chief complaints of dizziness and exertional dyspnea. She was tall 146 cm (less than the fifth percentile) and sexually developed normally. But she experienced intermittent menorrhagia. She had a shield chest, a low-set nuchal hairline and a short left metatarsal bone. There were no other dysmorphic facial features, no webbed neck, no cubitus valgus, & no mental retardation. The blood hemoglobin was 6.2 g/dl and peripheral blood smear showed hypochromic microcytic red blood cells. Bone marrow showed moderate erythroid hyperplasia and normoblast with scant cytoplasm, and it was not stained by Prussian Blue stain. She had a mosaicism of 45.X/46.XXr in the cells, cultured from the peripheral blood. Fifty five cells were examined. Forty-two cells had 45 chromosome, with one X. The remaining thirteen cells had 46 chromosomes per cell, with a normal X and a ring X chromosome. The mother was 155 cm tall and had normal karyotype. We herein report a Turner syndrome patient with a ring X chromosome with a brief review of literature.

제2형 당뇨병 환자에서의 혈중 렙틴 농도

김현리,배학연,장성종,김희중,정재용,김양수,김태균,박유환,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.2

Objective: Leptin, the product of obesity (ob) gene, is a 16-kDa peptide hormone secreted by adipocytes and is thought to be a homeostatic signal that contributes to body weight regulation through modulating feeding behavior and/or energy expenditure. Mutations of the ob gene that led to leptin deficiency or production of a truncated inactive protein are associated with hyperphagia, hypometabolism, obesity, and noninsulindependent diabetes mellitus(NIDDM) in obese ob/ob mice. Leptin' s role in humans with obesity and NDDM is not known. Plasma leptin concentrations are shown to be elevated in obese humans. We questioned whether subjects with NIDDM have an altered regulation of serum leptin levels. Therefore, the object of this study is to evaluate the relationships between the serum leptin level and BMI, NIDDM. Method: This study were made of 70 subjects(control: 35, NIDDM:35) at Chosun University Hospital in Kwangju from March, 1998 to September, 1998. We measured the height and weight for BMI. Also, we measured leptin and C-peptide through radioimmunoassay. Result: The serum leptin concentration were not different in patients with type II diabetic and nondiabetic subjects (6.3 0.86/7.22 0.96, p=0.476) and the BMI was similar in diabetic and nondiabetic subjects(24 0.57/24 0.45, p=0.93). The leptin concentration were higher in women than in men regardless of diabetic status (diabetes: male 3.07 0.40 / female 8.20 1.18, p<0.05 control: male 4.88 1.28 / female 8.60 1.25, p<0.05). Conclusion: We concluded that the leptin concentrations were not different in diabetic and nondiabetic subjects and that the association of leptin with sexual dimorphism was similar in diabetic and nondiabetic subjects.