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20대 이하 간세포암종의 증례 : 20세 미만의 젊은 연령에서 발병한 간세포암종 1예
정주원 ( Joo Won Chung ),김승업 ( Seung Up Kim ),박준용 ( Jun Yong Park ),안상훈 ( Sang Hoon Ahn ),한광협 ( Kwang Hyub Han ),전재윤 ( Chae Yoon Chon ),고흥규 ( Heung Kyu Ko ),성진실 ( Jin Sil Seong ),장종희 ( Jong Hee Chang ),김 대한간암연구회 2009 대한간암학회지 Vol.9 No.-
Hepatocellular carcinoma (HCC) is very rare in young age. Most young patients tend to receive the evaluation only when they experience intractable or persistent symptoms. Therefore, HCC in young patients is often diagnosed at advanced stage and thus, young HCC patients have a worse prognosis than older HCC. However, because young HCC patients show well-preserved liver function than older HCC, they are tolerable to more aggressive treatments. We report a case of advanced HCC in 13-year and 8-month old male who has been a B-viral carrier. Despite the tumor size decreased after concurrent chemoradiation therapy, multiple lung and brain metastases developed. He underwent radiofrequency ablations on lung metastases and gamma-knife surgery on brain metastasis, and he has received systemic and intra-arterial chemotherapy. The screening and early diagnosis of HCC in young age is needed especially for B-viral carrier with a family history of HCC.
정주원 ( Joo Won Chung ),박재준 ( Jae Jun Park ),임윤정 ( Yun Jeong Lim ),이준 ( Jun Lee ),김선문 ( Sun Moon Kim ),한정호 ( Joung-ho Han ),전성란 ( Seong Ran Jeon ),이홍섭 ( Hong Sub Lee ),김용성 ( Yong Sung Kim ),송시영 ( Si You 대한소화기학회 2018 대한소화기학회지 Vol.71 No.6
Background/Aims: This study was performed to evaluate the relationship between family history of gastrointestinal (GI) cancers and incidence of any GI cancer in the Korean population. Methods: Between January 2015 and July 2016, 711 GI cancer patients and 849 controls in 16 hospitals in Korea were enrolled. Personal medical histories, life styles, and family history of GI cancers were collected via questionnaire. Results: There was a significant difference in the incidence of family history of GI cancer between GI cancer patients and controls (p=0.002). Patients with family history of GI cancer tended to be diagnosed as GI cancer at younger age than those without family history (p=0.016). The family members of GI cancer patients who were diagnosed before 50 years of age were more frequently diagnosed as GI cancer before the age of 50 years (p=0.017). After adjusting for major confounding factors, age (adjusted odds ratio [AOR] 1.065, 95% confidence interval [CI]; 1.053-1.076), male gender (AOR 2.270, 95% CI; 1.618-3.184), smoking (AOR 1.570, 95% CI; 1.130-2.182), and sibling’s history of GI cancer (AOR 1.973, 95% CI; 1.246-3.126) remained independently associated with GI cancers. Conclusions: GI cancer patients tended to have a first relative with a history of concordant GI cancer. Personal factors (old age and male) and lifestyle (smoking) contribute to the development of GI cancer, independently. Individuals with high risk for GI cancers may be advised to undergo screening at an earlier age. (Korean J Gastroenterol 2018;71:338-348)
샘근육종 과증식을 동반한 십이지장 구부 거대 Brunner선 과증식
정주원 ( Joo Won Chung ),서주희 ( Joo Hee Seo ),박승우 ( Seung Woo Park ),송시영 ( Si Young Song ),정재복 ( Jae Bock Chung ),김상겸 ( Sang Kyum Kim ),김호근 ( Ho Keun Kim ),방승민 ( Seung Min Bang ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.6
Brunner`s gland hyperplasia is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding. In symptomatic patients, treatment requires either surgical resection or endoscopic polypectomy. We report a case of upper gastrointestinal bleeding from a pedunculated Brunner`s gland hyperplasia in the duodenal bulb. Endoscopic resection using the detachable snare and hemoclipping was instituted to remove a large pedunculated polyp. The pathologic diagnosis was Brunner`s gland hyperplasia with adenomyomatous hyperplasia.
정주원(Chung, Joo Won) 서양미술사학회 2016 서양미술사학회논문집 Vol.44 No.-
미국 미술가 재스퍼 존스(Jasper Johns, b.1930)는 예술이 일상과 구별된다는 1950년대 뉴욕 미술계의 지배적인 논리를 비판하였던 네오-다다(Neo-Dada) 미술가로 현대미술사에서 중요하게 논의된다. 선행 연구들은 주로 존스가 예술이 개인의 독창적인 표현이라는 규범을 따르는 대신 누구나 알고 있는 대중문화 이미지에 따라 작품을 제작한 미술사적 의의에 치중할 뿐, 미술가로서 ‘자아(self)’의 표현을 견제한 이유에 대해서는 간과하였다. 본고는 그가 예술가의 시각적 창작물이 저자의 내면을 반영한다는 당대 ‘추상표현주의(Abstract Expressionism)’ 담론에 대항하여 개성을 억제하는 작업을 추구하였을 것이라는 추정에서 출발하였다. 본 연구는 존스가 1958년과 1960년에 집중적으로 제작한 상품 모양의 조각들을 중심으로 그가 미술가에 대하여 새로운 생각을 가졌음을 고찰한다. 이 상품 모양의 조각들은 모두 고급 미술의 지위를 가지고 소비되는 미술 작품이므로 본고에서는 이 작품군을 미술사학자 할 포스터(Hal Foster)가 지칭한 바와 같이 ‘상품 조각(Commodity Sculpture)’으로 명명하였다. 그리고 상품 조각에 나타난 손자국에 주목하여 1960년에 이르러 존스가 미술가의 존재를 지문으로 드러낸 과정을 살펴보았다. 당시 교류하던 예술가 및 문학가와 함께 인간 자아의 본질을 성찰하던 존스는 미술가의 존재를 지문에 한정시켜 나타내는 독자적인 전략을 통하여 예술가의 정체성을 대표 양식과 동일시하던 추상표현주의에 대안을 제시하였다. 독창적인 표현에 대한 기존의 믿음을 전복시킨 존스에게 미술가란 일반인처럼 지문을 통해서만 개별성을 인식할 수 있는 존재였다. 예술과 일상의 경계를 흐리는 작업을 통하여 존스가 명시한 미술가의 개념은 상품 조각과 더불어 향후 1960년대 초·중반 사이에 전개된 그의 작업들을 이해할 수 있는 중요한 실마리이다. A series of sculptures on the forms of manufactured commodities by Jasper Johns (b.1930), produced in two bursts of concentrated activity in 1958 and 1960, highlight the ways in which the artist revealed an invalid mythology of the artistic self and genuine subjectivity, which was the subject of Abstract Expressionism and that permeated the culture of the 1950s. Insofar as these sculptures have been considered and consumed as ‘high’ art, Johns’s three-dimensional artwork can be collectively described as what art historian Hal Foster has termed ‘Commodity Sculpture.’ Production of Commodity Sculpture began in January 1958 when Johns held his first solo show at Leo-Castelli Gallery in New York and established his reputation as the most important transitional figure on the art scene. What is intriguing about the Commodity Sculpture is that even though these works seem to be simple replicas of lightbulbs, flashlights and tin cans, they are not: these sculptural objects are striking in their meticulous craftsmanship with the complexity of palpable effects and touches, showing implications for factitious manual labor without the creative act. More important is Johns’s unprecedented use of fingerprint and thumbprint, reflecting his unconventional engagement with a fingerprint identity in art for manifestation of the artist in the critique of orthodox aesthetics of exposure of expressionistic mindscape in a self-identical painting. Despite frequent reviews by art historians since 1958, Johns’s underlying ideas about the fingerprints on the sculptural renderings have remained little explored. This study thus seeks a fundamental understanding of the puzzle of making Commodity Sculpture, clarifying that the artist’s philosophical concern with the indeterminate nature of the self, which led him to step back from framing the image of the artist as the example of autonomous master. My purpose is to point out the way Johns shared the ideas with his circle including artists and a writer who meditated on the qualities of the self through their visual practices and literary works in the late 1950s, shifting attention to ideological underpinnings of Johns’s distinct use of his biological device, or a means of forensic identification: fingerprinting.
베체트 장염에서 발생한 8번과 9번 삼염색체를 동반한 재생불량성 빈혈
정주원 ( Joo Won Chung ),천재희 ( Jae Hee Cheon ),이경주 ( Kyong Joo Lee ),김진석 ( Jin Seok Kim ),장선정 ( Seon Jung Jang ),양우익 ( Woo Ick Yang ),김태일 ( Tae Il Kim ),김원호 ( Won Ho Kim ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.4
Behcet`s disease is a multisystemic inflammatory disease characterized with recurrent oral ulcer, genital ulcer, and multiple organ involvement. Aplastic anemia is one of the rarest complications of Behcet`s disease. There were only several reports about Behcet`s disease associated myelodysplatic syndrome worldwide. Moreover, aplastic anemia in intestinal Behcet`s disease was rarely reported. Here, we present a case of aplastic anemia with trisomy 8 and trisomy 9 in intestinal Behcet`s disease and a review of the literatures. To the authors` knowledge, this is the first case ever reported in Korea. (Korean J Gastroenterol 2010;55:256-260)
국내 한 3차 병원 중환자실에 입원한 중증지역획득폐렴 환자의 원인 미생물과 경험적 항균제 치료 성적의 고찰
이재승 ( Jae Seung Lee ),정주원 ( Joo Won Chung ),고윤석 ( Yun Suck Koh ),임채만 ( Chae Man Lim ),정영주 ( Young Joo Jung ),오연목 ( Youn Mok Oh ),심태선 ( Tae Sun Shim ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Don 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.5
지정근 ( Jung Geun Ji ),정주원 ( Joo Won Chung ),남승우 ( Seung Woo Nam ),최승규 ( Seung Kyu Choi ),이동원 ( Dong Won Lee ),김대인 ( Dae In Kim ),전병관 ( Byung Gwan Jeon ),신윤재 ( Yun Jae Shin ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.2
Leptomeningeal carcinomatosis (LMC) is rare metastatic form of gastric cancer. Most cases are diagnosed in the final stage after multiple distant metastasis. An 84-year-old woman was admitted with melena, headache and vomiting. Esophagogastroduodenoscopy showed an ulceroinfiltrating lesion at the stomach (Borrmann class III), and biopsy revealed a signet ring cell carcinoma. The abdominal-pelvic CT showed no evidence of metastasis. A sudden decrease of consciousness was noted, but the brain CT showed no active lesion while the brain MRI revealed enhancement of leptomeninges. A lumbar puncture was performed and the cerebrospinal fluid study revealed malignant neoplastic cells. With family consent, no further evaluation and treatment were administered and she died six weeks after the diagnosis of gastric cancer. We report an extremely rare case of a patient who initially presented with neurologic symptoms, and was diagnosed LMC from advanced gastric cancer without any evidence of metastasis in abdomen and pelvis. (Korean J Gastroenterol 2016,68:93-98)
증례 : 혈액종양 ; AML1-ETO 양성인 양표현형 급성 백혈병의 1예
서주희 ( Ju Hee Seo ),이혜원 ( Hye Won Lee ),임주은 ( Ju Eun Lim ),정주원 ( Joo Won Chung ),최종락 ( Jong Rak Choi ),양우익 ( Woo Ick Yang ),민유홍 ( Yoo Hong Min ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
BAL은 일반적으로 기타 급성 백혈병보다 예후가 나쁘다고 알려져 있으나, 그 치료방침이 아직 확립되어 있지 않다. AML1-ETO 유전자 재배열은 BAL에서도 좋은 예후인자 중 하나로 제시된 적이 있으며 본 증례에서도 1차례의 관해 유도요법 후 완전관해를 보였고, t(8:21) 즉, AML1-ETO 정량검사상 전사 정도가 현저히 감소함을 경험하였다. 특히, AML에 준한 치료만으로 성공적 관해가 유도되었으며, 이는 BAL에 있어서도 AML1-ETO 종양단백이 병태생리에 주 역할을 할 것임을 짐작할 수 있다. AML에서와 마찬가지로 AML1-ETO 유전자 재배열은 향후 BAL 환자의 치료 효과와 예후를 알 수 있는 지표로 사용될 수 있을 것이다. Biphenotypic acute leukemia (BAL) is a subtype of acute leukemia that expresses two different immunophenotypic lineages, most commonly myeloid and either B- or T-lymphoid lineages. This entity has been defined by a scoring system proposed by the European Group for the Immunological Characterization of Leukemias (EGIL). The prognosis of BAL is regarded as being worse than either acute lymphoid or myeloid leukemia that does not show lineage ambiguity. However, a treatment strategy for BAL has not yet been established. We experienced a case of BAL with the t(8;21) translocation, a favorable cytogenetic rearrangement in acute myeloid leukemia (AML). The patient was successfully treated with cytarabine and anthracycline for induction and consolidation. The quantitative value of the AML1-ETO gene decreased after achieving complete hematologic remission. Thus, the AML1-ETO gene rearrangement in BAL may be associated with an acceptable response to the treatment strategy for AML. (Korean J Med 76:617-621, 2009)
김석원 ( Seok Weon Kim ),권혁춘 ( Hyeok Choon Kwon ),남승우 ( Seung Woo Nam ),최종경 ( Jong Kyung Choi ),정주원 ( Joo Won Chung ),장동원 ( Dong Won Jang ),박수연 ( Soo Yoen Park ) 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.1
Amebic liver abscess (ALA) is the most common extraintestinal manifestation of amebiasis. Amebiasis, a parasitic infection caused by Entamoeba histolytica, used to be a prevalent protozoan disease in Korea, however, with an improving sanitary system, it has been among very uncommon etiology of liver abscess. A recent report suggested that ALA is an emerging parasitic infection in human immunodeficiency virus (HIV)-infected patients even in areas where the disease is not endemic and recommended HIV screening in patients in areas where ALA is not endemic, particularly those without history of travel to a disease-endemic area. We report on two patients who were admitted for treatment of ALA and then diagnosed as HIV infec-tion. We also reviewed the etiology and characteristics of ALA in our hospital during the last 5 years.
윤진영 ( Jin Young Yoon ),김도경 ( Do Kyung Kim ),천재희 ( Jae Hee Cheon ),문창모 ( Chang Mo Moon ),박재준 ( Jae Jun Park ),정주원 ( Joo Won Chung ),김은영 ( Eun Young Kim ),김태훈 ( Tae Hoon Kim ),이찬주 ( Chan Joo Lee ),박은영 ( 대한장연구학회 2010 Intestinal Research Vol.8 No.1
Post-radiation soft tissue sarcomas are recognized as rare complications of radiation therapy. The most common type of post-radiation soft tissue sarcoma is a malignant fibrous histiocytoma (MFH), which originates from mesenchymal cells with a predominance of histiocytes and fibroblasts. The two most common sites of occurrence for post-radiation soft tissue sarcomas are the chest wall and pelvic cavity. Post-radiation colorectal MFHs are extremely rare and all of the reported cases of post-radiation sarcomas have occurred >3 years after radiation therapy. Recently, we managed a case of colorectal MFH which developed in a 48-year-old male who had undergone a low anterior resection for rectal adenocarcinoma and had received chemoradiotherapy as adjuvant treatment. Twelve months after radiotherapy, a 4 cm mass was detected 8 cm superior to the anastomosis site on colonoscopic examination. A soft tissue sarcoma was suspected on pathologic examination of the biopsy specimen. Therefore, he underwent a Hartmann’s operation and the final pathologic finding revealed MFH with a storiform pattern of tumor cells composed of pleomorphic, multinucleated giant cells. This is the first case of MFH that had a latency period <3 years (i.e., 1 year) between the time of radiotherapy and diagnosis. (Intest Res 2010;8:75-79)