Non - Hodgkin`s lymphoma of the thyroid and adrenal glands

이대호(Dae Ho Lee),박재홍(Jae Hong Park),이제정(Je Jung Lee),정익주(Ik Joo Chung),정동진(Dong Jin Chung),정민영(Min Young Chung),이태희(Tai Hee Lee) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

Non-Hodgkin`s Lymphoma of the thyroid and adrenal glands

이대호 ( Dae Ho Lee ),박재홍 ( Jae Hong Park ),이제정 ( Je Jung Lee ),정익주 ( Ik Joo Chung ),정동진 ( Dong Jin Chung ),정민영 ( Min Young Chung ),이태희 ( Tai Hee Lee ) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1

스테로이드 치료로 회복된 루푸스 장염 3세

권순대 ( Sun Dae Kwon ),이태희 ( Tae He Lee ),권진경 ( Jin Kyung Kwon ),박성배 ( Sung Bae Park ),김현철 ( Hyun Chul Kim ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.2

Systemic lupus erythematosus is a systemic disorder which has frequent involvement of gastrointestinal tract. Non-specific symptoms such as anorexia, nausea, diarrhea and abdominal pain are well known symptoms when the gastrointestinal tract is involved. The most feared gastrointestinal complication of systemic lupus erythematosus is lupus enteritis. The pathological change in lupus enteritis is usually a result of mesenteric vasculitis. Major complications such as intestinal bleeding and perforation may occur and sometimes result in sugery. Because of high mortality rate in case of major complications, early diagnosis and appropriate treatment is very important. We experienced three patients with lupus enteritis who presented with severe abdominal pain and dirrhea. They were diagnosed by characteristic radiographical findings of small bowel series and barium study. All radiographical findings has been resolved completely with the steroid therapy. Conclusively we can induce complete remission by steroid therapy alone, if we diagnose lupus enteritis in the early period of disease course.

학술발표회 초록 : ( 에너지 / 환경 Poster 발표 ) ; 화학적 제조법에 의한 PEMFC 전극의 제조 및 특성화

박대진,이승재,설용건,이태희 ( Dae Jin Park,Seung Jae Lee,Yong Gun Sul,Tae Hee Lee ) 한국화학공학회 1994 추계학술발표회 Vol.- No.-

일반연제 발표 : 당뇨병성 신병증 환자에서 관상동맥 협착증 예측을 위한 비침습적 임상 지표의 유용성

강병승 ( Kang Byeong Seung ),이태희 ( Lee Tae Hui ),황학진 ( Hwang Hag Jin ),박형천 ( Park Hyeong Cheon ),강신욱 ( Kang Sin Ug ),최규헌 ( Choe Gyu Heon ),이호영 ( Lee Ho Yeong ),한대석 ( Han Dae Seog ),하성규 ( Ha Seong Gyu ) 대한신장학회 2003 춘계학술대회 초록집 Vol.22 No.1

단시간의 혈당량 변화에 따른 당화혈색소량의 변동

안재수 ( An Jae Su ),최은진 ( Choe Eun Jin ),박상선 ( Park Sang Seon ),이대호 ( Lee Dae Ho ),정민영 ( Jeong Min Yeong ),이태희 ( Lee Tae Hui ) 대한내과학회 1993 대한내과학회지 Vol.44 No.1

연구배경 : 혈당농도가 올라감에 따라 혈중의 혈색소가 당화되어 당화혈색소가 증가됨은 잘 알려져 있다. 이러한 당화혈색소는 적혈구 성숙과정동안 서서히 당화되므로 이를 측정함으로써 수주전의 혈당조절 상태를 알수 있다. 이렇게 당화혈색소는 장기간에 걸쳐 서서히 당화되는 것으로 알려져 있으나, 저자들은 짧은 시간의 혈당농도 변화에도 약간의 변동이 있음을 경험할 수 있었다. 이에 저자들은 인슐린 비의존형 당뇨병환자를 대상으로 공복 및 식후 두시간의 혈당농도 및 당화혈색소량, 안정형 당화혈색소량, 불안정형 당화혈색소량을 측정한 후 비교검토하였다. 방법 : 인슐린 비의존형 당뇨병환자 166예를 대상으로 공복 및 식후 두시간의 혈당농도와 당화혈색소량을 동시에 측정한 후 식후 두시간에 공복시의 당화혈색소량을 뺀 값이 -0.3%이하를 Ⅰ군(n=9), +0.3%이상을 Ⅱ군(n=88), 그 사이를 Ⅲ군(n=69)으로 나누어 공복 및 식후 두시간의 혈당농도 변화에 따른 당화혈색소량의 변동을 고찰 하였다. 음식 및 치료에 따른 당화혈색소량의 변화를 배제하기 위하여 15예의 치료받지 않은 인슐린 비의존형 당뇨병환자에서 75g 경구당부하 검사를 하면서 혈당농도 변화에 따른 당화혈색소량의 변화를 관찰하였다. 단시간의 당화혈색소량 변동이 불안정형 당화혈색소량의 변동에 의한 것인가를 알아보기 위하여 37예의 인슐린 비의존형 당뇨병환자에서 식사전후에 혈당량 및 안정형 당화혈색소량과 불안정형 당화혈색소량을 측정한 후 비교 검토하였다. 혈당은 glucose oxidase 법으로 측정하였고 당화혈색소는 HPLC 법을 이용하여 측정하였다. 불안정형 당화혈색소는 식염수로 전항온을 이용하여 얻어진 안정형 당화혈색소를 총당화혈색소에서 빼내어 구하였다. 결과 : 1)공복시 혈당농도는 Ⅰ, Ⅱ, Ⅲ군에서 각각 264.9±51.63(평균±SEM)mg/dl, 203.1±12.16mg/dl, 205.5±13.40mg/dl였고, 공복시 당화혈소량은 11.1±1.37%, 9.8±1.32%, 10.5±0.36%로 각군간의 유의한 차이는 없었다. 2) 식후 두시간 혈당농도는 Ⅰ, Ⅱ, Ⅲ군에서 각각 185.1±33.42mg/dl, 306.3±13.69mg/dl, 248.4±10.25mg/dl로 각군간에 유의한 차이를 보였으나(p<0.01), 식후 두시간 당화혈색소량은 10.5±1.42%, 10.5±1.22%, 10.6±0.36%로 유의한 차이가 없었다. 3) 식후 두시간 혈당농도에서 공복시 혈당농도를 뺀값은 Ⅰ, Ⅱ, Ⅲ군에서 각각 -79.8±43.79mg/dl, 103.2±14.61mg/dl, 42.9±11.17mg/dl,로 각군간의 유의한 차이를 보였고 (p<0.001), 당화혈색소량의 찻값은 각각 -0.6±0.49%, 0.6±0.33%, 0.08±0.01%로 각군간의 유의한 차이를 보였다(p<0.001). 4) 75g 경구당부하 검사를 시행한 치료받지 않은 15예의 인슐린 비의존형 당뇨병환자에서 당부하전의 혈당농도가 113±13.4mg/dl에서 당부하후 두시간에 222±11.3mg/dl로 증가함에 따라 당화혈색소량은 7.2±1.3%에서 7.8±1.9%로 증가하였다(p<0.001). 5) 37예의 인슐린 비의존형 당뇨병환자에서 공복시, 식후 두시간 혈당농도가 164.1±9.61mg/dl에서 285.3±14.42mg/dl로 증가함에 따라 불안정형 당화혈색소량은 0.6±0.08%에서 1.3±0.16%로 유의한 증가를 보였으나(P<0.001), 안정형 당화혈색소량은 유의한 변화가 없었다. 6) 혈당농도와 당화혈색소량의 상관계수는 불안정형 당화혈색소량에서는 0.41, 안정형 당화혈색소량에서는 0.28로 불안정형 당화혈색소와의 상관계수가 더 높았다(p<0.001). 결론 : 이상의 결과로 단시간의 혈당량 변동이 HPLC법에 의한 당화혈색소량의 측정에 영향을 미칠수 있는 인자의 하나로 생각되며, 이는 단시간의 혈당농도 변동에 따른 불안정형 당화혈색소량의 변동에 의한 것임을 시사한다. Background : HbA_1C is formed slowly throughout the 120-day life span of the red blood cell by non-enzymatic glycosylation of HbA_O. HbA_1C concentrations reflect mean blood glucose levels over the previous several weeks, but we experienced the changes of hemoglobin A_1C values according to the short term changes of blood glucose levels. We investigated the changes of HbA_1C values with a HPLC technique according to the short term changes of blood glucose concentration. Method : HbA_1C values were measured at fasting and postprandial 2-hour state with a HPLC method in 166 NIDDM patients, and they are divided into three groups (Group Ⅰ : ??HbA_1C<-0.3%, Group Ⅱ : ??HbA_1C>0.3%, Group Ⅲ : -0.3%≤??HbA_1C≤0.3, ??HbA_1C : postprandial 2 hour HbAlc values-fasting HbA_1C values) and compared respectively. In 15 untreated NIDDM patients, blood glucose and HbA_1C were measured during the oral glucose tolerance test to exclude the influence of food and treatment on the HPLC method. Stable HbA_1C and labile HbA_1C were measured in 37 NIDDM patients to evaluate the influence of labile HbAlC on the HPLC method. Results : 1) In group Ⅰ, Ⅱ, Ⅲ, Postprandial 2-hour blood glucose levels (man±SEM) were 185.1±33.42mg/dl, 306. different respectively (p<0.01). fasting blood glucose levels, fasting HbA_1C values and postprandial 2-hour HbA_1C values were not significantly different among three gruops. 2) In group Ⅰ, Ⅱ, Ⅲ, the differences between postprandial 2-hour levels and fasting blood glucose levels were -79.8±43.79mg/dl, 103.2±14.61mg/dl, 42.9±11.17mg/dl, and the differences were highly significant (p<0.001). The mean ??HbA_1C values were -0.6±0.49%, 0.6±0.33, 0.08±0.01% respectively. 3) In 15 untreated NIDDM patients, HbA_1C values were significantly increased from 7.2±1.3% to 7.8±1.9% according to the increment of blood glucose levels from 164.1±9.61mg/dl to 285.3±14.42mg/dl (p<0.001), but stable HbA_1C values were not significantly changed. 5) Correlation between labile HbA_1C and blood glucose (r=0.41, p<0.001) was higher than that between stable HbA_1C and blood glucose (r=0.28, p<0.001). Conclusion :From the above results we can find that HbA_1C values measured with a HPLC technique change according to the short term changes of blood glucose levels, and the changes of HbA_1C values are caused by the short term changes of labile HbA_1C values.

함침 - 환원법에 의한 고분자 전해질형 연료전지의 막 - 전극 어셈블리의 제조 및 특성화

박대진,조원일,노용우,고영태,이승재,설용건,이태희 ( Dae Jin Park,Won Ihl Cho,Yong Woo Rho,Young Tai Kho ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.2

함침 - 환원법에 의한 고분자 전해질형 연료전지 막/전극 어셈블리의 제조 및 특성화

이태희,이승재,설용건,최경환,박대진 한국화학공학회 1997 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.35 No.1

고분자 전해질형 연료전지의 막/전극 어셈블리를 함침-환원법으로 제조하고, 그 제조 조건과 어셈블리의 구조가 전지의 성능에 미치는 영향을 단전지에서 살펴보았다. 본 실험에서 막/전극 어셈블리의 최적 제조 조건은 1 mM Pt(NH₃)₄Cl₂로 60분 동안 함침 후, 1 mM NaOH₄로 2시간 동안 환원한 경우이었다. 연료전지의 성능은 막 표면에 과도한 입자 성장 및 촉매층 형성이 일어나지 않도록 전극 구조를 만듬으로써 향상시킬 수 있었다. 교류 임피던스법으로부터 산서전극의 제면저항이 작을수록, 이중층 전기용량이 클수록 연료전지의 성능이 향상됨을 알 수 있었다. Membrane/electrode assemblies for polymer electrolyte membrane fuel cell were fabricated by impregnation-reduction method, and effects of fabrication conditions and assembly structures on the cell performance were investigated in a single cell. The optimal fabrication condition of the membrane/electrode assembly was 1 mM Pt(NH₃)₄Cl₂ impregnation for 60 minutes and 1 mM NaOH₄ reduction for 2 hours in this experiment. The fuel cell performance could be improved by making the electrode structure not to have large particle creation and thick catalyst layer formation on the membrane. The AC impedance measurement showed that high cell performance corresponded to low interfacial resistance of the oxygen electrode and to high double layer capacitance.

모야모야 병, 관상동맥 협착 및 확장형 심근병증을 동반한 말단비대증 1예

박재홍,이태희,김용주,정민영,이대호,정동진,이대배 대한내과학회 2000 대한내과학회지 Vol.58 No.2

A 19-year-old girl with typical features of acromegaly, duration of which was thought to be above 10 years, presented with dyspnea. After serial studies, dilated cardiomyopathy and critical stenosis of left anterior descending coronary artery were demonstrated. Brain MRI revealed the following changes: the pituitary gland was enlarged and its upper margin was upwardly convex; severe cerebral atrophy and multiple signs of vascular abnormalities were present. Cerebral angiographic studies demonstrated the presence of complete occlusion of left carotid artery and severe stenosis of right carotid artery with the formation of collateral networks of vessels. The patient was thus diagnosed as having moyamoya disease that was thought to be congenital according to her past histories. Her cardiac function was slightly improved after percutaneous transluminal coronary angioplasty. Operation for the pituitary lesion and moyamoya disease was not performed due to poor general condition, but serum growth hormone concentration was adequately suppressed after octreotide therapy. We consider that this is a very rare case of acromegaly associated with moyamoya disease, coronary arterial disease and dilated cardiomyopathy.(Korean J Med 58:227-233, 2000)

갑상선 기능항진증 환자에서 인슐린감수성 및 인슐린분비능의 변화

최은진,강호철,이태희,정민영,이대호,장연진,박상선,조재현 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.2

The impairement of glucose metabolism is frequently associated in hyperthyroidism. The present study was performed to determine the effect of the thyroid hormone excess on insulin sensitivity and on insulin secretory function in vivo. Ten newly diagnosed hyperthyroid patients and fifteen healthy control subjects were subjected to frequently sampled intravenous glucose tolerance tests(FSIGT) after an overnight fast. Insulin sensitivity, represented by the insulin sensitivity index(S_1), was assessed by minimal model analysis of FSIGT data. Insulin secretion was measured by the total area under the insulin curve after glucose load. The results were as follows. 1) The K_G values, which represent glucose tolerance, were not different between the hyperthyroid patients and the normals(2.2+-0.3 vs. 2.5+-0.3%/min, p$gt;0.05). 2) S_1 was significantly decreased in the hyperthyroid patients in comparison to the normals(7.5+-1.4 vs. 2.6+-0.3X10^-4 min^-1/uU/ml, p$lt;0.05). 3) The basal insulin concentration was higher in the hyperthyroid patients than in the normals(8.3+-2.4 vs. 4.6+-0.4 uU/ml, p=0.07). In addition, the insulin secretory response to a glucose load was increased in the hyperthyroid patients as evidenced by the peak plasma insulin level(168.2+-30.4 vs. 89.2+-13.9 uU/ml, p$lt;0.05) and by the total area under the insulin curve(2641.1+-443.2 vs. 1696.7+-204.3 min uU/ml, p$lt;0.05). These results clearly demonstrated that insulin sensitivity was impaired in these newly diagnosed hyperthyroid patients. However, glucose tolerance was maintained by the increased insulin secretion (J Kor Soc Endocrinol 9:108-114, 1994).