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가상 생체외 사체 실험용 경추 다물체 동역학 모델 개발
임대섭(Dae Seop Lim),이기석(Ki Seok Lee),김윤혁(Yoon Hyuk Kim) 대한기계학회 2013 大韓機械學會論文集B Vol.37 No.10
본 연구에서는 가상 생체외 사체실험을 수행할 수 있는 경추 다관절 동역학 모델을 개발하였다. 평균크기 한국인 의료영상과 관절 및 연부조직의 물성 정보를 기반으로 하여 경추 동역학 모델을 개발하였다. 개발된 모델의 검증을 위하여 경추 단분절 및 다분절 모멘트-각도 관계, 인대 하중 및 후관절 접촉력 등을 문헌의 사체실험 결과와 비교한 결과 매우 유사한 경향을 확인하였다. 본 연구에서 개발된 경추 동역학 모델은 앞으로 경추 사체실험 연구 뿐만 아니라 자동차 충돌시 경추 상해 분석 등의 다양한 경추 생체역학 연구 연구에 활용될 수 있을 것이다. In this study, a multibody dynamic model of the cervical spine was developed for a virtual in-vitro cadaveric experiment. The dynamic cervical spine model was reconstructed based on Korean CT images and the material properties of joints and soft tissue obtained from in-vitro experimental literature. The model was validated by comparing the inter-segmental rotation, multi-segmental rotations, load-displacement behavior, ligament force, and facet contact force with the published in-vitro experimental data. The results from the model were similar to published experimental data. The developed dynamic model of the cervical spine can be useful for injury analysis to predict the loads and deformations of the individual soft-tissue elements as well as for virtual in-vitro cadaveric experiments.
임대섭 ( Dae Seop Lim ),정은수 ( Eun Soo Jeong ),정진성 ( Jin Sung Jung ),장세헌 ( Se Heon Chang ),유승현 ( Seung Hyen Yoo ),장우진 ( Woo Jin Jang ),정시정 ( Shi Jung Chung ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
Paradoxical embolism is a kind of stroke caused by embolism of thrombus of venous origin through a lateral opening in the heart, such as a patent foramen ovale (PFO). Although the most frequent manifestation of paradoxical embolism is cryptogenic stroke, noncerebral paradoxical embolism is also associated with PFO. We experienced a case of cryptogenic renal infarction in a previously healthy 70-year-old man. He had no cardiac thrombus on transthoracic echocardiography and electrocardiogram revealed a normal sinus rhythm. Because it was cryptogenic renal infarction, we performed transesophageal echocardiography with microbubble test. Microbubble test using agitated saline proved the presence of right-to-left shunt and patent foramen ovale was diagnosed. We also performed lower leg doppler ultrasonogram, but there was no evidence of deep vein thrombosis. Although only the presence of a right-to-left shunt is not enough to establish the diagnosis of paradoxical embolism, it is uncommon for the source of the embolism to be identified. In this case, we concluded that paradoxical embolism is the cause of renal embolism. We report paradoxical renal embolism through PFO with review of relevant literatures.
증례 : 순환기 ; 수술적 치료로 완치된 대동맥궁 혈전 1예
김정혁 ( Jung Hyuk Kim ),장우진 ( Woo Jin Jang ),서정연 ( Jung Yeon Seo ),임대섭 ( Dae Seop Lim ),최진오 ( Jin Oh Choi ),박승우 ( Seung Woo Park ),김은영 ( Eun Young Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.4
Thrombi within the aortic arch are rare, and are generally detected after cerebral, visceral, or peripheral embolization. Although the indications for treatment remain controversial, there is increasing interest in the etiopathogenesis of this rare clinical entity and the development of appropriate diagnostic and therapeutic approaches. We report a case in which a thrombus was detected in the proximal aortic arch on echocardiography and computed tomography angiography as the origin of upperextremity ischemia. This pedunculated thrombus was attached to the atherosclerotic aortic wall and was removed surgically. (Korean J Med 2012;82:476-480)
소화기 ; Lansoprazole 근간 3제요법과 병합 투여된 Ecabet Sodium이 Helicobacter pylori 제균율에 미치는 효과
서정연 ( Jung Yeon Seo ),김민정 ( Min Jeong Kim ),고규한 ( Kyu Han Ko ),김동현 ( Dong Hyun Kim ),임대섭 ( Dae Seop Lim ),전해리 ( Hae Ri Chon ) 대한내과학회 2011 대한내과학회지 Vol.80 No.5
목적: 위세포벽을 보호하는 효과로 소화성 궤양환자에 사용되는 ecabet sodium은 H. pylori 요소분해효소를 억제함으로써 H. pylori의 활동과 성장을 억제시키는 약물로 알려져 있다. 이에 기존의 LAC 삼제요법과 ecabet sodium을 병합한 LAC 삼제요법(lansoprazole+amoxicillin+clarithromycin)을 사용한 환자들 간의 H. pylori 제균율의 차이를 비교하여 ecabet sodium이 H. pylori 제균율에 미치는 효과를 평가하고자 하였다. 방법: 상부위장관 내시경으로 H. pylori 양성 소화성 궤양 또는 미란성 위염으로 진단받고 LAC (lansoprazole 30mg b.i.d., amoxacillin 1.0g b.i.d., clarithromycin 500mg b.i.d.) 또는 LACE (lansoprazole 30mg b.i.d., amoxacillin 1.0g b.i.d., clarithromycin 500mg b.i.d., ecabet sodium 1g b.i.d.)로 2주간 H. pylori 제균 치료를 받았던 두 군을 투약종료 4-5주 후에 13C요소호기검사를 실시하여 두 군 간 H. pylori 제균율을 비교하였다. 결과: 대상 환자는 LAC군 204명, LACE군 159명으로 총 363명이었고, 양 군 간의 흡연력, 나이, 성별 및 진단명에는 유의한 차이는 없었다. H. pylori 제균율에 있어서 LAC군은 81.4%, LACE군은 86.2%로 ecabet sodium을 사용한 군에서 사용하지 않은 군과 비교 시 제균율에 차이가 없었다(p=0.159). 결론: H. pylori의 제균 요법으로 ecabet sodium을 병합 투여한 3제 요법은 기존의 3제 요법과 제균율에 있어서 차이 가 없었다. Background/Aims: Ecabet sodium is used for treating gastric ulcers and gastritis. It exhibits a bactericidal effect against Helicobacter pylori by inhibiting bacterial urease activity. Thus, ecabet sodium has been suggested to improve the efficacy of the H. pylori eradication in patients with peptic ulcers. The aim of this study was to compare the H. pylori eradication rate of lansoprazole-based triple therapy versus lansoprazole-based triple therapy plus ecabet sodium. Methods: The subjects consisted of 363 H. pylori-positive patients who had undergone eradication therapy from February 2007 to February 2010. In total, 363 patients with H. pylori-positive peptic ulcer disease or symptomatic erosive gastritis received LAC (lansprazole 30mg b.i.d., amoxicillin 1.0g b.i.d., clarithromycin 500mg b.i.d.) or LACE (lansoprazole 30mg b.i.d., amoxicillin 1.0g b.i.d., clarithromycin 500mg b.i.d., ecabet sodium 1g b.i.d.) for 1 week. Successful eradication was defined as a negative 13Curea breath test 4-5 weeks after treatment completion. Results: H. pylori eradication rates were 81.4% (166/204) in the LAC group and 86.2% (137/159) in the LACE group (p=0.159). No significant difference in eradication was observed. No significant difference was observed in the side effects experienced by the patients in the two treatment groups. Conclusions: Our results suggest that adding ecabet sodium did not improve the H. pylori eradication rate significantly in standard lansoprazole-based triple therapy for H. pylori.
인간공학적 작업개선을 위한 농업인 안전 기술 동향 연구
이경숙(Kyung Suk Lee),김효철(Hyo Cher Kim),채혜선(Hye Seon Chae),김경란(Kyung Ran Kim),이수진(Soo Jin Lee),임대섭(Dae Seop Lim) 대한인간공학회 2010 大韓人間工學會誌 Vol.29 No.2
A high prevalence of farmer's work-related musculo-skeletal disorders (MSDs) have been reported in precedent studies. Risk factors - physical, chemical, biological, ergonomic risk factor etc. - in farm-work were identified by previous studies. To prevent farmers from exposing to them and reduce, Agricultural Safety Technology were introduced and used on farm. The purpose of this study is to review and summarize the agricultural safety technology on farm in Korea. According to strategy principles, this technology is classified as four criteria - workload reduction by reducing awkward posture, workload reduction by using manual material handling aids, Comfort improvement by protecting worker from hot, cold environment and work efficiency improvement by workplace redesign and cultivation modification. This technology includes transporting tools, working cloth, personal protective equipment, and pesticide-proof Clothing. Anthropometric study of Korean farmers was also carried out to support the development of equipment and clothes. In long terms, it needs to precaution activity from risk factors by using cultivation modification and working improvement. Although working condition gets better and workload reduce by this technology, it required customized safety technology in each crops - rice cultivation, horticulture and livestock farming. And farmers should use the assistive technology and participate voluntarily in ergonomic intervention program.
Enterococcus hirae 균혈증을 동반한 급성신우신염 1예
김훈일,임대섭,서정연,최석훈 대한감염학회 2009 감염과 화학요법 Vol.41 No.6
Enterococcus hirae infection is rare in humans. We describe a case of pyelonephritis that was caused by Enterococcus hirae in a 57-year-old woman. E. hirae was isolated from both blood and urine. This is the 2nd case report on bacteremia caused by E. hirae in Korea.