와류의 열전달 촉진에 관한 실험적 연구

송시영(Si- young Song),유성연(Seong-yeon Yoo),박종학(Jong- hark Park) 대한기계학회 2002 대한기계학회 기타 간행물 Vol.2002 No.11

악성고형종양 환자에 있어서 Neoplastic Fever 와 Infectious Fever 의 감별을 위한 Naproxen 의 투여

송시영(Si Young Song),김준명(June Myeong Kim),김주항(Joo Hang Kim),김웅(Eung Kim),홍천수(Chein Soo Hong) 대한내과학회 1989 대한내과학회지 Vol.37 No.4

N/A Recurrent unexplained fever as a manifestion of certain malignancies is a well described phenomenon and is usually attributed to infection related to the immunocompromised state, from either the cancer itself or chemotherapy. However, fever might originate from the tumor per se, namely neoplastic fever, and the differential diagnosis of the infectious fever and the neoplastic fever becnmes a true challenge to the clinician due to its urgency and necessity for appropriate treatment. Thus, we evaluated the antipyretic effect of naproxen in 18 febrile patients who were diagnosed with a malignant solid tumor for the purpose of differentiation of the neoplastic fever and the infectious fever. All 10 patients with neoplastic fever showed complete lysis and an afebrile stafe was sustained while the patients were maintained on naproxen. Among 8 patients with infectious fever, 4 patients showed no lysis, 3 patients partial response, and 1 patient complete lysis. Even though the naproxen dosage was increased to a dose of 250 mg every 6 or H hours in the patients who showed no response, partial response was noticed only in two patients and the remaining two patients continued to show no response. Naproxen is well known to cause gastrointestinal side effects and functional platelet defects. However, in our experience, the side effects have been minimal because most of the patients have received a relatively short course of therapy. In conclusion, naproxen appears to be a very effective tool in assisting in the differential diagnosis of infectious fever and neoplastic fever in patients with a malignant solid tumor.

소화기암에서 나노의학의 향후 발전방향

송시영 ( Si Young Song ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.5

Cancer is one of the leading causes of death in human, and among various cancers, gastrointestinal cancers occupy more than 55%. Gastric cancer is the first leading cause of cancer-related mortality in the world and the number of pancreas and colon cancers are increasing remarkably during last two decades which will continue to increase in the future. Even though the clinical importance of gastrointestinal cancers is very high and endless efforts has been made to develop novel diagnostic and therapeutic methods to improve the patient`s quality of life and survival, the realistic advance in the actual survival benefit of the cancer patients are still strongly required. Nanotechnology has the power to radically change the way of cancer diagnosis and treatment. Currently, there is a lot of researches on novel nanodevices capable of detecting cancer at its earliest stage, pinpointing its location within the body, and delivering anticancer drugs specifically to the malignant cells. Nanoscale devices can readily interact with biomolecules both on the cell surface and within the cell. In addition, nanoscale devices are already proven that they can deliver therapeutic agents to target cells even within specific organelles. Major areas in which nanomedicine is being developed in cancer include early detection and proteomics, imaging diagnostics and multifunctional therapeutics. Because nanotechnology would provide a technical power and tool that enable new diagnostics, therapeutics, and preventives to keep pace with today`s explosion in knowledge in the future, it would be very useful to know the perspectives in the direction of nanotechnology as a major clinician responsible for the patients with gastrointestinal malignancies. (Korean J Gastroenterol 2007;49:271-279)

기획종설 : 췌장암 ; 췌장암의 원인 및 발암기전

송시영 ( Si Young Song ) 대한소화기학회 2007 대한소화기학회지 Vol.51 No.2

Pancreatic cancer is currently the major leading cause of cancer-related deaths in the Western countries with an overall 5-year survival rate of less than 3%. The key aim of investigation is to identify the cellular population in which some of the earliest molecular events occur, presumably the ultimate target for carcinogenic insult. Advances in pathological classification and genetics have improved our descriptive understanding of this disease. However, important aspects of pancreatic cancer biology remain poorly understood. Factors associated with the increased risk of pancreatic cancer include smoking, chronic pancreatitis, diabetes, prior gastric surgery, and exposure to radiation or chemicals. A number of syndromes have been identified with the increased incidence of pancreatic cancer, including familial atypical multiple-mole melanoma syndrome, hereditary nonpolyposis colorectal cancer, and hereditary pancreatitis, etc. Recently, there have been growing evidences that stem cell biology could provide new insights into the understanding of cancer biology. Three postulates regarding the relationship between stem and tumor cells have been proposed. First, the similarities in the mechanims that regulate self-renewal of normal stem cells and cancer cells. Second, the possibility that tumor cells might arise from normal stem cells and third, the notion that tumors might contain ``cancer stem cells`` - rare cells with indefinite proliferative potential which drive the formation and growth of tumors. New insights for the cancer stem cells and their possible markers in pancreatic cancer have been suggested recently. Further observations of molecular and cellular events in the early stage of pancreatic carcinogenesis may have important implications regarding the cellular lineage responsible for pancreatic ductal metaplasia and neoplasia, and provide further support for the presence of stem cell capabilities within mature pancreatic epithelium. (Korean J Gastroenterol 2008;51:71-83)

Desferoxamine 이 시험관내 인체 간암세포 성장에 미치는 영향

송시영(Si Young Song),김원호(Won Ho Kim),전미연(Mi Yun Chon),한광협(Kwang Hyub Han),정재복(Jae Bock Chung),전재윤(Chae Yoon Chon),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),최흥재(Heung Jai Choi),윤정구(Jung 대한내과학회 1994 대한내과학회지 Vol.47 No.3

N/A Objectives: It has been known that excessive iron promote the growth of cancer cells aad suggested that iron oversupply in cancer patients may enhance tumor growth and adversely affect cancer therapy and that desferoxamine (DFO) as a iron chelating agent may have a place in anticancer agents, which acts as a potent inhibitor of DNA synthesis via inhibition of the ribonucleotide reductase. However there have been no reports on the combined effect of DFO with other chemotherapeutics in vitro, This study was done to answer the questions: Does DFO inhibit the growth of cultured hepatoma cells? and Does the combination of DFO and chemotherapeutic agents have a synergistic effect on inhibition of tumor growth? Methods: Using PLC/PRF/5 and Hep G2 cells as hepatoma cells and normal diploid cells of WI-38 as control, the MTT assay was performed for evaluation of the cytotoxicity and an isobologram method to analyze the combined effects of DFO and other chemotherapeutic agents. Results: 1) The hepatoma cells grew faster in an iron-enriched medium than in the medium without additional iron supplementation but the normal diploid cells of WI-38 did not. 2) The 50% inhibitory concentrations (IC50) on PLC/ PRF/5 and Hep 62 cells were 75.1 and 29.1 ㎍/ml, respectively. But the growth of WI-38 was not inhibited below 74.4% with even 200 ㎍/ml of DFO. 3) On both hepatoma cells, the growth inhibitory effects of DFO were reversed with simultaneous administration of stoichiometric doses of ferric citrate. 4) Adriamycin (ADR), 5-fluorouracil (5-FU) and cisplatin (DDP) inhibited the growth of all 3 cell lines, but larger doses were required to inhibit the WI-38 to obtain the same effect. 5) When DFO was combined with chemotherapeutic agents, a marked synergistic effect was observed with the combination of DFO and 5-FU on PLC/PRF/5 cells. The synergistic effect was also noted in Hep G2 cells with all three combinations of DFO-ADR, DFO-5-FU and DFO-DDP. Conclusion: Iron oversupply may enhance the hepatoma growth and this should be taken into consideration treating patients with hepatoma. And the antitumor effect of DFO and its synergistic effect with other chemotherapeutic agents may suggest that iron chelator like the DFO may be a useful treatment for patients with hepatoma in conjuction with other anticancer drugs.

Cholecystokinin 길항제인 L-364 , 718이 시험관내 췌장암세포 성장에 미치는 영향

송시영(Si Young Song),정재복(Jae Bock Chung),강진경(Jin Kyung Kang),박인서(In Suh Park),김경환(Kyung Hwan Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6

N/A Background/Aims: It has been reported that some gastrointestinal regulatory peptides including cholecystokinin(CCK) may ac: as growth modulators of pancreatic cancer and CCK antagonists have antitumor effect. However, there have been still debates on the role of CCK antagonists. This study was done to answer the guestions: Does L-364,7 l8 inhibit the growth of cultured pancreatic cancer cells?, What is the growth inhibitory mechanism and is it cell-cycle specific?, and finally, Does the combinatior with L-364,718 and 5-fluorouracil(5-FU) have a synergistic effect on the growth inhibition? Methods: Using Panc-1 and Capan-2 cells, the effects of caerulein, I -364,718 and 5-FU were evaluated, respectively and combined effect of L-364,718 and 5-FU measured. To evaluate the effect of L-364,718 on DNA synthesis and cell cycles, [3H]-thymidine uptake and flow cytometric analysis were performed. The in vitro cytotoxicity was measured by MTT assay and an isobologram model used to analyze the synergism. Results: The both cells, especially Capan-2 cells, grev faster in a medium of CCK supplementation. Dose-dependent powth inhibition o, both cell.', was noted by L-364,718. The IC50 of Panc-1 and Capan-2 cells were 2.43x10-5 M/L and 3.25:cl0-5 M/L, respectively. The IC50 of 5-FU on Panc-I and Capan-2 cells were 13.83 pg/ml and 2.19 pg/ml, respectively. ['H]-thymidine uptake of both cells decreased dose-dependently by L-364,715. The proportion of S phase cells decreased and that of G0/G1 phase cells increased dose-dependently by L-364,718. When L-364,718 was combined with 5-FU, a synergistic effect was observed in 62.5% in Capan-2 cells, however 14.3% in Panc-1 cells. Conclusions: L-364,718 has a antitumor effect on pancreatic cancer cells cultured in vitro and its synergistic effect with certain anticancer agent can be expected. The antiproliferative effect of L-364,718 is considered as the inhibition of DNA synthesis, which cause the blockage of GO/Gl phase of cell cycle.(Korean J Gastroenterol 1996; 28:861-873)

손자녀 양육이 조부모의 우울감에 미치는 영향에 대한 주관적 건강상태의 조절효과

송시영(Si Young Song),전혜정(Hey Jung Jun),주수산나(Susanna Joo) 한국노년학회 2020 한국노년학 Vol.40 No.3

본 연구는 손자녀가 있는 조부모를 대상으로 손자녀 양육이 우울감에 미치는 영향이 주관적 건강에 따라 달라지는지 살펴보고자 하였다. 이를 위해 고령화연구패널조사(KLoSA)의 4차년도(2012년) 자료를 분석에 사용하었다(N=650). 또한 손자녀 양육에 참여한조부모와 참여하지 않은 조부모의 선택에서 무작위성을 보장하기 위해 Coarsened Exact Matching(CEM) 방법을 적용하여 타당성을높이고자 하였다. 종속 변수는 우울감이며, 독립 변수는 손자녀 양육, 조절 변수는 주관적 건강상태이다. 통제 변수로는 교육 수준, 연령, 가구 소득, 성별, 결혼 상태, 삶의 만족도를 투입하였다. STATA 13.0를 이용하여 CEM을 적용하여 데이터를 매칭 한 후에 가중다중 회귀 분석을 실시하였다. 또한 상호작용항 해석을 위해 Simple slope analysis와 Region of significance를 실시하였다. 분석 결과주관적 건강상태의 조절 효과가 확인되었다. 구체적으로, 주관적 건강이 보통 이상으로 높다고 응답한 조부모의 경우에는 손자녀 양육에참여하는 조부모들이 참여하지 않는 조부모들보다 우울감이 낮았다. 반대로 주관적 건강이 낮다고 응답한 조부모의 경우에는 손자녀양육 참여 여부에 따른 차이가 나타나지 않았다. 이러한 결과를 바탕으로 손자녀 양육을 하는 조부모에게 주관적 건강상태에 관한고려가 필요함을 논의하였다. This study examined the moderating effect self-rated health has on the association between grandparenting and depressive symptoms. The fourth wave (in 2012) of the Korean Longitudinal Study of Ageing (KLoSA) was used for the analyses (N=650). The Coarsened Exact Matching (CEM) method was applied in order to ensure randomness in the selection of grandparents who participated in grandparenting and those who did not. The dependent variable was depressive symptoms, the independent variable was grandparenting, and the moderating variable was self-rated health. Control variables were education level, age, household income, gender, marital status and life satisfaction. After matching data by CEM, weighted multiple regression was applied with STATA 13.0. Also, simple slope analysis and region of significance were performed to interpret the interaction terms. The results showed that self-rated health had a significant moderating effect. Specifically, for grandparents with high self-rated health, grandparenting was associated with a lower level of depressive symptoms. On the contrary, for grandparents with low self-rated health, there was no difference depending on whether they participated in raising grandchildren. Based on these results, we discussed the need for consideration of self-rated health for grandparents who participated in grandparenting.

구연발표 : 만성 B 형 활동성 간염 환자에서 혈청 HBeAg 양상에 따른 추적관찰

송시영(Si Young Song),한광협(Kwang Hypb Han),김경희(Kyung Hee Kim),김재윤(Jea Yun Kim),강진경(Jin Kyoung Kang),최흥재(Heung Jae Choi) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

미혼여성의 결혼과 출산에 관한 인식: 육아 예능 프로그램 <슈퍼맨이 돌아왔다> 시청 경험을 중심으로

송시영 ( Si Young Song ),박하영 ( Hayoung Park ),주수산나 ( Susanna Joo ),김성희 ( Seong Hee Kim ) 한국가족관계학회 2021 한국가족관계학회지 Vol.25 No.4

연구목적: 본 연구는 육아 예능 프로그램인 KBS2 TV <슈퍼맨이 돌아왔다> 시청경험을 토대로 결혼과 출산에 관한 인식을 살펴보고자 20대 중후반 미혼여성들을 대상으로 심층면접을 실시하였다. 연구방법: 수집된 자료를 Creswell의 나선형 자료분석 절차를 토대로 분석한 결과, 크게 결혼과 출산에 관한 인식과 이를 바탕으로 한 프로그램에 대한 해석의 주제가 도출되었다. 연구결과: 결혼과 출산에 관한 인식은 상호작용적 요소와 결혼과 출산 희망 여부로 구분되었으며, 프로그램에 대한 해석은 결혼과 출산 희망 여부에 따라 나뉜 네 집단의 해석을 바탕으로 긍정적인 해석과 부정적인 해석으로 나뉘었다. 결과적으로 연구 참여자들은 본인의 기존 가치관, 사회경제적 배경, 주변 사례와 가정환경을 바탕으로 평소에 지니고 있던 결혼과 출산에 관한 기존의 생각과 가치관을 그대로 유지하거나 이것이 더욱 구체화되고 강화되는 것으로 나타났으며, 주체적으로 프로그램에 공감하거나 비판적인 해석을 하고 있었다. 논의 및 결론: 본 연구는 20대 중후반 미혼여성의 육아 예능 프로그램 시청경험과 결혼 및 출산에 관한 인식을 연결 짓는 과정을 경험적으로 탐색했다는 점에서 의의가 있다. Objectives: This study was conducted to explore the perception of marriage and childbirth among unmarried women through the experience in audience reception of parenting entertainment TV program < The Return of Superman >. Method: In-depth interviews were conducted for unmarried women in their mid to late 20s, and the collected data were analyzed based on Creswell's data analysis spiral. Results: As a result, the theme of perception of marriage and childbirth and interpretation of the program were largely drawn. The perception of marriage and childbirth was divided into interactive elements and whether or not marriage and childbirth were desired, and the interpretation of the program was divided into positive and negative interpretations. Furthermore, participants watched the program and maintained their existing thoughts and values of marriage and childbirth, which they usually had, or it was found to be more concrete and strengthened based on their existing values, socio-economic background, surrounding cases and family environment. Conclusions: This study is meaningful in that specifically examining the process of linking the experience of watching the parenting entertainment TV program and the perception of marriage and childbirth of unmarried women in their mid to late 20s.

노년기 경제활동이 우울감과 삶의 만족도에 미치는 영향 : 성향점수매칭(PSM) 과 이중차이(DD) 분석

송시영(Si Young Song),전혜정(Hey Jung Jun),최봄이(Bomi Choi) 한국노년학회 2020 한국노년학 Vol.40 No.5

본 연구는 한국복지패널(Korean Welfare Panel Study: KoWePS)의 12차(2017), 13차(2018) 자료를 사용하여 노년기 경제활동이 우울감과 삶의 만족도에 미치는 영향을 살펴보았다. 이를 위해 첫째, 성향점수매칭을 통해 12차에는 경제활동을 하지 않았으나 13차에는 경제활동을 한 집단(실험집단)과 12, 13차년도 모두 경제활동을 하지 않은 집단(비교집단)간 성향점수가 비슷한 자료를 매칭하여 최종 연구대상을 구성하였다. 둘째, 성향점수매칭으로 도출된 집단 더미변수(실험집단, 비교집단)를 독립변수로 하고 우울감과 삶의 만족도를 각각 종속변수로 한 중다회귀분석을 실시하였다. 셋째, 경제활동의 순효과를 보다 타당성 있게 도출하기 위해 실험집단의 결과 변수(우울감, 삶의 만족도)와 실험집단이 경제활동을 하지 않지 않았다고 가정한 상태에서 얻게 되는 결과변수 간 차이를 비교할 수 있는 이중차이 분석을 실시하였다. 분석 결과 경제활동 참여 시 삶의 만족도를 높이고 우울감을 낮추는 긍정적 효과가 일부 뒷받침되었다. 먼저 성향점수 매칭 후 중다회귀분석을 실시한 결과, 노년기 경제활동이 우울감과는 부적, 삶의 만족도와는 정적 상관이 있는 것으로 나타났다. 성향점수와 이중차이 결합분석을 실시한 결과, 노년기 경제활동에 참여할 때 그렇지 않은 경우와 비교하여 삶의 만족도를 높이는 효과가 유의확률 0.1 범위에서 통계적으로 유의하였다. 반면 경제활동 참여가 우울감에 미치는 영향은 유의하지 않았다. 본 연구는 선택편의와 내생성 문제를 보완하여 노년기 경제활동의 효과를 보다 타당성 있게 도출하였다는 데 의의가 있다. 본 연구의 결과는 노년기 경제활동 참여의 중요성을 알리고 이를 촉진하기 위한 복지정책을 수립하는데 참고자료로 활용될 수 있을 것으로 기대된다. The objective of this study is to examine the effects of the economic participation of older people on mental health (life satisfaction and depressive symptoms) with robust adjustment on selection bias and the endogeneity problem. Propensity Score Matching (PSM) and Difference-in-Difference (DD) were applied using two waves (2017, 2018) of the Korean Welfare Panel Study (KoWePS). To perform PSM analysis, the treatment group was selected to include people who transitioned to economic participation within two waves and the control group was selected to include people who did not work on both waves. Multiple regression analyses on the matched sample revealed the protective effect of economic participation on depressive symptom. The beneficial effect of economic participation on life satisfaction was also found. DD analyses on the matched sample showed a significant positive effect of economic participation only on life satisfaction (p <.01). The results of this study partly support the health-promoting effects of economic participation among older people with robust statistical methods that control selection bias and the endogeneity problem. The findings of this research have important implications for strengthening policy interventions on job creation projects for older people.