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내피세포 Nitric Oxide 유리를 통한 산사의 혈관이완 작용
채종구,김길훤,신흥묵 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.1
It had been known for a while that Crataegi Fructus(CF; Crataegus pinnatifida Bunge) had only a digestive effect. Recently, it has been demonstrated that CF also has an ant-hypertensive effect. However, its mechanism of relaxant effect has not been investigated yet This study was examined to investigate the mechanism of vascular relaxation effect of CF in isolated rat thoracic aorta. CF revealed significant relaxation to phenylephrine(PE)-induced arterial contraction but much less to KCI-induced one. When CF was pretreated, it inhibited PE-induced contraction non-competitively. Methylene blue(10^(-6)M) completely blocked the relaxant effect of CF whereas L-NAME(10^(-5)M) did almost completely. However, atropine(10^(-6)M) did not have any influence on vascular relaxation effect of CF. Regarding cNOS activity, CF significantly increased its activity from rat whole brain homogenate in a dose dependent manner which was inhibited by L-NAME(10^(-5)M). On the other hand, CF did not affect on expression of TNF-α mRNA in RAW 264.7 calls, suggesting that CF is not related to iNOS activity. These results indicate that CF would be effective in relaxing vascular contraction through release of endothelial nitric oxide.
간장질환 환자의 혈중 α₁ - Antitrypsin 과 Prealbumin 에 관한 연구
채종구(Jong Koo Chae),배학연(Hak Yeon Bae),김만우(Man Woo Kim),장경식(Kyoung Sig Chang),정춘해(Choon Hae Chung),조건국(Kun Kook Cho) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A The alpha-1-antitrypsin and prealbumin concentrations were measured in sera of 34 cases of liver cirrhosis, 20 cases of liver cirrhosis with hepatocellular carcinoma, 18 cases of primary hepatocellular carcinoma and 30 normal control cases in Chosun University Hospital from Jan. 1985 to July 1986. The results are follows: 1) The mean concentration of alpha-1-entitrypsin in blood of normal control group was 141±39.9mg%, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were increases each 151.4±93.0, 185.8±71.8 (P<0.05) and 163.4±88.6 mg% in comparison with the mean value of normal control group. 2) The mean concentration of prealburnin in blood of normal control group was 174±65 mg9o, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were significantly decreased each 101±49, 82±16 and 75±26 mg% fall P<0.01). 3) The mean concentrations of serum prealbumin in each group of liver diseases with low serum alpha-1-antitrypsin levels: liver cirrhosis (79.1±21.1), liver cirrhosis with hepatocellular carcinoma (41.0±12.0) and primary hepatacellular carcinoma (52.5±17.0 mg%) were significantly decreased (all P<0.01). Consequently, in chronic liver diseases, the serum alpha-1-antitrypsin levels were usually increases and prealbumin levels were significantly decreased in comparison with mean value of normal control group. In chronic liver diseases with low serum alpha-1-antitrypsin level, serum prealbumin concentrations were significantly decreased, This study show that patients with low serum alpha-1-antitrypsin level in chronic liver diseases have severe damage of parenchymal cells in liver.