장내세균에서 ${\beta}$-lactam 항균제의 내성기전별 항균제 감수성검사의 해석

이채훈,Lee, Chae-Hoon 영남의대학술지편집위원회 2010 Yeungnam University Journal of Medicine Vol.27 No.1

It is important to select appropriate antimicrobials for the treatment of infection according to the results of antimicrobial susceptibility tests (ASTs), yet the clinical isolates are sometimes susceptible to antibiotics that are clinically ineffective or this is due to technical error of the ASTs. So, interpretive reading of ASTs is needed and especially for the ${\beta}$-lactams for treating $Enterobacteriacae$. This review describes the interpretive reading of ASTs according to natural antimicrobial resistance and the mechanisms of mechanisms, with giving special attention to the antibiotics phenotypes for $Enterobacteriacae$. Further, as all the diffent tissues have a different antimicrobial concentration for identical antimicrobials, more information is needed on the antimicrobial tissue distribution for the appropriate treatment of infection. (ED note: I hope you send me the paper.)

위진 죽림칠현에 대한 한국 문인의 수용

이채훈(Lee Chae-Hoon) 경북대학교 인문학술원 2019 동서인문 Vol.0 No.12

위진 죽림칠현은 위진 교체기에 활동한 명사들을 대표하며, 완적, 혜강, 산도, 유령, 완함, 상수, 왕융을 가리킨다. 그리고 위진 죽림칠현의 행적은 논어의 은자 칠인 개념과 결합하여 한자문화권의 전통으로서 중국은 물론 한국의 문인들에게도 오랫동안 많은 영향을 끼쳤다. 위진 죽림칠현은 장기간에 걸친 한중 양국 상호간의 왕래와 문화교류를 통해 한국에 전파되었고, 그들의 생애와 독특한 행태가 한국 문인들에게 깊은 인상을 남겨, 한국 문학 작품에 다양한 형태의 죽림칠현 전고가 인용되는 방식으로 수용되었다. The seven sages of the bamboo grove represent celebrities who are active in the timing of Wei-Jin regime change. The seven sages of the bamboo grove include Ruan-ji, Ji-kang, Shan-tao, Liu-ling, Ruan-xian, Xiang-xiu, Wang-rong. And Their activities combined with a reference to 『the Analects』 have influenced Korea as well as China as a tradition of chinese culture circle. The seven sages of the bamboo grove was spread to Korea through long-term exchanges and cultural exchanges between Korea and China, and their lives and unique behaviors impressed Korean writers. As a result, Korean literary works were accepted by Korean writers in a way that cites various forms of The seven sages of the bamboo grove.

영화,영상에서 3D Computer Graphic을 이용한 특수효과에 관한 연구

이채훈 ( Chae Hoon Lee ),정진헌 ( Jean Hun Chung ) 한국영상미디어협회 2006 예술과 미디어 Vol.5 No.1

컴퓨터 하드웨어와 소프트웨어의 급속한 발전으로 영화영상 제작에 사용되는 특수효과도 엄청난 발전을 이루었고 그에 따라 과거에는 독립적으로 아주 특별한 부분에만 쓰이던 특수효과 영화의 전반적인 부분에 포괄적으로 사용되는가 하면 몇 가지 효과와 컴퓨터 그래픽이 합쳐져서 또 더 훌륭한 효과를 얻어내기 에 이르렀다. 최근에 개봉되었던 수많은 영화들 중 특수효과를 사용하지 않은 영화는 거의 없을 정도로 현대는 특수효과 의 절정기라고 해도 과언 이 아니다. 컴퓨터 그래픽을 사용한 특수효과는 그 시대의 최첨단 기술의 집합체 이고 미래를 바라보는 창이다. 이제 영화에 있어 특수 효과는 선택이 아닌 필수이며 차별화된 영상을 위한 가장 중요한 요소가 되었다. Due to Rapid development of the com-puter hardware and software, the special effects to be used at a movie image man-ufacture consisted great development. And the special effects independently at the past according to him which is used in quite special part. Used inclusively at general part of the movie a some branch effectiveness and A computer graphic came to add and reached because we got more great effectiveness, Does not exist almost not to use the special effectiveness of the special effectiveness Among lots of movies to be opened recently. Modem stage is the summit of the special effects. This the special effectiveness to use a computer graphic the aggregate of "spearhead technique of his period and The window to watch the future. The special effectiveness now in the movie is the mandatory not to be the selection and became most important element for the image which is drawn a distinction.

감염부위의 항균제 침투를 고려한 항균제 감수성 검사의 해석

이채훈 ( Chae Hoon Lee ),조희순 ( Hee Soon Cho ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

Background:It is important to select appropriate antimicrobials for the treatment of infection according to the results of antibiotic susceptibility test(AST). AST interprets as susceptible, resistant or intermediate on the base of breakpoints of Clinical and Laboratory Standard Institute(CLSI), but do not take into account the antimicrobial concentrations of variable tissues. As different tissues have different distributions of antimicrobials, it is necessary to interpret AST according to the tissue concentration. Thereby we intend to evaluate the usefulness of interpretation of antimicrobial susceptibility depending on tissue distribution of antimicrobials. 1) Materials and Methods:Gram negative bacilli that isolated from clinical specimens in Yeungnam University Hospital from August to September, 2007 were evaluated retrospectively. The data of blood concentration and tissue distribution of antibiotics with variable administration route and dosage were collected and arranged in the forms of previous reported data and regarded as resistant if minimal inhibitory concentration (MIC) is higher than the expected concentration of each tissues. Results:Among the data reported as susceptible, aztreonam, imipenem and ciprofloxacin were relatively good relationship with AST. But, ampicillin, ticarcillin, cefazolin and cefotaxime of sputum or bronchial secretion were less effective with high MIC of organism. Gentamicin and amikacin also were shown as less effective in respiratory tissues and wound with high MIC of oganism. Conclusion:As different tissues have different antimicrobial concentrations for identical antimicrobial, more informations on antimicrobial tissue distribution is needed for appropriate treatment in infection. Reporting of MIC should be considered for selection of antimicrobials rather than AST with breakpoints. Therefore interpretation of AST considering tissue concentration is more helpful for prevention of major error and control of infection.

당귀념통탕(當歸拈痛湯)이 Collagen유발(誘發) 관절염(關節炎)에 미치는 영향(影響)

이채훈 ( Chae Hoon Lee ),이인선 ( In Seon Lee ) 대한한의학회 한방재활의학과학회 2001 한방재활의학과학회지 Vol.11 No.3

Efficacy of Self-manipulation Technique in the Treatment of Patients with Anterior Disc Displacement without Reduction

김주식,이채훈,김영구,Kim, Ju-Sik,Lee, Chae-Hoon,Kim, Young-Ku Korean Academy of Orofacial Pain and Oral Medicine 2007 Journal of Oral Medicine and Pain Vol.32 No.4

Internal derangement of the temporomandibular joint(TMJ) is defined as an abnormal relationship of the articular disc to the condyle. Mandibular manipulation is one of the conservative treatments to be considered first to manage the patients with anterior disc displacement without reduction. Mandibular manipulation is used to increase articular mobility and to restore the displaced disc into an anatomically normal position. While Farrar's technique has been popularly used, Minagi et al., Mongini and Suarez introduced the manipulation technique conducted by the patients themselves. But there is no study on the efficacy of self-manipulation technique, comparing with conventional one. The aim of this study was to investigate the efficacy of the conventional and self-manipulation technique, which was modified to complement the previously described technique by Minagi et al., in the treatment of patients with anterior disc displacement without reduction. TMD patients, who visited Department of Oral Medicine of Seoul National University Dental Hospital from December, 2002 to November, 2004 and were diagnosed as anterior disc displacement without reduction by TMJ magnetic resonance imaging (MRI) were enrolled. Conservative treatments including physical therapy, exercise, behavioral therapy, stabilization splint therapy, and manipulation therapy were done to every single patient until the symptomsimproved enough to discharge the patient. The charts were reviewed retrospectively according to the type of manipulation. In the results, patients whose maximum mouth opening was more than 40 mm was higher in the self-manipulation group(69.9%) than in the conventional manipulation group(42.9%). But difference between two groups was not significant. According to the fact that we decided to discharge the patients whentheir mouth opening increased to more than 40 mm and subjective symptoms such as pain and discomfort were improved as well, treatment period of discharged patients was significantly shorter in the self-manipulation group($29.2{\pm}12.3$ weeks) than in the conventional manipulation group ($61.0{\pm}38.0$ weeks) (p<0.01). In conclusion, in the treatment of TMD patients with anterior disc displacement without reduction, the self-manipulation technique which is performed by patients themselves is an effective treatment modality for increasing the range of mouth opening and shortening the total treatment period.

영남대학교병원에서 동정된 비예기 항체의 빈도 및 분포: 2002년 1월에서 2006년 12월까지 최근 5년간의 경험

조희순 ( Hee Soon Cho ),이채훈 ( Chae Hoon Lee ),김경동 ( Kyung Dong Kim ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

Background:Unexpected antibodies can cause hemolytic transfusion reaction or decrease the survival of transfused red blood cells. Type and screen is recommended for efficient transfusion, so we perform antibody screening test for pre-transfusion test. In this study, we investigated the frequency and distribution of unexpected antibodies at Yeungnam University Hospital during recent 5 years. 1) Methods:We analyzed the results of 28,944 antibody screening test that were performed for preparation of packed red cells from 2002 to 2006. Screening and identification of unexpected antibodies were carried out using a column agglutination method with the DiaMed ID system. Results:Unexpected antibodies were detected from 234 samples (0.84%) out of 28,944 samples. After exclusion of samples from same patients, 185 patients had unexpected antibodies. Identification of unexpected antibodies were performed from 108 patients. Antibody that was detected most frequently was anti-E (36.1%), followed by anti-C and anti-Lea (6.5%), anti-c (4.6%), anti-D (3.7%), anti-Jkb (3.0%), anti-Jka, anti-S, anti-Xga (1.9%), anti-e, anti-Fya, anti-M, anti-Jsa and anti-Lub (0.9%). 15 patients (13.9%) had autoantibodies and 20 cases (18.5%) could not be identified by LISS/Coombs method. Conclusion:The frequency of unexpected antibodies at our hospital was 0.84%, and the most identified unexpected antibodies were clinically significant. Therefore, antibody screening and identification tests are critical step in pre-transfusion test.

Ti-6AI-4V 고강도 볼트 성형 기술 개발

김정한(Jeoung Han Kim),이채훈(Chae Hoon Lee),홍재근(Jae Keun Hong),김재호(Jae Ho Kim),염종택(Jong Taek Yeom) 한국소성가공학회 2008 한국소성가공학회 학술대회 논문집 Vol.2008 No.10

Ramjet 고속 추진체용 Alloy 718 합금 노즐 단조품 개발

박노광,김정한,김남용,이채훈,염종택,홍재근,백동규,최성규,Park, Nho-Kwang,Kim, Jeoung-Han,Kim, Nam-Yong,Lee, Chae-Hoon,Yeom, Jong-Taek,Hong, Jae-Keun,Baek, Dong-Kyu,Choi, Sung-Gyu 한국군사과학기술학회 2008 한국군사과학기술학회지 Vol.11 No.4

Alloy 718 nozzle component was manufactured by hot forging and electron beam welding process. In this process, 718 billets produced in domestic company were used and evaluated. Before performing industrial scale hot forging, small size hot compression tests were carried out under various process conditions and then microstructural evaluations were analyzed. Using the results, FEM simulations were performed in order to optimize the hot working process. After hot working, forged work-pieces were machined and welded by electron beam. Final nozzle components were heat treated and their microstructure and mechanical properties were investigated.

건강한 한국인 성인의 혈청 갑상선호르몬 참고치

장윤영,김창윤,황태윤,김경동,이채훈,Jang, Yoon-Young,Kim, Chang-Yoon,Hwang, Tae-Yoon,Kim, Kyung-Dong,Lee, Chae-Hoon 대한예방의학회 2008 예방의학회지 Vol.41 No.2

Objectives : This study was conducted to determine the reference interval of serum thyroid hormones(TSH, $FT_3$, $FT_4$) in healthy Korean adults. Methods : Health examination data from 1,591 healthy Korean adults who visited an university hospital were analyzed. Patients with specific health conditions capable of altering laboratory results were excluded from the study. Serum thyroid hormones were measured using IMMULITE 2000 (DPC, USA, 2002). Subjects were 18-65 years old; 911 were male, and 690 were female. Results : The arithmetic means of TSH, $FT_3$, and $FT_4$ values for male subjects were $1.28{\pm}1.84\;{\mu}IU/ml$, $3.23{\pm}0.57\;pg/ml$, and $1.42{\pm}0.22\;ng/dl$, respectively. In female subjects, the arithmetic means of TSH, FT3, and FT4 values were $1.49{\pm}2.08\;{\mu}IU/ml$, $3.08{\pm}0.54\;pg/ml$, and $1.29{\pm}0.24\;ng/dl$, respectively. The arithmetic mean $FT_4$ value for males decreased with age (p<0.01). The arithmetic mean $FT_3$ value for females increased with age (p<0.01). The arithmetic mean thyroid hormone values of all study subjects differed significantly based on season. The arithmetic mean of male $FT_4$ decreased with increasing BMI (p<0.01). The arithmetic mean of female $FT_3$ increased with increasing BMI (p<0.01). The reference intervals recommended by the IMMULITE 2000 manufacturer are $0.40-4.00\;{\mu}IU/ml$ for TSH, 1.80-4.20 pg/ml for $FT_3$, and 0.80-1.90 ng/dl for $FT_4$ (same values for both genders). Conclusions : There was a significant difference in the interval of thyroid hormones between males and females, but the reference interval of IMMULITE 2000 was not established by gender. There is a need to reestablish the reference interval for thyroid hormones in Korean healthy adults.