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세계 명문대학 순례 - 1850년 개교 '호주 시드니대학교'
이상억,Lee, Sang-Eok 한국과학기술단체총연합회 1996 과학과 기술 Vol.29 No.12
1850년 호주에서 최초의 대학으로 문을 연 시드니대학교는 4천여명의 교직원과 3만명의 학부 대학원생이 재학하고 있는 명문대로 4백50만권의 장서를 소장하고 있는 대학도서관을 비롯해 시드니를 중심으로 한 11개 지역에 3백17개 빌딩으로 이루어져 있다. 지난 7월에는 제3회 환태평양 한국학 국제회의가 이곳에서 열려 1백30여편의 논문이 발표되었으며 91년에는 한국어강좌도 개설되어 현재 1백40여명의 수강생이 언어 문학 및 역사를 배우고 있다.
나유미,이상억,최인석,최원준,민현식,윤대성,Yu Mi Ra,Sang Eok Lee,In Seok Choi,Won Jun Choi,Hyun Sik Min and Dae Sung Yoon 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.1
Traumatic thyroid hematoma is a rare problem in cases of blunt trauma, but it can be a life-threatening condition. We report here on a case of thyroid hematoma that was complicated with unexpected airway obstruction due to blunt trauma on the anterior neck. A 23-year-old man who developed neck painful swelling and dyspnea was admitted to the emergency room with a blunt neck injury after motor-bicycle accident, and he hit his anterior neck against the handle-bar. He had no previous thyroid pathology and other medical problems. On the initial examination, his vital signs were stable and the oxygen saturation was 97.8%. A computed tomography (CT) scan of the neck showed fragmentation and extensive hematoma within the right thyroid gland and dislocation of the trachea. No definite bleeding focus was identified on the angiography that was done through the carotid artery. Two hours later, the patient experienced sudden respiratory distress and the oxygen saturation dropped rapidly. The patient needed emerg encyendotracheal intubation and surgical intervention. He successfully underwent right lobectomy of the thyroid gland, and was discharged on the 6th hospital day without any complications. The thyroid function was normal after 3 months. (Korean J Endocrine Surg 2010;10:39-41)
악성부신피질종양의 거대 간전이에서 사이버나이프 치료 후 시행한 간절제술
권성욱(Sung Wook Kwon),최인석(In Seok Choi),이상억(Sang Eok Lee),최원준(Won Joon Choi),윤대성(Dae Sung Yoon),민현식(Hyun Sik Min) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.6
Surgical resection is the best treatment for operable metastatic liver cancer. Large metastatic cancer usually has low operability, so a debulking modality of mass is needed to increase operability. Chemotherapy and radiotherapy were commonly used as neoadjuvant treatments. Cyberknife stereotactic radiosurgery systems were only considered as one of the palliative treatment modalities for inoperable or surgically complex tumors. But, in this case, we applied Cyberknife as the preoperative debulking modality for large hepatic metastasis of adrenocortical carcinoma. After Cyberknife treatment 3 cycle×2,700 cGY, tumor size decreased (metastatic liver mass decreased to 15×9 ㎝ from 19×12.5 ㎝, adrenal mass decreased to 5×3 ㎝ from 7.4×4.5 ㎝). We could then resect the tumor completely by extended right hemihepatectomy & right adrenalectomy. A preoperative multidisciplinary approach, including chemotherapy and radiation therapy can be considered to increase operability. So, cyberknife can be considered an additional modality as a neoadjuvant radiotherapy.
유방암으로 항암 치료받는 환자에서 발생하는 과도한 골수 억제의 예측인자
이정석(Jung Suk Lee),이혜윤(Hye Yoon Lee),성낙송(Nak Song Sung),전기원(Ki Won Cheon),문주익(Ju Ik Moon),이상억(Sang Eok Lee),최인석(In Seok Choi),최원준(Won Jun Choi),윤대성(Dae Sung Yoon) 대한종양외과학회 2016 Korean Journal of Clinical Oncology Vol.12 No.1
Purpose: Myelosuppression, particularly neutropenia, is one of the most frequent and serious toxicity seen in patients with breast cancer undergoing systemic chemotherapy. However, the predictive factors for development of severe neutropenia in chemotherapy remain unknown. We therefore evaluated predictive factors for excessive myelosuppression. Methods: We retrospectively analyzed 341 patients with breast cancer treated with chemotherapy from 2000 to 2012. Clinicopathological characteristics, number of using of granulocyte colony-stimulating factor (G-CSF), and pretreatment hematologic values were extracted from the electronic medical record system. Patients were sorted 2 groups by number of using G-CSF in each chemotherapeutic regimens; group 1 is more G-CSF (within high 20 percentile) and 2 less G-CSF using group (within lower 20 percentile). Results: Number of using G-CSF was ranged 0–83 (mean 10.76). One hundred one patients were in group 1 and 65 patients were in group 2. Mean of number of G-CSF using was 0.21 in group 1 and 28.02 in group 2. Pretreatment white blood cell, hemoglobin and platelet count were lower in group 2 than in group 1 (6.88×103/μL vs. 5.97×103/μL, 12.63 g/dL vs. 11.90 g/dL, and 275.95×104 μL vs. 227.37×104 μL). There were no statistically differences in other clinicopathologic characteristics such as age, body mass index or comorbidities, hormonal receptor, stage, and other pretreatment hematologic values. Conclusion: Pretreatment white blood cell count, hemoglobin and platelet count can be used to identify patients at increased risk of significant myelosuppression undergoing chemotherapy with breast cancer. This information can be used to target high-risk patients for prophylactic treatment.
조기위암에서 E-cadherin, VEGF-C, VEGF-D의 발현과 Cytokeratin 18로 면역화학염색 한 림프절 전이와의 연관성
김대훈,윤효영,송영진,류동희,민인철,성노현,이상억,Kim, Dae Hoon,Yun, Hyo Yung,Song, Young Jin,Ryu, Dong Hee,Min, In Choel,Sung, Rohyun,Lee, Sang Eok 대한위암학회 2008 대한위암학회지 Vol.8 No.2
목적: VEGF-C와 VEGF-D는 맥관형성성 인자이고, E-cadherin의 비정상 발현은 위암의 진행에 중요한 역할을 한다. 이 연구의 목적은 조기위암에서 E-cadherin, VEGF-C, -D 그리고 cytokeratin 18번을 이용하여 정확하게 측정된 림프절 전이와의 연관성을 연구하는데 있다. 대상 및 방법: 1997년 3월부터 2002년 12월까지 49명의 조기 위암환자들을 대상으로 E-cadherin, VEGF-C와 VEGF-D 면역화학염색을 시행하였다. 림프절 전이를 정확하게 측정하기 위하여 49명 환자들의 1,562개의 림프절을 cytokertin 18을 사용하여 재검사 하였다. 결과: 11 (0.7%)개의 림프절이 12.2% (n=6)의 환자들로부터 새롭게 발견되었다. 정확한 림프절 전이는 점막암에서 3.6%였고, 점막하암에서 38.1%였다. 병기 이동은 3명(6.1%)의 환자에서 관찰되었다. E-cadherin의 비정상 발현은 36.7%에서 발견되었고, VEGF-C와 VEGF-D의 발현은 각각 16.3%와 36.7%에서 관찰되었다. E-cadherin의 비정상 발현은 종양의 분화도(P<0.0103)와 Lauren 분류(P<0.0001)와 뚜렷한 연관성이 있었다. VEGF-C와 VEGF-D는 조기위암에서 림프절 전이를 포함한 임상병리학적 연관성이 없었다. 그러나 E-cadheirn이 비정상 발현되고 VEGF-C 또는 VEGF-D의 발현이 동반되는 환자들에서 림프절 전이의 빈도가 높았다(P=0.0031). 결론: 본 연구에서 조기위암에서 림프절 전이와 VEGF-C, VEGF-D의 발현과의 관계를 증명할 수 없었다. 하지만 E-cadherin이 비정상 발현을 하면서 VEGF-C 또는 VEGF-D의 발현을 동반할 경우 림프절 전이와 연관성이 있었다. Purpose: VEGF-C and VEGF-D are angiogenetic factors, and abnormal expression of E-cadherin hasa role in the progression of gastric carcinoma. The aim of this study was to evaluate the relationship between the expression of E-cadherin, VEGF-C and VEGF-D with the presence of lymph node metastases (LNM) using cytokeratin 18 in early gastric cancer (EGC). Materials and Methods: Immunohistochemical staining for E-cadherin, VEGF-C and VEGF-D was performed in 49 EGC patients from March 1997 to December 2002. To evaluate the real extent of LNM, 1,562 lymph nodes from 49 patients were re-examined with the use of cytokeratin 18. Results: Eleven (0.7%) LNM were newly found in 12.2% (n=6) of patients. The real LNM rate was 3.6% in mucosal invasive (m) cancer and 38.1% in submucosal invasive (sm). Stage migration was seen in three patients (6.1%). Abnormal expression of E-cadherin was detected in 36.7% of the patients and expression of VEGF-C and VEGF-D was detected in 16.3% and 36.7% of the patients, respectively. Abnormal expression of E-cadherin was significantly correlated with tumor differentiation (P=0.0103) and Lauren classification (P<0.0001). There was no positive relationship of VEGF-C and VEGF-D expression with the clinicopathological findings for EGC including LNM. However, the frequency of lymph node metastases was significantly higher in patients that demonstrated abnormal expression of E-cadherin with positive immunoreactivity of VEGF-C or VEGF-D (P=0.031). Conclusion: In present study, we could not demonstrate a relationship between the presence of LNM and expression of VEGF-C and VEGF-D in EGC. However, VEGF-C or VEGF-D expression, in addition to the abnormal expression of E-cadherin, was correlated with the real extent of LNM in EGC.
Development of an Ultrasonic Doppler Sensor-Based Swallowing Monitoring and Assessment System
Younggeun Choi(최영근),Minjae Kim(김민재),Baekhee Lee(이백희),Xiaopeng Yang,Jinwon Kim(김진원),Dohoon Kwon(권도훈),Sang-Eok Lee(이상억),HyangHee Kim(김향희),Seok In Nam(남석인),Saewon Hong(홍세원),Giltae Yang(양길태),Duk L. Na(나덕렬 대한인간공학회 2020 대한인간공학회 학술대회논문집 Vol.2020 No.10
정태호(Tae-ho Jung),박동식(Dong-Sik Park),남희승(Hee-Seung Nam),이상억(Sang-Eok Lee),김동현(Dong-Hyun Kim) 대한임상노인의학회 2008 대한임상노인의학회지 Vol.9 No.4
Background: Peripheral neuropathy is a frequent complication of chronic alcoholic patients. This study was to evaluate nutritional status, electrophysiological study, and to correlate alcohol history with Toronto Clinical Neuropathy Scoring System (TCNSS) and nutritional parameters. Methods: The study involved 34 patients aged 56.7±10.6 years who were diagnosed as chronic alcoholism according to DSM-IV criteria. Alcohol history was evaluated with multiplying Standard Drink (SD) with duration (year) of alcohol abuse and it was 495.24±384.81 (SD*years). Electrophysiological studies including sensory and motor conduction, H-reflex, F-wave were performed. TCNSS combines information obtained from score of symptoms, reflex test, sensory test. For nutritional status, laboratory test included hemoglobin, mean corpuscular volume (MCV), folate, albumin in blood. Results: Electrophysiological studies showed small amplitude of sensory nerve action potential in 5 (5.8%) cases of median nerve, 14 (41.1%) and 13 (38.2%) cases of superficial peroneral and sural nerve. For motor conduction studies, 3 (8.8%) and 3 (8.8%) cases of peroneal and tibial compound muscle action potential showed small amplitude. H-reflex of onset latency showed abnormal in 17 (50%) cases and F-wave of onset latency showed abnormal in 15 (44.1%) cases. Laboratory evaluation shows 2 (5.8%) cases of low hemoglobin, and 6 (17.6%) cases of low albumin level. There were no significant correlations between alcohol history and TCNSS, nutritional parameters. Conclusion: This study showed that nerve conduction studies were abnormal about half of the patients and sensory fibers are more frequently involved, especially in the lower limbs, mostly axonal neuropathy. Serum albumin deficiency was the most frequent abnormal nutritional parameter. There were no correlations between alcohol history and Toronto Clinical Neuropathy Scoring System, nutritional parameters.