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흰쥐 해마에서 Norepinephrine 유리에 미치는 Protein Kinase C 의 영향
김도경,이영수,최봉규,Kim, Do-Kyung,Lee, Young-Soo,Choi, Bong-Kyu 대한약리학회 1995 대한약리학잡지 Vol.31 No.2
The effects and interactions of $4{\beta}-phorbol$ 12,13-dibutyrate(PDB) and polymyxin B(PMB) with adenosine on the electrically-evoked norepinephrine (NE) release were studied in the rat hippocampus. Slices from the rat hippocampus were equilibrated with $^3H-noradrenaline$ and the release of the labelled product, $^3H-NE$, which evoked by electrical stimulation$(3\;Hz,\;2\;ms,\;5\;VCm^{-1},\;rectangular\;pulses)$ was measured. PDB$(0.3{\sim}10\;{\mu}M)$, a selective protein kinase C(PKC) activator, increased the evoked NE release in a dose related fashion while increasing the basal rate of release. And the effects of $1\;{\mu}M$ PDB were significantly inhibited by $0.3\;{\mu}M$ tetrodotoxin(TTX) pretreatment or $Ca^{++}-free$ medium. $PMB(0.03{\sim}1\;mg)$, a specific PKC inhibitor, decreased the NE release in a dose dependent manner while increasing the basal rate of release. Adenosine $(1{\sim}10\;{\mu}M)$ decreased the NE release without changing the basal rate of release, and this effect was significantly inhibited by 8-cyclopentyl-1,3-dipropylxanthine$(2\;{\mu}M)$, a selective $A_1-receptor$ antagonist, treatment. Also, adenosine effects were significantly inhibited by PDB-and PMB-pretreatment. These results suggest that the PKC plays a role in the NE release in the rat hippocampus and might be participated in a post-receptor mechanism of the $A_1-adenosine$ receptor.
SHS법에 의한 Ti-Si계 세라믹스의 합성 및 소결체의 특성에 관한 연구
김도경,박성,조덕호,조건,이형복,Kim, Do-Kyung,Park, Sung,Cho, Duk-Ho,Cho, Kurn,Lee, Hyung-Bock 한국세라믹학회 1994 한국세라믹학회지 Vol.31 No.3
Intermetallic Ti-Si system ceramics were synthesized from stochiometric mixtures of titanium and silicone powders in vacuum by Self-propagating High-temperature Synthesis(SHS). In each cases of Ti5Si3, Ti5Si4 and TiSi, and TiSi2 synthesis, 20wt% product dilution, direct ignition and SHS chemical furnace method were employed. The combustion modes, which were observed during the synthesis process by using the high speed camera, of Ti5Si3, Ti5Si4, TiSi, and TiSi2 exhibit spin, osciallatory, steady-state, and spin combustion, respectively. With increasing Ti/Si molar ratio an decrease of combustion velocities was found. From the results on the measurement of the flexural strength, the specimen hot pressed at 135$0^{\circ}C$ for 30 min using synthesized Ti5Si4 powders showed the highest flexural strength at 215 MPa.
김도경,박성,조건,이형복,Kim, Do-Kyung,Park, Sung,Cho, Kurn,Lee, Hyung-Bock 한국세라믹학회 1994 한국세라믹학회지 Vol.31 No.11
Ultra-fine $\beta$-SiC powders were fabricated by self-propagating high temperature synthesis process (SHS) using chemical furnace. The dependences of the C powders with different surface areas, the molar ratios of C/Si, the weight ratios of chemical fuel content, and pellet diameter-size on synthesis were investigated. Compositional and structural characterization of these powders was carried out by scanning electron micrograph and X-ray diffraction. The $\beta$-SiC powders which had C/Si mole ratio=1.05, 3 times chemical fuel contents, and pellet diameter=20 mm were optimum for synthesis efficiency. By optimizing process-variables, it is possible to fabricate $\beta$-SiC powders which have little secondary phases ($\alpha$-SiC).
아급성 육아종성 갑상샘염의 세침흡인 세포소견 -아급성 육아종성 갑상샘염 10예의 임상-세포소견 및 면역세포염색 소견 분석-
김도경,표주연,박종필,김연화,정우희,손은주,홍순원,Kim, Do-Kyung,Pyo, Ju-Yeon,Park, Jong-Pil,Jin, Lian-Hua,Jeong, Woo-Hee,Son, Eun-Ju,Hong, Soon-Won The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.1
Although subacute granulomatous thyroiditis(SGT) is usually diagnosed clinically, papillary carcinoma or other thyroid conditions must be considered in the differential diagnosis. We retrospectively reviewed the clinical and fine-needle aspiration(FNA) cytologic findings seen in 10 SGT cases to decide what are the most reliable cytologic findings and the most helpful molecular tools for reaching a confident cytologic diagnosis. The most representative smear slides were retrieved to perform immunocytochemistry for cytokeratin 19(CK19) and Ret protein. Five papillary carcinomas(PTCs) were included as controls. The constant and typical cytologic findings of SGT were multinucleated giant cells(MGCs) (100%), epithelioid granulomas(90%), an inflammatory dirty background(90%) and plump transformed follicular cells(80%) without fire-flare cells, oncocytic cells or transformed lymphocytes. The immunoreactivities for CK19(37.5%) and Ret(10%) of the follicular cells of SGT were less than those(CK19 and Ret:100%) of PTC. CK19 immunoreactivity of the MGCs was seen in only one case of PTC. There was no significant difference between CK19 and Ret immunocytochemical staining for the MGCs of both SGT and PTC. The results of this study demonstrate that the cytological diagnosis of SGT can be improved by employing a combination of the typical and constant diagnostic cytological features and immunocytochemical results.
김도경(Kim, Do Kyung),김윤신(Kim, Yoon Shin),송기민(Song, Ki Min) 한양대학교 고령사회연구원 2013 한양고령사회논집 Vol.4 No.1
본 연구의 목적은 서울ㆍ경기 수도권에 거주하는 중장년층 성인의 종교에 따른 노후준비 정도를 파악하는데 있다. 2013년 4월 22일~5월 5일 사이에 서울ㆍ경기 수도권지역을 중심으로 만30세~64세 중장년기 성인 총 300명이 응답한 설문지 자료를 SPSS WIN 18.0으로 분석하였다. 주요연구결과를 요약하면 다음과 같다. 첫째, 대상자의 인구사회학적 특성에서 남성이 164명(54.7%)으로 여성(45.3%)보다 많았고, 연령에서는 30대 119명(39.7%)으로 가장 높게 나타났다. 또한 대상자의 종교유형에 따라서는 무교가 125명(41.7%)으로 가장 높게 나타났고, 1주 종교활동 시간에 따라서는 없음 186명(62.0%)으로 가장 높게 나타났다. 둘째, 대상자의 종교유형에 따른 노후준비 정도를 분석한 결과, 통계적으로 유의미한 차이를 보이지 않았지만, 1주 종교활동 시간에 따른 노후준비도는 유의미한 차이가 있는 것으로 나타났다. 특히, 1주 4시간 미만의 종교활동은 경제적, 신체적, 정서적 노후준비도가 가장 높은 것으로 나타나 적당한 종교활동은 노후준비에 긍정적인 영향을 미치는 것으로 보인다. Recently, the improvement of standard of living and the development of medical technology have extended the average life expectancy in our country, which resulted in the aging society with increased numbers of the aged population. This increase of the aged population is changing the viewpoint about the old age from the life extension to the healthy aged life, and to more attention to the quality of life. (Sin mee Kim, Sun yee Kim, 2009). This research collected the questionnaires polled three hundreds of the middle aged people and seniors who are living in Seoul and Gyeonggi-do metropolitan area. The followings are the brief outcome of the research. The research reveals the preparation level for the declining life in accordance with sociological characteristics of the population varies as per the age, weekly religious activity, marriage status, the type of family, monthly average income, subjective financial status, and subjective health condition. This research may have the limits, one may be the regional limit because the sampling method of the research objectives was restricted to Seoul and a part of Kyeong Gi Do metropolitan area, and the other may be the error of generalization because only the aged people and seniors were collected for questionnaires. The aim of the study was to discover the relation between the religion and prepare for their old age. especially, the variables of religion is the religious type and religious activity time in a week In this study, Christianity, Buddhism, Catholicism, such as old age religions according to the type of preparation showed no significant differences. However, It is found to have a significant difference between the religious activitiesone in a week and prepare for their old age.
노인 남성에 있어서 C-반응성 단백질(CRP)과 근력과의 관련성
김도경 ( Do Kyung Kim ),박원하 ( Won Hah Park ) 대한스포츠의학회 2010 대한스포츠의학회지 Vol.28 No.1
Decline in muscle mass and muscle strength characterizes normal aging. As clinical studies show a relationship between high C-reactive protein (CRP) level and low muscle mass. The aim of this study was to investigate whether CRP level of inflammatory markers is associated with muscle strength in older persons by cross-sectional analysis with a sample 170 elderly men. We measured CRP levels, included isokinetic knee extensor strength and isometric back extensor strength among the subjects. Lower extremity strength (Isokinetic test) and lumber extensor muscle strength (Isometric test). From the result of this study, higher CRP level was generally associated with lower muscle strength and was significantly correlated with knee extensor strength and knee flexor strength (r=-0.353, r=-0.342, respectively). It was moderately correlated with lumbar extensor muscle strength (r=-0.233, p=0.05). After adjustment for covariates, higher CRP level was associated with knee strength and back extensor strength. Higher CRP level were generally associated with muscle strength in older men. Higher CRP level may contribute to the loss of muscle mass and strength that accompanies aging.