한국인의 흡연과 사망 위험에 관한 코호트 연구

이은하,박수경,고광필,조인성,장성훈,신해림,강대희,유근영,Lee, Eun-Ha,Park, Sue-K.,Ko, Kwang-Pil,Cho, In-Seong,Chang, Soung-Hoon,Shin, Hai-Rim,Kang, Dae-Hee,Yoo, Keun-Young 대한예방의학회 2010 예방의학회지 Vol.43 No.2

Objectives: The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults. Methods: A total of 14 161 subjects of the Korean Multi-center Cancer Cohort who were over 40 years of age and who were cancer-free at baseline enrollment reported their lifestyle factors, including the smoking status. The median follow-up time was 6.6 years. During the follow-up period from 1993 to 2005, we identified 1159 cases of mortality, including 260 cancer mortality cases with a total of 91 987 person-years, by the national death certificate. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cigarette smoking for total mortality, cancer mortality and disease-specific mortality, as adjusted for age, gender, the geographic area and year of enrollment, the alcohol consumption status, the education level and the body mass index (BMI). Results: Cigarette smoking was significantly associated with an increased risk of total mortality, all-cancer mortality and lung cancer mortality (p-trend, < 0.01, <0.01, <0.01, respectively). Compared to non-smoking, current smokers were at a higher risk for mortality [HR (95% CI)=1.3 (1.1 - 1.5) for total mortality; HR (95% CI)=1.6 (1.1 -2.2) for all-cancer mortality; HR (95% CI)=3.9 (1.9-7.7) for lung cancer mortality]. Conclusions: This study's results suggest that cigarette smoking might be associated with total mortality, all-cancer mortality and especially lung cancer mortality among Korean adults.

항공기 탑재 능동 위상배열 레이더의 자원관리 알고리즘 설계 및 구현

노지은(Ji-Eun Roh),전상미(Sang-Mi Chon),안창수(Chang-Soo Ahn),장성훈(Seong-Hoon Jang) 한국전자파학회 2013 한국전자파학회논문지 Vol.24 No.12

능동 위상배열 레이더(AESA radar: Active Electronically Scanned Array radar)는 전자적으로 빔을 조향함으로써 빔 조향 시간이 비약적으로 빨라져 기존의 기계식 빔 조향 레이더에 비해 다중 임무 처리 능력이 크게 향상되었다. 이러한 이유로 레이더에 주어진 시간, 에너지, 처리능력 등의 한정된 자원을 실시간으로 효율적으로 관리, 운용할 수 있는 레이더 자원관리 기술의 중요성이 크게 대두되었다. 본 논문은 항공기 탑재 능동 위상배열 레이더 연구 시제 개발에 적용된 자원관리 주요 알고리즘의 설계 내용과, 이를 반영하여 구축한 시뮬레이터에 대해 기술하였다. 또한, 설계된 자원관리 알고리즘을 항공기 탑재 능동 위상배열 레이더 시스템에 실제 구현하여 동시 표적 추적 및 탐지 능력에 대한 요구 성능이 충족됨을 확인하였다. AESA(Active Electronically Scanned Array radar) radar is able to instantaneously and adaptively position and control the beam, and such adaptive beam pointing of AESA radar enables to remarkably improve the multi-mission capability. For this reason, radar resource management(RRM) becomes new challenging issue. RRM is a technique efficiently allocating finite resources, such as energy and time to each task in an optimal and intelligent way. This paper deals with a design of radar resource management algorithms and simulator implemented main algorithms for development of airborne AESA radar. In addition, evaluation results show that developed radar system satisfies a main requirement about simultaneous multiple target tracking and detection by adopting proposed algorithms.

진성다혈구증이 병발된 IgA 신증

김지혜 ( Ji Hye Kim ),최바울 ( Paul Choi ),정연순 ( Yeon Soon Jung ),장성훈 ( Seong Hoon Chang ),어완규 ( Wan Kyu Eo ),천봉권 ( Bong Kwon Chun ),임학 ( Hark Rim ) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.6

Secondary polycythemia occasionally associated with renal diseases such as renal tumors, cysts, hydronephrosis, renal transplantation, renal artery stenosis and Banter`s syndrome and is rarely associated wish nephrotic syndrome, nephrosclerosis, pyelonephritis, chronic gromerulonephritis and membranous nephropathy. The association of polycythemia vera and immunoglobulin A nephropathy (IgAN) is well not known, and there are only a few isolated reports presnting the concomitance of polycythemia vera and IgAN. We report one patient with concomitant polycythemia vera and Ig A nephropathy. A 53 year-old male visited our hospital because of elevated hemoglobin level. Blood value of hemoglobin was 22.1 g/dL. Isotopic blood studies with radioactive chromium (^51CO-labelled red blood cells revealed a total blood volume of 90 mL/㎏ and total red cell volume of 61.8 mL/㎏. The concentration of serum erythropoietin measured by radioimmunoassay was 14.29 mIU/mL (normal 10.2-25.2 mIU/mL). Bone marrow aspirate revealed hypercellularity and panmyelosis, characteristically, Renal biopsy specimens showed moderate mesangioproliferative lesions with mesangial IgA and C_3 deposition. Treatment with phlebotomy, hydroxyurea and oral prednisolone (1 ㎎/㎏/day) was done. There was no decrease of urinary protein following treatment of phlebotomy and hydroxyurea. But urinary protein decreased and hemoglobin level normalized following combination treatment of phlebotomy, hydroxyurea and oral prednisolone.

다발성 폐경색, 상대정맥 증후군 및 종격동 임파선 종대를 동반한 베체트 증후군 1예

장성훈,손호성,정연순,김진구,오세진,박무인,박선자,구자영 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Behcet's syndrome is a multisystemic disease involving mucocutaneous, cardiovascular, central nervous system, renal, articular, gastrointestinal, skin, pulmonary and lymphatic system. Intrathoracic manifestations of Behcet' s syndrome are thromboembolism of vena cava, arterial aneurysm, vasculitis, pulmonary infarct, pulmonary hemorrhage, pleural effusion, and rarely mediastinal or hilar lymphadenopathy. We report a case of Behcet's syndrome manifested as pulmonary infarct, superior vena cava syndrome, and mediastinal lymphadenopathy.

Von Recklinghausen;s Disease 환자에서 소장에 발생한 GIST 1예

김성만,장성훈,정연순,손호성,정한호,박무인,박선자,구자영,백승언 고신대학교 의학부 2000 고신대학교 의학부 학술지 Vol.15 No.1

궤양성 대장염의 임상적 관찰

손호성,장성훈,정연순,정한호,송수근,박무인,박선자,구자영 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Background Ulcerative colitis is a chronic inflammatory disease of colon, which is common in western countries but relatively rare in Korea. As the colonoscopic examination becomes popular, early detection rate is increasing in oriental countries, but its precise clinical aspects are still obscure in Korea due to its rarity. The purpose of this study is to review the clinical features and trends of newly diagnosed cases in Korea. Methods We studied 54 patients of ulcerative colitis, who were diagnosed by clinical findings, laboratory examinations, barium enema, sigmoidoscopic and colonoscopic examinations at Kosin Medical Center from January 1987 to December 1997. Results The most prevalent age was 4th decade, male to female ratio was 1 : 1.57 and the duration of symptoms was less than 1 year in 63% of the cases, and the recent increase in the incidence of total cases and cases of proctitis was evident. The most common clinical manifestation was bloody diarrhea, while anemia (37.3%) was the most common labo atory abnormality, and the most common complication was abnormal liver function (11.1%). Among the diseases misdiagnosed as ulcerative colitis, imtable bowel syndrome and internal hemorrhoid were common. The most common sigmoidoscopic finding was mucosal friability and the most common histopathologic change was non-specific inflammation (92.3%), while crypt abscess was present in 27.8% of cases. In 29 cases (53.7%), disease severity was of mild degree, while severe course was observed in 2 cases. We found positive correlation between the severity of disease and the extent of colitis (p<0.05), and marginal relationship between the seventy of disease and endoscopic grading (p=0.062), but there was no correlation between the severity of disease and the duration of disease(p=0.146). Of all cases, 35 cases (70%) showed longterm improvement to medical therapy, but 11 (22%) had recurrence. Operations were performed in 9 cases and its indications were confirming diagnosis in 3 cases, intractibility in 4 cases, severe dysplasia by histology in 1 case and accompanying adenomatous polyposis in 1 case. Conclusions For the accurate and early diagnosis of ulcerative colitis, routine use of sigmoidoscopy in suspected cases is mandatory, especially to exclude hemorrhoid, cancer or irritable bowel syndrome. As the incidence of ulcerative colitis is apparently increasing in this study, more extensive, systematic, nationwide study for ulcerative colitis may be needed for the better description and management of this disease in korea.

Von Recklinghausen's Disease환자에서 소장에 발생한 GIST 1예

김성만,장성훈,정연순,손호성,정한호,박무인,박선자,구자영,백승언 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1

Neurofibromatosis (von Recklinghausen's disease) is a neuroectodermal disorder characterized by autosomal dominant inheritance, cafe-au-lait spots, neurogenic tumors of the skin and internal organs and systemic abnormalities. Despite typical cutaneous findings, the involvement of gastrointestinal tract is not common. We experienced a case of GIST in Von Recklinghausen's disease. The patient was a 40 years old female who had suffered from chronic iron deficiency anemia and intermittent melena due to GIST of ileum, which was diagnosed by enteroclysis, and treated by segmental resection of ileum with end to anastomosis.

비 전형적 형태를 지닌 일차성 형질세포 백혈병 1례

최병주,서수홍,장성훈,김양수,어완규,김효경 고신대학교 의학부 2002 高神大學校 醫學部 論文集 Vol.17 No.1

Plasma cell leukemia is a rarely occurring plasma cell disease which is classified to primary plasma cell leukemia and secondary plasma cell leukemia. The clinical manifestations and pathological features are similar to acute leukemia and the prognosis is poor with median survival rate of 4-6 months after diagnosis. When diagnosing plasma cell leukemia, it is often difficult to differentiate plasma cell leukemia from chronic lymphoid leukemia due to the similar cellular morphology of lymphocytes and plasma cells. We report a case of plasma cell leukemia with unusual morphological feature diagnosed by a cell surface marker study. A 81 year old man was presented with renal failure, anemia, thrombocytopenia and atypical lymphoid leukocytosis. Bone marrow examination and peripheral blood smear revealed a large number of pleomorphic cells with some grooving nuclei. Immunophenotype feature of these cells were suggestive of plasma cell origin with positivity for CD38. Furthermore an urine & serum protein electrophoresis showed monoclonal gammopathy of lambda light chain type. The disease initially responded to melphalan and prednisolone, but eventually relapsed.

Ethyoene Oxide 폭로 근로자의 말초 임파구 자매염색분체 교환에 관한 연구

황천현,박종태,장성훈,김대성,이원진,김청식,김영환 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Operators of hospital sterilizers who use ethylene oxide(EtO) were studied to determine the exposure of EtO level and the frequency of sister chromatid exchanges(SCEs) from June 12 to July 20, 1997. To evaluate SCEs in the peripheral blood cells, we selected 22 workers at the central supply room of 4 university hospitals and 22 unexposed workers at the same hospitals according to match sex, age, and smoking habit and also did questionnaires. The mean air concentrations(8-hr TWA) of EtO at 4 university hospitals were less than 1 ppm. The SCE frequencies in exposed workers to EtO and controls were normally distributed. The SCE frequencies in exposed workers to EtO and controls were 6.42±0.63, 5.86±0.69, respectively and their differences were statistically significant(p=0.0093). But there were no statistically significant differences in smoking, alcohol intake, coffee drinking. Especially smokers who exposed to EtO were increased SCE statistically significant than the exposed group who did not smoke.

원발성 담즙성 간경변증에 병발한 다발성 골수종 1예

한병훈,김진구,오세진,이상욱,윤병철,장희경,장성훈 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6

Primary biliary cirrhosis with multiple myeloma is very rare, and there have been only 7 case reports in the literature to date. Simultaneous occurrence of primary biliary cirrhosis and multiple myeloma seemed to be related to the hypothesis that chronic antigenemia can result in an expansion of a monoclonal population of B-lymphocytes. The chronic antigenemia is a persistent antigenic stimulation of the reticuloendothelial system, which has been explained through the incapacity of the liver to clear the antigen from the gut. Such clone may be subsequently transformed into a malignant clone by a mutagenic stimulus. We experienced a 52-year-old male patient who had been complaining of generalized pruritus for 9 months. This patient was confirmed to be in early stage of primary biliary cirrhosis complicated by IgG-λtype multiple myeloma. We compared this case with others reported in literatures.