진행성 대장직장암 환자군에 있어서 5-FU 혹은 capecitabine의 최적 시간 치료법에 대한 체계적 고찰 : 메타분석

이지영,오혜경,류한성,윤성우,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Yoon, Seong Woo 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.1

Background : The purpose of this study is to investigate the efficacy and safety of the circadian delivery schedule of fluorouracil or capecitabine based chemotherapy for advanced colorectal cancer. Patients and methods : A meta-analysis was performed using individual data from eight international randomized clinical trials, especially phase II or III trials, comparing 5-fluorouracil, or capeticabine in chronomodulated or conventional schedule. The data from 8 studies was composed of 692 patients receiving chronomodulated chemotheray and 684 patients receiving conventional chemotherapy. The main end point was response rate. Results : Response rate was insignificantly different from each group (RR 1.14, 95%CI 0.74-1.74, p=0.55). Overall survival and progresseion-free survival were not significant either. Chemotherapy induced anemia, diarrhea, and nausea/vomiting were worse in the chronotherapy group, with statistic significance respectively. On the other hand, chemotherapy induced thrombocytopenia, stomatitis, peripheral neuropathy, and dermatotoxicity were better but they were not statistically significant results. Conclusions : Patients lived longer but not significantly on chronomodulated chemotherapy rather than on conventional chemotherapy. Patients on chronomodulated chemotherapy experienced adverse events more. The chronomodulated chemotherapy schedule needs adjustment of its delivery schedule and further research is required.

해암단이 수종의 암세포에 미치는 항암 효과

이지영,오혜경,류한성,김남재,정원용,오현아,최혁재,윤성우,류봉하,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Kim, Nam Jae,Jung, Won-Yong,Oh, Hyun-A,Choi, Hyuck Jai,Yoon, Seong Woo,Ryu, Bong-Ha 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Objective : The objective of this study was to investigate the anti-tumor activity of the complexed herbal formula, Haeamdan (HAD). Methods : Seven Cancer cell lines, LoVo, MCF-7, AGS, Sarcoma 180, HL-60, NCI-H69, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. HAD was applied with various concentrations from 0.1 to 1.0 mg/ml to figure out the appropriate dosage. ICR male mice were intraperitoneally implanted with Sarcoma 180 and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with HAD 1g/kg. Results : Among seven cancer cell lines, HAD exhibited strong cytotoxic activities to followed four cancer cell lines, that is, Sarcoma 180, HL-60, NCI-H69, and LL/2. These cytotoxic activity was expressed under 0.50 mg/ml of IC50 under 0.1~1mg/ml of OBW. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the HAD, HAD prolonged the median overall survival for 3.6 days, from 17.5 to 21.1 days. Conclusion : HAD showed strong cytotoxicity to the cancer cells, Sarcoma 180, HL-60, NCI-H69, on in vitro study and it showed anti-tumor activity in vivo with the peritoneal cancer mice by prolonging the median survival for 3.6 days. Further researches would be expected to support the anti-tumor efficacy of HAD.

점토와 전기로 제강분진의 콜로이드/계면 특성 분석

이지영,이기강,김유택,강승구,김정환,Lee, Jee-Young,Lee, Ki-Gang,Kim, Yoo-Taek,Kang, Seung-Gu,Kim, Jung-Hwan 한국결정성장학회 2006 韓國結晶成長學會誌 Vol.16 No.2

중금속 이온의 용출거동은 콜로이드/계면 성질에 의존하는데, 이를 알아보기 위해 ICP와 SEM 분석을 하였다. 전기로 제강분진에 포함된 중금속은 '양쪽성 금속'으로 pH 10에서 중금속이 가장 적게 용출되는 것을 알 수 있었고 pH 8보다 pH 12에서 중금속 이온이 상당량 용출되어 나왔다. 그리고 전기로 제강분진에 점토를 첨가함으로써 중금속 이온의 용출이 감소하는 것을 알 수 있었다. 특히 pH 12의 경우에 pH 8에 비해서 중금속 이온의 용출이 큰 폭으로 감소하였으며 콜로이드계면 성질 관찰 결과, 점토의 경우 pH 12에서 점토에서 녹아나온 Si 수화물이 점토 입자표면을 둘러싸고 있음을 관찰할 수 있었다. 전기로 제강분진과 점토의 혼합 슬러리에서 pH 8의 경우보다 pH 12에서 중금속 이온의 농도가 크게 감소한 것은 PSHP의 형성에 의한 것으로 사료된다. The leaching behavior of heavy metal ions with pH and colloid/interface property was analyzed by ICP and SEM. The heavy metals in EAF dust are 'amphoteric metal' and the heavy metal ions leached a little at pH 10. And the leaching concentrations of heavy metals at pH 12 were higher than the that at pH 8. The leaching concentrations of heavy metal ion were decreased with adding the clay to the EAF dust. Especially, the leaching concentrations of heavy metal ion were effectively decreased at pH 12. The observation of colloid/interface properties shows that the soluble silicon hydroxide from clay at pH 12 was precipitated at the surface of the heavy metal and clay particles. This silicon hydroxide precipitates were named the PSHP. The leaching concentrations of heavy metal ion were effectively decreased by the formation of PSHP when adding the clay to the EAF dust and controlling the pH of the slurry at 12.

EAF 더스트-점토계의 중금속 용출 및 안정화에 미치는 pH의 영향

이지영,이기강,김유택,강승구,김정환,Lee, Jee-Young,Lee, Ki-Gang,Kim, Yoo-Taek,Kang, Seung-Gu,Kim, Jung-Hwan 한국결정성장학회 2006 韓國結晶成長學會誌 Vol.16 No.2

유해한 중금속을 다량 함유하는 EAF(electric arc furnace) 더스트를 세라믹 원료로 재활용하기 위해서 EAF 더스트, EAF 더스트-점토에 대해서 pH와 혼합비에 따른 중금속 용출농도의 변화를 분석하였다. 소성과정 중에서 발생하는 중금속의 휘발량을 소지 내의 중금속 이온의 총량을 측정하여 평가하였으며 TCLP(toxicity characteristic leaching procedure)분석을 통해 중금속 이온의 안정화 정도를 평가하였다. EAF 더스트-점토 슬러리의 pH를 10으로 조절하였을 경우에 습식혼합 여액중의 중금속 이온의 농도가 가장 낮은 값을 가졌다. pH 10의 슬러리에 대해서 혼합비와 소성온도에 따른 소지내 중금속 이온의 총량을 측정한 결과 소성온도와 EAF 더스트의 함량이 증가할수록 중금속의 휘발이 증가하였으며, 점토의 혼합비가 증가할수록 중금속 이온의 휘발이 억제되었다. TCLP 분석결과 점토의 혼합비와 소성온도가 증가할수록 중금속의 용출은 감소하였으며 중금속의 용출농도는 기준치 이하로 안정화되었음을 확인할 수 있었다. To recycle the electric arc furnace (EAF) dust as a ceramic raw materials, the leaching concentrations of heavy metals (Zn, Pb, Cr, Cd) were analysed with various pH and mixing ratios for EAF dust and EAF dust-clay mixtures. The evaporation amounts of the some heavy metals were evaluated by measuring their total concentrations in the sintered bodies of EAF dust-clay mixtures with various mixing ratio and sintering temperature. Toxicity characteristic leaching procedure (TCLP) test was conducted for evaluating the chemical stabilities of the heavy metal elements. Leaching concentrations of heavy metal ions shows minimum leaching concentration at the pH 10. Evaporation amount of heavy metals in the sintered bodies were evaluated for the mixtures of pH 10 depenidng on mixing ratio and sintering temperature. Evaporation of heavy metal components were increased with increasing the sintering temperature and contents of the EAF dust. The evaporation of the heavy metal components in EAF dust was effectively suppressed by increasing the clay content. The leaching concentrations of heavy metal components were decreased with increasing clay content and temperature.

개 심장사상충 추출액 투여에 의한 Anaphylactoid Reaction

이지영,송근호,권현주,김명철,윤효인,김덕환,Lee, Jee-young,Song, Kun-ho,Kwon, Hyun-ju,Kim, Myung-cheol,Yun, Hyo-in,Kim, Duek-hwan 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.3

This study was performed to clarify the induction possibility of anaphylactoid reactions by the administration with the heartworm extracts, and, if any, to elucidate different virulences in terms of the protein concentrdtions and sexes of Dirofilaria immitis. Twenty three clinically healthy D. immitis-free adult dogs were used in the present study. The experimental animals were divided into 5 groups. Group A (5 heads) was administered with an female heartworm extract containing 0.1 g/dl protein concentration. Group B (4 heads) was administered with an male heartworm extract containing 0.1g/dl protein concentration. Group C (5 heads) was administered with an female heartworm extract containing 0.2 g/dl protein concentration. Group D (4 heads) was administered with an male heartworm extract containing 0.2 g/dl protein concentration. Group E (5 heads) was administered with an female heartworm extract containing 0.4 g/dl protein concentration. The changes of clinical symptoms and vital signs (body temperature, heart rate and respiration rate) were examined before and 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours and 24 hours after injection with the extracts, respectively. In addition, the changes of hematological values (RBC, PCV and total leukocytes counts), serum chemical values (ALP and CK) were determined. It was considered that heartworm extract could induce anaphylactoid reaction and adult female heartworm extract was more affective than those of adult male heartworm extract in the changes of clinical symptoms, vital signs, hematological values and serum chemical values.

온백원이 암세포에 미치는 항암활성 효과

이지영,오혜경,류한성,김남재,정원용,오현아,최혁재,윤성우,류봉하,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Kim, Nam Jae,Jung, Won-Yong,Oh, Hyun-A,Choi, Hyuck Jai,Yoon, Seong Woo,Ryu, Bong-Ha 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Objective : The objective of this study was to investigate the experimental efficacy of anti-tumor activity of the complexed herbal formula, Onbaekwon (OBW), which was derived from the literature of Traditional Korean Medicine, Dongeuibogam. Methods : Nine Cancer cell lines, LoVo, MCF-7, HepG2, AGS, A549, NCI-H69, HL-60, Sarcoma 180, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. Four of them, NCI-H69, HL-60, Sarcoma 180, and LL/2, showed strong cytotoxic activities and they were additionally undergone flow cytometry to find out their effects on apoptosis. ICR male mice were implanted with Sarcoma 180 intraperitoneally and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with OBW 1 g/kg. Results : Among 9 cancer cell lines, NCI-H69, HL-60, Sarcoma 180, and LL/2, expressed less than 0.10 mg/ml of $IC_{50}$ under 0.1~1mg/ml of OBW. NCI-H69, HL-60, Sarcoma 180, and LL/2, showed dose-dependent efficacy of apoptosis. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the OBW, they prolonged the median overall survival for 0.8 days, from 17.5 to 18.3. Conclusion : OBW showed strong cytotoxicity to some cancer cells, which are NCI-H69, HL-60, Sarcoma 180, and LL/2, and its apoptotic activity was dose-dependent. OBW prolonged the median survival of mice implanted with Sarcoma 180. Further researches would be expected to support the efficacy of OBW.

간호대학생의 MBTI 성격유형과 자기효능감 및 스트레스 대처방식

이지영(Jee Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

본 연구는 간호대학생의 MBTI 성격유형을 4가지 선호지표로 나누어 각각의 선호경향에 따른 자기효능감과 스트레스 대처방식간의 차이를 규명하고, 스트레스 대처방식에 미치는 영향을 탐색하기 위해 수행되었다. 연구도구는 한국형 MBTI 성격유형검사와 자기효능감, 스트레스 대처방식 측정도구를 이용하였으며, 총 135부의 자료를 기술통계와 t검정, 다중회귀분석을 이용하여 분석하였다. 간호대학생의 MBTI 선호지표에 따른 자기효능감의 차이에서는 외향형이 내향형보다 사회적 자기효능감과 일반적 자기효능감이 모두 높았고, 사고형이 감정형보다 일반적 자기효능감이 높은 것으로 나타났다. MBTI 선호지표에 따른 스트레스 대처방식의 차이에서는 외향형이 내향형보다 사회적 지지추구 대처와 능동적 문제해결 대처에서 모두 높아 문제중심 대처를 많이 하는 것으로 나타났고, 사고형과 판단형도 감각형과 인식형보다 능동적 문제해결 대처를 더 많이 사용하는 것으로 나타났다. 한편 내향형은 외향형보다 소망적 사고대처가 높고, 감정형은 사고형보다 소망적 사고대처와 정서적 완화대처에서 모두 높아 정서중심 대처를 많이 하는 것으로 나타났다. 간호대학생의 스트레스 대처방식에 대한 MBTI 선호성과 자기효능감의 설명력은 능동적 문제해결 대처에서 가장 높았고(30.6%), 판단형 선호성과 일반적 자기효능감이 능동적 문제해결 대처의 유의한 예측요인으로 나타났으며, 사회적 자기효능감이 사회적 지지추구 대처의 예측요인이며, 내향형 선호성이 소망적 사고 대처의 예측요인인 것과 감정형 선호성이 정서적 완화 대처의 유의한 예측요인임이 각각 밝혀졌다. 본 연구는 간호대학생의 개인적 특성인 성격유형 및 자기효능감이 스트레스 대처방식에 미치는 영향력에 대한 의미있는 결과를 제공함으로써 스트레스 관리 및 중재프로그램 개발과 연구의 기초자료로 활용할 수 있다는 데 그 의의가 있다. The purpose of this study was to identify the influences of MBTI preference and self-efficacy on ways of coping in Nursing Students. A descriptive survey study conducted visit-surveys with questionnaires and sampled 135 female nursing students in Seoul, Daejeon, and Chungnam. Korean version of MBTI (Myers-Briggs Type Indicator), Self- efficacy scale, and Ways of coping checklist was used. Data was analyzed by t-test, and multiple regression analysis using SPSS/WIN 12.0. The results of this study are following. The degree of self-efficacy according to personality preference were significantly different in Extroversion and Thinking preference. And the degree of problem-focused coping according to personality preference were significantly different in Extroversion, Thinking and Judgement preference. On the other hand, In the emotion-focused coping, Introversion and Feeling preference was significantly different. Multi regression analysis showed Judgement preference and self-efficacy significantly influenced problem-focused coping and Introversion and Feeling preference significantly influenced emotion-focused coping. The findings suggest that health professionals, while developing and providing the stress management program need to be aware of the personality type and self-efficacy and ways of coping in nursing students. (Korean J Str Res 2010;18:219∼227)

일반 논문 : 인쇄 광고 표제 표현의 형식과 기능 연구 -교육 광고 표제 표현을 중심으로-

이지영 ( Jee Young Lee ) 한국어교육학회(구 한국국어교육연구학회) 2011 국어교육 Vol.0 No.135

The purpose of this study is to analyze printed advertising language. For this purpose, this study examine the types of form and function of headline in printed advertising language. The form of headline in printed advertising language has been classified into phrases and clauses form, sentence form, discourse form. Sentence form divided into five types. Discourse form classify into quotation and explanation, explanation and quotation, opinion versus opinion, question and answer, question and explanation. The function of headline in printed advertising language has been classified question function, request function, wish function, explain function, greeting function, time limitation function, compensation offer function, interesting function, discourse start function.

숲가꾸기 산물의 최적용도 개발을 위한 연구 (제2보)

이지영(Jee-Young Lee),김철환(Chul-Hwan Kim),박현진(Hyun-Jin Park),김성호(Sung-Ho Kim),김경철(Gyung-Chul Kim),M.I. Sheikh,조후승(Hu-Seung Cho),심성웅(Sung-Woong Shim),이영민(Young-Min Lee),안병일(Byung-il Ahn) 한국펄프·종이공학회 2012 펄프.종이기술 Vol.44 No.6

키워드 네트워크 분석을 통한 가족 및 부부상담 영역의 최근 연구경향

이지영(Lee, Jee-Young),천성문(Cheon, Seong-Moon) 한국부부가족상담연구학회 2020 부부가족상담연구 Vol.1 No.2

본 연구는 키워드 네트워크 분석을 통하여 가족 및 부부상담 영역에 있어서의 연구 동향을 살펴보는 데 목적이 있다. 이를 위해 한국교육학술정보원의 데이터베이스를 활용하여 2015년-2020년에 발표된 235편의 논문을 분석대상으로 선정하였다. Textom과 UCINET을 활용하여 단어출현빈도를 분석하고 네트워크를 시각화하였다. 연구 동향을 살펴보기 위하여 전반적인 추이 분석을 위한 빈도 분석과 전체 네트워크의 구조적 속성, 중심성 분석, 구조적 등위성 분석을 적용하였다. 연구 결과는 다음과 같다. 첫째, 연구의 전반적인 추이 분석 결과, 최근 6년 동안 가족 및 부부상담 영역의 연구가 감소하고 있음을 확인하였다. 연구방법별 추이는 문헌연구의 경우 점차 덜 사용되고 있으며, 최근에는 학술지논문에서 질적연구가 학위논문에서 혼합연구가 각각 비율이 높아지고 있음을 확인하였다. 연구주제별 추이는 가족 및 부부상담에 대한 주요 개념과 모델을 주제로 하는 연구가 꾸준히 발표되고 있으며, 가족 및 부부가 경험한 문제 상황이나 특수 대상을 주제로 한 연구가 학술지논문을 통해서 다수 발표되고 있음을 확인하였다. 둘째, 키워드 간 평균 연결정도와 연결선 간 평균거리를 살펴보았을 때 대부분의 키워드들이 서로 연결되어 있는 것으로 나타나 연구 변인들 간의 연관성이 높고 주요 주제 간의 연결성과 맥락 등이 유사한 것으로 확인되었다. 셋째, 유사성 집단을 확인하기 위한 CONCOR 분석 결과 가족 및 부부상담 영역에서 이루어진 연구는 주로 가족치료기법, 부부, 소통과 갈등, 위기 및 극복, 부부 상담 프로그램 등의 범주 내에서 이루어지는 것으로 확인되었다. 가족 및 부부상담 영역의 연구 경향성에 나타난 이와 같은 특징들이 후속 연구의 방향성을 제시하는 기초자료로 활용될 수 있을 것으로 기대한다. The purpose of this study is to examine the research trends in the family and couple counseling area through keyword network analysis. For this purpose, using the database of the Research Information Sharing Service, 235 papers published in 2015-2020 were selected for analysis. The key words were selected using Textom and UCINET 6 s NetDraw program, the frequency of word occurrence was analyzed and visualized. In order to examine the research trend, frequency analysis, structural characteristic analysis, structural equivalence analysis, entire network, and centrality analysis were applied. The major findings are briefly presented as follows. First, in the last 6 years, studies in the field of family and couple counseling have decreased. As a result of analyzing the trend in research methods, literature research is gradually decreasing. And in recent years, qualitative research methods are increasing in journal papers, and mixed research methods are increasing in degree thesis. As for the research subject, research on the concept and model of family and marital counseling have been steadily published. And on the subject of Special group, problem situations experienced by families and couples were also being published through journal articles. Secondly, analyzing the average degree of connection between keywords and the average distance between connection lines, most of the keywords were connected to each other. This means that the relationship between the research variables is high, and the connection and context between the main topics are similar. Thirdly, the results of CONCOR analysis to confirm the similarity group are as follows. Research conducted in the area of ​​family and couple counseling which was confirmed to be conducted within the categories of family therapy techniques, couples, communication and conflict, crisis and overcoming, and couple counseling programs. Therefore, this study is expected to be used as a basic data to suggest the direction of subsequent research in areas of ​​family and couple counseling.