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기관지천식 환자에서 Interleukin (IL)-13 유전자 다형성
김건우 ( Gun Woo Kim ),손자영 ( Ja Young Son ),최은정 ( Eun Jung Choi ),신재대 ( Jae Dae Shin ),이응갑 ( Eung Kab Lee ),정덕원 ( Duk Won Chung ),이종명 ( Jong Myung Lee ),김능수 ( Nung Soo Kim ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.4
Background: Asthma is characterized by airway hyperresponsiveness, eosinophilic inflammation, airway mucus hypersecretion, and elevated serum immunoglobulin E (IgE). IL-13 is an important cytokine in the pathogenesis of asthma through the production of IgE, stimulation of bronchial epithelial mucus production, and smooth muscle hyperreactivity. Previous studies have shown that the polymorphisms in IL-13 gene are associated with asthma, atopy, or total IgE. Objective: We investigate whether the polymorphism Arg 110Gln within the IL-13 gene is associated with asthma, atopy, serum total IgE, asthma severity and airway hyperresponsiveness in adult asthma. Method: One hundred fifty-five asthmatic adults and 147 non-asthmatic healthy adults were enrolled. Asthma phenotype and bronchial responsiveness to methacholine were determined by the same physician. IL-13 Arg110Gln polymorphism was genotyped using PCR-RFLP assay. Result: Genotype frequency of IL-13 Arg110Gln polymorphism was significantly different between asthmatic patients (P=0.021), especially between atopic asthma (P=0.024) and controls, and was associated with elevated levels of serum total IgE (P=0.009), asthma severity (P=0.026), pulmonary function (P=0.017), and airway hyperresponsiveness (P=0.025) in patients with asthma. Conclusion: IL-13 Gln110 variant may be an asthma susceptibility gene in Korean adults. In addition, IL-13 Gln110 variant is associated with elevated levels of serum total IgE and severity of asthma. (Korean J Asthma Allergy Clin Immunol 2006;26:302-309)