익상편조직의 섬유모세포에 미치는 사이클로스포린의 영향

이종수,이승욱,이상준,김나미,Jong Soo Lee,Seung Wook Lee,Sang Jun Lee,Na Mi Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.3

Purpose: To evaluate the response and cellular damage of cultured human pterygial cells according to the concentration and exposure time of topical cyclosporin. Methods: Human pterygial cells were exposed to a cyclosporin A concentrations of 0.1 μg/ml (0.0001%), 1 μg/ml (0.0001%), 10 μg/ml (0.001%), 100 μg/ml (0.01%), or 500 μg/ml (0.05%) for 5 or 10 minutes. An MTT-based colorimetric assay was performed to assess the metabolic activity of cellular proliferation, and a lactate dehydrogenase (LDH) leakage assay was used to determine cellular damage. The extra-cellular matrix of PIP, laminin and MMP were evaluated, and the measurement of pro-inflammatory cytokine, TNF-α and IL-1b. IL-6, IL-8 was performed using ELISA kits. Results: The pterygial cellular inhibitory effect of cyclosporin was similar to that of the control according to the concentration and exposure time (p > 0.05). Compared with the control, the level of LDH did not show a statistically significant difference between concentration and exposure time (p > 0.05). There was no significant difference of inhibitory effects by PIP, laminin, or MMP between the experimental and control groups (p > 0.05). The production of TNF-α and IL from the experimental pterygial cells due to the effect of cyclosporin was not significantly different from that of the control at a longer exposure time or stronger concentration (p > 0.05). Conclusions: The response of pterygial cells to topical cyclosporin A at concentrations less than 0.05% for less than 10 minutes of exposure time showed no prevention of pterygial recurrence. With regard to cellular damage, little effects on inhibition of PIP, laminin, MMP, IL, and TNF-α were observed compared with that of the control. J Korean Ophthalmol Soc 2012;53(3):466-472

정상 및 원추각막에서 각막 전, 후면의 융기 및 시상면만곡도의 비교분석

이종수,이승욱,이승민,이미현,Jong Soo Lee,Seung Wook Lee,Seung Min Lee,Mi Hyun Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.10

Purpose: To compare changes of anterior and posterior corneal elevation, and sagittal curvature according to the severity of keratoconus and to compare differences between keratoconus and normal cornea. Methods: A total of 81 eyes diagnosed with keratoconus and 20 eyes of normal subjects were evaluated with a Pentacam Scheimpflug camera. The keratoconus eyes were divided into 3 groups according to mean keratometer (K): mild (K ≤ 47.0 diopters (D)), moderate (47.0 to 52.0 D), and severe (52.0 D≥). The following parameters were obtained to evaluate the correlation of keratoconus: corneal thickness, anterior and posterior corneal elevation, and sagittal curvature. Results: Out of 81 keratoconus eyes, 56 eyes were mild, 12 eyes were moderate, and 13 eyes were severe keratoconus. The mean central corneal keratometer, anterior and posterior corneal elevation, and sagittal curvature of the keratoconus eyes were 49.7 D, 22.07 μm, 38.16 μm, 52.76 D and the values increased statistically compared to the normal eyes. Furthermore, the values increased significantly with the severity of keratoconus. ROC curve analysis showed the estimated meaningful value for anterior and posterior corneal elevation and sagittal curvature of keratoconus for diagnosis; there were no diagnostic values for corneal thickness and refractive power. Conclusions: The index of 5.5 μm for mean anterior elevation, 12.5 μm for mean posterior elevation, and 44.5 μm for mean sagittal curvature using the PentacamⓇ are useful to diagnose keratoconus. Variation of anterior and posterior elevation, and sagittal curvature measured by PentacamⓇ are useful in understanding the process of keratoconus. J Korean Ophthalmol Soc 2012;53(10):1432-1437

출연연 성과급 집단중심의 인센티브제도로 개선해야

이종수,Lee, Jong-Su 한국과학기술단체총연합회 2005 과학과 기술 Vol.38 No.6

공무원의 전문성 향상방안으로서 경력개발제도(CDP)에 관한 연구 : CDP의 시각에서 분석한 한국 인사행정체계의 문제점과 개선방안

이종수 한국행정연구원 2002 韓國行政硏究 Vol.11 No.4

인사행정의 본질적 과제 가운데 조직의 수요와 개인의 욕구를 결합시키는 역할이 중요성을 더해가고 있다. 이를 위해 최근 각 국 정부는 경력개발제도(CDP)를 주목하고 있으며, 한국의 중앙인사위원회도 2002년 대통령에게 경력개발제도의 도입검토를 보고한 바 있다. 본 연구에서는 최근 정부의 인력관리에 적용가능성이 타진되고 있는 경력개발제도의 개념을 소개하고, 공무원들의 이에 관련된 인식을 분석하며, 나아가 경력개발제도의 적용을 위한 개선과제를 검토하여 보았다. 이를 위해 연구방법으로 문헌연구와 설문조사, 심층면접, 브레인스토밍(Brain Storming)방법을 병행하였다. 분석 결과, 한국의 공무원 인사행정 체계에서 나타나는 계급제적 채용제도, 직위분류제도의 미정착이 경력개발제도의 요소를 필요로 하는 기본배경이 되고있다. 조직문화와 순환보직제도, 짧은 보직기간, 직무수행을 위한 know-how의 취득원과 교육훈련의 불일치 등은 경력개발을 통한 전문성 제고를 저해하는 요소로 분석되었다. 결론적으로, 경력개발제도는 한국 공무원의 전문성 제고와 직무수행 역량의 향상을 위한 다양한 쟁점을 제기하고 있고, 발전방안을 시사하고 있다. The findings suggest a modification to the current uni-dimensional approach to study organizational culture. Public personnel administration has been subjected to virtually uninterrupted wave of reforms under the legacy of New Public Management. It has been the key area of governmental reforms during the past two decades. Many efforts were made to initiate structural changes also in Korea. However. since the feature of traditional class system prevails in the human resource management of the Korean government, it is difficult to achieve the utmost cfficiency. This paper examines major issues of public personnel administration in Korea, particularly form the viewpoint of CDRCareer Development Program). The purpose of this paper is threefold. First, the notion of CDP is introduced to the field of public personnel administration research. Second, the current problems of personnel administration in Korea are analysed from the views of Career Development Program. Third, policy alternatives are developed for the improvement of job competency of public officials in Korea. To accomplish these objectives, this research adopts questionnaire survey method and Brain Storming approach in part. Seven policy alternatives are presented in this study. In order to successfully achieve the unification of South and North Korea, it is necessary to carry out a systematic study as to how the political and administrative systems of North Korea could be transformed into a democratic system. Such a transformation implies the fundamental reconstruction of a nation, accompanied by drastic changes in political and administrative systems. In the case of the former East Germany, the nations statehood itself changed as a result of German unification. Regardless of the method, if the product of Korean unification were a democratic, constitutional, free-market economy and a welfare society, North Korea would inevitably undergo a transformation of its state system. In particular, the transformation of human

보강된 복합재 패널의 최적설계를 위한 유전알고리듬의 연구

이종수,Lee, Jong-Su 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.5

The paper describes the use of genetic algorithms (GA's) to the minimum weight design of stiffened composite panels for buckling constraints. The proposed design problem is characterized by mixture of continuous and discrete design variables corresponding to panel elements and stacking sequence of laminates, respectively. Design space is multimodal and non-convex, thereby introducing the need for global search strategies. Advanced strategies in GA's such as directed crossover, multistage search and separated crossover are adopted to improve search ability and to save computational resource requirements. The paper explores the effectiveness of genetic algorithms and their advanced strategies in designing stiffened composite panels under various uniaxial compressive load conditions and the linrlit on stacking sequence of laminates.

기술이야기-기술혁명과 기술혁신

이종수,Lee, Jong-Su 한국과학기술단체총연합회 1998 과학과 기술 Vol.31 No.2

기술혁신이란 말을 국어사전에서 찾아보면 새로운 기술 도입으로 일어나는 경제구조 등의 변혁을 이른다고 풀이하고 있다. 1958년 일본정부는「경제백서」를 발간하면서, '기술혁신'이란 말을 처음 사용하여 신어로 정책했다. 그 후 호시노라는 사람이 기술혁신문제를 체계적으로 정리해 "기술혁명이란 프로펠러 비행기에서 제트비행기로, 견사에서 나일론사로 변한 것처럼 어떤 새로운 원리에 의하여 폭발적인 발전을 하는 것을 말한다"고 했다. 그는 기술환경은 기술혁신 중의 혁신을 의미한다고 덧붙였다.

위치지정 변이기법을 이용한 Bacillus thuringiensis var. kurstaki NRD 6-Stu 1의 육성

이종수,Lee, Jong-Su 배재대학교 자연과학연구소 1993 自然科學論文集 Vol.6 No.1

위치지정 변이기법을 이용하여 Bacillus thuringiensis var. kurstaki NRD 6의 내독소 유전자의 N말단 독성부위를 변이시켜 Bacillus thuringiensis var. kurstaki NRD 6-Stu 1을 육종하였다. 내독소에 대한 염기서열 조사결과, 변이주의 내독소 유전자부위에 Stu 1 인식부위가 생성되었고 특히, 이부위의 177번 염기 A가 C로 치환된 silent mutation이 일어났음을 확인하였다. 변이주의 내독소 유전자의 항원성질은 친주와 차이가 없었고 Choristoneura femiferana-1에 대한 독성도는 0.015~0.030ng으로 친주의 0.01~0.024ng과 유사하였으나 다른 친주계열인 B.t.kurstaki NRD 5의 500~1000ng과 B.t.kurstaki NRD 4(무독성)보다 강하였다. A cloned delta-endotoxin gene from Bacillus thuringiensis var. kurstaki NRD 6 was mutated at N-terminal toxic portion of the protoxin by site-directed mutagenesis. A Stu 1 restriction site was created in protoxin region of the mutant B.t.kurstaki NRD 6-Stu 1 which changed A to C in 177 region of the protoxin(silent mutation). Antigenic property of crystalline inclusion (delta-endotoxin) of the mutant was no difference to intact strain by the western blot analysis and its toxidity threshold value was also showed 0.015~0.030ng against Choristoneura femiferana-1 insect, similar with 0.01~0.024ng of parent strain, but stronger than that of B.t.kurstaki NRD 5 (500~1000ng) and B.t.kurstaki NRD 4(none toxic).

'학습'이란 불순한 의도로 만든 허접한 '합체로봇'

이종수,Lee, Jong-Su 대한출판문화협회 2005 출판저널 Vol.357 No.-

향부자에 대한 소론

이종수,Lee, Jong-Su 대한한약협회 1997 大韓漢藥 Vol.1 No.-

건강열전 - 이 시대 최고의 CEO, 스티브 잡스

이종수,Lee, Jong-Su 한국건강관리협회 2010 건강소식 Vol.34 No.1

매력적인 CEO 이야기라면 이 정도는 돼야 하지 않을까. 젊은 창립자가 1980년대 자기 회사에서 쫓겨나 1990년대에 되돌아오고, 그 다음 10년간 두 번의 죽을 고비와, 한 번의 증권 스캔들, 항상 끼어드는 경쟁 제품들을 이겨냈다. 그리고 가끔은 불쾌한 태도가 혁신적이고 창의적인 아이디어로 연결됐고, 매번 억만장자가 되기도 했으며, 실리콘밸리에서 제일 가치 놓은 회사의 CEO가 되기도 했다. 다음에는 무엇을 기대할 것인가? 비밀주의와 쇼에 대한 취향, 그리고 검증된 CEO의 영특함까지. 준비가 됐을 때에만 우리를 깜짝 놀라게 하는 이 시대 최고의 CEO, 그가 스티브 잡스다.