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정욱진 ( Wook Jin Chung ) 대한내과학회 2010 대한내과학회지 Vol.78 No.1
폐고혈압의 치료에서 비-폐동맥 고혈압에서는 그 원인 질환에 맞는 치료를 한다. 폐고혈압 환자에서 제일 많은 폐정맥 고혈압(PVH)을 일으키는 좌측 심장질환의 경우 일부에서 경중도에 비해 많이 높은 폐동맥압을 갖는 `과잉(disproportionate)` PH인 경우는 PAH와 같은 약물 치료를 시도하는 연구도 있다. 폐동맥 고혈압(PAH) 환자의 고식적 치료는 산소, 항응고제, 이뇨제, 디곡신 치료를 하고, 급성 약물 반응 검사를 통해 칼슘차단제 사용 유무를 결정한다. PAH 치료에 있어 `targeted therapy`로 우리나라에서 사용할 수 있는 약제들은 WHO 기능분류 II, III에서 endothelin 수용체 길항제인 경구용 bosentan과 ambrisentan, phosphodiesterase-5 저해제인 경구용 sildenafil이 있고, WHO 기능분류 III, IV에서는 흡입용 iloprost 등이 있다. PAH는 희귀질환이지만 치명적인 질환으로, 특별한 이유 없이 운동 시에 숨이 찰 때 감별진단이 필요하다. 의심되면 심초음파 검사 등의 스크리닝 검사를 시행하여 조기에 발견하고 진단하는 것이 가장 중요한 치료의 첫걸음이다. Most commonly encountered pulmonary hypertension is pulmonary venous hypertension (PVH) accompanying elevated left ventricular filling pressure. So, the treatment for the underlying left heart disease should be mainstay of PVH treatment. On the contrary, pulmonary arterial hypertension (PAH) is an `orphan` disease, which means a very rare one. To the date, PAH have been one of diseases showing high mortality rate. But, recently, `targeted therapies` were introduced and several novel treatment guidelines for PAH were recommended. This review discusses new insights into the recent trend focusing on novel therapies and the necessity of specialized referral centers for PAH in Korea. (Korean J Med 78:28-35, 2010)
정욱진 ( Wook Jin Chung ),최승원 ( Seung Won Choi ),이승근 ( Seung Keun Lee ),이상길 ( Sang Gil Lee ),권진욱 ( Jin Wuk Kwon ),최승혁 ( Seung Hyuk Choi ),송정식 ( Jung Sik Song ),이찬희 ( Chan Hee Lee ),송창호 ( Chang Ho Song ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Sacroiliitis is a prototyical feature of the seronegative spondyloarthropathies. It has been reported rarely in patients with systemic lupus erythematosus. We report a case of bilateral sacroiliitis in a 26 year-old female who presented 5 out of 11 ARA criteria for systemic lupus erythematosus. She complained of right low back pain since 1 week after delivery. Plain roentgenogram, computed tomogram and magnetic resonance imaging revealed no evidence of subluxation or pyogenic infection that may be possibly related to delivery, but bilateral sacroiliitis especially more severe in the right side that showed concordantly increased uptake on bone scan. Also she had neither HLA DR-3 nor B-27 antigens and had no other clinical findings of limitation of motion of spine and chest expansion, which suggest that there is a less likelihood of coexistent ankylosing spondylitis. In this case, we suggested that sacroiliitis may be a infrequent manifestation of systemic lupus erythematosus.
증례 : 순환기 ; 좌회선지 원위부에서 우관상동맥이 기원하는 단일 관상동맥 기형 1예
박하욱 ( Ha Wook Park ),류시영 ( Si Young You ),윤재승 ( Jae Seung Yun ),이해미 ( Hae Mi Lee ),이수연 ( Soo Yeon Lee ),정욱성 ( Wook Sung Chung ),오용석 ( Yong Seog Oh ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
선천성 심장이상을 동반하지 않은 단일 관상동맥 기형은 매우 드물고, 특히 우관상동맥이 좌회선지의 원위부에서 기시하는 경우는 현재까지 국내에서 1예, 전 세계적으로는 18예에서만 보고되었다. 단일 관상동맥 기형은 분류에 따라 급성 심장사를 일으킬 수 있는 경우가 있어 임상적으로 중요한 의의를 갖지만, 환자의 평가 및 치료에는 정확한 지침이 없는 실정이다. 저자들은 미세혈관 협심증으로 진단된 좌회선지 원위부에서 기원하는 우관상동맥을 보이는 단일 관상동맥 기형 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Single coronary artery (SCA) is a rare congenital anomaly and commonly associated with other congenital cardiac malformations. Some subgroups of SCA can lead to angina pectoris, acute myocardial infarction, or even sudden cardiac death in the absence of atherosclerosis. An anomalous origin of the right coronary artery, arising from the distal portion of the left circumflex artery, has previously been reported in a few cases. In this article, we report a case of a right coronary artery arising from the distal portion of the left circumflex artery with no other cardiac congenital anomaly. (Korean J Med 2011;80:S172-S177)
정규원(Kyu Won Chung),차상복(Sang Bok Cha),선희식(Hee Sik Sun),김부성(Boo Sung Kim),최규용(Kyu Yong Choi),이영석(Young Suk Lee),정욱성(Wook Sung Chung),홍영선(Young Sun Hong),박승만(Seung Man Park),이안희(Ahn Hee Lee),김진(Jin Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1
Rectal carcinoid tumor is relatively rare neoplasm orignated in Kulchitszky cell and clinicians have the difficulties in predicting their malignant potential and in proper treatrnent. The vast majority of rectal carcinoid tumors are benign and can be safely treated by local excision. Lesions larger than 2 cm and invading the muscular wall of the rectum should be considered rnalignant and treated by more radical surgery such as abdominoperineal resection. 3Ve had a case of 35-year-old male patient with a malignant rectal carcinoid tumor 2 cm in the length diagnosed by colonofiberscopy. So we present this case with a review of relevant literatures.
딥러닝 모델을 이용한 휴대용 무선 초음파 영상에서의 경동맥 내중막 두께 자동 분할 알고리즘 개발
최자영,김영재,유경민,장영우,정욱진,김광기,Choi, Ja-Young,Kim, Young Jae,You, Kyung Min,Jang, Albert Youngwoo,Chung, Wook-Jin,Kim, Kwang Gi 대한의용생체공학회 2021 의공학회지 Vol.42 No.3
Measuring Intima-media thickness (IMT) with ultrasound images can help early detection of coronary artery disease. As a result, numerous machine learning studies have been conducted to measure IMT. However, most of these studies require several steps of pre-treatment to extract the boundary, and some require manual intervention, so they are not suitable for on-site treatment in urgent situations. in this paper, we propose to use deep learning networks U-Net, Attention U-Net, and Pretrained U-Net to automatically segment the intima-media complex. This study also applied the HE, HS, and CLAHE preprocessing technique to wireless portable ultrasound diagnostic device images. As a result, The average dice coefficient of HE applied Models is 71% and CLAHE applied Models is 70%, while the HS applied Models have improved as 72% dice coefficient. Among them, Pretrained U-Net showed the highest performance with an average of 74%. When comparing this with the mean value of IMT measured by Conventional wired ultrasound equipment, the highest correlation coefficient value was shown in the HS applied pretrained U-Net.