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- 저자 : 전호종(Ho-Jong Jeon) (검색결과 53 건)
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전호종,이미자,이미숙,정유경,이영미,최형호,Jeon, Ho-Jong,Lee, Mi-Ja,Lee, Mi-Sook,Jeong, Yu-Kyung,Lee, Young-Mi,Choi, Hyung-Ho 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Reactive humsn mesothelial cells were examined by immunocytochemical stain with intermediate filaments (cytokeratin [CK1, CK7, CK8, CK18, CD19), vimentin, desmin, actin), epithelial membrane antigen, carcinoembryonic antigen (CEA), MHC class II antigen (HLA-DR), LeuM-1 (CD15), $\alpha1-antitrypsin$(ACT), $\alpha1-antichymotrypsin$ (ACHT), CD68(KP-1) and FcyRIII(CD16). The mesothelial cells were isolated from patients with liver cirrhosis and pleural effusion, and short-term cultured in RPMI 1640 media containing 10% heat inactivated fetal calf serum and 1% identical supernatant fluid of the patients' transudates. The results obtained are as follows 1. The cultured-reactive mesothelial cells were positive for the protein of cytoskeleton such as cytokeratin and vimentin, but negative for desmin and actin. The resting mesothelial cells showed positive reactions for cylokeratin, but negative for vimentin, desmin and actin. 2. The primary antibodies to the cytokeratin were strongly reactive for CK1, CK8 and CK18 but negative for CK7 and CK19 in both reactive and resting mesothelial cells. 3. Resting mesothelial cells showed negative reactions for CEA, but strong positive reactions in cultured-reactive mesothelial cells. 4. The markers for the monocytes/histiocytes(CD11b, CD14, CD16, CD68, Iysozyme and $\alpha1-antitrypsin$ and $\alpha1-antichymotrypsin$) were nonreactive in resting mesothelial cells, but lysozyme and $\alpha1-antitrypsin$ were weakly reactive in reactive and proliferative mesothelial cells. 5. MHC Class II molecule(HLA-DR antigen) was negative in both resting and reactive mesothelial cells. These results suggest that the short-term cultured, reactive mesothelial cells show a newly aberrant expression of the vimentin and calcine-embryonic antigen. The reason of the aberrant expression of the intermediate filament and oncofetal antigen in reactive and proliferative mesothelial cells should be further evaluated.
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HTLV - I 의 불멸화에 의한 T 세포의 특성 및 한국인 악성 림프종과 Retrovirus 감염과의 관계
전호종(Ho Jong Jeon),서재홍(Chae Hong Suh),기근홍(Keun Hong Kee),김윤신(Yun Sin Kim),이미숙(Mi Sook Lee),정춘해(Choon Hae Chung),정종훈(Jong Hoon Jung),박영진(Young Jin Park),김향우(Hyang Woo Kim),아카키타다쯔(Tadaatsu Akagi) 대한내과학회 1995 대한내과학회지 Vol.49 No.3
N/A Objectives: 1) The relationship between malignant T-cell lymphoma and retroviral infection was examined in sixty-two cases of non Hodgkin's lymphoma arising in nodal and extranodal site to presume the etiologic factors in the pathogenesis of T-cell lymphoma arising in Korean. 2) Human T-cell leukemia/lymphoma virus type I(HTLV-1) is known as an etiologic agent of adult T-cell leukemia/lymphoma(ATL), however, the precise role of the HTLV I on the genesis of ATL is unclear. To elucidate the mechanism of the leukemogenesis on the ATL, establishment of cell line harboring HTLV-I is indispensable. Methods: 1) Sixty- two cases of malignant lymphoma were examined with a battery of monoclonal and polyclonal antibodies directed to T-cell, B-cell and macrophage-lineage to determine the immunophenotypes. Reverse transcriptase activity and the pol gene region in HTLV-I were examined by RNA directed DNA polymerase assay and polymerase chain reaction. 2) Two helper T-cell lines, designated JP(JP-1 and JP-2), were established by co-culturing normal human cord leukocytes with a lethally irradiated HTLV-I-harboring human leukocytes cell line(MT-2). Results: 1) There are no evidence of retroviral infection including HTI.V-I in examined 7 cases of peripheral T-cell lymphama. 2) JP-1(interleukin 2 dependent) had a normal karyotype, and expressed the surface markers CD3+, CD4+, CD8-, CD19-, CD25+ and HLA-DR+. JP-2(IL-2 independent) had tetraploidy on the 22nd passage, and exhibited the surface markers CD3-, CD4+, CD8-, CD19-, CD25+ and HLA-DR+. T-cell receptor(TCR)-β chain gene was detected in these two cell lines by Southern blot hybridization techniques with (32)P-labelled DNA probe Jpconfirming T-cell nature. Jβ2 cells were all immunoreactive with anti-HTLV-1, p 19, p 24, gp46 and pX antibodies. The proviral genome of HTLV-1 was detected in these cell lines by Southern blot hybridization by the (32)P-labelled DNA probe, pHT-1 (M)3.9. Electron microscopy of JP 2 cells revealed a few of type C virus particles. Conelusion: 1) These results suggest that the evidence of retroviral infection as an etiological factors in the pathogenesis of T-cell lymphoma is poor. 2) HTLV-1 was transmitted from the infected human leukocyte cell line to human cord helper T-cells with the development of immortalized HTLV-1 producing T-cell lines, and IL-2 independent cell line(JP-2) lost their CD3 antigen, It is suspicious that there is the second factors to induce malignant transformation in the genesis of adult T-cell leukemia/lymphoma because of absence of the tumorigenecity in the JP cell lines harboring HTLV-1.
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갑상선종에서 발생한 다양한 조직학적 양상을 보인 역형성 암종의 세포학적 소견 - 1예 보고 -
이미자,이미숙,정유경,임성철,기근홍,전호종,Lee, Mi-Ja,Lee, Mi-Sook,Jeong, You-Kyung,Lim, Sung-Chul,Kee, Keun-Hong,Jeon, Ho-Jong 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Anaplastic carcinoma of the thyroid (ACT) is a rare subtype of thyroid neoplasm. This tumor represents approximately 5-10% of all thyroid malignancies and has poor prognosis ACT often arises on a long-standing thyroid nodule and has been documented to be associated with a variety of more well-differentiated thyroid carcinomas. We experienced a case of anaplastic thyroid carcinoma who had had about a year history of thyroid getter. The patient had been injected with sclerosing agents in treatment of preexisting golfer. The ACT in this case had varied cytologic and histologic appearances: pleomorphic, giant cell, spindle and squamoid. Immunohistochemically, strong cytoplasmic positivity for cytokeratin was seen in all kinds of tumor cells. Ultrastructurally, the evidences of epithelial differentiation were seen such as intercellular junctions and tonofibrils.
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Ki-1 양성 역형성 대세포 림프종의 체액 세포학적 소견 - 1예 보고 -
이미숙,이미자,정유경,임성철,기근홍,전호종,Lee, Mi-Sook,Lee, Mi-Ja,Jeong, Yu-Kyung,Lim, Sung-Chul,Kee, Keun-Hong,Jeon, Ho-Jong 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Ki-1 positive anaplastic large cell lymphoma is a newly described high-grade lymphoma and is defined by histopathological and immunologic criteria. We experienced a case of systemically involving Ki-1 positive anaplastic large cell lymphoma in a 44 year-old female which initially manifested as pleural effusion. Abdominopelvic CT scan showed the evidence of marked lymphadenopathy in retroperitoneal and both external and inguinal lymph nodes. On cytologic examination of pleural fluid, tumor cells revealed pleomorphic large isolated cells with prominent nucleoli and abundant cytoplasms. The nuclei were large with irregular profiles including some deep invaginations. Also, occasional multilobed/multinucleated and binucleated nuclei were seen. Immunohistochemical examination was performed to differentiate from the undifferentiated adenocarcinoma, Hodgkin's disease, non-Hodgkin's lymphoma and malignant histiocytosis. The neoplastic cells were positive for leukocyte common antigen, CD3, CD30(Ki-1) but negative for cytokeratin, epithelial membrane antigen, and CD15. A histologic diagnosis of Ki-1 positive anaplastic lymphoma was made by biopsies of the inguinal lymph node, polypoid lesions of the stomach and cecum.
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오윤경(Yoon Kyeong Oh),박희철(Hee Chul Park),기근홍(Keun Hong Kee),전호종(Ho Jong Jeon),박유환(You Hwan Park),정춘해(Choon Hai Chung) 대한방사선종양학회 2000 Radiation Oncology Journal Vol.18 No.4
자궁 평활근육종의 경부림프절로의 전이는 지금까지 보고되지 않았으며 타 부위로의 전이 시에도 방사선치료는 드물게 이용되어왔다. 저자들은 자궁 평활근육종 환자에서 수술과 골반부 방사선치료를 시행 받고 10개월 후에 경부림프절 전이가 발생하여 인접한 후두주위공간, 척추골, 척추관을 함께 침습하였기에 방사선치료와 화학요법의 경험과 함께 보고하는 바이다. 전이된 종양은 수술이 불가능하여 방사선치료가 의뢰되었으며 총 6,000 cGy의 경부 방사선치료와 taxol과 carboplatin으로 화학요법을 시행하였다. 전이 암은 점차로 크기가 감소하여서 거의 만져지지 않을정도로 되었다. 환자는 경부 방사선치료와 화학요법을 시행 받은 후 8개월간 척수압박증상을 발생하지 않았고, 연하곤란은 회복되어서 좋은 상태를 유지하였다. 광범위한 경부전이 암이 고선량 경부방사선치료와 화학요법에 좋은 국소 반응을 보였기에 수술이 불가능한 전이성 평활근육종 환자에서 이 두 가지 치료법이 고려될 수도 있겠다. The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma.
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오윤경(Yoon Kyeong Oh),이미자(Mi Ja Lee),전호종(Ho Jong Jeon) 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.1
목적: 종양의 성장은 세포의 증식과 소실의 순수한 결과이며, 대부분의 종야들에서 아포프토시스는 계속되는 세포 소실의 가장 중요한 부분을 차지하고 있다. 본 연구에서는 비호지킨림프종 환자들을 REAL 분류에 따라 재분류한 다름 면역조직화학 염색을 이용하여 아포프토시스 지수, Ki-67 세포증식지수, Bcl-2 단백 발현, P53 단백 발현을 관찰하여 종양의 성장에 영향을 주는 여러 인자들의 관련 양상을 알아보고자 하였다. 대상 및 방법: 비호지킨림프종 환자 67명을 대상으로 하였다. Working Formulation을 이용하여 분류하였을 때 저등급 3명, 중등급이 64명이었다. 세포 표현형은 전체 67명의 혼자 중 47명(70%)이 B세포 표현형이었고, 18(27%)이 T세포 표현형이었으며, 2명세서는 분류할 수 없었다. 환자의 파라핀 포매 조직을 이용하여 면역조직화학 염색을 실시하여 아포프토시스 지수와 Ki-67 세포증식지수, Bcl-2 단백발현, P53 단백발현을 관찰하였다. 결과: Bcl-2 단백의 발현은 40$ (26/65)에서 양성 반응을 보였다. P53 단백의 발현은 31%(20/65)에서 보였다. 아포프토시스 지수는 0%와 15% 사이의 범위에 있었으며 평균은 2.16이고 중앙값은 1.2이었다. 아포프토시스 지수는 세포 표현형이나 P53 단백발현 여부에 따라 의미 있는 차이를 보이지 않았으나, Bcl-2 단백발현 여부에 따라서는 통계학적으로 의미 있는 차이를 보였다(p=0.005). Bcl-2 단백발현이 양성이면 아포프토시스 지수가 낮았다. Ki-67 세포증식지수는 1%와 91% 사이의 범위에 있었으며 평균은 55.4%이었다. Ki-67 세포증식지수는 세포표현형이나 Bcl-2 단백발현 여부에 따라 의미 있는 차이를 보이지 않았으나, P53 단백발현 여부에 따라서는 통계학적으로 의미 있는 차이를 보였다.(p=0.000). 전체 환자군에서는 아포프토시스 지수와 ki-67 세포증식지수 사이에 관련이 없었으나, Bcl-2 단백발현 양성인 황자에서는 아포프토시스 지수가 증가하면 Ki-67 세포증식지수가 증가하는 경향이 있었다.(p=0.012) 결론: Bcl-2 단백발현이 양성이면 아포프토시스 지수가 낮았고, P53 단백발현이 양성이면 Ki-67 세포증식지수는 높았다. 또한 Bcl-2 양성인 환자에서는 아포프토시스 지수와 Ki-67 세포증식지수사이의 양성 연관성을 보였는데 이는 아포프토시스가 종양의 성장에 있어서 세포의 증식과 별도로 분리하여 생각할 수 없는 것임을 시사해준다고 본다. Purpose: Tumors growth in a given neoplasm is the net result of cell proliferation and cell loss, and apoptosis is the most significant component of continuous cell loss in most tumors. In this study, we examined non-Hodgkin's lymphoma (NHL, n=67) immunohistochemically for the presence of Bcl-2 oncoprotein and P53 protein and compared apoptotic indices (Als) and Ki-67 proliferative indices (percentages of Ki-67) positive cells). Materials and Methods: 67 patients with NHL were evaluated : 3 low-grade and 64 intermediate-grade. The phenotype was determined in 65 cases: 47(70%) were B cell type and 18(27%) were T cell type. Als and Ki-67 proliferative indices were determined immunohistochemically and the overexpression of P53 and Bcl-2 protein were also evaluated. Results: The overexpressions of Bcl-2 protein and P53 protein were found in 40% (26/65) and 31%(20/65). The Al ranged from 0% to 15% (mean 2.16, median 1.2) Cellular Bcl-2, which counteracts apoptosis, was significantly (p=0.005) associated with Als. Ki-67 proliferative indices ranged from 1% to 91% (mean 55.4), and P53 was significantly (p=0.000) associated with Ki-67 proliferative indices. A positive correlation between Als and Ki-67 proliferative indices was revealed (p=0.012) in Bcl-2 positive patients. Conclusion: In NHL, we observed a correlation between Als and Bcl-2 expression, between Ki-67 proliferative indices and P53 expression, and between Als and Ki-67 proliferative indices in Bcl-2 positive patients. Our results suggest that cell apoptosis may be inseparable from cell proliferation during tumor growth.
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