우리나라 병원감염관리 활성화를 위한 모형 개발

이성은,Lee, Sung-Eun 한국지역사회간호학회 1997 지역사회간호학회지 Vol.8 No.2

In Korea, the nosocomial infection control program is not well developed. This situation is created by a lack of interest from medical personnel and the medical payment system. This study identifies current problems and develops a model for nosocomial infection control. The studies of Lee & Kim(1995), Lee (1993) and SENIC project model were used to construct this model. 1. The problems of nosocomial infection control were identified as the following: dis approval by hospital authorities, lack of sources for program direction, lack of overall structure and function in the program, inadequate direct action, lack of education and training, and so on. 2. The problems are reorganized according to the 5 elements of system theory. 3. As a result, the new nosocomial infection control model was developed. The inputs of the model were the elements, resources and boundaries of nosocomial infection. With the new model, each hospital can evaluate their current programs and plan a new program for the better control of nosocomial infection.

The First Total Syntheses of Prenyllicoflavone A and Licoflavone A and Biological Evaluation as Inhibitors of Bone Resorption Pits Formation

이성은,김재곤,이종건,이진수,임문정,정용호,송영옥,서홍석,Lee, Seong Eun,Kim, Jae Gon,Lee, Jong Geon,Lee, Jin Su,Im, Mun Jeong,Jeong, Yong Ho,Song, Yeong Ok,Seo, Hong Seok Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.12

Piperlongumine 유도체 합성과 $Aflatoxin\;B_1$ 생성 억제 효과

이성은,최원식,이현상,이영행,박병수,Lee, Sung-Eun,Choi, Won-Sik,Lee, Hyun-Sang,Lee, Young-Haeng,Park, Byeoung-Soo 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.4

Anti-aflatoxigenic studies on synthetic pyridione alkaloids were conducted. Seven derivatives using piperlongumine as a leading compound were prepared from 3,4,5-trimethoxycinnamic acid (TMCA). These derivatives were analyzed for their structural confrmation and purity by HPLC, GC, GC/MS and $1^H-NMR$. 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1) reaction with piperidine; 1-morpholin-4-yl-3-(3,4,5-trimethoypenyl)propenone (2) with morpholine; 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3) with 3,5-dimethylpiperdine; 1-(2-methylpiperidine-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4) with 2-methylpiperidine; 1-(3-hydroxypiperidin-1-yl)-3- (3,4,5-trimethoxyphenyl)propenone (5) with 3-hydroxypiperidine hydrochloride; 1-[3- (3,4,5-trimethoxyphenyl)acryloyl]piperidin-2-one (6) with ${\delta}-valerolactam;\; and\;ethyl\;1-[3-(3,4,5-trimethoxyphenyl)acyloyl]piperidine-4-carboxylate$ (7) with ethyl isonipectotate were synthesized respectively. All derivatives showed an inhibitory activity on aflatoxin $B_1$ production. In conclusion, we believe that they might be an agent for the control of mycotoxin in agricultural commodities. 필발 열매로부터 추출 및 분리한 piperlongurnine (1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-5,6-dihydro-1H-pyridin-2-one)이 aflatoxin $B_1\;(AFB_1)$ 생성억제에 있어서 탁월한 효과가 입증되어 3,4,5-trimethoxycinnamic acid (TMCA)를 모체로 하여 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1), 1-morpholin-4-yl-3-(3,4,5-trimetholfrphenyl)propenone (2), 1- (3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3), 1-(2-methylperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4), 1- (3-hydroxypiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (5), 1-[3-(3,4,5-trimethoxy-phenyl)acryloyl]piperidin-2-one (6) 및 ethyl 1-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperidin-4-carboxylate (7)의 유도체를 합성하여 구조를 확인하고, 이 화합물들을 이용하여 $AFB_1$ 생성저해 효과를 측정하였다. Aspergillus flavus NRRL 2061로부터 생성되는 $AFB_1$ 생성저해에 대한 실험한 결과 모든 유도체 화합물에서 활성을 나타내었으며, 특히 화합물 (3)이 1000, 500, 250, 100및 $50\;{\mu}g/ml$에서 100, 95, 90, 53 및 10%의 생성저해를 나타냈다. 이러한 연구 결과 유도체 화합물 (3)은 항진균 독소제 개발을 위한 선도화합물로 이용하여 새로운 농약으로 개발이 가능할 것이라고 판단된다.

하중흐름을 통한 대형구조실험용 반력시설물의 설계

이성은,고동우,Lee, Sung-Eun,Ko, Dong-Woo 한국공간구조학회 2016 한국공간구조학회지 Vol.16 No.2

The purpose of this study is to present a method that can estimate the height of reaction facilities for large structural experiment through load flow as primary design procedure. The characteristic of the load transmission according to the type of experiment was analyzed to obtain tensile and compressive forces occurring on the reaction facilities. Strong walls that are affected by the bending moment is applied the post-tensioning method, and the strong floor under the control of the tension and compression is designed in accordance with the load flow. And the optimum cross-section of the reaction facilities was obtained by comparing the stresses of the tensile stress and crack the concrete. Through validating elastic analysis, the design results were satisfied a given design conditions.

P507 추출수지를 이용한 중희토류 원소(Gd, Tb, Dy)의 흡탈착 분리특성에 관한 연구

이성은,김정운,전종혁,전홍명,이진영,한춘,Lee, Sungeun,Kim, Joung Woon,Jeon, Jong Hyuk,Jun, Hong Myeong,Lee, Jin Young,Han, Choon 한국자원리싸이클링학회 2016 資源 리싸이클링 Vol.25 No.4

본 연구에서는 P507을 포함하고 있는 추출수지를 사용하여 중희토류 원소인 Gd, Tb, Dy의 흡 탈착 반응 메커니즘을 고찰하고 분리를 위한 최적 크로마토그래피법의 반응조건을 도출하였다. 흡 탈착 반응 메커니즘은 흡착등온식인 Langmuir, Freundlich 흡착등온식과, 흡착속도모델인 유사 1차, 2차 반응속도식을 적용하여 고찰하였다. 중희토류 원소의 흡착반응은 단분자층으로 일어난다고 가정하여 흡착등온식을 적용하였고, 잘 일치하여 흡착반응이 단분자층으로 이루어짐을 추측할 수 있었다. 시간별 실험을 진행하여 유사 1차, 2차 반응속도식에 적용한 결과 유사 2차 반응속도식이 추출수지의 중희토류 흡착 메커니즘을 더 잘 표현하였고, 평형흡착량의 실험값은 이론값에 부합하였다. 크로마토그래피법을 이용하여 용리액 HCl 0.25 M 농도조건에서 ${\alpha}^{Tb}_{Gd}=1.24$, ${\alpha}^{Dy}_{Tb}=1.03$으로 분리계수 1이상의 높은 분리조건을 확인하였다. HCl 용리액을 사용하였을 때, 용리액의 농도가 높을수록 분리도는 감소하고 용출구간은 줄어드는 경향을 확인하였다. This study was conducted to establish the adsorption-desorption mechanism and the optimum condition of chromatographic operation for separations of heavy rare earth elements (Gd, Tb, Dy) using a p507-containing resin. By employing Langmuir and Freundlich isotherm together with pseudo first and second order kinetics, absorption-desorption reaction mechanism was investigated. Langmuir and Freundlich isotherm was applied under assumption that adsorption reaction occurs in form of monolayer, and because the result was identical to the assumption, now we know adsorption of heavy rare earth elements occurs in form of monolayer. Concerning the pseudo first and second order kinetic, the pseudo second order seemed to be more suitable to represent heavy rare earth element adsorption mechanism. By using the extraction chromatography to separate heavy rare earth elements, ${\alpha}^{Tb}_{Gd}=1.24$, and ${\alpha}^{Dy}_{Tb}=1.03$ were confirmed in eluent HCl 0.25 M which indicates almost perfect separations of three elements. Furthermore, as concentrations of eluent became higher, the resolution value decreased and the elution area got shortened.

45Mb/s 광통신 시스템의 자동절체 장치

이성은,정진우,강민호,Lee, Seong-Eun,Jeong, Jin-U,Gang, Min-Ho 한국전자통신연구원 1983 전자통신 Vol.5 No.3

코우히어런트 광전송 기술의 개관

이성은,Lee, Seong-Eun 한국전자통신연구원 1987 전자통신 Vol.9 No.2

코우히어런트 광전송에 관한 연구의 현황을 간략히 기술하였다. 그 내용은 광원인 단일 주파수 레이저의 안정화 방법, 광의 변조 방식, 국부 발진광의 주파수 변환 방법, 평형 광검파 방법, 수신 광신호와 국부 발진광의 편극 상태를 정합시키는 기법 및 파장 분할 다중화 기술등이다.

OFDMA 하향링크 시스템에서의 PAPR 저감을 위한 다단계 및 가변길이 첨두 윈도윙 기법들

이성은,민현기,방극준,홍대식,Lee, Sung-Eun,Min, Hyun-Kee,Bang, Keuk-Joon,Hong, Dae-Sik 대한전자공학회 2008 電子工學會論文誌-TC (Telecommunications) Vol.45 No.2

본 논문에서는 OFDMA 하향링크 시스템에서 PAPR를 저감할 수 있는 두 가지 새로운 첨두 윈도윙(peak windowing) 기법을 제안한다. 제안한 첨두 윈도윙 기법들은 기존의 첨두 윈도윙 기법에서 매우 인접한 여러 개의 첨두들 또는 주변 신호에 비해 상대적으로 큰 첨두에 의해 발생하는 과도한 신호 왜곡 효과를 완화시킨다. 여러 단계의 임계치를 이용한 다단계 첨두 윈도윙(multi-stage peak windowing) 기법은 인접 신호에 비해 상대적으로 매우 큰 첨두들을 우선적으로 제거함으로써, 윈도우가 과도하게 인접 신호를 억제할 수 있는 경우를 방지한다. 다음으로 가변적인 윈도우 길이를 이용하는 가변길이 첨두치 윈도윙(variable-length peak windowing) 기법은 연속적인 첨두가 매우 인접하여 발생하였을 경우 여러 첨두에 적용되는 윈도우들이 중첩되지 않도록 윈도우 길이를 줄여서 과도하게 인접 신호가 억제되는 경우를 줄이게 된다. 제안한 첨두 윈도윙 기법들은 인접하여 발생하는 연속적인 첨두치나 상대적으로 큰 첨두에 의한 과도한 신호 억제를 미연에 방지함으로써 기존의 첨두 윈도윙 기법에 비해서 우수한 성능을 나타낸다. 기존의 첨두 윈도윙 기법 및 제안한 첨두 윈도윙 기법의 수신비트 오율(BER), 스펙트럼 특성은 OFDMA를 적용한 WiBro 하향링크 모의 실험 환경을 통해서 평가되며, 이를 통해 제안한 첨두 윈도윙 기법이 월등한 성능을 나타냄을 검증한다. This paper proposes two peak-windowing algorithms for peak-to-average power reduction(PAPR) of orthogonal frequency division multiple access(OFDMA) downlink systems. The Proposed algorithms mitigate the effect of excessive suppression due to successive peaks or relatively high peaks of the signal. First, multi-stage peak windowing algorithm is proposed, which exploits multiple threshold of target PAPR in order to step down the peaks gradually. Secondary, variable-length peak windowing algorithm is proposed, which adapts the window length with respect to the existence of successive peaks within a half of window length. Therefore, the proposed method reduces the distortion of signal amplitude caused by window overlapping. The proposed algorithms outperform the conventional peak windowing with the aid of window-length adaptation or sequential peak power reduction. Simulation results show the efficiency of the proposed algorithms over OFDMA downlink systems, especially WiBro systems.

자바 프로그램의 재사용을 위한 자바 빈즈 컴포넌트의 추출 및 명세화 기법

이성은,김영익,류성열,Lee, Seong-Eun,Kim, Yeong-Ik,Ryu, Seong-Yeol 한국정보처리학회 2000 정보처리논문지 Vol.7 No.5

An important technical issue in recent software development is to make needed software by the composition of components that are assemblable, and configurable, and independently extracted. The main advantage of component-based software development is reducing development time and cost. It is more cost-effective in development time to use components that are already developed than developing from scratch. There are two ways of component-based software development: one is to compose self-developed components, and the other is to by the components developed by third-parties and compose them. In the second case, existing non component programs must can be used for reuse in the component development. In this paper, we approach two methods for increase of reusability of Java program. First, we suggest the technique of extracting the elements suitable for the Beans component model from Java program, and then we show a process and a guideline of converting the extract elements into the Beans component model. Second, we suggest a technique of automatically extracting component information from the Java Beans component, expressing them in XML, its is possible to reuse the efficient component environment.

확장 칼만필터를 이용한 수중 표적의 불안정 주파수선 추출 기법

이성은,황수복,남기곤,김재창,Lee, Sung-Eun,Hwang, Soo-Bok,Nam, Ki-Gon,Kim, Jae-Chang 한국음향학회 1996 韓國音響學會誌 Vol.15 No.6

수동 소나 시스템에서는 표적을 탐지, 추적 및 식별을 위하여 표적의 방사 소음으로부터 발생되는 주파수선을 주요 특징 인자로 활용한다. 이 연구에서는 수중 표적의 방사 소음으로부터 시간 영역의 표본화된 데이타를 이용한 불안정 주파수선의 추출 기법에 대하여 연구하였다. 불안정 주파수선은 시간에 따라 주파수선이 변화되어 나타나므로 불안정 주파수선 추출을 위하여 비선형 시스템에 유용한 확장 칼만 필터 알고리듬을 적용하였다. 모의 실험 및 표적 신호에 적용하여 제시한 방식이 불안정 주파수선을 추출할 수 있음을 보인다. In passive sonar system, frequency lines generated by underwater target are very important for detection, tracking and classification. In this paper, the extraction method of unstable frequency line from the time samples of the radiated noise of underwater target is studied. As unstable frequency line is time varying, an extended Kalman filter algorithm which is desirable for nonlinear system is applied to extract unstable frequency line. The proposed method shows good extraction of unstable frequency line by application of simulated signal and real target.