생체신이식에서의 술전 24시간 공여자 특이 수혈

정선동,김대영,김경원,공진민 대한신장학회 1997 춘계학술대회 초록집 Vol.1997 No.-

인삼의 황노화효과와 미래의 연구 방향

박영철,이선동,정해원 대한보건협회 1999 대한보건연구 Vol.25 No.2

인간의 평균수명 증가와 함께 노년인구의 증가로 인한 노인층이 차지하는 비율이 증가함에 따라 최근에 노화의 원인과 기전에 대한 연구가 진행되면서 다양한 항노화성 물질이 소개되고 있다. 지금까지 알려진 노화설은 여러가지로 추정되고 있는데 예를 들어 유전자설(genome-based theory), 프리라디칼설(Free radical theory)과 최근의 복제적 세네센스 현상(replicative senescence), 세포노화에 따라 telomere의 길이가 짧아지는 이론 등이다. 이중 인삼의 항노화작용에 대한 연구는 프리라디칼 생성에 대한 세포내 몇가지 방어적 시스템과 관련하여 연구가 이루어졌다. 인삼의 ginsenoside에 의해 SOD를 비롯하여 항산화효소의 발현 및 라디칼에 의한 상해를 수복하는 수복효소 등의 발현에 관여하여 직접적으로 라디칼 제거기능과 특히 Gensenoside의 예방적 항산화제 기능측면내에 SOD발현에 신호전달기전에 대한 규명은 한약제의 항노화적 효능을 과학적으로 입증했다는데 큰 의의가 있다. 특히 세포의 신호전달체계와 관련하여 NO의 역할이 second messenger로서 최근에 활발히 연구되고 있는데 Gensenoside 역시 NO synthase활성을 유도하여 NO 생성, SOD와 Catalase 등의 활성유도를 촉진시키며 또한 세포내 지질과 단백질 등 거대분자에 작용하여 라디칼을 제거하는 항산화기능을 확인하였다. 이러한 점은 인삼의 抗老化機能이 다양한 경로를 통해 이루어지며 인삼의 중요한 항노화기전으로 이해할 수 있다. 그러나 인삼의 항노화성의 우수성을 입증하기 위해서는 앞으로 무엇보다도 한의학적 약효에 대한 좀더 깊은 이해와 과학적인 기전연구와 지속적 접근이 매우 필요할 것이 사료된다. From the turn of this century, human life span has been abruptly increased. In recent decades, interest in various aspects of aging has accelerated in great park owing to the realization that not only do the elderly form an increasing percentage of the population. There are two main theory for aging mechanisms known up to now, for example, genome based theory and free radical theory. Here, the studies on anti-aging function of ginseng have been reviewed in terms of free radical theory. The ginsenoside has the function that remove free radical at first band, concerning expression of anti oxidant enzyme, SOD. Especially, the finding that ginsenoside participates in signal transduction pathway for SOD expression is very important in proving anti aging function of ginseng. Moreover, related to the signal transduction, the NO's role has been recently empathized as second messenger. The ginseng induces expression of NO synthase and generates NO which also activate the induction of SOD. Besides, ginseng's role for anti-aging has been achieved through various ways. However, such studies are too far way from recent trends for aging, especially in the field of free radical theory. Thus, ginsenoside should be applied to recent trends of aging study such as telomere and restriction diet related to free radical generation.

인삼의 황노화효과와 미래의 연구 방향

박영철,이선동,정해원 사단법인 대한보건협회 2005 대한보건연구 Vol.31 No.2

고지방식이 마우스 비만모델에서 발효대두파우더의 체중증가량 변화와 지방간 개선

총배금,이희영,이혜림,정해경,윤연미,윤미정,박선동,신순식,Tsung, Pei-Chin,Lee, Hee-Young,Lee, Hye-Rim,Jeong, Hae-Gyeong,Yin, Yuan-Mi,Yoon, Mi-Chung,Park, Sun-Dong,Shin, Soon-Shik 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

Objectives : We investigated the effects of fermented soybean(FSOB) on body weight and examined whether hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, FSOB(1), (2) and (3). After mice were treated with FSOB for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Results : 1. Compared with controls, FSOB-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in FSOB(3) and FSOB(1). 2. Compared with controls, FSOB-treated mice had lower feeding efficiency ratio and blood plasma leptin levels, the magnitude of which was prominent in FSOB(3). 3. Compared with controls, FSOB-treated mice had lower blood plasma total cholesterol and LDL-cholesterol levels. 4. Blood plasma AST and ALT concentrations were not changed by FSOB, indicating FSOB do not show any toxic effects. 5. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by FSOB, whereas the adipocyte number per unit area was significantly increased, suggesting that FSOB decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by FSOB. Conclusions : These results demonstrate that FSOB effectively reduces body weight gain, feeding efficiency ratio, blood plasma leptin level and improves hepatic lipid accumulation.

만성 골수성 백혈병 환자에서 척수압박증을 유발한 과립구성 육종 1례

김근태,이지현,이용환,정선동,장미화,김호균,옥종환,김병창 大韓血液學會 1998 大韓血液學會誌 Vol.33 No.2

산이식후 당뇨병의 위험인자와 임상적 고찰

이용환,장미화,이지현,정선동,김근태,공지민 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.6

To investigate the risk factors and clinical characteristics of post-renal transplant diabetes mellitus (PTDM), we reviewed the records of 177 renal allograft recipients in Maryknoll Hospiatal whose allografts had functioned longer than 6 months. Nineteen patients(10.7%) developed PTDM at 5.0±7.8(1-52)months; 9(47%) of these within 1 month. PTDM patients were older than non-diabetic renal transplants(42±2 vs 37±1 years, P$lt;0.05). Body mass index tended to be higher in PTDM(23.5±1.0 vs 21.8±0.3kg/m2, P=0.09). Number of acute rejections (0.6±0.2 vs 0.5±0.1) and serum creatinine at 1 year after transplantation(1.2±0.8 vs 1.3±0.3mg/dL) were not different. Fasting(103.6?10.4 vs 84.4±1.6mg/dL, P$lt;0.05) and postprandial(189.2±24.8 vs 118.6±2.3 mg/dL, P$lt;0.01) blood sugars, measured before transplantation, were higher in PTDM. CsA blood level at 1 month posttransplantation was higher in PTDM (350±34 vs 279±8ng/mL, P$lt;0.05). Fasting serum insulin was significantly higher(28.2±12.2 vs 7.3±2.0μU/dL, P$lt;0.0tide tended to be higher in PTDM patients compared with euglycemic renal recipients(6.3±1.6 vs 3.8?0.9ng/dL, P=0.08). All the PTDM patients were treated by either insulin or oral agent; 15 of 19 required no treatment after 4.7±6.9 months. In conclusion, prevalence of PTDM was 10.7%. PTDM patients were older. Body mass index was tended to be higher. Fasting and postprandial blood sugars, measured before transplantation, were higher in PTDM. Faslting serum insulin was higher and C-peptide tended to be higher in diabetics. These results suggested that increased insulin resistance plays a major role in the pathogenesis of PTDM.

급성 골수성 백혈병으로 이행된 본태성 혈소판증가증 1례

이지현,김태익,김근태,이용환,정선동,장미화,김호균,김병창 大韓血液學會 1997 大韓血液學會誌 Vol.32 No.3

생체 신이식에서의 술전 24시간 공여자 특이 수혈

김경원,이용환,김대영,장미화,이지현,공진민,정선동,김근태 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1

The goal of the immunologic maneuvering for organ transplantation may be the donor specific immune tolerance rather than non-specific immunosuppression. Although DST is one of the most extensively studied methods for donor specific immune hyporesponsiveness, it is not widely used in recent years because of possible sensitization and overall improvement of graft survival without DST. Several human and animal studies showed that -24h DST with concomitant cyclosporine administration improved graft survival. -24 DST may not induce adverse sensitization that preclude subsequent transplantation and the procedure is simple and does not delay the operation in living donor transplantation. Between Feb. 1994 and Jan. 1997, 33 patients received 100-200ml of fresh whole blood from the kidney donor 1 day before transplantation. Twenty donors were living related and 13 donors were non-related. Mean age was 40(22-52). Two patients was diabetic. All but one received primary allograft. Cyclosporine and prednisolone were the primary immunosuppressants that started 2-3 days before transplantation. Acute rejection occurred in 11 recipients(33.3%). Acute rejection tended to occur earlier. Eight of 11 first episodes were within 3 days posttransplant, which were all recovered by either steroid pulse or OKT3. Mean follow up was 35 months. Two patients died with functioning graft. Three-year graft survival rate was 93.9%. There was no immunologic graft loss. We conclude that -24h DST may be a valuable option of immune modulation for renal transplantation with no demonstrable adverse reaction. It's beneficial effect needs to be confirmed by a larger controlled study.

상부 위장관 내시경으로 증명된 속발성 혈색소증 1예

김호균,장미화,이지현,박희욱,이용환,정선동,김근태,옥종한 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.6

A patient who underwent a transfusion due to an aplastic anemia subsequently experienced secondary hemochromatosis, which is very rare in Korea. The 56 year old female was admitted to our hospital with complaints of general weakness, fatigue, a brown-colored facial complexion, dyspnea upon exertion, and abdominal distension. Laboratory examination disclosed functional impairment of the liver and echocardiography revealed a congestive heart failure pattern. Gastrofiberscopy revealed brown colored gastric mucosa, and a fundal mucosa biopsy revealed a hemosidt pigment in iron stain.