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Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells
이준혁 ( Jun Hyuk Lee ),강경화 ( Gyung Hwa Kang ),김경철 ( Kyung Chul Kim ),김경미 ( Kyoung Mi Kim ),박동일 ( Dong Il Park ),최병태 ( Byung Tae Choi ),강호성 ( Ho Sung Kang ),이용태 ( Yong Tae Lee ),최영현 ( Yung Hyun Choi ) 동의대학교 한의학연구소 2002 동의한의연구 Vol.6 No.-
결직장암에서 CD44v6단백질 발현과 예후 관련 인자와의 관계
김종우,정은미,황성규,이준성,홍성표,박필원,오도연,홍창권,김경철,임규성,오성욱,안희정 대한소화기학회 2000 대한소화기학회지 Vol.36 No.6
Background/Aims: CD44 is a cell surface molecule which is divided into CD44s and CD44v subsets. The relationship between th expressions of CD44 variant and progression of colorectal carcinoma has not been defined. The aims of this study were to analyze the expressions of CD44s and CD44v6 in colorectal adenoma and colorectal carcinoma by immunohistochemical methods and to evaluate the relationship between their expressions and various clinicopathological prognostic factors. Methods: We evaluated retrospectively the records of 20 cases of colorectal adenoma and 56 cases of colorectal carcinoma. The expressions of CD44s and CD44v6 were investigated by immunohistochemical staining. Results: CD44s was expressed in all cases of adenoma and in 86% of colorectal carcinoma (p$gt;0.05). The expression rates of CD44v6 were 20% in colorectal adenoma and 80% in colorectal carcinoma (p$lt;0.01). In colorectal carcinoma, the expression of CD44s showed no significant relationship with various prognostic factors, but the expression rate of CD44v6 was significantly increased according to histologic grade. There was no significant difference in the expression rate of CD44v6 according to the stage of the disease and tumor invasion. Conclusions: In colorectal carcinoma, CD44v6 expression was significantly increased in relation with histologic grade and lymph node metastasis. These results suggested that CD44v6 could be useful as a marker of tumor progression and metastasis, but further study is needed.
원위부 대장 선종의 특성에 따른 근위부 대장 선종 빈도에 대한 연구
이준성,황성규,홍성표,박필원,홍창권,권창일,김경철,임규성 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.3
Background/Aims: The aim of this study was to examine the incidence of proximal colon adenoma according to characteristics of distal colon adenoma. Methods: Ninety-two colon adenoma patients who underwent total colonoscopy and endoscopic polypectomy were analyzed retrospectively. Adenoma was classified as proximal when located in proximal to splenic flexure. The advanced adenoma was defined as an adenoma larger than 10 mm or any size with a villous component or severe dysplasia. Results: The incidence of proximal adenoma was increased significantly in those with old age (odds ratio (OR)=3.3), villous (OR=5.3) or dysplastic histology (OR=8.1) or the presence of advanced distal adenoma (OR=3.4). However, the incidence of advanced proximal adenoma was increased only in those with old age (OR=11.2). Nineteen in thirty-nine (48.7%) patients with proximal colon adenoma did not have distal colon adenoma, Conclusions: Various characteristics of distal colon adenoma couldn't exactly predict the presence of synchronous proximal adenoma and a greater percentage of subjects with proximal adenoma didn't have distal adenoma. So, colonoscopy could be a standard method for colon cancer screening in Korea.