Pimozide와 Haloperidol 과량 복용 후 반복적으로 발생한 심실 빈맥 1례

정진희,장혜영,어은경,Jung, Jin-Hee,Jang, Hye-Young,Eo, Eun-Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1

Pimozide and haloperidol are typical antipsychotics. They share a similarity in pharmacotherapeutic and adverse effect profiles. Cardiovascular effects may be seen as alterations in heart rate, blood pressure, and cardiac conduction. Conduction disturbances may occur ranging from asymptomatic prolongation of the QT interval to fatal ventricular arrhythmia. So in the case of anti psychotics overdose, the patient must be carefully monitored by continuous electrocardiography (ECG). We experienced a 34-year-old woman of schizophrenia with recurrent ventricular tachycardia after pimozide and haloperidol overdose. Initially she was slightly drowsy, however her ECG showed normal sinus rhythm. After 6 hours on emergency department entrance, her ECG monitoring showed ventricular tachycardia and we successfully defibrillated. There were five times events of ventricular arrhythmia during the in-hospital stay. She was discharged 5 days later without any other complications.

혈액관류 요법과 함께 L-카르니틴을 투여한 valproic acid 중독 환자 1례

정진희,김기범,안기옥,어은경,Jung Jin Hee,Kim Gi Beom,Ahn Ki Ok,Eo Eun Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Valproic acid (VPA) is used in the management of a variety of conditions including simple and complex absence seizure disorder. bipolar disorder, and migraine prophylaxis. Clinical manifestation of VPA overdose vary in severity from mild confusion and lethargy to severe coma and death. The treatment of VPA toxicity is mainly supportive. There is no specific antidote, nor are there specific guidelines for the management of VPA intoxication. Anecdotal reports describe the efficacy of naloxone and L-carnitine, but the data are insufficient to make strong conclusions. Various techniques of extracoporeal therapy for the management of VPA toxicity have been described, but none has prevailed as standard therapy. We report a patient with VPA overdose who was successfully treated with hemoperfusion with activated charcoal and L-carnitine. VPA levels of the patient was more than 1,000 ${\mu}g$/ml and was normalized after 3 times hemoperfusion. The patient was injected with L-carnitine by maximum 600 mg/kg/day for 5days without complications.

이질형 바이오 데이터베이스 통합을 위한 게이트웨이 시스템

정진희,정민아,Jung, Jin-Hee,Jung, Min-A 한국정보통신학회 2005 한국정보통신학회논문지 Vol.9 No.8

이질적인 생물 데이터베이스의 통합은 데이터간의 연계 분석의 필요성이 높아짐에 따라 중요한 문제로 대두되고 있다. 그러나 이러한 데이터베이스들은 초기에 이질적 환경에서 각기 다른 목적에 의해 생성되므로 포맷, 설계자가 불일치하는 등 여러 가지 문제점으로 인해 통합하는데 어려움이 따른다. 그러므로 이질적인 데이터베이스의 통합을 위해서는 초기단계의 설계가 무엇보다도 중요하다. 본 논문에서는 대표적인 핵산 데이터베이스인 Genbank와 단백질 데이터베이스인 Swiss-Prot을 통합하기 위해 ER 모델을 사용하여 개념적 모델을 보인 후, 이를 합병하여 통합모델을 제시한다. 또한, 핵산-단백질 자료로 연계되는 정보를 통합 서비스할 수 있는 시스템 구조를 제안한다. 제안된 바이오 게이트웨이 시스템은 개념적 설계 단계에서 가장 원자적인 단위로 분할하여 모델링 함으로써 정교한 질의 처리가 가능하고, 사용자가 상세 조건을 알고 있을 경우에 기존의 검색시스템과 달리 여러 번의 검색 과정을 거치지 않고, 단시간에 원하는 결과를 얻을 수 있다는 장점을 지닌다. The Integration of biological databases is critically important because of the interconnectedness of biological research. But it's not easy to integrate these databases for the different formats and designers in heterogeneous environments. So initial design is indispensable to integrate heterogeneous databases. In this paper, after we performed conceptual modeling on a popular nucleotide database, GenBank and a protein database, Swiss-Prot and integrated them by considering cross-reference. we also propose the integration system architecture called Bio-Gateway System, which can help users query closely linked information between two biological databases within one system differently from existing systems as well as query easily on condition that user knows fine condition for less effort.

의료보장 형태가 혈액투석 서비스 제공에 미치는 영향에 대한 다수준 분석

정진희,권순만,김경훈,이선경,김동숙,Jung, Jin-Hee,Kwon, Soon-Man,Kim, Kyoung-Hoon,Lee, Seon-Kyoung,Kim, Dong-Sook 대한예방의학회 2010 예방의학회지 Vol.43 No.3

Objectives: This study aims to compare quality indicators for the hemodialysis services between patients with health insurance and those with medical aid. Methods: This study used data from sampled hospitals that provided a hemodialysis service. A total of 2287 patients were selected, and the information for hemodialysis service has been granted from medical record reviews. A multi-level regression analysis was used to examine the differences in process and outcome indicators for hemodialysis between patients with health insurance and those with medical aid. Process indicators were defined as: frequency of hemodialysis, hemodialysis time, erythropoietin (EPO) use, measurement of hemodialysis dose at least once a month, measurement of phosphate at least once every three months, and measurement of albumin at least once every three months. Outcome indicators were defined as: hemodialysis adequacy, anemia management, blood pressure management, and calcium, phosphate and nutrition management. The total scores for outcome indicators ranged from 0 (worst) to 4 (best). Results: There was a significant difference in the measurement of hemodialysis dose at least once a month between patients with health insurance and those with medical aid (OR 0.66, 95% CI = 0.43 - 0.99). However, frequency of hemodialysis, hemodialysis time, EPO use, measurement of phosphate at least once every three months, measurement of albumin at least once every three months, hemodialysis adequacy management, Hb${\geq}$11 g/dL, blood pressure within the range of 100-140 /60-90 mmHg, calcium x phosphate${\leq}$55 $g^2/dL^2$ and albumin${\geq}$4 g/dL were not significantly different between the groups. Conclusions: There were no significant differences in outcome indicators for hemodialysis between the groups. Further studies are warranted into the mechanism that results in no differences in the outcome indicators for hemodialysis.

안드로이드 자바를 이용한 슈팅게임

정진희 ( Jin Hee Jung ),박두순 ( Doo-soon Park ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2

본 게임은 옛날부터 인기를 가지고 있던 고전 게임인 갤러그를 모델로 안드로이드 자바를 이용하여 만든다. 본 논문에서는 사용자의 호기심 유발과 스트레스 해소를 시키는 슈팅게임을 제시한다. 즉, 관심을 끌 수 있는 이미지 사용과 나이, 성별 등을 따지지 않은 단순한 게임 방법으로 사용자에게 흥미와 재미를 주기 위한 가장 적합하고 개선된 슈팅게임이다.

中國熾盛光如來圖像考察(중국치성광여래도상고찰)2

정진희(Jin Hee Jung) 동국대학교 불교문화연구원 2012 佛敎學報 Vol.0 No.63

9세기 초반 이후에 성립 되어진 치성광여래도상은 시대에 따라 전승되며 변화를 보이는데 이는 신앙의 성격이 변화하였음을 보여주는 것이다. 9세기 중기 五星이 眷屬으로 그려진 초기도상은 외래신앙인 九曜信仰을 받아들이는 과정에서 중국인들에게 익숙한 전통점성신앙인 오성신앙과 연관지어 치성광여래신앙을 이해하였다는 것을 의미한다. 그리고 12궁과 28수가 나타나는 10세기 이후 강림형식의 개인공덕용 도상과 설법회형식의 예배용도상의 유행은 당시 신앙이 정착되어 대중의 인기를 얻었다는 사실을 알려준다. 14세기 이후 도상에서 12궁과 28수가 사라지고 있는 현상과 치성광여래가 화면에서 강조되고 대승의 보살행을 의미하는 白牛車가 출현하는 것은 신앙의 내용이 초기 星變과 관련된 특수한 목적의 소재길상에서 수명장수와 부귀영화를 희망하는 일반적인 기복신앙으로 변화하고 있다는 것을 의미한다. 이와 같은 이유로 도상에서도 星宿像은 본질적인 의미를 잃고 불화의 일반권속들과 같은 의미로 그려져 전승되고 있었다. The periodical transformation which has been shown in the transmission of the icon of Buddha in China indicates that the characteristics of Buddhist faith in the country had also been changed with the course of time. During the formation of the belief of Tejaprabha Buddha(熾盛光如來), Chinese had understood the Navagraha(九曜) faith introduced from India as their traditional astrology. As a result of this inclination, the initial form of the icon ``the Advent of Buddhas in Progression’(降臨圖上) in Tang(唐) Dynasty and Five Dynasties and Ten Kingdoms(五代十國) period had a transitional feature in which Tejaprabha Buddha depicted with the Five Stars(五星) or the Big Dipper(七星). Most of the icons with this initial form had narrow width, and more related to ``the Print of Invoking A Blessing’(消災吉祥圖) which had been used to practice the Buddhist merit of an individual person, rather than the Scene Painting of a Buddhist(後佛畵) used for worship. By the 10th century, the full-scaled icon of worship that illustrates the assembly of Tejaprabha Buddha(說法形式) had begun to emerge with the icon of the Advent of Buddhas in Progression for private practice of virtue. This phenomenon refers to the prosperity and establishment of the faith on the country. The reconciliation of tradition had progressed as a branch of the establishment, which is characterized by the advent of the icon of a government official(卿相形) holding chinese ritual baton(笏板) and the transformation of the form of the Star Icon(星宿) into a hermit in a robe of feathers. Furthermore, the Golden Wheel(金 輪) known as the distinct symbol of Tejaprabha Buddha had been firmed in China and become the significant feature of the icons after the 12th century. Since astronomical knowledge in Islamic culture had been introduced into China in the 14th century, Constellations of the Zodiac and Twenty-eight mansions(十二 宮·二十八宿) disappeared from the icons. The trait of the belief of Tejaprabha Buddha had also changed to focus mainly on the wish of good auspices(消災吉祥), and there had been a change of the figures in the icons to be arranged with Tejaprabha Buddha as the central figure. The icon which was painted as the scene painting in a royal palace(殿閣) for worship depicting the assembly of Tejaprabha Buddha, especially, was a large scale as a worship picture. In addition, multifarious figures appeared in the icon, including a attendant Bodhisattva(脇侍菩 薩) who had not been in existence in the icons of the earlier periods. The form of icons on the descent from heaven(降臨形式) is surmised that it had been transmitted by being used in smaller scale works, such as the icon giving an explanation as a picture of Sutra(經變相圖). Moreover, it is noticed that the shape of the Saturn(土曜) which had appeared in the icons illustrating the assembly of Tejaprabha Buddha and the Holy Crowd(聖衆) that had been shown in that of Yuan·Ming(元·明) Dynasty also exist in the form of icons on the advent.

마이크로나노버블 토양세척시스템 및 산세척 복합공정의 산 농도변화에 따른 중금속 제거효율에 관한 연구

정진희 ( Jin-hee Jung ),최호은 ( Ho-eun Choi ),정병길 ( Byung-gil Jung ),성낙창 ( Nak-chang Sung ),이기철 ( Gi-chul Yi ),최영익 ( Young-ik Choi ) 한국환경과학회 2017 한국환경과학회지 Vol.26 No.1

This study was aimed at determining the changes in heavy metal removal efficiency at different acid concentrations in a micro-nanobubble soil washing system and pickling process that is used to dispose of heavy metals. For this purpose, the initial and final heavy metal concentrations were measured to calculate the heavy metal removal efficiency 5, 10, 20, 30, 60, and 120 min into the experiment. Soil contaminated by heavy metals and extracted from 0~15 cm below the surface of a vehicle junkyard in the city of U was used in the experiment. The extracted soil was air-dried for 24 h, after which a No. 10 (2 mm) was used as a filter to remove large particles and other substances from the soil as well as to even out the samples. As for the operating conditions, the air inflow rate in the micro-nano bubble soil washing system was fixed at 2 L/min,; with the concentration of hydrogen peroxide being adjusted to 5%, 10%, or 15%. The treatment lasted 120 min. The results showed that when the concentration of hydrogen peroxide was 5%, the efficiency of Zn removal was 27.4%, whereas those of Ni and Pb were 28.7% and 22.8%, respectively. When the concentration of hydrogen peroxide was 10%, the efficiency of Zn removal was 38.7%, whereas those of Ni and Pb were 42.6% and 28.6%, respectively. When the concentration of hydrogen peroxide was 15%, the efficiency of Zn removal was 49.7%, whereas those of Ni and Pb were 57.1% and 42.6%, respectively. Therefore, the efficiency of removal of all three heavy metals was the highest when the hydrogen peroxide concentration was 15%.

어린이집 평가인증 현장관찰자로 살아가기

정진희(Jung, Jin-Hee),이대균(Lee, Dae-Kyun) 한국열린유아교육학회 2019 열린유아교육연구 Vol.24 No.2

본 연구는 어린이집 평가인증 현장관찰자들이 현장관찰직을 수행하면서 겪고 있는 어려움은 무엇이고 어떻게 개선되기를 바라고 있는지, 현장관찰자들의 이야기를 분석한 질적 연구이다. 이를 위해 어린이집 평가인증 현장평가 경력 5년 이상의 현장관찰자들을 심층 면담하여 상위범주로 분석한 결과는 다음과 같다. 첫째, 현장관찰자의 어려움은 ‘새롭고 긴 여정, 늘 다른 일터’, ‘정확하고 확실하게’, ‘모든 책임이 우리에게’, ‘동전의 양면과 같은 직업’이다. 둘째, 현장관찰자의 바람은 ‘한국보육진흥원의 기능과 위상이 강화되어야’, ‘정확한 지표 평정을 위해’, ‘평가인증의 실효성을 위해’이다. 이러한 연구결과를 토대로 현장관찰자들의 체계적인 교육 및 처우 개선의 필요성, 한국보육진흥원의 법정기관화, 보육교사의 상호작용에 대한 지원, 평정기준의 명확성 등 정확한 현장평가를 위한 구체적 개선방안에 대해 논의하였다. 본 연구는 현장관찰자들의 경험을 분석하여 어린이집 평가인증제를 개선하고 현장평가의 정확성을 높이기 위한 기초자료를 제공했다는 데 의의가 있다. This study is a qualitative study analyzing the story of the field observers to see what difficulties they are experiencing while observing the field for child care center accreditation and how the difficulties can be improved. For this purpose, the field observers with more than 5 year career participated in in-depth interviews and the results are as following. First, the difficulties of the field observers were ‘new and long journeys, always different workplace’, ‘precisely and surely’, ‘all responsibilities to us’, and ‘occupation like a coin with two sides’. Second, the wishes of the field observers were ‘the function and status of KCPI(Korea Childcare Promotion Institute) should be strengthened’, ‘for accurate assessment indicators’, and ‘for the effectiveness of accreditation’. Based on the results of this study, specific improvement plans for accurate assessment such as the need for systematic education and treatment of the field observers, becoming a legal agency of KCPI, support for interactions of child care teachers, and clear evaluation standard were discussed. This study is significant in that it provides a basic data for improving the accuracy of on-site evaluation and the accreditation system for child care centers by analyzing experiences of the field observers.

생물고분자로 이루어진 저독성 흡수제의 팽윤거동

정진희(Jin Hee Jung),김진(Jin Kim),이기영(Ki Young Lee) 한국고분자학회 2013 폴리머 Vol.37 No.4

본 연구에서는 식품첨가물로 승인되어 있는 생물고분자 물질을 이용하여 신속팽윤성과 고흡수성을 갖는 하이드로젤을 제조하고 팽윤특성을 분석하였다. 하이드로젤을 제조하는 과정에서 기포발생제를 이용하여 기공을 형성시켜 기존 하이드로젤의 팽윤성 향상을 시도하였고 각 하이드로젤의 평형 팽윤도, 팽윤속도 및 세포독성을 비교하였다. Alginate hydrongel에서는 digital microscope 관찰을 통해 수백 ㎛ 크기의 열린 채널로 다공성 구조를 관찰하였으며 제조된 모든 하이드로젤들은 poly(acrylic acid)에 비해 높은 세포생존율을 보였다. In this study, hydrogels with fast swelling and high absorbent properties were prepared using biopolymers approved as a food additive and their swelling properties were characterized. To improve the swelling properties of con-ventional hydrogels, we formed gas bubbles using a foaming agent in the process of preparing hydrogels and char-acterized in terms of equilibrium swelling ratio, swelling kinetics and cytotoxicity. In particular, alginate hydrogels observed by a digital microscope have an open-pore channels structure with the sizes of hundreds micrometers. Also, the cell viabality of all hydrogels were found to be much higher than that of poly(acrylic acid).

서울 안양암(安養庵) 금륜전(金輪殿) 치성광 여래(熾盛光如來) 조상과 불화 연구

정진희(Jung jin hee) 서울시립대학교 서울학연구소 2017 서울학연구 Vol.- No.69

1889년에 창건된 서울 종로 창신동 안양암의 연혁은 급변하는 근대기 불교계의 변화와 행보를 같이 한다. 도성에서 승려들의 신앙 활동이 금지되었던 19세기말, 서울에서 불교에 의탁하여 사회적 정체성을 찾고자 하였던 武任집단들의 儒佛道 삼교융합적 불교사상이 안양암 창건의 사상적 배경이 되고 있었다. 안양암 치성광여래와 칠원성군 조상들은 도교 성수신앙과 강한 친연성을 나타내었던 근대기 서울의 치성광여래 신앙의 다양한 특징을 가지고 있다. 안양암 금륜전의 칠원성군 소상들은 서울의 사찰에서 칠성의례가 도교 성수초례로 이해되고 있는 신앙의 지역적 특징을 반영하는 유물이다. 사료를 통해서만 검증되었던 성신조상을 실증하는 작품이라는 사실과 더불어 소격서에서 성신을 조상으로 만들어 모셨던 전통을 확인할 수 있다는 점에서 안양암 칠원성군소상들의 가치는 크다. 관우가 모셔져 있는 동묘와 지척의 거리에 위치한 안양암 금륜전에 소장된 20세기 초반 치성광여래 강림도 2점은 신앙의 변화에 따라 도상이 만들어지는 신앙과 도상의 유기적 관계를 보여준다. 이 그림을 그린 고산 축연은 설법회도라는 시대적 양식을 벗어나 근대기 민중적 호응을 얻었던 관성신앙을 적극적으로 수용하여 강림도 형식으로 그림을 그렸다. 근대기 서울지역에서 삼교융합적 사상을 배경으로 창건되어진 사찰에 녹아든 관성교의 흔적을 실증적인 예로 보이고 있다는 사실에서 안양암 치성광여래 강림도의 가치는 높게 평가될 수 있을 것이다. Tejaprabha Buddha, Constellational Faith of Buddhist came to actively reflect the taste of the general people along with the stream of time since its transmission to the Korean Peninsula from China. In Korea, the identity of Tejaprabha Buddha faith as Constellational Faith of Buddhist, as it was mixed with Constellational Faith of Taoism along with Bhaisajyaraja and the multiple divine guardians of the Dharma faith(神衆信仰) along with the stream of time, accordingly, it is consistently perceived by the general people so far as Big Dipper faith, misunderstood as a belief to wish fortune revealed among people. Since Buddhist art, as a religious art, differs the iconology along with the change of faith, Tejaprabha Buddha iconology also showed a process of several changes in appearance along with change of faith. History of Changshin-dong Anyang-am of Jongno, Seoul, built in 1889, shows a similar stream to rapidly changing modern Buddhism. During the late 19th century, when Buddhist monks’ religious activity was prohibited in the capital city, the Buddhist idea with strong characteristic of Confucianism, Buddhism, Taoism(儒佛道) three religions’ fusion(三敎融合的) of military (naval) officer groups(武任), who searched for their social role in Seoul relying on Buddhism became the background of foundation of Anyang-am. The iconologies of Tejaprabha Buddha and the Big Dipper displayed in Anyang-am Geumryunjeon, are significnat in respect of showing various characteristics of Tejaprabha Buddha of modern period Seoul, which displayed intensive affinity with Taoist Constellational Faith, compared to the province. Enshrinement of Bhaisajyaraja in Chilseongjeon along with Bhaisajyaraja while building a small Buddhist temple indicates transmission of the characteristic of Tejaprabha Buddha faith, identified with early Joseon Yaksayeorae, to the modern period. Also, putting Chilseongwongun made of clay(塑像) in temple building shows the tradition of picture each part of the Big Dipper(七星各部圖), which rapidly emerged as the characteristic of Sinjung of mid Joseon. Also, 2 pieces of The Descent of Tejaprabha Buddha, which show the aspect of Gwanu faith(關聖信仰), gained popularity of the publid during the modern times, are enshrined in Anyang-am Geumryunjeon along with Tejaprabha Buddha and Chilwonseonggun(七元星君). Accordingly, iconology of Tejaprabha Buddha of Anyang-am is significant in respect of showing the change process of Tejaprabha Buddha faith of Joseon with art work. Gosandang Chugyeon, who painted Anyang-am Tejaprabha Buddha painting, bravely painted works reflecting the social atmosphere of modern times, without following the mode of the period when the painting style was handed down. He created differentiated Tejaprabha Buddha painting, reflected with the existing Tejaprabha Buddha iconology of Seoul area and Gwanu faith, which gained popularity by the people, through the Descent of Tejaprabha Buddha of Anyang-am, located nearby Dongmyo(東廟), where Gwanu is enshrined. The researcher considers that the value of the Descent of Tejaprabha Buddha can be highly estimated, in respect that it shows the trace of Gwanseong-gyo(關聖敎), melted into the temple, founded based on the idea of three religions’ fusion in Seoul as an empirical case.