http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 채성철(Sung Chul Choi) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
김태석(Tae Sug Kim),김이근(Ih Geun Kim),김지희(Chi Hui Kim),김채기(Chae Gi Kim),최정윤(Jung Yoon Choe),장성국(Sung Gug Chang),이봉열(Bong Ryeol Lee),채성철(Sung Chul Choi),전재은(Jae Eun Jun),정태훈(Tae Hoon Jung),박의현(Wee Hyun Par 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: Despite the fact that determinations of cadiorespiratory fitness levels by exercise stress tests are becoming widely used in healthy individuals as well as in patients with cardiopulmonary diseases, the normal standards in this field have not been well established in Korea. The purpose of this study is to provide normal standards or reference values for the VO2 max, HR max and O2 pulse max for normal Korean adults by age and sex, along with the derivation of regression formulae of these parameters. Methods: In 1,000 healthy adults (20-66years) consisting of 603men and 397women, symptomlimited maximal exercise was carried out by Bruce protocol, allowing holding on to the hand rail of the treadmill during exercise for the safety purpose. All the subjects were non-athletes and were members of a health center and were more conscious about their health and physical fitness than the ordinary population. Results: The VO2 max and HR max were decreased with age as expected and, as a whole, the values of the VO2 max and HR max of females were approximately 84% and 90% of those of males, respectively. Estimated yearly reductions in the V max for males and females were 0.45 and 0.32mL/kg/min, respectively and those of the HR max were 0.72 and 0.76/min, respectively. The O2 pulse max of the female was approximately 70% of that of the male, and was slightly related to weight and exercise time. The regression equations of the parameters obtained using exercise time (ET, sec), age (A, year), weight (W, kg) and sex (S, O=male; 1= female) were: HR max=215.3-0.74A-5,04S, O2 pulse max= 5.371+0.216W+0.0107ET-1.505S and VO2 max=40.612+1.950ET-0.206A-0.147W-6.060S, Conclusion: The VO2 max in our study was higher than hitherto reported. This was primarily due to longer exercise time of the subjects on the treadmill, because they were allowed to hold on to the hand rail during exercise. And also, the fact that our subjects, being members of a health center, might have had higher physical fitness levels than general population could have contributed to the high VO2 max. Thus, we feel that our results could be the ideal target or- reference values to be achieved for those patients or individuals who have to do the tests with holding on to the rail of a treadmill for safety purpose.
-
항산화비타민제의 보충과 혈중 Cellular Adhesion Molecule치의 변화
송경은,채성철,전재은,박의현,천병렬,정효지,최영선,조성희 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1
배경: 죽상경화증의 진행의 초기 단계에 있어서 혈관내피세포에 상해가 생기면 단구 등의 백혈구가 혈관내피세포에 부착되고 내피하층으로 이동하여 지질을 탐식한 세포로 된다. Cellular adhesion molecule은 이 과정을 매개하고 조장하며, 또한 산화 스트레스에 의해 생기는 산화저밀도지단백과 세포막의 인지질들의 산화는 혈과내피세포의 기능장애를 초래하여 더욱 죽상경화의 진행을 가속화시킨다. 따라서 여러 연구에서 항산화제의 투여로 죽상경화의 진행을 막을 수 있다고 보고하였다. 이에 지자들은 항산화영양소 중 특히 비타민의 투여가 항산화계 효소의 활성도와 cellular adhesion molecule의 방출에 미치는 영향을 살펴보았다. 방법: 경북대학교병원 순환기내과를 방문한 관상동맥질환 환자 중 연령, 성별, 진단명, 흡연 상태, 이환 기간 등을 일치시켜 무작위로 선택한 실험군 38명, 대조군 39명을 대상으로 하였다. 실험군에는 비타민 C 50mg, β-cartene 15mg, 비타민 E 50IU, 셀레늄 50μg으로 구성된 항산화비타민제를, 대조군에는 위약을 3개월간 투여하였다. 투약 전, 후에 각각 채혈하여 비타민 항산화계 효소 중 superoxide dismutase (SOD), glutathione peroxidase (GPX)와 catalase, 그리고 cellular adhesion molecule인 ICAM-1 (intercellular adhesion, molecule-1)VCAM-1 (vascular cell adhesion molecule-1), E-selectin을 측정하였다. 결과: 실험군에서 항산화비타민제를 투여한 후 비타민, C, β-cartene, α-tocopherol은 투여전에 비해 유의하게 증가하였다. 항산화계 효소인 SOD는 실험군에서 항산화비타민제 투여 전 15.50±2.1 unit/mg hemoglobm, 투여 후 16.34±2.5 unit/mg hemoglbm으로 유의한 차이를 보였지만(P<0.05) catalase와 GPX는 투약전, 후에 유의한 차이가 없었다. 실험군에서 항산화 비타민제 투여 전 ICAM-1, VCAM-1, E-selectin 치는 각각 234.4±72.1 ng/mL, 665.±155.8 ng/mL, 47.4±18.9ng/mL이었고, 투여 후에는 각각 20.8±55.4ng/mL, 631.4±127.8ng/mL, 46.5±16.2ng/mL로서, 통계학적으로 유의한 차이는 없었다. 결론: 항산화비타민제의 투여로 실험군에서 항산화계 효소 중 SOD의 활성도가 유의하게 증가되었음을 알 수 있었으나 혈 중 soluble cellular adhesion moleculecl에는 유의한 차이를 찾을 수 없었다. Cellular adhesion molecule의 측정이 항산화제의 투여로 인체내 항산화체계의 개선에 따른 혈관내피세포의 손상 정도나 활성을 파악하는 지표로 이용되기 위해서는 앞으로 더 많은 연구가 필요하리라 생각된다. Background : The oxidative modification of lipids and the endothelial expression of adhesion molecules are key events in the pathogenesis of atherosclerosis. The appropriate antioxidants that protected and slowed the progression of the disease were reported. We measured the antioxidant enzyme activities and the levels of soluble cellular adhesion molecules in order to evaluate whether antioxidant vitamin supplementation affected the oxidative changes and the expression of cellular adhesion molecules. Methods : Seventy-seven patients participated in a randomized, double blind, placebo-controlled trial. The test group(38 patients) was given antioxidant vitamin doses including a daily dose of vitamin C 500㎎, β-carotene 15㎎, vitamin E 400 IUS, and selenium 50㎍. The control group(44 patients) received placeboes for three months. We measured the vitamin serum levels, intercellular adhesion molecules-1(CAM-1), vascular cell adhesion molecule-1(VCAM-1), E-selectin and activity of erythrocyte enzymes such as superoxide dismutase(SOD), catalase, and glutathione peroxidase(GPX) before and at 3 months after supplementation. Results : After supplementation, the serum vitamin levels increased significantly(p<0.05) and the activity of the erythrocyte SOD significantly increased by 0.85unit/㎎ hemoglobin(p<0.05) in the test group Soluble ICAM-1, VCAM-1 and E-selectin levels did not change significantly in the test group after supplementation. Conclusions : These results suggest that the antioxidant vitamin supplementation may affect erythrocyle SOD activity, but not soluble cellular adhesion molecule levels.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
