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백서 심장 및 현장독성에 대한 Doxorubicin 과 Epirubicin 의 영향
박유환(You Hwan Park),정희상(Hoe Sang Jung),김완중(Wan Jung Kim),권희식(Hee Sik Kwon),김용태(Young Tae Kim),문철웅(Chul Oong Moon),박찬국(Chan Kook Park),이승일(Seung Il Lee),홍순표(Soon Pyo Hong) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A Doxorubicin is an antibiotic of the anthracycline group which has proven effective in treating a variety of malignant disorders. Its use in cancer chemotherapy has been limitd, however, because of the its cardiotoxic side effects. Attempts to reduce the cardiotoxicity of anthracycline antibotics include the synthesis of structural analogs, e.g., epirubicin, the coupling of active drugs to carriers, and the discovery of new types of anthracyclines. In this experiment, the toxicity of epirubicin was examined in various organs of rats for levels of malondialdehyde and activity of free radical scavengers (superoxide dismutase and catalase) and compared with the toxicity of doxorubicin. The following results were obtained: 1) Doxorubicin increased the quantity of malondiadehyde by 519% (p<0.01) in the heart, 45% (p<0.01) in the kideny, 35%(p<0.05) in the lung, and 41% (p<0.05) in the liver. Epirubicin increased the quantity of malondiadehyde by 10%(p<0.05) in the heart and 26%(p<0.01) in the kidney, but there was little change in the lung and liver. 2) Doxorubicin and Epirubicin decreased the activities of catalase in the heart by 11% and 17% but increased the it in the kidney by 27% and 19%, respectively (p<0.05). 3) Doxorubicin and Epirubicin increased the activities of SOD in the heart by 24% (p<0.01) and 199%(p<0.05) and in the kidney by 23%(p<0.01) and 34% (p<0.05) respectively. In conclusion, Epirubicin shows less toxicity in the heart than the kidney and has less cardiorenal toxicity in rats compared to Doxorubicin for same doses.
Ti-6Al-4V 합금의 고온 성형시 미세조직 예측에 관한 연구
이유환,신태진,박노광,심인옥,황상무,이종수,Lee You Hwan,Shin Tae Jin,Park No Kwang,Shim In Ok,Hwang Sang Moo,Lee Chong Soo 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.4
A study has been made to investigate the high temperature deformation behavior of Ti-6Al-4V alloyand to predict the final microstructure under given forming conditions. Equiaxed and $Widmanst\ddot{a}tten$ microstructures of Ti-6Al-4V alloys were prepared as initial microstructures. By performing the compression tests at high temperatures$(700\~1100^{\circ}C)$ and at a wide range of strain rates$(10^{-4}\~10^2/s)$, various parameters such as strain rate sensitivity(m) and activation energy(Q) were calculated and used to establish constitutive equations. When the specimens were deformed up to strain 0.6, equiaxed microstructure did not show any significant changes in microstructure, while $Widmanst\ddot{a}tten$ microstructure revealed considerable flow softening, which was attributed to the globularization of a platelet at the temperature range of $800\~970^{\circ}C$ and at the strain rate range of $10^{-4}\~10^{-2}/s$. To predict the final microstructure after forming, finite element analysis was performed considering the microstructural evolution during the deformation. The grain size and the volume fraction of second phase of deformed body were predicted and compared with the experimental results.
Ti-6Al-4V합금의 열간 후방압출에 대한 성형 안정성 평가모델의 고찰
염종택,박노광,이유환,신태진,황상무,홍성석,심인옥,이종수,Yeom Jong-Taek,Park Nho-Kwang,Lee You-Hwan,Shin Tae-Jin,Hwang Sang-Mu,Hong Sung-Suk,Shim In-Ok,Lee Chong-Soo 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.3
The metal forming behavior of Ti-6Al-4V tube during hot backward extrusion was investigated with various forming stabilities or instabilities criteria. that is, Ziegler's instability criterion, dynamic materials model(DMM) stability criteria and Rao's instability criterion. These approaches also were coupled to the internal variables generated from FE simulation. In order to validate the reliabilities of three criteria, hot backward extrusions for Ti-6Al-4V tube making were carried out with different backward extrusion designs. The useful model for predicting the forming defects was suggested through the comparison between experimental observations and simulation results.
신태진,이유환,염종택,홍성석,박노광,심인옥,이종수,황상무,Shin Tae-Jin,Lee You-Hwan,Yeum Jong-Taek,Hong Sung-Suk,Park No-Kwang,Shim In-Ok,Lee Chong-Soo,Hwang Sang-Moo 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.2
Titanium alloys are vital elements for developing advanced structural components, especially in aerospace applications. However, process design for successful forming of titanium alloys is a difficult task, which has to be achieved within a very narrow range of process parameters. In this paper is a finite element based optimal design technique is presented and applied to volume fraction optimization process design in backward extrusion of titanium alloys.
오윤경(Yoon Kyeong Oh),박희철(Hee Chul Park),기근홍(Keun Hong Kee),전호종(Ho Jong Jeon),박유환(You Hwan Park),정춘해(Choon Hai Chung) 대한방사선종양학회 2000 Radiation Oncology Journal Vol.18 No.4
자궁 평활근육종의 경부림프절로의 전이는 지금까지 보고되지 않았으며 타 부위로의 전이 시에도 방사선치료는 드물게 이용되어왔다. 저자들은 자궁 평활근육종 환자에서 수술과 골반부 방사선치료를 시행 받고 10개월 후에 경부림프절 전이가 발생하여 인접한 후두주위공간, 척추골, 척추관을 함께 침습하였기에 방사선치료와 화학요법의 경험과 함께 보고하는 바이다. 전이된 종양은 수술이 불가능하여 방사선치료가 의뢰되었으며 총 6,000 cGy의 경부 방사선치료와 taxol과 carboplatin으로 화학요법을 시행하였다. 전이 암은 점차로 크기가 감소하여서 거의 만져지지 않을정도로 되었다. 환자는 경부 방사선치료와 화학요법을 시행 받은 후 8개월간 척수압박증상을 발생하지 않았고, 연하곤란은 회복되어서 좋은 상태를 유지하였다. 광범위한 경부전이 암이 고선량 경부방사선치료와 화학요법에 좋은 국소 반응을 보였기에 수술이 불가능한 전이성 평활근육종 환자에서 이 두 가지 치료법이 고려될 수도 있겠다. The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal canal. The metastatic neck mass was inoperable, and was treated by neck radiotherapy (6,000 cGy) and chemotherapy including taxol and carboplatin. The mass has regressed progressively to a nearly impalpable state. She has never developed spinal cord compression syndrome, and has maintained good swallowing for eight months since the neck radiotherapy and chemotherapy. Since the extensive metastatic neck mass showed good local response to high dose radiotherapy and chemotherapy, both treatments may be considered for an unresectable metastatic leiomyosarcoma.
박치영,모성환,문철호,곽재정,김태종,전용준,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2
von Willebrand's disease (vWD) is the most common autosomal-dominant inherited disorder resulting from a quantitative or a qualitative defect of von Willebrand factor (vWF). The most diagnostic pattern is the combination of a prolonged bleeding time, a reduction in plasma vWF concentration, a parallel reduction in ristocetin cofactor activity, and reduced factor Ⅷ activity, In this case, ristocetin-induced platelet aggregation data were compatible with that of vWD. Bleeding times were prolonged over 4 minutes, vWF antigen levels were 45%. vWF ristocetin cofactor activities were 0~1% and factor Ⅷ levels were 31%, when compared to the normal control. We report the case of a family with vWD. characterized by a quantitative defect in vWF
박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.
조은택,박용관,김진호,강정원,천영욱,전익섭,박유환,전춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Malignant histiocytosis, originally described in 1939 as histiocytic medullary reticulosis by Scott and Robb-Smith, is a rare histiocytic proliferative disorder that often shows an acute onset and used to progress to death within a few months. This disorder characterized clinically by fever, generalized weakness, lymphadenopathy and hepatosplenomegaly, and shows a variable range of pancytopenia. Extranodal involvement is common, with an incidence ranging from 50% to as high as 90%, skin involves8ment was noted in 10% to 15%. Typical skin lesions were mainly founded in extremity. i.e. erythematous papule and nodule occasionally become to necrosis and ulceration. We experienced one case of malignant histiocytosis in a 46-years-old female. The major clinical findings are fever, malaise, hepatosplenomegaly and erythematous skin lesion. In the laboratory study, pancytopenia is noted on the peripheral blood. And also aggregation of many atypical histiocytes were shown on skin and bone marrow biopsy. So we reported one related case with malignant histiocytosis as well as reviewing literature .