Epinephrine 이 수축기시간간격에 미치는 영향

박희명 ( Hi Myung Park ),장성국 ( Sung Gug Chang ),최용환 ( Yong Hwan Choi ),최창필 ( Chang Pill Choi ) 대한내과학회 1981 대한내과학회지 Vol.24 No.3

고혈압의 심박출량

박희명 ( Hi Myung Park ),장성국 ( Sung Gug Chang ) 대한내과학회 1984 대한내과학회지 Vol.27 No.6

전신성 홍반성 루푸스 환자에서 Total Anti-oxidant Capacity와 질병활성도의 상관성

정원태 ( Won Tae Chung ),이성원 ( Sung Won Lee ),김경희 ( Kyung Hi Kim ),김정만 ( Jung Man Kim ),김채기 ( Chae Gi Kim ),윤원찬 ( Wern Chan Yoon ),류재근 ( Jae Kean Ryu ),장성국 ( Sung Gug Chang ),송용호 ( Yong Ho Song ),최정윤 ( J 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3

Objective: To determine the correlation between total anti-oxidant capacity (TAOC) and lipid peroxidase (LPO) levels in serum and disease activity in systemic lupus erythematosus (SLE). Methods: The study population consisted of 99 patients with SLE according to the 1982 revised ACR criteria and 83 healthy controls. The serum TAOC levels in 99 patients with SLE and 83 healthy controls by the ABTS(R) inhibition method (Randox Ltd, Antrim, UK) and serum malondialdehyde (MDA) levels in 37 out of 99 patients with SLE were measured. Anti-dsDNA antibody (anti-dsDNA), albumin, AST, ALT, cholesterol, uric acid and creatinine were measured to determine the association with the serum TAOC levels. The correlation between the serum TAOC levels and nephritis in 27 cases with nephritis out of 99 SLE patients was also investigated. The SLE disease activity was determined by the SLE disease activity index (SLEDAI) at the time of sample collection. Results: Compared to the controls (1.37±0.127mmol/L), serum TAOC levels were significantly decreased (1.29±0.124mmol/L) in SLE patients (p=0.001). And there was a negative correlation between serum TAOC levels and SLEDAI total scores in the SLE patients (r=-0.388, p=0.0001), but no significant correlation between TAOC levels and C3 and anti-dsDNA. Further, a significant difference (p<0.04) in TAOC levels was found in SLE patients with and without nephritis. In comparison with other parameters such as AST, ALT, and cholesterol which might change anti-oxidant level, there was no correlation between the serum TAOC levels and them, except for serum uric acid (r=0.387, p=0.0001), creatinine, and albumin (r=0.507, p=0.0001). Additionally, we couldn`t find significant correlation between the serum TAOC levels and MDA. Conclusions: The serum TAOC levels correlate significantly with SLE disease activity and are associated with nephritis. Also, this study showed a significant correlation with serum albumin levels in these patients. Conclusively, the measurement of the serum TAOC levels in patients with SLE will provide useful information on SLE disease activity.

흡연이 수축기 시간간격에 미치는 영향

박희명 ( Hi Myung Park ),박의현 ( Wee Hyun Park ),김능수 ( Nung Soo Kim ),곽규식 ( Kyu Sik Kwak ),장성국 ( Sung Gug Chang ) 대한내과학회 1979 대한내과학회지 Vol.22 No.5

성인심장병 ( 5 , 000 예 ) 의 역학적 고찰 - 성별빈도로 수정한 추정환자에 대한 통계를 포함하여

박희명 ( Hi Myung Park ),이장백 ( Jang Baik Lee ),이시래 ( Si Rhae Lee ),박의현 ( Wee Hyun Park ),김능수 ( Nung Soo Kim ),한경훈 ( Kyung Hoon Han ),장성국 ( Sung Gug Chang ),전재은 ( Jae Eun Jun ),구자영 ( Ja Young Koo ),김수영 ( 대한내과학회 1977 대한내과학회지 Vol.20 No.8

최대운동시의 산소섭취량 , 심박수 및 산소맥

김태석(Tae Sug Kim),김이근(Ih Geun Kim),김지희(Chi Hui Kim),김채기(Chae Gi Kim),최정윤(Jung Yoon Choe),장성국(Sung Gug Chang),이봉열(Bong Ryeol Lee),채성철(Sung Chul Choi),전재은(Jae Eun Jun),정태훈(Tae Hoon Jung),박의현(Wee Hyun Par 대한내과학회 1997 대한내과학회지 Vol.52 No.3

N/A Objectives: Despite the fact that determinations of cadiorespiratory fitness levels by exercise stress tests are becoming widely used in healthy individuals as well as in patients with cardiopulmonary diseases, the normal standards in this field have not been well established in Korea. The purpose of this study is to provide normal standards or reference values for the VO2 max, HR max and O2 pulse max for normal Korean adults by age and sex, along with the derivation of regression formulae of these parameters. Methods: In 1,000 healthy adults (20-66years) consisting of 603men and 397women, symptomlimited maximal exercise was carried out by Bruce protocol, allowing holding on to the hand rail of the treadmill during exercise for the safety purpose. All the subjects were non-athletes and were members of a health center and were more conscious about their health and physical fitness than the ordinary population. Results: The VO2 max and HR max were decreased with age as expected and, as a whole, the values of the VO2 max and HR max of females were approximately 84% and 90% of those of males, respectively. Estimated yearly reductions in the V max for males and females were 0.45 and 0.32mL/kg/min, respectively and those of the HR max were 0.72 and 0.76/min, respectively. The O2 pulse max of the female was approximately 70% of that of the male, and was slightly related to weight and exercise time. The regression equations of the parameters obtained using exercise time (ET, sec), age (A, year), weight (W, kg) and sex (S, O=male; 1= female) were: HR max=215.3-0.74A-5,04S, O2 pulse max= 5.371+0.216W+0.0107ET-1.505S and VO2 max=40.612+1.950ET-0.206A-0.147W-6.060S, Conclusion: The VO2 max in our study was higher than hitherto reported. This was primarily due to longer exercise time of the subjects on the treadmill, because they were allowed to hold on to the hand rail during exercise. And also, the fact that our subjects, being members of a health center, might have had higher physical fitness levels than general population could have contributed to the high VO2 max. Thus, we feel that our results could be the ideal target or- reference values to be achieved for those patients or individuals who have to do the tests with holding on to the rail of a treadmill for safety purpose.

膵炎 및 基他 急性腹症例에 있어서의 Amylase/Creatinine淸淨率

金秉九,張性國,郭圭植,鄭俊謨,鄭克守 慶北大學校 醫科大學 1977 慶北醫大誌 Vol.18 No.1

著者는 1975年 10月1日부터 1976年 9月30日까지 慶北大學校 醫科大學 附屬病院에 入院한 急性膵炎 23例, 急性膵炎을 同伴한 단도질환 9例, 慢性再發性膵炎2例, 急性膵炎을 同伴하지 않은 단도질환 25例 그리고 肝疾患 14例, 胃疾患 16例 및 正常成人 25例를 對象으로 amylase-Creatinine 淸淨率을 測定하여 다음과 같은 成績을 얻었다. 1) 正常成人의 Cam./Ccr. 比는 1.86±0.38%이었고 急性膵炎을 同伴하지 않은 단도질환, 肝疾患, 胃疾患例에서는 各各 1.89±0.41%, 1.92±0.63%, 1.76±0.52%로 거의 正常 範圍이었다. 2) 急性膵炎에서와 急性膵炎을 同伴한 단도질환 및 慢性再發性膵炎 例들의 Cam./Ccr. 比는 各各 4.75±1.38%, 4.36±1.31% 4.28±1.87%로 正常人例의 1.86±0.38%에 比해2.3-2.9倍의 有意한 數値를 보였다.(*P〈0.05) 急性膵炎例의 血淸 amylase値는 發病後 1∼4日까지는 正常人例(105.2±38.2 units)에서 보다 높은 426.3±177.6 units를 보이다가 그후 점차 減少하며 24時間尿中의 amylase 値는 發病 第 5∼10日까지는 正常人例(2,151.2±682.7 units)에서 보다 增加한 뒤(4,963.5±1,838.2 units) 다시 減少하나 第 10∼15病日까지도 다소 높은 數値(2,963.9±1,058.3 units)를 유지했고 Cam./Ccr. 比는 發病 初期부터 增加하여 (4.62±1.29%) 第 5∼10病日에 最高値(6.39±1.57%)에 達하였다가 그후 低下하지만 第 10∼15日 病에도 正常人例(1.86±0.38%)보다는 높은 數値 (3.96±0.97%)를 나타냈다. 血淸 amylase値가 300 Somogyi units以上으로 增加되어 있으면서 臨床像이나 理學的所見 및 其他 檢査室 所見으로 急性膵炎과 단도질환과의 鑑別이 因難한 例에 있어서의 Cam./Ccr. 比도 急性膵炎및 急性膵炎을 同伴한 患者例들에 있어 各各 5.31.±0.84%, 4.93±1.20%로 急性膵炎을 同伴하지 않은 단도질환의 1.92±0.51% 보다 2.6∼2.9倍의 意義한 數値를 보였다. (*P〈0.05) 이와 같은 成績은 急性膵炎의 診斷에 있어서 Cam./Ccr. 比測定이 보다 有意있고 診斷에 도움을 주는 方法임을 立證하는 所見이라고 할 수 있겠다. The serum amylase test is routinly used as a diagnostic method of acute pancreatits. However in many non-pancreatic conditions such as acute cholecysititis, ileus, mumps, intestinal perforation and kidney trouble, we can observe hyperamylasemia. Therefore, hyperamylasemia only have not specific diagnostic meaning for acute pancratitis. Also urine amylase test is available but its data is conflicting and in consequence urine amylase test is infrequently used in practice. Recently in 1969, Levitt et al introduced amylasc-creatinine clearance ratio which would enhance the diagnostic value of amylase determination in actue pancreatitis. Thereafter many interesting data were reported for supporting Levitt's results. The author examined on amylase-creatinine clearance ratio in total 89 cases of various diseases with acute abdominal pain including 23 cases of acute pancreatitis, 9 cases of biliary tract diseases accompanying acute pancreatitis, 2 cases of relapsing pancreatitis, 9 cases of biliary tract diseases without pancreatitis, 14 cases of liver diseases and 16 cases of various gastric diseases and results obtained were as follows. Amylase-creatinine clearance ratio(Cam/Ccr) of the liver, biliary tract and stomach diseases were 1.92±1.63%, 1.89±0.41% and 1.76±0.52% respectively (Cam/Ccr in healthy Korean adult as a control was 1.86±0.3%) Cam/Ccr in acute pancreatitis, acute pancreatitis accompanied by biliary tract diseases and relapsing pancreatitis were 4.75±1.38%, 4.36±1.31% and 4.28±1.87% respectively and they were significantly higher than healthy control (*P<0.05). Serum amylase in acute pancreatitis was seen to be elevated on 1-4 days of illness while urine amylase remained more or less higher level than the healthy control up to 10-15days. Cam/Ccr of acute pancreatitis showed significantly high level from the first day of illness, recording peak level on 5-10 illness days. And then it gradually came down but still showed higher level than the control even on 10-15 illness days when the serum amylase level had become within normal range. Cam/Ccr in those with acute pancreatitis, acute pancreatitis, accompanied by biliary tract diseases and in those with biliary tract disease without pancreatitis, who showed high serum amylase level of over 300 Somogyi units and differential diagnosis by physical examination or usual laboratory findings was difficult, were 5.13±0.8%, 4.93±1.20% and 1.92±0.51% res pectively and the former two (cases with acute pancreatitis, primary or secondary) were significantly higher than the last (cases without pancreatitis) (p<0.05).

Clostridium Perfringens 에 의한 위막성 대장염 1예

전창호,이창형,박재복,배정동,장성국,이상채,김호각,신재욱 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.2

A 62-year-old female was adrnitted to the Catholic University Hospital of Taegu-Hyosung with an intracerebral hemorrhage. She was operated on successfully, but developed bacterial pneumonia. She was then treated with sulperazone, tobramycin, and metronidazole for 1 month. After the antibiotic treatment, she suffered from a fever and bloody, mucoid diarrhea for 3 days, and was examined with a sigmoidoscope. The sigmoidoscopic examination revealed yellow patches of ulcerations and swelling covered with thick sero- sanguinous exudate in the distal transverse colon and sigmoid colon. A latex agglutination test for C. was performed on her stool, whereby difficile cytotoxin was negative, however, metronidazole resistant C. perfringens was isolated from anaerobic culture of the biopsied colon tissue. She recovered with 15 days using oral vancomycin treatment. The possibility of C. perfringens as a causative organism of pseuclomernbraneous colitis was discussed.

膵炎 및 其他 急性腹症例에 있어서의 Amylase/Creatinine淸淨率

金秉九,張性國,郭圭植,鄭俊謨,鄭克守 慶北大學校 醫科大學 1977 慶北醫大雜誌 Vol.18 No.1

虛血性心臟病에서 心機能을 反影하는 非觀血的인 指標의 比較檢討

徐承旭,長性國,李忠基,李亨雨,全材殷,朴義顯,朴熙明 慶北大學校 醫科大學 1984 慶北醫大誌 Vol.25 No.3

허혈성심장병 13예에서 동시에 기록한 M형 심초음파도, 심전도, 심음도, 경동맥파 및 심첨박동도에서 구한 심기능을 반영하는 여러 지표들의 성적을 건강인 22예에서의 그것과 비교관찰하고 또한 허혈성심장병에서 이들 지표의 예민도, 특이도 및 추정정확도를 검토하였다. 심초음파도에서 계측한 좌심실내경이나 좌심실의 두께는 환자군에서 대조군보다 유의하게 커져 있었으나 이들로부터 유도된 FS, EF 및 Vcf는 양군 사이에 차이가 없었다. 그러나 IVI, EPSS, PEP/LVET 및 A/E-O비는 환자군에서 유의한 증가를 보였다. 그리고 허혈성심장병에서 심기능의 이상을 시사하는 이들 지표 가운데 예민도, 특이도 및 추정정확도가 높았던 것은 IVI, EPSS 및 PEP/LVET의 증가였고 그 가운데서도 IVI과 EPSS의 하나 또는 양자가 이상치를 나타내는 경우가 가장 예민한 지표임을 알 수 있었다. Comparison of various cardiographic paramenters reflecting left ventricular (LV) function was made in 13 cases of ischemic heart disease and 22 normals. The parameters studied were derived from simultaneously recorded M-mode echocardiograms, electrocardiograms, phonocardiograms and apexcardiograms or carotid arterial pulse tracings; and their sensitivity, specificity and predictive accuracy for the presense of the disease and associated LV dysfunction were also analyzed. The mean values of LV internal dimensions and wall thickness, isovolumic index(IVI), E point-septal separation (EPSS) and ratios of preejection period to left ventricular ejection time (PEP/LVET)and A/E-O were significantly increased in patinents with ischemic heart disease compared with those in the control. However, there were no significant differences in fractional shortening, ejection fraction and mean velocity of circumferential fiber shortening between two groups. The increase in IVI, EPSS and PEP/LVET were found to be high in sensitivity, specificity and predictive accurracy for the presense of the disease with LV dysfunction, and the sensitivity was even higher when either IVI or EPSS, or both were abnormal.