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RISS 인기검색어
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- 저자 : 노순백(Soon Back Rho) (검색결과 3 건)
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각종 간담도질환에 있어서의 혈청단백여지전기 영동분획상에 관한 연구
노순백(Soon Back Rho),정종훈(Jong Hoon Jung),채종구(Jong Koo Chae),정춘해(Choon Hai Jung),홍순표(Soon Pyo Hong),조건국(Kun Kook Cho) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A There are many reports on the changes of the protein fractions in healthy individuals and in the various disease states, but there are few published data on the relationship between each of the protein fractions and a specific disease entity. In order to investigate whether the changes of any of specific protein fractions in the serum A/G ratio and A/r ratio and A/r ratio have any value in differentiating each of hepatobiliary diseases, 165 patients with hepatobiliary diseases were examined by means of the Helena procedure(Tris- barbital-sodium, barbital buffer pH 8.8, ionic strength 0.067, Wartman No. 1 filter paper under 180 volt/cm and ponceau-s dye). Fifty normal Korean adults were served as the control group. The results were as follows: 1) In fifty normal subjects, the distributions of paper electrophoretically fractionated serum albumin, a1-, a2-, β-and γ-globulin were 54.72±4.52 %, 5.00±1.62%, 7.54±l.63%, 11.92±1.92%, 19.20±3.11% respectively. The albumin/globulin ratio was 1.42±0.31, and A/r ratio 3.17±0.58. 2) Generally, γ-globulin fraction was increased in patients with hepatobiliary diseases, and the markedly increased γ-globulin with markedly decreased albumin was the most outstanding feature with liver cirrhosis. 3) The pattern of abnormally decreased albumin, a2-and β-globulin with markedly increased γ-globulin was the characteristic feature in the cases with the advanced liver cirrhosis but not in the cases with early cirrhosis. 4) Serum albumin, a1-, a2- and β-globulins were progressively increasing as the disease progresses to the chronic state. 5) Alph 1-, a2-and β-globulin were increased in the patients with malignant hepatic diseases. 6) Alpha 1-and alpha 2-globulins were increased in the patients with liver abscess, cholecystitis or cholelithiasis.
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Paraquat 투여에 의한 백서 간장의 변화에 관한 연구
홍순표,조건국,정춘해,오덕환,노순백,서용태 대한내과학회 1986 대한내과학회지 Vol.30 No.3
We observed SGOT, SGPT, alkaline phosphatase, superoxide dismutase activity and lipoperoxide in liver cytosol of rats treated with paraquat. Paraquat was injected to the rats intrape-ritoneally 10 mg/kg(A group) and 20 mg/kg(B group) each. The rats were sacrificed 24 hours after paraquat administration, and above mentioned items were tested. The following results were obtained: 1) SGOT, SGPT, alkaline phosphatase were all elevated in proportion to the paraquat dosage. 2) The mean cytosolic protein value of the liver was 125.9±19.8 mg/g by Biuret method in control group. In paraquat group, A and B, the values were 155.4±19.0 mg/g and 174.0±15.2 mg/g after 24 hours, respectively. 3) The cytosolic superoxide dismutase activity of the liver was 2375.0±250. 8 U/g in control group, whereas in paraquat treated group the values were increased in proportion to the dosage (A group: 2567.3±297,4 IU/g, B group: 2840.1±274.2 IU/). 4) The mean cytosolic lipoperoxide value of the liver in control group was 55.2±11.0 ut in B group, a significantly increased mean value (122.5±25.9 nM/g) was obtained after 24 hours of paraquat administration. These results suggest that hepatic changes of rats treated with paraquat may be due to lipoperoxide and superoxide radicals formed by paraquat.
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김만중,조승렬,노순백,채종구,정춘해,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1
Clinical observation on 127 cases of aplastic anemia at diagnosed at Chosun University Hospital from January, 1976 to December, 1985 were reviewed. 1. The annual distribution of aplastic anemia showed no significant annual change during this Priod. The highest incidence were observed on second decade, 75 cases (59.1%) were observed below 30 years old and male to female sex ratio was 1.4 : 1. 2. Exposure to possible toxic agent were in 3o cases(27.6%), among which chloramphenicol was counted in 8 cases (6.3%), herb agent 6 cases (4.7%), analgesics 5 cases (3.9%), heavy metal 4 cases (3.1%), benzene 3 cases (2.4%), insecticides 3 cases (2.4%), parathion 3 cases (2.4%), and other various agents. The unknown causes are largely distributed 92 cases (72.4%). 3. Initial symptoms and signs on admission were anemia and pallor in 79 cases(62.2%), dizxness and weakness in 61 cases (48.0%), bleeding in 57 cases (44.9%), fever in 30 cases (23.6%), Petechia and ecchymosis in 22 cases (17.3%), hepatomegaly in 21 cases (16.5%), splenomegaly in 12 cases (9.5%), headache in 7 cases (0.5%) and other symptoms and signs in 13 casea (10.2%). 4. Among the laboratory findings, severe anemia with hemoglobin level of 5.0gm/㎗, or less were noted in 58 cases (45.7%). Neutrophil count of less than 2,000/㎣ found in 51 cases (10.2%) and platelet count of less than 50,000/㎣ in 68 cases (53.5%). Findings of bone marrow aspiration and biopsy were revealed hypercellularity in 4 cases (3.2%), normocellularity in 13 cases (10.2%), hypocellularty in 93 cases (73.2%) and dry tap in 17 cases (13.4%). 5. On the 95 cases which were follow-up for evaluation of prognosis, remission in 19 cases (15.0%), steady states in 58 cases (45.7%) and death in 18 cases (14.2%) were noted, So, Prognosis was not favorable in 32 cases (25.2,%). The causes of death of 18 cases by follow-up evaluation revealed infection in 7 cases (38.9%). bleeding in 5 cases (27.8%) and progressive anemia in 4 cases (22.2%), The unknown causes were counted in 2 cases (1.1%). 6. The treatment of aplaatic anemia consisted of blood transfusion, anabolic-androgenic steroid, adrenal corticosteroid hormone, and conservative or symptomatic management.
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