Insulin Resistance is Associated with Gallstones Even in Non-obese, Non-diabetic Korean Men

장유수,성은주,유승호,박용우,장유미,박민선 대한의학회 2008 Journal of Korean medical science Vol.23 No.4

It remains unclear as to whether insulin resistance alone or in the presence of wellknown risk factors, such as diabetes or obesity, is associated with gallstones in men. The aim of this study was to determine whether insulin resistance is associated independently with gallstone disease in non-diabetic men, regardless of obesity. Study subjects were 19,503 Korean men, aged 30-69 yr, with fasting blood glucose level <126 mg/dL and without a documented history of diabetes. Gallbladder status was assessed via abdominal ultrasonography after overnight fast. Body mass index and waist circumference were measured. Insulin resistance was estimated by the Homeostasis Model Assessment of insulin resistance (HOMA-IR). The prevalence of obesity, abdominal obesity, and metabolic syndrome in the subjects with gallstones were higher than in those without. The prevalence of elevated HOMA (>75 percentile) in subjects with gallstones was significantly higher than in those without, and this association remained even after the obesity stratification was applied. In multiple logistic regression analyses, only age and HOMA proved to be independent predictors of gallstones. Insulin resistance was positively associated with gallstones in non-diabetic Korean men, and this occurred regardless of obesity. Gallstones appear to be a marker for insulin resistance, even in non-diabetic, nonobese men.

추출용매에 따른 어성초 추출물의 항산화 및 항노화 활성

장유수,서수정,김남우,이양숙 대한미용학회 2019 대한미용학회지 Vol.15 No.2

This study aimed to investigate antioxidant, anti-aging and cytotoxicities of Houttuyniae herba extracts in different solvents, viz. WE; water extract, EE; 70% ethanol extract, BGE; 1,3-butylene glycol. The contents of total polyphenol and flavonoid compounds of EE were 3,083.33 μg/mL and 728.79 μg/mL, respectively. The ABTS radical scavenging activity at 0.5% concentration in EE was 67.62%. The DPPH radical scavenging effect and SOD-like activity showed the highest effect of 74.65% and 43.83%, respectively in BGE at 3.0% concentration. Furthermore, the xanthine oxidase inhibition activity of BGE at 3.0% concentration in EE was 38.26%. Tyrosinase inhibition activity for whitening effect showed the highest value of 20.93% in WE. In the analysis of anti-wrinkle effect, the highest collagenase and elastase inhibition activities, viz. 53.70% and 47.51%, respectively were observed in EE. In the cytotoxicity test of the extracts on RAW264.7 macrophages and HaCaT keratinocytes using the MTT assay, RAW264.7 macrophages viability in WE decreased by about 30%, and decreased by about 22% in both EE and BGE. The HaCaT cell viability of WE decreased at the concentration of over 50 μg/mL. However, as the concentration of EE and BGE increased, the viability of RAW264.7 macrophage also increased. These results indicated that the ethanol extracts (EE) of Houttuyniae herba have useful ingredients, an excellent antioxidant and anti-aging activity. In addition to the water and ethanol, 1,3-butylene glycol can be used as a solvent for functional cosmetics materials extraction.

포도 'Campbell early'의 비가림 시설의 효과

장유수 경북대학교 농업개발대학원 1997 最高農業經營者課程 論文集 Vol.- No.3

Colonoscopic Screening and Risk of All-Cause and Colorectal Cancer Mortality in Young and Older Individuals

이정아,장유수,김예진,박동일,박수경,박혜인,고재우,이수진,류승호 대한암학회 2023 Cancer Research and Treatment Vol.55 No.2

Purpose The incidence of early-onset colorectal cancer (CRC) and associated mortality have been increasing. However, the potential benefits of CRC screening are largely unknown in young individuals. We aimed to evaluate the effect of CRC screening with colonoscopy on all-cause and CRC mortality among young (aged < 45 years) and older (aged ≥ 45 years) individuals. Materials and Methods This cohort study included 528,046 Korean adults free of cancer at baseline who underwent a comprehensive health examination. The colonoscopic screening group was defined as those who reported undergoing colonoscopy for CRC screening. Mortality follow-up until December 31, 2019 was ascertained based on nationwide death certificate data from the Korea National Statistical Office. Results Colonoscopic screening was associated with a lower risk of all-cause mortality in both young and older individuals. Multivariable-adjusted time-dependent hazard ratios (95% confidence intervals) for all-cause mortality comparing ever- to never-screening were 0.86 (0.75-0.99) for young individuals and 0.71 (0.65-0.78) for older individuals. Colonoscopic screenings were also associated with a reduced risk of CRC mortality without significant interaction by age, although this association was significant only among participants aged ≥ 45 years, with corresponding time-dependent hazard ratios of 0.47 (0.15-1.44) for young individuals and 0.52 (0.31-0.87) for those aged ≥ 45 years. Conclusion Colonoscopic CRC screening decreased all-cause mortality among both young and older individuals, while significantly decreased CRC mortality was observed only in those aged ≥ 45 years. Screening initiation at an earlier age warrants more rigorous confirmatory studies.

일개 대학병원 수진자를 대상으로 한 혈중 호산구증과 관련이 있는 기생충 감염

류진환,장유수,조비룡,허봉렬,조현정 대한가정의학회 2006 Korean Journal of Family Medicine Vol.27 No.7

A Parasitic Infection with Eosinophilia in a University Medical CenterJin Hwan Ryu, M.D., Hyun Jeong Jho, M.D., Yoo Soo Chang, M.D.*, Be Long Cho, M.D.†, Bong Yul Huh, M.D., Ph.D. 연구배경: 호산구증의 원인으로는 알레르기성 질환, 기생충 감염, 약물 복용, 피부 질환 등으로 다양하다. 하지만 우리 나라에서는 호산구증의 원인에 대한 논문은 많지 않은 상태이다. 본 연구는 호산구증과 관련된 요인 및 호산구증과 관련이 있는 기생충 감염에 대해 조사하였다. 방법: 1995년 5월 1일부터 2004년 2월 14일까지 일개 대학병원 건강검진센터를 방문한 환자를 대상으로 자가 기입식 설문지, 혈액 검사, 대변 검사 결과를 이용하여 호산구증과 기생충 감염의 연관성을 조사하였다. 결과: 호산구증이 있었던 대상자 1,471명 중 5.0%가 대변 검사에서 윤충 감염이 있었고, 호산구증이 없는 사람에 비해 특히 간흡충 감염이 유의하게 많았다(호산구증군 3.9%, 비호산구증군 1.2%; P<0.05). 호산구증과 관련된 인자로는 고령, 높은 BMI, 남성, 음주군, 흡연군, 검사 당시 계절, 윤충 감염군, 간흡충 감염군이었으며, 알레르기 과거력은 관련이 없었다. 윤충 감염은 비감염군에 비해 호산구증의 교차비가 2.280 (confidence interval, CI: 1.694~3.068)이며 간흡충 감염은 비감염군에 비해 호산구증의 교차비가 2.391 (CI: 1.716~3.331)이었다. 결론: 우리나라에서 일개 대학병원 건강검진자료상 호산구증이 있는 사람 중 5.0%가 대변 검사에서 윤충 감염이 있었고, 호산구증이 없는 사람에 비해 특히 간흡충 감염이 유의하게 많았다. 호산구증과 관련이 되는 인자로는 고령, 높은 BMI, 남성, 음주군, 흡연군, 검사 당시 계절, 윤충 감염군, 간흡충 감염군이었으며, 알레르기의 과거력 여부는 관련이 없는 것으로 나왔다.

메조테라피(Mesotherapy)의 복부 국소지방감량 효과 : 무작위 대조군 임상시험

박용우,장유수 대한임상건강증진학회 2007 Korean Journal of Health Promotion Vol.7 No.1

건강기능식품 섭취 실태와 관련인자

이경미,장유수,유태우,박동훈,안은미,강승완,유상호 대한임상건강증진학회 2006 Korean Journal of Health Promotion Vol.6 No.2

Background This study was performed to describe the relationship between lifestyle and the use of functional food and to evaluate associated factors affecting functional food use.Methods The subject of this study included 12,057 adults(males 6,446, females 5,611) aged 20years or older who visited the Health Promotion Center of SNUH. This study was conducted by direct questionnaire about socio-demographic characteristics, use of functional food, lifestyle pattern and perceived health status from the January 2000 to the January 2004.Results forty-nine percent of the respondents had previously taken functional food and others had not. Those with lower educational level showed more use rate of functional food. Analysis of lifestyle patterns and the use of functional food showed that those with higher use rate of functional food reported more exercise, more periodic screenings. But there were no associations of functional food use withsmoking and alcohol drinking. Those who have used functional food more often had history of admission and operation andpoorer perceived health status. There were no associations of functional food use with age, sex, monthly income, occupation or marital status.Conclusions More use of functional food has associations with a concern about health and poorer perceived health status. 연구배경건강에 대한 관심이 높아짐에 따라 건강기능식품에 대한 수요가 증가하고 있다.건강기능식품 이용은 다른 의료이용이나 생활습관등과 관련이 될 것으로 생각되나 이에 대한 연구는 미비한 실정이다. 따라서 본 연구에서는 건강기능식품 섭취군의 생활습관 양태와 건강기능식품 섭취에 관련된 요인들을 알아보고자 한다.방 법2000년 1월부터 2004년 1월까지 일개 대학병원 건강증진센터를 방문한 수진자 중에서 20세 이상의 성인 12,057명(남성 6,446명, 여성 5,611명)을 연구 대상으로 하였다. 자기 기입식 설문지를 이용하여 조사 대상자의 일반적 특성, 건강기능식품 섭취 여부, 생활 습관, 건강에 대한 주관적 평가 등을 조사하였다.결 과설문 응답자 중 최근 1년간 건강기능식품 섭취율은 49.0%였고 학력이 낮을수록 건강기능식품 섭취율이 높은 경향을 보였다. 건강기능식품 섭취군에서 규칙적으로 운동하는 비율과건강검진 수진율이 높았으나 흡연이나 음주 등은 관련이 없었다. 또한 건강기능식품 섭취군에서 입원력이나 수술력이 있는 비율이 높았고 주관적 건강평가에서 자신의 건강상태가 나쁘다고 평가하는 비율이 높았다. 연령, 성별 가계 월수입, 직업, 혼인상태는 건강기능식품 섭취율과 관련이 없었다.결 론건강에 대한 관심과 주관적인 건강 평가가 건강기능식품 섭취율과 관련성이 높으며건강기능식품의 사용이 건강행태 및 건강상태에 어떤 영향을 미치는지에 대한 전향적 연구가 필요하겠다.

Limaprost and the Risk of Bleeding: A Self-Controlled Case Series Study

이은주,정한얼,장유수,신주영 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To investigate the association between the use of limaprost and the risk of bleeding. Methods: A self-controlled case series analysis was conducted using the National Health Insurance Service-National Sample Cohort database in South Korea. We identified patients aged 18 years or older who had at least one prescription of limaprost and were diagnosed with at least one case of bleeding between 2003 and 2019. The incidence rate ratio (IRR) of bleeding was calculated by dividing the incidence rate in the exposed period to limaprost by that in the unexposed period and adjusted for age using conditional Poisson regression model. Results: Among 72,860 patients with limaprost prescriptions and bleeding diagnoses, there were 184,732 events of bleeding. After adjusting for age, the IRR was 1.47 (95% confidence interval [CI], 1.43–1.50), wherein the IRR was the highest during the 0–7 days after limaprost initiation (IRR, 2.11; 95% CI, 2.03–2.18). Risk of bleeding was higher when limaprost was concomitantly used with antithrombotics or other drugs for spinal stenosis treatment, and when higher daily doses of limaprost were administered. Conclusion: Our findings suggest that the risk of bleeding increased by 1.5-fold in periods of limaprost exposure compared to unexposed periods, with particularly higher risks observed during the first week after limaprost initiation, with concomitant drugs related to bleeding, and with a higher daily dose. A careful risk-benefit assessment is warranted when initiating limaprost, especially when administered with other medications or in higher daily doses.

Alcoholic and Nonalcoholic Fatty Liver Disease and Liver-Related Mortality : A Cohort Study

김건화,조용균,장유수 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1

Metabolic Obesity Phenotypes and risk of cellulitis: a cohort study

김보미,정혜숙,장유수,주은정,조아라,유승호 대한내과학회 2018 대한내과학회 추계학술대회 Vol.2018 No.1