신증후군 환자에서 스테로이드 충격요법과 경구용 면역억제제 치료 중 발생한 가역성 후백질뇌병증 1례

서주희,신정욱,김지홍,윤춘식,Seo Joo Hee,Shin Jung Wook,Kim Ji Hong,Yoon Choon Sik 대한소아신장학회 2005 Childhood kidney diseases Vol.9 No.2

저자들은 정맥 주사용 스테로이드 충격요법과 경구 cyclophosphamide 치료를 받던 신증후군 환아에서 가역성 후백질뇌병증 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. The syndrome of reversible posterior leukoencephalopathy syndrome(RPLS) is characterized clinically by acute neurologic signs such as headache, vomiting, confusion, seizures, and visual abnormalities. Radiologically, abnormalities consistent with reversible white matter edema in the occipital and parietal lobes are characteristic. RPLS has often been associated with various systemic disorders, such as hypertensive encefhalopathy, eclampsia, and the use of intravenous or intrathecal immunosuppressive drugs. We report a case of RPLS that occurred after intravenous steroid pulse therapy and treatment with oral cyclophosphamide in a child with nephrotic syndrome, and we emphasize the importance of early recognition of RPLS in the treatment of nephrotic syndrome and appropriate management tn prevent Permanent neurologic disability. (J Korean Soc Pediatr Nephrol 2005;9:245-250)

한약복합물 HT008-1의 인지기능 및 기억력 향상효과

서주희 ( Joo Hee Seo ),우소영 ( So Young Woo ),김윤태 ( Yun Tai Kim ),김미연 ( Mi Yeon Kim ),김진화 ( Young Mi Park ),박영미 ( Zhen Hua Jin ),부영민 ( Young Min Bu ),김호철 ( Ho Cheol Kim ) 대한본초학회 2007 大韓本草學會誌 Vol.22 No.4

초위성체 마커를 이용한 산양의 분자유전학적 고찰

서주희(Joo Hee Seo),이윤석(Yoonseok Lee),전광주(Gwang Joo Jeon),공홍식(Hong Sik Kong) 한국데이터정보과학회 2017 한국데이터정보과학회지 Vol.28 No.5

본 연구는 산양 7 품종을 대상으로 (Saanen (88), Laoshan (67), Toggenburg (32), Alpine (12), Anglonubian (9), Jamnapari (7), Black Bengal (4)) 13종의 초위성체 마커 (microsatellite marker)를 활용하여 유전적 다형성 분석을 실시하였다. 대립유전자 수는 4개 (INRA005) 부터 18개 (SRCRSP23)까지 확인되었으며, 관측이형접합율 (Hobs)과 기대이형접합율 (Hexp) 그리고 다형성 정보지수 (PIC) 값은 각각 0.482 ∼ 0.786, 0.476 ∼ 0.923 그리고 0.392 ∼ 0.915로 나타났다. 품종별 유전적 거리를 확인하기 위하여 실시한 주성분분석 (PCoA) 결과는 요인대응분석 (FCA) 분석과 유사한 결과를 보였으며, 동일개체출현빈도는 2.47 × 10<SUP>−15</SUP> 으로 확인되었다. 따라서 본 연구 결과는 산양 품종 개량 및 보존에 있어 기초자료로써 유용한 자료로 활용 가능 할 것으로 사료된다. In this study, genotyping was executed by using 13 microsatellite markers for genetic diversity of 224 Gorals (Saanen(88), Laoshan(67), Toggenburg(32), Alpine(12), Anglonubian(9), Jamnapari(7) and Black Bengal(4)). The number of alleles was observed 4 (INRA005) to 18 (SRCRSP23) each markers. Observed heterozygostiy (Hobs), expected heterozygosity (Hexp) and polymorphism information content (PIC) were observed 0.482 to 0.786, 0.476 to 0.923, and 0.392 to 0.915, respectively. Principal Components Analysis(PCoA) results were similar to the results of FCA. NE-I(on-exclusion probability for identity of two unrelated individuals) was estimated at 2.47×10<SUP>−15</SUP>. In conclusion, this study shows the useful data that be utilized as a basic data of Gorals breeding and development.

망막파열이 동반된 구기작통증(九氣作痛症) 환자 1례(例) 증례보고

서주희 ( Joo Hee Seo ),장하정 ( Ha Jeong Jang ),김자영 ( Ja Young Kim ),성우용 ( Woo Yong Sung ),임호제 ( Ho Jea Lim ),김주원 ( Ju Won Kim ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.2

Pain disorder is a category of somatoform disorder that be diagnosed when the pain is starting and getting worse associated with psychological factors. At the recent study, it revealed that stress might be more strong factor in occurring and sustaining the somatoform disorder. In this case, a 42 years old female patient had a chronic pain disorder 3 years ago, suddenly complained of an eyeball pain due to retina rupture induced by severe stress. In the view of oriental medicine, pain disorder belongs to GuQiJakTongJung. So, we diagnosed her state as GuQiJakTongJung and treated her such as herbal medicine, acupunture and phlebotomy therapy.In result, the chronic pain of the patient was improved, and also general condition was getting better.

Microsatellite Marker를 활용한 한국 토종닭 품종의 유전적 다양성 및 유연관계 분석

서주희(Joo Hee Seo),오재돈(Jea-Don Oh),이준헌(Jun-Heon Lee),서동원(Dongwon Seo),공홍식(Hong Sik Kong) 한국가금학회 2015 韓國家禽學會誌 Vol.42 No.1

& & Microsatellite(MS) marker는 가축의 유전적 특성 및 계통간의 유연관계 분석에 있어 많이 이용되고 있는 분자유전학적 유전표지로 유전체 상에 널리 분포하고 있으며, 높은 변별력과 검출이 간편하다. 본 연구는 한협 8개 계통과 토종닭 순계 12 계통을 대상으로 27종 MS marker의 유전자형을 분석하고, 이를 기반으로 유전적 특성 및 계통간 유연관계를 구명함으로써 한협에서 생산되고 있는 토종닭 계통들의 유전적 배경이나 특성에 대한 기초자료를 제공하고자 실시하였다. 연구 결과, 27종 MS marker 분석 결과, 평균 11.7개의 대립유전자가 확인되었으며, Hexp와 PIC의 경우 MCW0288이 각각 0.688, 0.646으로 가장 낮았고, MCW0104가 0.881, 0.869로 가장 높게 확인되었으며, 집단별 Fis(f )값을 통해 한협 H 계통(HH)은 집단 내 개체 간 상관 정도가 가장 적은 것으로 확인되었다. 계통 간 유연관계를 분석한 결과, 전체 20계통 중 로드 아일랜드 레드 계통(NC와 ND)이 가장 가까운 것(0.175)으로 확인되었으며, 반면에 레그혼 F(NF)와 로드 아일랜드 레드 D(ND) 계통이 가장 먼 것(0.710)으로 확인되었다. MS marker의 효율성을 검증하기 위해 동일개체 출현확률(PI)을 분석한 결과, 전체 계통에 대한 동일개체 출현확률(PI)과 한협 8계통의 동일개체 출현확률(PI)은 27종의 MS marker를 사용하였을 경우, 각각 8.80×10<SUP>—83</SUP>, 3.87×10<SUP>—117</SUP>으로 확인되었다. 따라서 본 연구는 토종닭 시장에서 높은 점유율을 보유한 한협의 실용계 계통의 유전적 배경과 특성 분석을 통해 향후 소비자의 요구에 부합하는 토종닭의 개량 및 실용계 계통의 개발을 위한 기초자료로 유용하게 활용될 것으로 기대된다. & & In this study, genotyping was executed by using 27 microsatellite markers for genetic diversity of 469 Korean Native Chickens [20 population, each population is 24 samples but Hanhyup A line is 13 samples). in total 469 samples were collected from National Institute of Animal Science (Korean Native Chicken (NR, NY, NG, NL and NW), Ogye (NO), Leghorn F,K (NF and NK), Black and Brown cormish (NH and NS), Rhode Island Red C, D (NC and ND), Total is 12 populations] and Hanhyup [H line (HH), F line (HF), G line (HG), V line (HV), S line (HS), W line (HW), Y line (HY), A line (HA), total is 8 populations]. [The allele number were observed 5 (ADL0268) to 20 (MCW0127) each markers. Observed heterozygostiy (Hobs), expected heterozygosity (Hexp), polymorphism Information Content (PIC) were observed 0.359 to 0.677, 0.668 to 0.881 and 0.646 to 0.869, respectively. Using these markers, the calculated the heterozygote deficit within chicken line (Fis) value each population from mean 0.117. Phylogenetic tree showing the genetic relationship among 20 population using standard genetic distance calculated from 27 microsatellite markers. genetic distances revealed the closest (0.175) between NC and ND. on the other hand, Farthest genetic distances (0.710) revealed between NF and HV. STRUCTURE analysis and Principal Components Analysis (PCA) showed that results of similar phylogenetic tree. The expected probability of identity values on random individuals (Total population and only Hanhyup line) was estimated at 8.80×10<SUP>—83</SUP> and 3.87×10<SUP>—117</SUP>, respectively. In conclusion, This study shows the useful data that be utilized as a basic data of Korean Native Chicken breeding and development for commercial chicken industry to meet the consumer’s demand.

시호거 조가 모려탕으로 호전된 산후풍 환자 치험 1례

서주희(Joo-Hee Seo) 대한모유수유한의학회 2019 대한모유수유한의학회지 Vol.5 No.1

Objectives: The purpose of this study is to present of a woman treated by Korean herbal medicine(KHM) for postpartum pain. Methods: A patient visited a Korean medicine clinic because of the postpartum pain in wrist and fingers. She was treated by KHM for physical pain in 20 days. Results: After 1 month, the clinical symptoms improved. Conclusions: KHM improved the postpartum pain in one case.

증례 : 혈액종양 ; AML1-ETO 양성인 양표현형 급성 백혈병의 1예

서주희 ( Ju Hee Seo ),이혜원 ( Hye Won Lee ),임주은 ( Ju Eun Lim ),정주원 ( Joo Won Chung ),최종락 ( Jong Rak Choi ),양우익 ( Woo Ick Yang ),민유홍 ( Yoo Hong Min ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

BAL은 일반적으로 기타 급성 백혈병보다 예후가 나쁘다고 알려져 있으나, 그 치료방침이 아직 확립되어 있지 않다. AML1-ETO 유전자 재배열은 BAL에서도 좋은 예후인자 중 하나로 제시된 적이 있으며 본 증례에서도 1차례의 관해 유도요법 후 완전관해를 보였고, t(8:21) 즉, AML1-ETO 정량검사상 전사 정도가 현저히 감소함을 경험하였다. 특히, AML에 준한 치료만으로 성공적 관해가 유도되었으며, 이는 BAL에 있어서도 AML1-ETO 종양단백이 병태생리에 주 역할을 할 것임을 짐작할 수 있다. AML에서와 마찬가지로 AML1-ETO 유전자 재배열은 향후 BAL 환자의 치료 효과와 예후를 알 수 있는 지표로 사용될 수 있을 것이다. Biphenotypic acute leukemia (BAL) is a subtype of acute leukemia that expresses two different immunophenotypic lineages, most commonly myeloid and either B- or T-lymphoid lineages. This entity has been defined by a scoring system proposed by the European Group for the Immunological Characterization of Leukemias (EGIL). The prognosis of BAL is regarded as being worse than either acute lymphoid or myeloid leukemia that does not show lineage ambiguity. However, a treatment strategy for BAL has not yet been established. We experienced a case of BAL with the t(8;21) translocation, a favorable cytogenetic rearrangement in acute myeloid leukemia (AML). The patient was successfully treated with cytarabine and anthracycline for induction and consolidation. The quantitative value of the AML1-ETO gene decreased after achieving complete hematologic remission. Thus, the AML1-ETO gene rearrangement in BAL may be associated with an acceptable response to the treatment strategy for AML. (Korean J Med 76:617-621, 2009)

닭의 경제 형질에 미치는 TSH-β 유전자 변이 효과 분석

서주희(Joohee Seo),오재돈(Jae Don Oh),최은지(Eun Ji Choi),임희경(Hee Kyong Lim),성지연(Jiyeon Seong),송기덕(Ki Duk Song),이준헌(Jun Heon Lee),이학교(Hak Kyo Lee),공홍식(Hong Sik Kong),전광주(Gwang Joo Jeon),손영곤(Young Gon Shon),최강덕 한국가금학회 2013 韓國家禽學會誌 Vol.40 No.2

샘근육종 과증식을 동반한 십이지장 구부 거대 Brunner선 과증식

정주원 ( Joo Won Chung ),서주희 ( Joo Hee Seo ),박승우 ( Seung Woo Park ),송시영 ( Si Young Song ),정재복 ( Jae Bock Chung ),김상겸 ( Sang Kyum Kim ),김호근 ( Ho Keun Kim ),방승민 ( Seung Min Bang ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.6

Brunner`s gland hyperplasia is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding. In symptomatic patients, treatment requires either surgical resection or endoscopic polypectomy. We report a case of upper gastrointestinal bleeding from a pedunculated Brunner`s gland hyperplasia in the duodenal bulb. Endoscopic resection using the detachable snare and hemoclipping was instituted to remove a large pedunculated polyp. The pathologic diagnosis was Brunner`s gland hyperplasia with adenomyomatous hyperplasia.

산후풍에 관한 국내 한의학 임상연구동향 분석

이희정(Hee Jung Lee),서주희(Joo hee Seo) 대한모유수유한의학회 2017 대한모유수유한의학회지 Vol.3 No.1

Objectives: Sanhupung is not completed golden standards of diagnosis therefore doctors dignose through symptoms and signs of patients in clinic same as progress of treatment. The present study explored studies directed at the trends of Korean medicine in the treatment of Sanhupung. Methods: We searched clinical studies about Korean medicine of Sanhupung from the OASIS (Korean Medicine Information System), RISS (Research Information Sevice System), KISS (Korean studies Information Service System), DBpia, www.koreantk.com (January 2000 to September 2017). Results: 38 papers were selected from studies. The number of the thesis published based on the publication trend from 2001 to 2015 has presented 5 in 2001 and 2014, 4 in 2004, 3 in 2003, 2005, 2007, 2008 and 2010, 2 in 2009 and 2014, and 1 in 2015. Analysis of the published Journals of Clinical study with regard to postpartum syndrome indicates that 26 articles, the highest amount, were published in The Journal of Oriental Gynecology. Analysis of the Journals demonstrates that the number of patients who were the subject for the clinical research on the postpartum syndrome were 1 patient in 21 articles, 2 in 3, 3 in 1, 10-49 in 4, 50-100 in 7, and above 100 in 2. Kihyulheoyack, weakened energy symptom, was reported the most with 11 cases from reports identifying the diseases from the case reports. The most used herbal medicine prescription are Gami-sanghwa-tang, Bohun-tang-gami, and Hwanggikyejiomul-tang in 3 cases respectively. For the evaluation index, VAS (12 cases) and EPDS (9 cases) were utilized the most. Having used BMI, DITI, ODI, MMPI, SF-MPQ, BMD, etc. shows that mental evaluation is also considered as well as physical evaluation. Conclusions: To sum up, Korean medicine has been shown as effective on Sanhupung. But it seems necessary in the future to improve the papers in these repects for the development of Korean medicine Sanhupung treatment with a good basis through the more systematic and accurate study method.