체성 연부 조직에 생긴 평활근육종: 1예 보고

이경지 ( Kyung Ji Lee ),이안희 ( An Hi Lee1 ),김진아 ( Jea Na Kim ),김형민 ( Hyoung Min Kim ),이교영 ( Kyo Young Lee ) 대한임상종양학회 2009 Korean Journal of Clinical Oncology Vol.5 No.2

체성 연부 조직에 생기는 평활근육종은 매우 드물다. 66세 남자 환자가 방사선 소견상 경계가 좋은 양성 종양이 의심되어 절제술을 시행 받았다. 육안조직소견상 경계가 좋은 둥근 종괴이나, 현미경 소견에서 세포충실도가 증가되고 부분적으로 중증도의 핵이형성을 보였다. 또한 면역조직화학염색상 Smooth muscle actin과 Desmin에 동시에 양성이어 평활근세포 기원으로 생각되었다. 저자들은 괴사가 없고 유사분열은 단 한 개만이 관찰되었으나 중증도의 핵이형성을 보였기에 평활근육종으로 진단한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Leiomyosarcoma of somatic soft tissue is a rare tumor compared with retroperitoneal lesion. We report a case of a leiomyosarcoma of the somatic soft tissue in a 66-year-old man. He presented as an enlarging mass in the left thigh for eight months. Radiologic examinations revealed a well defined round mass, suspicious of benign tumor, such as hemangioma or leiomyoma. He underwent surgical resection. The mass was 3.0 cm in diameter, and it was confined within adductor longus muscle without any connection to adjacent neurovascular bundles. Histologic examination showed moderately cellularity and focal marked atypia with a fascicular growth pattern of spindle cells showing blunt ended nuclei. In addition, the proliferation index was 2~3% by immunohistochemistry using monoclonal antibody MIB-1. But only one definite microscopic mitotic feature was found. Although it showed low mitotic activity without necrosis, this case was diagnosed leiomyosarcoma according to marked cellular atypism.

비구주변 골반골 악성 골종양에서 재건술을 시행하지 않은 내골반골 절제술의 기능적 결과

정양국,강용구,이승구,박원종,이안희,박정미,이교선,이형주,Chung, Yang-Guk,Kang, Yong-Koo,Lee, Seung-Koo,Bahk, Won-Jong,Lee, An-Hi,Park, Jung-Mi,Lee, Kyo-Sun,Lee, Hyung-Ju 대한근골격종양학회 2007 대한골관절종양학회지 Vol.13 No.1

목적: 비구주변 악성 골종양에 대한 재건술을 동반하지 않은 내골반골 절제술의 기능적 결과를 알아보았다. 대상 및 방법: 1996년 1월부터 2005년 12월까지 비구주변을 침범한 악성 골종양에 대하여 내골반골 절제술 후 특별한 재건술을 시행하지 않았던 8예의 기능적 결과를 평가하였다. 남자가 6명, 여자가 2명이었으며 평균연령은 42세였다. 골육종이 3예였고, 연골육종 3예, 전이성 골종양2예였다. 골반골 절제유형은 I+II+III 형 6예, I+II형 1예, II+III형 1예였다. 기능적 결과는 ISOLS의 수정된 기준에 따라 평가하였으며 추시 기간은 최단 6개월에서 최장 84개월이었다. 결과: 최종 추시시 무병생존이 5예, 유병생존이 2예였고 나머지 1예는 질병으로 인하여 사망하였다. 기능적 평가에서 통증, 기능, 정서적 만족도, 보조기구 사용, 보행능력, 보행양상은 각각 4.9, 2.9, 2.9, 1.5, 2.3 및 2.5점이었으며 정상 측의 37~70%(평균 56%)에 해당하였다. 3예에서 일시적인 신경마비가 발생하였다. 결론: 비구주변 악성 골종양에 대한 제건술을 동반하지 않은 내골반골 절제술은 합병증 발생이 적고 양호한 기능적 결과를 보여 재건이 어려울 것으로 예상되는 환자들에게 적용할 수 있는 방법으로 생각된다. Purpose: The purpose of this study was to evaluate the functional outcomes of periacetabular malignant bone tumors treated by internal pelvectomy without reconstruction. Materials and methods: Between January 1996 and December 2005, eight patients with primary malignant or metastatic periacetabular bone tumors were treated by internal pelvectomy without reconstruction. There were 6 men and 2 women. Mean age was 42 years old. There were 3 osteosarcomas, 3 chondrosarcomas and 2 metastatic carcinomas. The type of pelvic resections were 6 type I+II+III, 1 type I+II and 1 type II+II resection. The functional outcomes were evaluated with ISOLS revised criteria. The follow up period ranged from 6 to 84 months. Results: At last follow up, 5 patients showed CDF, 2 patients, AWD and the remained 1, DOD. The mean functional score for pain, functional activity, emotional acceptance, use of external support, walking ability and gait were 4.9, 2.9, 2.9, 1.5, 2.3 and 2.5 respectively. The total functional score ranged from 37% to 70%(average: 56%). There were three temporary nerve palsies. Conclusion: The internal pelvectomy without reconstruction for selective difficult periacetabular malignant tumors could be a viable option with fewer complications and fair functional outcomes.

소아의 견갑골에 생긴 투명세포연골육종 - 1예 보고 -

이경지,이안희,김진아,김형민,이교영,Lee, Kyung-Ji,Lee, An-Hi,Kim, Jean-A,Kim, Hyoung-Min,Lee, Kyo-Young The Korean Musculoskeletal Tumor Society 2009 대한골관절종양학회지 Vol.15 No.2

투명세포연골육종은 모든 연골육종의 2%를 차지하는 매우 드문 저등급성 종양이다. 주로 긴뼈의 뼈끝에서 발생하며 대퇴골과 상완골의 근위부에서 가장 흔하고, 견갑골을 포함한 납작뼈에는 드물다. 25-50세 사이의 연령에서 호발하며, 20세 이전의 발생은 흔치 않다. 조직학적으로 종양 세포는 소엽상 무리를 지어 관찰되며, 투명하고 풍부한 세포질을 특징적으로 가진다. 저자들은 8세 여아의 견갑골에서 발생된 투명세포연골육종을 보고하고자 한다. Clear cell chondrosarcoma is a rare, low-grade variant of chondrosarcoma that comprises approximately 2% of all chondrosarcomas. This tumor usually involves the epiphysis and epimetaphysis of long bones, especially the proximal part of the femur or humerus, whereas involvement of the scapula is rare. It occurs at any age, but the peak is third to fifth decade, and is rarely seen in the first and second decades of life. Histologically, tumor cells with abundant clear cytoplasm and benign giant cells are usually found. We report on a case of clear cell chondrosarcoma of the scapula in an 8-year-old girl.

아가미 암종의 세침흡인 세포학적 소견 - 1예 보고-

맹이소,이안희,강창석,김경미,Maeng, Lee-So,Lee, An-Hi,Kang, Chang-Suk,Kim, Kyoung-Mee The Korean Society for Cytopathology 2004 대한세포병리학회지 Vol.15 No.1

Development of an invasive squamous cell carcinoma within a branchial cleft cyst (branchiogenic carcinoma) is very rare and this case is the first description of cytologic findings in Korea. A 62-year-old man presented with a 5-month history of an enlarged right neck mass. Fine needle aspiration cytology of the mass showed low cellularity and the background containing proteinaceous debris, inflammatory cells, and histiocytes suggested a cystic nature. Abundant lymphocytes, a few anucleated squames, and rare atypical squamous cells with pyknotic nuclei and abnormal keratinization were also noted. After excision of the mass, histologic findings were consistent with a branchiogenic carcinoma. We recommend to raise the possibility of carcinoma (primary or metastatic) when we observe a few dyskeratotic cells in a cystic mass within the neck area, especially in an old male.

유방의 원발성 편평상피암종의 세침흡인 세포학적 소견 - 1예 보고 -

김경미,이안희,이교영,서은주,심상인,문한림,Kim, Kyoung-Mee,Lee, An-Hi,Lee, Kyo-Young,Seo, Eun-Joo,Shim, Sang-In,Moon, Han-Lym 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

A primary squamous cell carcinoma of the breast was evaluated by fine needle aspiration cytology in a 60 year-old female. Squamous cell carcinoma is a rarely encountered lesion in the breast and nine cases of cytologic findings of mammary squamous cell carcinoma have been reported in the world literature. Our case appears to be one of these rare pure squamous cell tumors. The cytologic diagnosis was possible because of the well defined characteristics of the malignant squamous cells, similar to those found in other locations. Thorough examination of the patient did not reveal squamous cell carcinoma elsewhere.

폐 과오종의 세침흡인 세포학적 소견 - 2예 보고 -

김진아,김영실,이안희,심상인,김병기,김경미,Kim, Jean-A,Kim, Young-Sill,Lee, An-Hi,Shim, Sang-In,Kim, Byung-Kee,Kim, Kyoung-Mee 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1

Pulmonary hamartoma is an uncommon benign tumor consisting of a mixture of loose fibromyxoid tissue, cartilage, fat, and cleft-like spaces lined by cuboidal or ciliated epithelium. Cytologically, the presence of a mesenchymal component is essential for the diagnosis of pulmonary hamartoma. We report the fine needle aspiration cytologic findings of two cases of pulmonary hamartoma. Case 1 was a 71-year-old woman with a mass, measuring $1.8{\times}1.5cm$ in the upper lobe of the right lung. Case 2 was a 51-year-old woman with a mass, measuring $2.3{\times}2.0cm$ in the lower lobe of the right lung. Fine needle aspiration cytology of both pulmonary masses revealed several sheets of loose fibromyxoid tissue fragments with focal cartilaginous differentiation and a few clusters of bland cuboidal epithelial cells on the bloody background. The diagnosis was histologically confirmed by needle biopsy.

파골세포모양 거대세포를 동반한 갑상선 미분화 암종의 세침흡인 세포학적 소견 - 1예 보고 -

맹이소,이제훈,이안희,강창석,김경미,Maeng, Lee-So,Lee, Je-Hoon,Lee, An-Hi,Kang, Chang-Suk,Kim, Kyoung-Mee 대한세포병리학회 2003 대한세포병리학회지 Vol.14 No.1

Multinucleated giant cells of osteoclast-like appearance can be seen in a type of anaplastic carcinoma of thyroid and only a few case reports for fine needle aspiration cytologic findings are found in the literatures. Recently, we experienced a case of anaplastic carcinoma of thyroid with many osteoclast-like giant cells in a 72-year-old woman. The cytologic features and immunohistochemical results are described with special emphasis on differential diagnosis.

뺨 점막에 발생한 충실성 선양낭성암종의 세침흡인 세포학적 소견 - 1예 보고 -

김진아,김영실,이안희,심상인,김병기,김경미,Kim, Jean-A,Kim, Young-Sill,Lee, An-Hi,Shim, Sang-In,Kim, Byung-Kee,Kim, Kyoung-Mee 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.2

Adenoid cystic carcinoma constitutes 4 percent of ail benign and malignant epithelial salivary gland tumors and is a highly malignant tumor of the salivary glands. The cytologic presentation in aspirates is usually characteristic with spherical clusters(balls) of small tumor cells filled with hyaline material. But in case of the poorly differentiated variety(solid type), it is difficult to differentiate from other tumors because sheets of small, fairly monotonous malignant cells, with somewhat larger and more conspicuous nuclei are only seen. The cytologic findings of fine needle aspiration of solid type adenoid cystic carcinoma of buccal mucosa in a 51-year-old man are presented. On cytologic findings, solid sheets of monotonous tumor cells with focal necrosis was noted on a hemorrhagic background and the characteristic cytologic features of adenoid cystic carcinoma was absent.

장관골에 발생한 Stage IIB 골육종의 치료결과

정양국,이승구,김형민,박원종,이안희,박정미,강용구,최광천,Chung, Yang-Guk,Rhee, Seung-Koo,Kim, Hyung-Min,Bahk, Won-Jong,Lee, An-Hi,Park, Jung-Mi,Kang, Yong-Koo,Choi, Kwang-Cheon 대한근골격종양학회 2006 대한골관절종양학회지 Vol.12 No.1

목적: 장관골에 발생한 stage IIB 골육종의 치료결과를 분석하였다. 대상 및 방법: 1993년 2월 이후 장관골에 발생한 골육종에 대하여 수술 후 1년 이상 추시한 58예를 대상으로 하였다. 48예에서 광범위 절제술을, 2예에서 변연부 절제술을 시행했으며 나머지 8예에서는 절단술을 시행했다. 평균 추시기간은 4.1년 이었고 국소 재발, 원격 전이, 합병증, 생존율과 함께 종양학적 및 기능적 결과를 평가하였다. 결과: 최종 추시시 지속적 무병생존 35예, 무병생존 9예, 유병생존 5예, 질병으로 인한 사망이 7예였으며 2예는 다른 원인으로 사망하였다. 국소 재발이 8예(13.8%)에서 있었고 원격전이는 18예(31%)에서 있었으며 재건술을 시행한 48예 중 9예(18.8%)에서 감염증이 발생했다. 기능적 결과는 평균 24.3점이었다. 5년 생존율은 84.6%였으며 지속적 무병생존율은 술후 5년에 68.7%, 10년에 42.3%였다. 결론: 총 58예의 장관골에 발생한 Stage IIB의 골육종 중 46예(79.3%)에서 평균 4.1년 추시상 지속적 무병생존 또는 무병생존을 보였다. 치료군 전체의 5년 생존율은 84.6%였고 기능적 결과는 평균 24.3점으로 우수하여 다른 연구자들의 결과와 비견할 만 하였다. Purpose: To analyze the clinical outcome of stage IIB osteosarcomas arisen in the long bones. Materials and Methods: Since February 1993, 58 Enneking stage IIB osteosarcomas arisen in long bones were managed and followed at least one year at our four university hospitals. There were 48 wide resections, 2 marginal resections and 8 amputations. The mean follow up period was 4.1years (up to 12.2years). Local recurrence, distant metastasis, complication, survival rate, and oncologic and functional results were evaluated. Results: At the last follow up, 35 patients were CDF, 9 were NED, 5 were AWD, 7 were DOD and the remained 2 died with unrelated disease. Eight local recurrences (13.8%) and 18 distant metastases (31.0%) were occurred. Nine infections were developed after 48 reconstructions (18.8%). Overall functional outcome was 24.3 (81.%). The 5 year overall survival rate was 84.6% and the continuous disease-free survival rate was 68.7% at 5 years and 42.3% at 10 years. Conclusion: Forty-six of 58 stage IIB osteosarcomas arisen in long bones (79.3%) showed CDF or NED at an average 4.1 year follow up. Overall 5-year survival rate was 84.6% and overall functional outcome score was 24.3, which were comparable to those of other studies.

건강소아에서의 임상화학 19항목 참고범위

이해순 ( Hae Soon Lee ),김종득 ( Jong Deuk Kim ),김혜자 ( Hye Ja Kim ),이안희 ( An Hi Lee ) 대한임상검사과학회 1997 대한임상검사과학회지(KJCLS) Vol.29 No.1