방광에 생긴 미세유두변이 요로상피세포암종의 임상 및 병리학적 분석

이경지,이아원,최영진,이교영,강창석,심상인 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.4

Background : Micropapillary urothelial carcinoma of urinary bladder is a rare and aggressive subtype of urothelial carcinoma (UC). Methods & Results : Seven UCs with a micropapillary component (MPC) were identified by reviewing 135 cystectomy specimens of UC (5.2% in incidence). MPC was associated with conventional UC in 6 cases and the plasmacytoid variant of UC in 1 case. Lymph node metastasis, that characteristically contained MPC was present in 60% (3 out of 5 cases of regional lymph node dissection). Three patients with extensive MPC showed laminar propria invasion (pT1; 33%) and perivesical fat invasion (pT3; 67%). Two out of 3 patients with extensive MPC showed distant metastasis into the colon after cystectomy. The colonic lesions showed exclusively micropapillary differentiation. Four patients with focal or moderate MPC (pT2, 25%; pT3, 75%) were alive without disease at the time of writing this article. All 3 cases with extensive MPC had surface and/or invasive MPC on the prior TURB specimen. Immunohistochemically, the tumor cells were positive for cytokeratin 7, cytokeratin 20, EMA and E-cadherin and tissue retraction spaces that simulate lymphatic spaces were negative for CD34 in all 7 cases. Conclusions : This study suggests that the micropapillary growth pattern in UC is a manifestation of aggressive behavior and UC with MPC must be included as part of the differential diagnosis when dealing with a metastatic lesion with a micropaillary structure.

Expression of pRb, p53, p16 and Cyclin D1 and Their Clinical Implications in Urothelial Carcinoma

이경지,정은선,최영진,이교영,이아원 대한의학회 2010 Journal of Korean medical science Vol.25 No.10

The aim of this study was to assess immunohistochemical expression of p53, pRb, p16, and cyclin D1, alone or in combination, as prognostic indicators and to investigate their correlation with clinocopathologic features of urothelial carcinoma. Immunohistochemical staining for p53, pRb, p16, and cyclin D1 was performed on a tissue microarray from 103patients with urothelial carcinoma who underwent radical cystectomy. Of the patient samples analyzed, 36 (35%), 61 (59%), 47 (46%) and 30 (29%) had altered expression of p53, pRb, p16, and cyclin D1, respectively. Abnormal expression of p53 and pRb correlated with depth of invasion (P=0.040 and P=0.044, respectively). Cyclin D1 expression was associated with tumor stage and recurrence (P=0.017 and P=0.036, respectively). Altered pRb was significantly correlated with overall survival (P=0.040). According to the expression pattern of pRb and p53, p53/pRb (altered/normal) had worse survival than p53/pRb (normal/altered) (P=0.022). Alteration of all markers had worse survival than all normal (P=0.029). As determined by multivariate analysis, tumor stage, lymph node metastasis and the combined expression of p53 and pRb are independent prognostic factors. In conclusion,immunohistochemical evaluation of cell cycle regulators, especially the p53/pRb combination, might be useful in planning appropriate treatment strategies.

갑상샘 유두암종에서 S100A4 및 COX2 발현과 침윤성과의 관련성

이경지,이연수,이교영,박우찬,김영실 대한내분비학회 2008 Endocrinology and metabolism Vol.23 No.3

Purpose: Tumor cell invasion is characteristic of malignant neoplasms. S100A4, a member of a family of small calcium binding proteins, and COX2, seem to have a role in promoting progression and invasion of many human cancers. The clinical stage of a papillary thyroid carcinoma (PTC) depends on age, tumor size, and extrathyroidal extension. Extrathyroidal extension is correlated with the invasiveness of a tumor. However, there are no reliable prediction markers for invasiveness. We evaluated S100A4 and COX2 expression in PTCs to determine if expression correlates with invasiveness, and if expression of S100A4 and COX2 are useful as prediction markers. Methods: The expression of S100A4 and COX2 were evaluated using immunohistochemical analysis in 35 PTC specimens. Results: More intense staining in cells that invaded the front portion rather than the central portion of a PTC was indicative of increased expression of S100A4 and COX2. Therefore, cases were analyzed for extent of staining in tumor cells that invaded the front portion of a PTC. High expression group (higher expression than average expression rate) of S100A4 and COX2 were significantly correlated with extrathyroidal extension (P = 0.0094 and P = 0.0433, respectively). However, no other clinicopathological factors including age, lymph node involvement, and multiplicity were related to expression of S100A4 and COX2, as determined in this study. Conclusion: Extrathyroidal extension of a PTC had an unfavorable effect on prognosis. S100A4 and COX2 expression were associated with extrathyroidal extension. These findings suggest that expression of S100A4 and COX2 could be prognostic markers for PTC. (J Korean Endocr Soc 23:186~192, 2008)

췌장의 점액 낭샘암종의 세침흡인 세포소견 -1예 보고-

이경지,이교영,강창석,심상인,이아원,Lee,, Kyung-Ji,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In,Lee, Ah-Won 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2

Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.

골반강 내에서 발생한 뇌실막세포종 -1예 보고-

이경지,정지한,이연수,이교영,김병기,강창석 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.2

We report here on a case of an ependymoma arising from the pelvis in a 25-year-old woman. She had no evidence of abnormality in her brain and bilateral ovaries. The diagnosis was based on light microscopic, immunohistochemical, and ultrastructural features of a typical ependymoma, including the patterns of pseudorosette or true ependymal rosette, the strong immunopositivity for glial fibrillary acid protein and intermediate filaments, and cilia of tumor cells. The mass was over 20 cm in maximum diameter, and it was located between the uterus and rectum without any connection to bilateral ovaries. There were many metastatic nodules in the pelvis and omentum. In addition, the proliferation index in the most active area was 10% by immunohistochemistry using monoclonal antibody MIB-1. Although the prognosis of the pelvic ependymoma is known to be difficult to evaluate, this case may serve to illustrate the poor prognostic course, according to the size of the tumor, the evidence of metastasis, and the MIB-1 labelling index.

소아의 견갑골에 생긴 투명세포연골육종 - 1예 보고 -

이경지,이안희,김진아,김형민,이교영,Lee, Kyung-Ji,Lee, An-Hi,Kim, Jean-A,Kim, Hyoung-Min,Lee, Kyo-Young The Korean Musculoskeletal Tumor Society 2009 대한골관절종양학회지 Vol.15 No.2

투명세포연골육종은 모든 연골육종의 2%를 차지하는 매우 드문 저등급성 종양이다. 주로 긴뼈의 뼈끝에서 발생하며 대퇴골과 상완골의 근위부에서 가장 흔하고, 견갑골을 포함한 납작뼈에는 드물다. 25-50세 사이의 연령에서 호발하며, 20세 이전의 발생은 흔치 않다. 조직학적으로 종양 세포는 소엽상 무리를 지어 관찰되며, 투명하고 풍부한 세포질을 특징적으로 가진다. 저자들은 8세 여아의 견갑골에서 발생된 투명세포연골육종을 보고하고자 한다. Clear cell chondrosarcoma is a rare, low-grade variant of chondrosarcoma that comprises approximately 2% of all chondrosarcomas. This tumor usually involves the epiphysis and epimetaphysis of long bones, especially the proximal part of the femur or humerus, whereas involvement of the scapula is rare. It occurs at any age, but the peak is third to fifth decade, and is rarely seen in the first and second decades of life. Histologically, tumor cells with abundant clear cytoplasm and benign giant cells are usually found. We report on a case of clear cell chondrosarcoma of the scapula in an 8-year-old girl.

편평세포암종으로 오인된 와르틴 종양의 세침흡인 세포소견 -증례 보고-

이경지,정찬권,이아원,강창석,이교영,Lee, Kyung-Ji,Jung, Chan-Kwon,Lee, Ah-Won,Kang, Chang-Suk,Lee, Kyo-Young 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2

We report a case of Warthin's tumor of the parotid gland in a 53 year old man, which is incorrectly diagnosed as squamous cell carcinoma. Fine needle aspiration cytology(FNAC) smear obtained from the right parotid gland revealed scattered epithelial cell clusters or nests in a diffuse inflammatory and necrotic background. Some epithelial cells had squamoid appearance showing variable sized bizarre shaped nuclei. They had abundant of dense eosinophilic keratinized cytoplasm. Occasionally, parakeratotic cells were also present. These cytologic findings with significant atypia and necrotic background made diagnosis as squamous cell carcinoma. But, the resection specimen from this patient showed classic Warthin's tumor in addition to abundant areas of inflammation and squamous metaplasia. Metaplastic or infarcted Warthin's tumor in the salivary gland may be confused with false positive diagnosis of malignancy on FNAC. Therefore, cytopathologist should have adequate awareness of potential of erroneous diagnosis in FNAC of Warthin's tumor.

복합 소재를 고려한 3륜 모빌리티 프레임의 소재-두께 최적화

경지수(J. S. Kyoung),박대호(D. H. Park),신동석(D. S. Shin),전의식(E. S. Jeon) Korean Society for Precision Engineering 2022 한국정밀공학회 학술발표대회 논문집 Vol.2022 No.5

免疫性 溶血性貧血에 關한 實驗的硏究

李敬智 大韓産婦人科學會 1966 大韓産婦人科學會雜誌 Vol.9 No.6

DMTO 기법을 이용한 모빌리티 프레임의 경량 최적화

경지수(J. S. Kyoung),신동석(D. S. Shin),전의식(E. S. Jeon) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월

개인 및 화물의 이동수단으로서 친환경 퍼스널 모빌리티(Personal Mobility)의 활용이 증가하고 있다. 퍼스널 모빌리티는 안전성과 편의성을 만족시키기 위하여, 박판 부품의 활용과 다양한 편의장치가 부가되어 있다. 그러나 박판 프레임은 가변이 불가하여 다목적 활용이 어렵고, 다양한 편의장치들은 중량을 증가시킴으로써 구동저항의 원인이 되고 있다. 그러므로 다목적성을 만족시키기 위해서 프레임을 골격형으로 선정해야 하고, 구동저항을 감소시키기 위해서 공학적인 최적화 방법으로 프레임 및 결합 부품들에 대한 소재 및 두께 최적화를 수행해야 한다. 본 논문에서는 골격형 퍼스널 모빌리티 모델에 대하여, 메타모델 기반 최적설계 이론을 이용하여 경량최적화 하는 과정을 제시했다. 먼저 퍼스널 모빌리티 모델에 대한 유한요소모델링을 수행했다. 그리고 프레임 부품들을 소재의 변화, 두께의 변화가 가능한 변수로 설정했다. 소재는 미리 입력되어 있는 경우의 수로 이산화 하였으며, 두께도 미리 입력된 경우의 수로 이산화 하였다. 각 부품의 소재와 두께의 조합은 실험계획법에 의거하여 배치하였고 각 실험점에 해당하는 유한요소해석을 수행하였다. 각 실험점의 반응은 강도와 중량을 취했으며, 실험계획표에 의거하여 반응표면생성을 수행하였다. 반응표면생성 모델은 2 차 다항식으로 선정했다. 반응표면에서 중량 최소화 조건과 강도기준을 만족하는 도출하기 위하여 유전알고리즘을 활용했다. 그리고 메타모델기반 최적점에 대한 유한요소해석을 통해 최적화 결과에 대한 검증을 수행했다. 이러한 연구 과정은 다양한 퍼스널 모빌리티 프레임의 개념설계 단계에서 활용할 수 있을 것으로 사료된다.