Clinical Application of Imatinib Mesylate in a Case of Feline Cutaneous Mast Cell Tumor: Clinical Progress, Histopathological, and Immunohistochemical Findings

장효미,송중현,황태성,이희천,유도현,서정향,강병택,조양래,정동인 한국임상수의학회 2017 한국임상수의학회지 Vol.34 No.6

A 1.5-year-old neutered male domestic short hair cat was presented with multiple nodular mass, and suspected mast cell tumor on the surface of the right ear, accompanied by submandibular lymph node involvement. Histopathological Examinations and KIT (CD117) immunohistochemical staining was performed after the surgical resection of the entire right ear pinna. This patient was diagnosed with an anaplastic mast cell tumor with a diffuse positive cytoplasmic expression of KIT. Imatinib mesylate was prescribed after surgical resection; the patient presented without recurrence or metastasis for 2 years. Mild leukopenia was observed as the only side effect of imatinib mesylate during medication.

Cervical Paraganglioma Originated from Lingual Vein in a Boston Terrier Dog

장효미,이희천,최을수,서정향,정동인 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.6

A 7-year-old castrated male Boston terrier dog was referred due to dyspnea and unilateral cervical mass. On physical examination, mass on left submandibular region was palpated. CT findings revealed this case could be the tumor originated from left lingual vein. The client refused further treatment and the patient expired because of respiratory failure 10 days after presentation. On necropsy, a well-defined firm mass which located in the left side of larynx was detected. Histopathological findings for the mass indicated polygonal tumor cells arranged in nest and separated by fibrovascular septa. We performed immunohistochemisry to evaluate of chromogranin A and tumor cells showed positive immunoreactivity for chromogranin A. Based on computed tomography (CT), histopathological and immunohistochemical findings, this case was definitely diagnosed to paraganglioma of the body on the lingual vein. This report describes the clinical findings, CT imaging characteristics, histopathologic and immunohistochemical features of paraganglioma arised from lingual vein in a dog.

초등학교 특수학급 수업 실행 관련 연구 동향-2010년부터 2022년까지 연구 논문 중심으로-

장효미,전병운 공주대학교 특수교육연구소 2023 특수교육논집 Vol.28 No.2

Purpose: This study aims to analyze general trends and topics of research related to class implementation and to suggest future research directions based on it. Method: To achieve this, 36 papers were selected and analyzed: from the general trends such as published year, research types and subjects, research class subjects, the relevance of classes to the Interventions and Strategies Method, to the specific factors of themes in elementary special class lessons. Results: As a result, it showed that the research on elementary special class lessons had been consistently published every year from 2010 to 2022. Quantitative research showed no significant differences in its numbers across the years, but qualitative research gradually has been increased from 2013 to the recent. Quantitative research primarily applied a Multiple Intermittent Baseline Design, while qualitative research predominantly utilized Action Research Methodology. The most common research subjects were the students with intellectual disabilities. Korean language and mathematics were the most frequently addressed as class subjects, and the Interventions and Strategies Method applied to the lessons were found to be integrated with the curriculum through its reconstruction. The themes of class implementation varied according to the characteristics of each subject, and many studies focused on applying the Interventions and Strategies Method to a small number of students. Studies analyzed the changed behavior of students through the lessons, in terms of academic learning abilities and classroom behaviors. Regarding the academic learning abilities, they examined the changes in the acquisition and improvement of subject-specific knowledge and skills, taking into account the characteristics of each subject. As for the classroom behaviors, many studied the changes in students' classroom participation behaviors. Discussion and Conclusion: The direction of future research on the implementation of special class classes in elementary schools was presented.

A retrospective study for allergic dermatitis in 35 dogs

장효미,정동인,강병택 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.4

Allergic disorders are exaggerated immune responses to foreign antigens, regardless of the mechanism, while atopic disorders are exaggerated IgE-mediated immune responses (type I hypersensitivity). Allergic dermatitis is a common pathological condition of skin in humans and dogs. Canine allergic dermatitis presents with clinical signs similar to those reported in humans, and its causes are complex; therefore, diagnostic tests and treatments may need to be adjusted for each patient. Dogs with allergic dermatitis can suffer from secondary infections, which must be considered and confirmed or excluded for successful treatment. In this report, 35 cases of canine allergic dermatitis diagnosed using variable methods, including histological and cytological examination, are described. Patients were treated with oral or topical medications (antimicrobials, anti-inflammatories, immune modulators, topical ointments, and medicated shampoos), and their diets and environmental surroundings were also modified. This report provides an analysis of the breed, gender, age of onset, clinical signs, diagnostic methods, and treatments for canine allergic dermatitis. The information on canine allergic dermatitis presented here could be helpful in the study of human cases because these two species often share living spaces, environments, and lifestyles more closely than other animals. However, previous reports have suggested that human and canine allergies differ in some features, such as involvement of histamine in induction of pruritus, and in histopathological characteristics such as cutaneous structures.

중도중복장애 선정에 대한 특수교육지원센터 교사의 경험과 요구

장효미,전병운,박선화,이원경 한국장애인재활협회 부설 재활연구소 2023 재활복지 Vol.27 No.3

본 연구의 목적은 「장애인 등에 대한 특수교육법」시행령의 일부 개정으로, 중도중복장애 특수교육대상자 기준이 마련됨에 따라 특수교육지원센터의 중도중복장애 특수교육대상자 진단·평가 실태 및 진단·평가 관련 특수교사의 지원 요구를 알아보는 것이다. 연구 방법은 특수교육지원센터에서중도중복장애 특수교육대상자로 의뢰된 학생에 대해 진단·평가 경험이 있는 특수교사 5명을 대상으로 개별 면담한 후 지속적 비교법으로 면담 전사 자료를 분석하였다. 연구 결과 중도중복장애 진단· 평가 관련 특수교사의 인식과 경험, 특수교육지원센터의 진단·평가 과정 및 실태, 중도중복장애 진단· 평가 과정에서 겪은 어려움, 그에 따른 지원 요구 등을 4개의 범주와 9개의 하위 범주, 19개의 의미단위로 도출하였다. 결론적으로 중도중복장애 선정기준에 대한 법적 기준의 모호함과 이에 대한 교사의 인식 부족 및 지침의 미비함으로 진단·평가 과정에서 다양한 어려움을 가지고 있으며, 중도중복장애 선정에 관한 현실적인 행정적 재정적 지원을 요구하고 있었다. The purpose of this research is to present what systematic supports special education teachers demand with reference to evaluation, diagnosis, and selection of students with severe and multiple disabilities as well as the actual administration at Special Education Support Centers. It has been due to the partial revision of Enforcement Decree of Act on special education for persons with disabilities, etc., and therefore the establishment of an additional clause to include severe and multiple disabilities as one of the criteria for Article 15 of the Act. Qualitative methodologies were used for this research, conducting individual interviews of five special education teachers who had experiences in administering assessments and evaluations of students with severe and multiple disabilities in order to determine their special educational needs. The transcribed data of the interviews were then analyzed with the constant comparative analysis. The research findings were categorized into 4 categories, 9 subcategories, and 19 semantic units, the 4 categories being 1) awareness and experiences of special education teachers in relation to severe and multiple disabilities, 2) the process and actual administration of evaluation and diagnosis of the disabilities at Special Education Support Centers, 3) challenges in evaluation and diagnosis of students with severe and multiple disabilities, and 4) systematic supports that special education teachers demand to overcome the challenges. In conclusion, in the process of evaluating and diagnosing students with severe and multiple disabilities, special education teachers deal with various challenges such as ambiguity of legal requirements for diagnosis and selection, lack of awareness in teachers about the legal selection criteria for the students, and the absence of clear guidelines. Therefore, they strongly demand administrative and financial supports that are more practical.

A Case of Canine Ectopic Parasitism of Heartworm in the Systemic Circulation

장효미,이희천,정동인 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.4

A 3-year-old intact female Dachshund was referred due to paraplegia and cool extremities. History taking, physical examination, neurological examination, and blood profiling studies were evaluated to determine the diagnosis. Based on abdominal ultrasound and echocardiograph, features suggestive of adult heartworm were detected in aberrant places. The result of enzyme-linked immunosorbent assay (ELISA) testing with a commercial heartworm antigen kit was positive. The dog fell into a comatose state, and the client requested the dog be euthanized. On post-mortem examination, the patient was diagnosed with ectopic parasitism of heartworm in the left side of heart, aorta, aorta abdominalis, and iliac arteries, a circumstance that induced systemic thromboembolism. This case report describes the clinical, diagnostic imaging, and necropsy findings of canine ectopic parasitism of heartworm.

은행 및 비은행 금융기관 차입금이 기업의 성과에 미치는 영향

장효미(Hyo Mi Jang),전봉걸(Bong Geul Chun) 한국경제통상학회 2015 경제연구 Vol.33 No.2

본 논문은 중소기업을 대상으로 은행 및 비은행금융기관의 차입과 기업의 경영성과 간 관계를 실증분석하였다. 첫째, 당기의 차입으로 분석했을 경우 비은행금융기관 차입에 비해 은행 차입이 기업의 경영 성과에 더 부정적인 영향을 미쳤다. 이는 차입의 과정에 대한 제도적 문제를 고려해 볼 수 있으며, 장기차입금에 대한 이자비용이 리스크로 작용했을 것이라 추론한다. 둘째, 1기전 차입으로 분석했을 경우 비은행은행금융기관의 차입보다 은행 차입이 기업의 경영성과에 더 긍정적인 영향을 미쳤다. 은행 차입의 경우 안정성면에서 기업에게 더 긍정적인 영향을 미치기 때문이라 추론한다. 셋째, 산업별 분석은 전기, 가스, 증기 및 수도사업을 나타내는 산업D와 전문 과학 및 기술 서비스업인 산업M에 대하여 실시하였으며, 앞서 분석하였던 실증분석과 같은 결과를 나타냈다. This Study analyzed relationship between business performance and corporate borrowing targeting small and medium-sized enterprises among the listed companies in Korea. By analyzing corporate borrowing separated to bank loans and non-bank loans, tried to the discussion about "Of the bank loans and non-bank loans, which one have a significant effect on the business performance". Firstly, there was a negative statistical correlation between business performance and corporate borrowing when analyzed by borrowing in the current period. also, Bank loans has had a negative impact on business performance than the non-bank loans. In this case, I infer that the interest cost about long-term bonds and institutional issues such as borrowing process and period is applied to the risk. Secondly, there was a positive statistical correlation between business performance and corporate borrowing when analyzed by borrowing in the previous period. also, Bank loans has had a positive impact on business performance than the non-bank loans. In this case, I infer that companies receive the profits from investment activities and revenue activities through borrowing. It is intended as another example, the safety of bank loans is affected more positive. Finally, In the industry D and industry M, Issued the same conclusions as a result it has been previously analyzed.

Tier2 방법에 따른 온실가스 인벤토리 불확실성 평가: 철강산업을 중심으로

장효미 ( Hyo Mi Jang ),전봉걸 ( Bong Geul Chun ) 경희대학교 사회과학연구원 2015 社會科學硏究 Vol.41 No.3

정밀한 온실가스 배출량을 산출하는 데 있어 국내의 상황은 객관적인 자료가 확보되지 못하는 부분이 존재하며, 측정기의 물리적 한계, 통계관리의 인적 오류 등으로 불확실성 분석이 정확하게 이뤄지지 않고 있다. 따라서 본 논문에서는 철강산업부문의 에너지원 사용에 따른 온실가스 배출량의 불확실성을 전문가 판단 조사 지침을 활용하여 Tier2 수준에서 평가하고자 한다. 전문가 판단 조사방법을 활용하여 에너지원 소비량과 배출계수 및 순발열량의 확률밀도함수를 도출하였으며 조사한 정보를 기반으로 몬테카를로 시뮬레이션을 수행하였다. 분석 결과, 철강산업부문에서 무연탄, 유연탄 및 도시가스의 소비로 인한 이산화탄소 배출량의 불확실성은 95% 유의 수준에서 유연탄 소비량에 삼각분포를 가정하였을 때 20% 수준으로 크게 나타났으며, 균등분포를 가정하였을 때는 8% 수준인 것으로 분석되었다. In domestic situation, there is a lack of objective data that is not ensured in the process of calculating accurate emissions of GHGs. Uncertainty analysis is not performed correctly due to human error of statistics management and physical limitations of the measuring instrument. Therefore, in this study, we evaluate the uncertainty of the GHG emissions in the steel industry by using expert judgement in Tier2 method. We derived the probability density function of the energy consumption, emission factor and net calorific value, and then, performed Monte carlo simulations on the basis of the survey information. The results of the analysis, in 95% confidence interval, uncertainty is around 20% when it is assumed a triangular distribution in flaming coal consumption. Another uncertainty is around 8% when it is assumed a uniform distribution.

Grain Foreign Body Embedded in the Spleen and Immune-Mediated Hemolytic Anemia in a Maltese Dog

송중현,장효미,이희천,서정향,강병택,정동인 한국임상수의학회 2017 한국임상수의학회지 Vol.34 No.1

An 8-month-old, intact male Maltese dog was referred to us because of anorexia, diarrhea, and jaundice. Hematologic examination revealed immune-mediated hemolytic anemia, and abdominal ultrasonography revealedheterogeneous changes in mesenteric fat and coarse echotexture in the splenic parenchyma. Septic peritonitis wasdiagnosed on the basis of a bacterial culture test of the peritoneal fluid. Exploratory laparotomy and subsequent omentalbiopsy and splenectomy were performed. On histopathological examination, the omental mass and splenic lesions werediagnosed as grain foreign body granulomas. This report describes a rare case in which a grain foreign body wasembedded in the spleen of a dog.

Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry

전준혁,정해원,장효미,문종현,박기태,이희천,임하영,서정향,강병택,하정임,정동인 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1

The purpose of this study was to identify time-related changes in clinical, MRI, histopathologic, and immunohistochemical findings associatedwith ischemic stroke in dogs. Additionally, the association of cerebrospinal fluid (CSF) and tissue levels of interleukin (IL)-6 with clinicalprognosis was assessed. Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO) in nine healthy experimentaldogs. The dogs were divided into three groups according to survival time and duration of the experimental period: group A (survived only1 day), group B (1-week experimental period), and group C (2-week experimental period). Neurologic status was evaluated daily. Magneticresonance imaging (MRI) was performed according to a predetermined schedule. Concentration of IL-6 in CSF was measured serially afterischemic stroke. Postmortem examination was performed for all experimental dogs. During histopathological examination, variable degreesof cavitation and necrosis due to neuronal cytopathic effects, such as pyknotic nuclei and cytoplasmic shrinkage, were observed on the affectedside of the cerebral cortex in all dogs. Immunohistochemistry specific for IL-6 showed increased expression in the ischemic lesions. CSF IL-6concentrations and ischemic lesion volumes 1 day after ischemic stroke were significantly higher in group A compared to groups B and C.