진행된 장관골 골육종의 수술 및 비수술적 강력 집속 초음파 치료의 장기 추적 결과

이승구,강용구,박원종,정양국,허성우,이은상,Rhee, Seung-Koo,Kang, Yong-Koo,Bahk, Won-Jong,Chung, Yang-Guk,Huh, Sung-Woo,Lee, Eun-Sang 대한골관절종양학회 2006 대한골관절종양학회지 Vol.12 No.1

목적: 장관골의 골육종 치료로써 한국에서 시행된 항암제 치료 및 수술적 치료 후의 결과와, 중국에서 시행된 비침습적인 초음파 치료(high intensity focused ultrasound, HIFU)간의 다국적 임상 결과를 비교하고자 한다. 대상 및 방법: 한국에서 1993년 이래로 통상적인 항암요법과 사지구제술을 시행한 총 67예(IIA; 4 cases, IIB; 58 cases, III; 5 cases)와, 중국에서 1997년 이래로 초음파 치료를 시행한 총 71예(II; 57 cases, III; 14 cases)를 연구 대상으로 하였다. 한국에서는 총 67예 중, 66예에서 수술 전 선행 화학치료를, 반면 중국에서는 총 71예 중, stage II의 34예에서 9회 이상의 full protocol 화학치료가 시행되었고, stage II의 23예와 stage III의 14예에서 8회 이하의 부분 화학치료를 시행하였다. 한국의 67예는 모두 광범위 절제술을 시행하였고, 56예에서 국소 재건술을 병행하였다. 5예에선 국소 재건 없이 광범위 절제만 시행하였고, 6예에선 절단술만을 시행하였다. 반면 중국의 총 71예는 평균 1.5회(1~4회)의 초음파 치료가 시행되었다. 결과: 한국의 stage II의 5년 생존율은 평균 92.7%(IIA 100%, IIB 85.5%), 반면, 중국의 5년 생존율이 평균 78.7%로써 항암제를 병행한 군은 91.8% 및 항암제 치료를 못 받은 군은 56.6%였다. Stage III의 3년 생존율은 한국 20%(5예중 1예 생존), 중국은 7.1%(14예 중 1예 생존)였으며, 전 예의 평균 생존율은 한국 65.2%, 중국 51.8%였다(Table 2). 한국 환자들의 ISOLS에 의한 최종 기능 평가 결과는 평균 24.3(81%)였고, 중국 환자들은 19.8(73%)였으며, 치료의 합병증은 한국 25.4%(17/67 cases), 중국 31%였다. 결론: 한국에서 시행한 수술적 치료전후 화학요법을 시행한 결과는 초음파 치료를 이용한 비침습적 열괴사 방법보다 양호하였으나, 골종양에 대한 초음파 치료도 적응증을 잘 선택한다면 장관골 골육종의 치유 및 국소 재발율을 감소시킬 수 있을 것으로 생각한다. Purpose: To evaluate the end results between the surgical treatment with neo-adjuvant chemotherapy in Korea and non-invasive high intensity focused ultrasound (HIFU) technique in China for osteogenic sarcomas. Materials and Methods: The surgical treatment with neoadjuvant chemotherapy for total 67 cases (4 IIA, 58 IIB, and 5 III) in Korea since 1993 and the HIFU therapy for total 71 cases (57 II and 14 III) in China since 1997 was performed. In Korea, neo-adjuvant chemotherapy in 66 cases out of total 67 patients, but the adjuvant chemotherapy in only one case was done. On the contrary, in China, full chemotherapy for more than 9 times for 37 patients with stage II out of total 71 cases, but for less than 8 times of partial chemotherapy for 23 patients (stage II) and 14 patients (stage III) was done. The surgical treatment in total 67 Korean patients was done with wide resection and reconstruction for 56 patients, but wide resection without reconstruction for 5 patients and amputation for 6 patients. In china, total 71 patients was treated with average 1.5 times (1~4 times) of HIFU, and if there are some evidences of residual tumor after HIFU with following MRI, the second HIFU therapy was given 2~4 weeks later. After then, the bony defect was in no touch, keep bracing for long time expecting regeneration. All of them were followed for average 46 Mo (12~150 Mo) in Korea, but followed for average 22 Mo (9 years~8 months) in China. Results: The 5 year survival rate (stage II), was average 92.7% (IIA 100%, IIB 85.5%) in Korea series, and average 78.7% (full chemotherapy 91.8%, part chemotherapy 56.6%) in China series. The 3 year survival rate (stage III) was 20% in Korea and 7.1% in China. So, the final overall survival rate was 65.2% in Korea and 51.8% in China. The overall functional outcome score by ISOLS was 24.3 (81%) in Korea and 19.8 (73%) in China. There are 25.4% (17/67 cases) of complications in Korea and 31% (27 complications in 22 patients out of total 71 cases) in China after each treatment. Conclusions: The end results of Korea series which was treated with neoadjuvant chemo- and surgical methods are better than that of non-invasive thermal ablation in china. But we also believe the HIFU, as one of, was also effective to decrease the local recurrence and symptomatic releaf for stage II or even in III of osteogenic sarcomas.

무지 중수지 관절의 외상성 탈구 치료

이승구,송석환,이화성,정진화,정도현,이원희,Rhee Seung-Koo,Song Seok-Whan,Lee Hwa-Sung,Chung Jin-Wha,Chung Do-Hyun,Lee Won-Hee 대한정형외과스포츠의학회 2002 대한정형외과스포츠의학회지 Vol.1 No.2

목적: 임상적으로드물며, 발생시도수정복이잘안되는무지중수지관절복합탈구의임상적결과를알아보고자하였다.대상및방법: 무지중수지관절의외상성탈구11예(10예후방탈구, 1예전방탈구)를대상으로초기에탈구의정복가능성,도수정복을방해하는해부학적요인, 수술적접근법에관하여조사하였다.결과: 모든증례에서초기에도수정복을시도하였으나, 2예에서만이정복이되었다. 8 례는전방도달법으로관혈정복을하였고, 1예는만성적인소견을보여관절고정술을시행하였다. 정복방해요인은파열된수장판내로근위부에서단무지굴건과요측종자골이감입되어있었고, 중수골두는파열된인대와단무지굴건사이에형성된간격사이로빠져나와있었다.결론: 과신전에의한중수지관절의후방복합탈구는드물지만, 정복이쉽지않아서주로관혈정복이요구되며, 이때정복방해요인인파열된수장판과관절막, 단무지굴건과종자골등에관심을갖고치료에임하여야한다. Purpose: We examined patients to evaluate the clinical results of traumatic metacarpophalangeal(M-P) dislocations of the thumb, uncommon and irreducible. Materials and Methods: In 11 traumatic M-P dislocations of the thumb, the types of dislocations were 10 dorsal and 1 volar dislocations resulted from the impacted and hyperextended forces on thumb. Authors evaluated the possibility of closed reduction, the anatomical structures interfering with closed reduction, and the surgical approaches. Results: Eight cases were treated with open reduction through volar approach and two cases were treated with closed reduction. Joint fusion was done with a plate in a chronic case. Initial closed reduction was attempted in all cases, but succeeded in only 2 cases because the interposed ruptured volar plate, the flexor pollicis brevis tendon and ulnar sesamoid bone at the volar side of the M-Pjoint were the obstacles to reduce. The metacarpal head was caught in button-hole slit between theflexor pollicis brevis and the ruptured volar joint capsule in all cases. Conclusion: Similar with the M-P joint dislocations of other fingers, the dorsal complex M-P dislocations of the thumb due to hyper extension are unusual and can't easily be reduced by closed manipulation. It is necessary to pay attention to the ruptured volar plate, capsule, the subluxated portion ofthe sesamoid and flexor pollicis brevis as interfering structures.

가족성 고콜레스테롤혈증 환자에서의 다발성 황색종 - 1례 보고 -

이승구,이화성,문찬웅,Rhee, Seung-Koo,Lee, Hwa-Sung,Moon, Chan-Woong 대한근골격종양학회 2000 대한골관절종양학회지 Vol.6 No.1

We experienced the case of familiar hypercholesterolemia with multiple xanthomas which was treated by combined surgical and medical therapy. He was 26-year-old male patient of familiar hypercholesterolemia with multiple xanthomas in 22 sites on whole body, and was treated by 17 surgical excisions of the xanthomas and by medical therapy of the hypercholesterolemia. There was a normal healing process of the surgical wounds. Continual postoperative medical therapy of the hypercholesterolemia was done. There was no recurrence of the symptoms during more than 13 months of follow-up. But the serum level of the cholesterol was not lowered significantly, so we are treating him with drug therapy. Familial hypercholesterolemia is caused by a specific disorder of lipid metabolism, and is characterized by increased LDL cholesterol, tendon xanthomas, coronary disease associated with autosomal dominant transmission. Xanthomas usually appear in the second decade of life with familiar hypercholesterolemia which may have high risk for premature coronary atherosclerosis, which might be prevented with early diagnosis and medical treatment. So, orthopedic surgeons do not only excise the xanthomatosis surgically but also can diagnose the underlying hypercholesterolemia. 다발성 황색종을 보이는 가족성 고콜레스테롤혈증 환자 1례를 경험하고 수술 및 내과적 치료를 병행하였으며, 계속 추적관찰 중이기에 문헌고찰과 함께 이에 보고하고자 한다. 전신 22 곳에 다발성 황색종을 보이는 26세 남자의 가족성 고콜레스테롤혈증 환자에서 17군데의 황색종을 수술적으로 절제하고, 고콜레스테롤혈증에 대하여는 내과적 약물치료를 병행하였으며, 술 후 13개월 이상 추적 관찰하였다. 환자는 정상적인 수술창의 치유과정을 보였고, 술 후 Simvastatin 약물치료를 병행하고 있으며, 1년 후 최종추시시 종괴의 재발은 없었으나 고콜레스테롤혈증의 치료는 미세한 변화만을 보여 계속 내과적 추적관찰 중이다. 가족성 고콜레스테롤혈증은 저밀도지단백 콜레스테롤의 증가, 건 황색종 및 관상동맥 질환을 특징으로 하며, 상염색체 우성으로 유전되는 지질대사의 장애를 보이는 질환이다. 황색종은 보통 10대에 처음 발견되고 조기 진단에 중요한 단서가 될 수 있으며, 특히 종골건 황색종은 가족성 고콜레스테롤혈증의 첫 번째 임상징후로 나타날 수 있다. 고콜레스테롤혈증은 관상동맥경화증의 위험이 높아 조기 진단과 치료가 중요하며, 이에 정형외과 의사도 황색종의 수술적 제거외에 이러한 숨어 있는 질환을 진단할 수 있어야 하겠다.

족관절의 골-연골성 골극증 - 족관절 전방 충돌 증후군 -

이승구,우영균,송석환,권순용,이화성,정진화,오재찬,Rhee Seung-Koo,Woo Young-Kyun,Song Seok-Whan,Kwon Soon-Yong,Lee Wha-Sung,Chung Jin-Wha,Oh Jae-Chan 대한정형외과스포츠의학회 2002 대한정형외과스포츠의학회지 Vol.1 No.1

목적 : 중년기이후의남성에서, 경골 원위 관절면의 전방이나, 거골경부의배부, 또는거골과경골의원위부관절면양측에골극이발생하여족관절배굴장애와통증을호소하는소위, 족관절전방충돌증후군(족관절전방부위골-연골성골극증)의수술경과및방사선학적검사상골극발생부위의특이성을알아보고자한다. 대상및방법 : 1994년3월부터2001년3월까지본대학부속성모병원정형외과에서족관절전방충돌증후군으로진단되어수술가료한14명17족관절(양측3예)를대상으로하였다. 14명17족관절(양측이환3예)중우측이13예, 좌측이4예였고, 14명모두남자였고, 평균연령은47세였다. 명백한족관절외상력은없었으나, 족관절통증(특히배굴시)과쪼그려앉기장애가주소로서평균15개월(4개월$\~$3년11개월) 이상증상이계속되었고, 특별한운동기왕력은없었다. 수술전X-선, 배굴및척굴위측방X-선, CT그리고, 술후X-선과임상과정을최단18주에서최장26개월(평균13개월)까지추적하였다. 결과 : 족관절측부X-선상거골골극이10예로가장많았고, 경골골극이5예(유리골편2례), 그리고거골과경골양측골극형성이2예였다. 14예는족관절전측방도달법을이용하여골극및유리골편을절제하였고, 나머지3예는관절경을이용하였다. 술 후 2주경부터는일상생활보행을허용하였으며, 수술후평균13개월추적조사에서골극이나충돌증후군의재발은없었다. 결론: 족관절전방충돌증후군은운동량이많은중년기남자에빈발하며, 거골경부전방의골극형성이주요원인이었다. 족관절배굴및척굴X-선및CT가진단에도움이되며수술적으로골극을제거하여치료할수있었다. Purpose : To evaluate the clinical and radiological characteristics of osteochondral ridges of talus and ankle. Materials and Methods : We have analyzed their clinical symptoms and signs, radiologic and CT findings and post-operative results in 17 ankle joints of 14 patients (bilateral in 3), followed them for average 13 months after surgical excision. Results : No definite trauma, but mostly in male after middle age. Their chief complaints are pain on ankle, especially in dorsiflexion or squatting position, and symptom durations are very long, more than average 15 months. Definite diagnosis was made by lateral radiograms of ankle joint. Osteochondral ridges are common in talar neck (10 cases), tibia (4 cases) and both side (3 cases). After excision of osteophytes, all patients gained normal ankle without pain and any limited motion. Conclusions : Anterior impingement syndromes are common in middle aged male, but no definite correlation with sports. Plantar and dorsiflexed lateral radiographs are helpful in definite diagnosis for impingement, and surgical excision is best for treatment.

백혈병 환자의 과립구 육종(녹색종양)

이승구,강용구,박원종,정양국,이상욱,정지호,Rhee, Seung-Koo,Kang, Yong-Ku,Bahk, Won-Jong,Jung, Yang-Kuk,Lee, Sang-Wook,Jeong, Ji-Ho 대한근골격종양학회 2005 대한골관절종양학회지 Vol.11 No.1

목적: 백혈병 환자의 사지와 척추 등에 발생하는 과립구 육종(녹색종)은 매우 드물고 그 치료나 예후도 확립되어 있지 않다. 본 연구에서는 과립구 육종 20 예를 대상으로 그 발병기전, 임상적 경과와 치료 결과를 보고하고자 한다. 대상 및 방법: 1998년 4월부터 2004년 9월까지 본 대학 혈액 종양 센터 및 정형외과학교실에서 치료한 총 2,197명의 백혈병 환자 중 척추 및 사지에 이환되었던 과립구 육종 20명(0.91%)을 연구 대상으로 하였고, 1-78개월(평균18개월)간 추적관찰하였다. 결과: 과립구 육종의 발생 빈도는 1998년 4월부터 2004년 9월 까지 6년 5개월 간 본 대학 혈액 종양 센터에서 가료한 급성 골수성 환자 1,331명중 15례, 만성 골수성 환자 744명중 4례, 혼합형 급성 백혈병 환자 122명중 1례가 발생하여 전체 백혈병에서의 발생율은 2,197명 중 20명이 발생하여 0.91%의 빈도를 보였다. 평균 연령은 28.3세(4~52)였고, 남자 13명, 여자 7명이었다. 단발성 병변은 11례, 다발성 병변은 9례였으며, 병변은 척추 12례, 뇌실질 5례, 사지 6례, 흉부 2례, 골반부 2례, 두개골 및 안구에 각각 1례씩 발생되었다. 과립구 육종은 급성 골수성 백혈병(acute myelogenous leukemia, AML)환자 15명, 만성 골수성 백혈병(chronic myelogenous leukemia, CML) 환자 4례에서 그리고 혼합형 급성 백혈병(acute biphenotype leukemia) 환자 1례 등 총 20명 환자에서 발생하였다. 백혈병의 치료 과정중 과립구 육종의 발병 시기별로는 완전 관해 되었을 때 발병한 것이 8례, 특히 이중에서 4례는 만성 골수성 백혈병이 급성 백혈병으로 재발 악화 되면서 육종이 발병하였고, 나머지 12례는 급성 골수성 백혈병 환자의 치료 과정 중 과립구성 육종이 병발하였다. 6례에서의 조직 검사상 미성숙한 골수모세포와 림파구 등이 혼재된 전형적인 과립구 육종을 확진하였고, 과립구 육종의 치료는 전예를 백혈병의 재발 또는 진행과정에 따라 글리벡 및 스테로이드를 이용한 백혈병 자체에 대한 항암치료만을 시행하였고, 6예에서는 항암치료와 함께 과립구 육종에 대한 국소 또는 전신 방사선 치료를 병합하였다. 평균 18개월의 추시 기간 중 만성 골수성 환자의 경우는 4명 모두 사망하였고, 전체 환자는 모두12명(12/20: 60%)이 과립구성 육종의 발병이후 6.5 개월 만에 사망하였으며, 연령과 예후는 고령 발생시 더욱 불량하였다. 결론: 백혈병 환자에서 발생한 척추 및 사지의 과립구 육종의 예후는 불량하였고, 특히 만성 골수성 환자에서 발생시 예후가 더욱 불량하였으나, 급성 골수성 환자의 경우는 반드시 불량한 예후를 보이는 것은 아니여서, 백혈병 자체에 대한 적극적인 항암 치료와, 사지 과립구 육종에 대한 방사선 치료의 병합 요법이 필요하였다. Purpose: The granulocytic sarcoma which developed in leukemic patients are quite rare and it will have bad prognosis, but it's tumor pathogenesis and also their treatment are not yet established. Through this study we have tried to know their clinical course, prognosis and their end result of recent treatment. Material and Methods: Total 20 patients of granulocytic sarcoma which were developed in total 2,197 leukemic patients from April, 1998 to September, 2004 were treated at the leukemic center and the orthopaedic department of St. Mary's hospital, Catholic University of Korea, and followed them for 1~78 months(average 18 months). Results: Total 20 cases of granulocytic sarcoma was found in 14 cases of total 1,331 acute myelocytic leukemic patients(AML), 4 cases of total 744 of chronic myelocytic leukemic patients(CML), and only one case in total 122 of acute biphenotype of leukemia. And so their occurrence rate in leukmic patients are actually 0.91%, total 20 cases of granulocytic sarcoma in total 2,197 leukemic patients at same period. Their ages are average 28.3 years(4~52 years), and male are predominant(13 cases) than female(7 cases). Single involvement was found in 11 cases but multiple lesions are in 9 cases, and spine, brain, extremities, chest, and pelvic bone are involved in frequency. The granulocytic sarcoma was developed in various stages of the leukemia, ie, 8 cases in complete remission of leukemia, and 12 cases in the treatment process of AML. The pathohistologic evaluation of granulocytic sarcoma was done in 6 cases which was developed in their extremities, and confirmed numerous immature myeloblasts and lymphocytes mixed. The treatment of these granulocytic sarcoma was mainly limited for the treatment of leukemia by Glivac and massive steroid therapy(19cases) and also combined with the bone marrow transplantation(13 cases), but radiation therapy with average 3,500 rads in 15 cases out of total 20 sarcomas was also done, and followed them for average 17.5 months after development of granulocytic sarcomas. Finally their prognosis was so bad that 12 patients(60%) out of total 20 granulocytic sarcoma were dead in 6.5 months after sarcoma developed and we found the granulocytic sarcoma was more fatal if they are developed during the process of CML(mortality: 100%(4/4cases). Conclusion: The prognosis of granulocytic sarcomas in leukemic patients are quite fatal, and much more studies for their pathogenesis and ways of treatment should be performed continuously.

강원도 폐광지역 관광개발에 대한 주민태도

이승구(Sung Koo Lee),최규성(Kyu Sung Choi) 한국관광연구학회 2006 관광연구저널 Vol.20 No.2

The main purpose of this study was to develop a residents` attitudes model by theoretically systematizing host attitudes based a review of the previous literature. Five factors were found to influence residents` attitude toward tourism development. These are state of the local economy, ecocentric value, awareness of tourism development projects in the community, perceived benefits, and perceived costs. A questionnaire was developed by utilizing residents` attitudes. To collect data distributed stratified judgement sampling and convenient sampling of simple random method was used. A self-administered survey was conducted for residents at abandoned mine areas in Kangwon-Do. These areas are currently strongly developing a mega resort complex. The 522 usable questionnaires were collected. By testing the hypotheses through an estimation of model, 5 of 5 hypotheses were adopted. The residents` attitude toward tourism development is influenced by the local economy, ecocentric value, awareness of tourism development projects in the community, perceived benefits, and perceived costs.

내시경적 점막 절제술로 치료한 동시성 대장암이 동반된 거치상 폴립증 증후군

이상훈 ( Sang Hoon Lee ),이성준 ( Sung Joon Lee ),박성철 ( Sung Chul Park ),남승주 ( Seung-joo Nam ),강명호 ( Myeong Ho Kang ),김태석 ( Tae Suk Kim ),이승구 ( Seung Koo Lee ) 대한소화기학회 2020 대한소화기학회지 Vol.76 No.3

Serrated polyposis syndrome (SPS) can transform to malignant lesions through the sessile serrated pathway and traditional serrated pathway. These pathways may cause rapid neoplastic progression compared to the adenoma-carcinoma sequence, which may cause interval colorectal cancer. The authors experienced a case of SPS with a synchronous colon adenocarcinoma that was treated with an endoscopic mucosal resection. In pathology reviews, other parts of the adenocarcinoma showed sessile serrated adenoma. Therefore, patients with SPS have a potential for malignant transformation, highlighting the need for strict colonoscopy surveillance starting at the time of SPS diagnosis. (Korean J Gastroenterol 2020;76:159-163)

내시경적 절제술을 시행한 목이 있는 폴립 형태의 대장 혈관확장증

이상훈 ( Sang Hoon Lee ),박성철 ( Sung Chul Park ),이성준 ( Sung Joon Lee ),남승주 ( Seung-joo Nam ),이승구 ( Seung Koo Lee ) 대한소화기학회 2019 대한소화기학회지 Vol.73 No.6

문합부 후방 탈장으로 발생한 위 허혈과 소장 경색 1예

이상훈 ( Sang Hoon Lee ),박성철 ( Sung Chul Park ),이성준 ( Sung Joon Lee ),강창돈 ( Chang Don Kang ),남승주 ( Seung-joo Nam ),이승엽 ( Seung Yup Lee ),홍성권 ( Seong Kweon Hong ),이승구 ( Seung Koo Lee ) 대한소화기학회 2019 대한소화기학회지 Vol.73 No.2

After gastrojejunostomy, a small space can occur between the jejunum at the anastomosis site, the transverse mesocolon, and retroperitoneum, which may cause an intestinal hernia. This report presents a rare case of intestinal ischemic necrosis caused by retroanastomotic hernia after subtotal gastrectomy. A 56-year-old male was admitted to Kangwon National University Hospital with melena, abdominal pain, and nausea. His only relevant medical history was gastrectomy due to stomach cancer. Endoscopic findings revealed subtotal gastrectomy with Billroth-II reconstruction and a bluish edematous mucosal change with necrotic tissue in afferent and efferent loops including the anastomosis site. Abdominopelvic CT showed strangulation of proximal small bowel loops due to mesenteric torsion and thickening of the wall of the gastric remnant. Emergency laparotomy was performed. Surgical findings revealed the internal hernia through the defect behind the anastomosis site with strangulation of the jejunum between 20 cm below the Treitz ligament and the proximal ileum. Roux-en-Y anastomosis was performed, and he was discharged without complication. Retroanastomotic hernia, also called Petersen’s space hernia, is a rare complication after gastric surgery, cannot be easily recognized, and leads to strangulation. (Korean J Gastroenterol 2019;73:109-113)

자궁절제술을 받은 후 발생한 단독 난관수종의 염전

이지연 ( Ji Yeon Lee ),신승호 ( Seung Ho Shin ),하중규 ( Joong Gyu Ha ),최성권 ( Song Kwon Choi ),이승구 ( Seung Koo Lee ),나성훈 ( Sung Hoon Na ),이향아 ( Hyang Ah Lee ),이동헌 ( Dong Heon Lee ),황종윤 ( Jong Yun Hwang ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.11

Isolated tubal torsion is a rare disease that causes acute lower abdominal pain. In most of cases, the ovary and the fallopian tube are together twisted due to an ovarian tumor, but the fallopian tube alone is rarely twisted. Tubal torsion mainly occurs in fertile women, and it rarely occurs prior to menarche and during menopause. We experienced a case where isolated tubal torsion occurred in a perimenopausal female with total abdominal hysterectomy, while the findings showed a normal ovary. We report this case with a brief review of related literature.