Thioacetamide 유발 간성뇌장애에서 뇌파 Power Spectra

김지희(Chi Hui Kim),최원진(Won Jin Choi),박정숙(Jung Sook Park),이향이(Hyang Yi Lee),하정희(Jeoung Hee Ha),이만기(Maan Gee Lee) 대한약리학회 1996 대한약리학잡지 Vol.32 No.3

흰쥐에 thioacetamide(TAA)를 투여하면 간성뇌장애가 유발된다. 두가지 행동 상태(꼬리 접촉자극 및 미자극)와 세 단계의 신경학적 이상의 단계(정상, 약한 운동실조, 심한 운동실조)별로 뇌파를 기록하였고, 뇌파 스펙트럼 및 대역 분석을 통하여 간성뇌장애 진행동안 뇌파의 정량적인 변동을 관찰하였다. 정상 쥐에서 자극은 theta(3.5 ~ 8 Hz) 및 gamma(30 ~ 50 Hz) 대역의 power을 증가시켰다. 운동실조가 있는 쥐에서 이러한 변화가 일어나지 못하였다. 꼬리 자극을 하는 상태에서 theta 대역의 변화는 gamma 대역의 변화 보다 더욱 일찍 관찰되었다. 신경학적 행동 단계가 심해짐에 따라서 β3(21 ~ 30 Hz) 및 gamma 대역에서 power가 점차적으로 감소하였다. 또한 간성뇌장애의 신경학적 증상은 benzodiazepine계 물질에 의하여 야기된다는 가설이 있으므로 beta power의 증가가 관찰될 것으로 기대하였으나 이 연구에서는 관찰하지 못하였다. 이 결과들로 미루어 볼때 이 연구에 사용된 스펙트럼 및 대역 분석이 간성뇌장애동안 신경학적 증상의 정도를 정량화 할 수 있다고 생각된다. During the development of hepatic encephalopathy after thioacetamide (TAA) injection to rat, EEG was recorded at two different states: without or with tactile stimulation of tail at regular intervals. Calculations based on the spectral and band analysis were used. The changes in the power spectra and bands were examined in 3 different behavioral stages: normal, mild ataxia and severe ataxia. In normal rats, the stimulation produced the increase in the power of the theta (3.5 ~ 8 Hz) and the gamma (30 ~ 50 Hz)$ bands. These changes could not be produced in rats with the mild and severe ataxia. The changes in the power of the theta band occurred earlier than those of the beta3 and the gamma bands in the stimulated state. Gradual decreases in the spectral power of the beta3 (21 ~ 30 Hz) and the gamma bands were correlated with the progress of the stages from normal condition to mild to severe ataxia in both unstimulated and stimulated states. The results indicate that the spectral and band analysis used in this study can quantify the severity of the neurological malfunction during HE.

최대운동시의 산소섭취량 , 심박수 및 산소맥

김태석(Tae Sug Kim),김이근(Ih Geun Kim),김지희(Chi Hui Kim),김채기(Chae Gi Kim),최정윤(Jung Yoon Choe),장성국(Sung Gug Chang),이봉열(Bong Ryeol Lee),채성철(Sung Chul Choi),전재은(Jae Eun Jun),정태훈(Tae Hoon Jung),박의현(Wee Hyun Par 대한내과학회 1997 대한내과학회지 Vol.52 No.3

N/A Objectives: Despite the fact that determinations of cadiorespiratory fitness levels by exercise stress tests are becoming widely used in healthy individuals as well as in patients with cardiopulmonary diseases, the normal standards in this field have not been well established in Korea. The purpose of this study is to provide normal standards or reference values for the VO2 max, HR max and O2 pulse max for normal Korean adults by age and sex, along with the derivation of regression formulae of these parameters. Methods: In 1,000 healthy adults (20-66years) consisting of 603men and 397women, symptomlimited maximal exercise was carried out by Bruce protocol, allowing holding on to the hand rail of the treadmill during exercise for the safety purpose. All the subjects were non-athletes and were members of a health center and were more conscious about their health and physical fitness than the ordinary population. Results: The VO2 max and HR max were decreased with age as expected and, as a whole, the values of the VO2 max and HR max of females were approximately 84% and 90% of those of males, respectively. Estimated yearly reductions in the V max for males and females were 0.45 and 0.32mL/kg/min, respectively and those of the HR max were 0.72 and 0.76/min, respectively. The O2 pulse max of the female was approximately 70% of that of the male, and was slightly related to weight and exercise time. The regression equations of the parameters obtained using exercise time (ET, sec), age (A, year), weight (W, kg) and sex (S, O=male; 1= female) were: HR max=215.3-0.74A-5,04S, O2 pulse max= 5.371+0.216W+0.0107ET-1.505S and VO2 max=40.612+1.950ET-0.206A-0.147W-6.060S, Conclusion: The VO2 max in our study was higher than hitherto reported. This was primarily due to longer exercise time of the subjects on the treadmill, because they were allowed to hold on to the hand rail during exercise. And also, the fact that our subjects, being members of a health center, might have had higher physical fitness levels than general population could have contributed to the high VO2 max. Thus, we feel that our results could be the ideal target or- reference values to be achieved for those patients or individuals who have to do the tests with holding on to the rail of a treadmill for safety purpose.

장천공과 Enteritis Cystica Profunda를 동반한 Peutz-Jeghers 증후군

안기성(Ki Sung Ahn),배정동(Jung Dong Bae),김호각(Ho Gak Kim),손호상(Ho Sang Shon),최정윤(Jung Yoon Choe),김지희(Chi Hui Kim),김이근(Ih Geun Kim),김태석(Tae Sug Kim),김채기(Chae Gi Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5

The Peutz-Jeghers syndrome is an autosornal dominant condition characterized by mucocutaneous pigmentation and hamartomatous polyps of the gastrointestinal tract. This syndrome is clinically important because of complications caused by gastrointestinal polyps, such as abdorninal pain, gastrointestinal bleeding and intussusception often leading to intestinal obstruction. The possibility of malignant change in the polyp has been a controversial issue. In the recent reviews of soe cases of Peutz-Jeghers syndrome, the reported lesions of small intestinal adenocarcinoma are regarded as the benign process of enteritis cystica profunda. We present herein a case of Peutz-Jeghers syndrome with small bowel perforation, a previously unreported instance, and enteritis cystica profunda. (Korean J Gastroenterol 1997; 29:677-682)

상부위장관질환 환자에서 H . pylori 감염에 의한 위점막의 조직학적 변화와 혈청 Gastrin 및 혈청 IgG항체가의 상관관계

손호상(Ho Sang Shon),최정윤(Jung Yoon Choe),김지희(Chi Hui Kim),김태석(Tae Sug Kim),김채기(Chae Gi Kim),김이근(Ih Geun Kim),안기성(Ki Sung Ahn),김호각(Ho Gak Kim),오훈규(Hoon Kyu Oh),김용진(Yong Jin Kim),배정동(Jung Dong Bae) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3

N/A Background/Aims: This study was performed to investigate the relationship between Helicobacter pylori infection and degree of gastric mucosal inflammation, IgG antibody titer against H. pylori, and fasting serum gastrin level. Methods: Patients were divided into 2 groups(H. pylori positive and negative) by identification of H. pylori in biopsied specimens with special staining. In H. pylori positive group, the density of gastric K. pylori colonization was further graded semiquantitatively from 1 to 3. The severity of gastritis in each group was scored according to the Sydney system from 0 to 3. Serum IgG antibody titer against H. pylori was detected by second-generation antigen based enzyme immunoassay(Cobas Core Anti-Helicobacter pylori EIA). Fasting serum gastrin level was measured by standard radioimmunoassay technique. Results: The severity of gastritis in H. pylori positive group was significantly higher than H. pylori negative group in mononuclear cell infiltration(pC0.001), activity of PMNL(pC0.001), and glandular atrophy(pC0.01). In H. pylori positive group, the density of H. pylori colonization was significantly correlated with mononuclear cell infiltration(r=0.67, p0.001), activity of PMNL(r=0.70, p0.001), and grandular atrophy (r=0.38, pC0.001). Neither density of H. pylori colonization nor severity of gastritis was correlated with fasting gastrin level and IgG antibody titer against H. pylori. Conclusions: H. pylori infection results in localized inflammatory reaction in gastric mucosa with relation to density of H. pylori colonization, but serum H. pylori IgG antibody titer does not reflect the severity of gastritis. Fasting serum gastrin level also has no relation with the density of H. pylori colonization and severity of gastritis. These findings suggest that the factor which cause inflammation in gastric mucosa may be different from that cause gastrin secretion or formation of IgG antibody. (Korean J Gastroenterol 1996; 28:311 - 319)

골 및 골수의 다발성 지방 괴사를 초래한 만성 췌장염 1예

이영학,김정균,최정윤,현동우,이재태,이규보,김이근,안병철,손상균,곽동석,배선근,김지희,김태석,김채기 대한내과학회 1996 대한내과학회지 Vol.51 No.3

Pancreatic and intra-abdominal fat necrosis are frequently in chronic pancreatitis, but fat necrosis of the bone marrow has been rarely reported. These extrapancreatic fat necrosis occur by circulating lipolytic enzymes. We report a case of multiple fat necrosis of the osseous medulla and skin associated with chronic recurrent pancreatitis.