가스분석(2)

이상권,Lee, Sang-Gwon 한국설비기술협회 1991 설비 : 공조ㆍ냉동ㆍ위생 Vol.8 No.11

위선암에서 Matrix Metalloproteinase-2, Cathepsin D 및 E-cadherin의 발현

이상권,박승철,김원우,김욱,이교영,전해명,김응국,고용복,Lee Sang Kuon,Park Seung Cheol,Kim Won Woo,Kim Wook,Lee Kyo Young,Jeon Hae Myung,Kim Eung Kook,Koh Yong Bok 대한위암학회 2002 대한위암학회지 Vol.2 No.3

Purpose: The prognosis of gastric cancer depends on the depth of invasion, lymph-node metastasis, invasion to adjacent tissues, and distant metastasis. Recently, it is known that tumor-associated proteases and adhesion molecules have been shown to play a relevant role in the process of progression and metastasis. The purpose of our study was to demonstrate the value of MMP-2 (matrix metalloproteinase), cathepsin D and E-cadherin as prognostic factors. Materials and Methods: In this study, formalin-fixed, paraffin-embedded tissue blocks from 69 patients with gastric cancer were immunohistochemically studied using antibodies to MMP-2, cathepsin D, and E-cadherin, and their expressions were analyzed according to the pathologic stage, lymph-node metastasis, histological differentiation, and patient survival. The medical records of these patients were retrospectively reviewed. Results: Increased expression of MMP-2 significantly correlated with advanced pathologic stage (P=0.026). Patients with lymph-node metastasis also had increased expression of MMP-2. Those patients with increased expression of MMP-2 showed a poorer survival; nevertheless, it was not statistically significant. Increased expression of cathepsin D significantly correlated with advanced pathologic stage (p=0.029). However, no correlation was observed between advanced pathologic stage and either lymph-node status or histological differentiation. Patients with increased expression of cathepsin D had a poorer survival, but that result was not statistically significant. No association was found between reduced expression of E-cadherin and pathologic stage, lymph-node status, or histological differentiation. Also, no correlation was found between the expression of E-cadherin and survival. In addition, when a combination of MMP-2 and cathepsin D expressions was analyzed, if both were negative, the survival seems to be longer, but it was not statistically significant. Conclusions: In patients with gastric cancer, expressions of MMP-2 and cathepsin D correlated with tumor stage; therefore, they may be considered as prognostic factors.

가스분석(1)

이상권,Lee, Sang-Gwon 한국설비기술협회 1991 설비 : 공조ㆍ냉동ㆍ위생 Vol.8 No.10

소프트웨어 분산공유메모리시스템을 위한 적응적 선인출 기법

이상권,윤희철,이준원,맹승렬,Lee, Sang-Kwon,Yun, Hee-Chul,Lee, Joon-Won,Maeng, Seung-Ryoul 한국정보과학회 2001 정보과학회논문지 : 시스템 및 이론 Vol.28 No.9

공유가상메모리 시스템은 적은 비용으로 고성능 계산 능력을 제공하지만, 메모리 접근 지연 시간이 길다는 문제점이 있다. 일반적으로 이 지연시간은 공유데이터에 대한 반복적인 무효화 작업에 의해 일어난다. 고유 데이터들은 동기화를 통해서 접근되고 쓰레드를 반복적 패턴에 의해 동기화 되기 때문에, 반복성에 기반한 선인출 기법은 메모리 지연시간을 효과적으로 줄일수 있다. 본 논문에서는 동기화 변수별로 접근 기록을 분석해서 미래의 메모리 접근을 예측하는 선인출 기법을 제안한다. 제안하는 기법은 8노드 클러스터상에서 SPLASH-2 응용들을 실행시켜 성능을 측정하였다. 그 결과, 제안하는 기법이 34%~45%정도의 메모리 접근 지연시간을 감소할수 있었다. Though shared virtual memory (SVM) system promise low cost solutions for high performance computing they suffer from long memory latencies. These latencies are usually caused by repetitive invalidations on shared data. Since shared data are accessed through synchronization and the patterns by which threads synchronizes are repetitive, a prefetching scheme bases on such repetitiveness would reduce memory latencies. Based on this observation, we propose a prefetching technique which predicts future access behavior by analyzing access history per synchronization variable. Our technique was evaluated on an 8-node SVM system using the SPLASH-2 benchmark. The results show the our technique could achieve 34%~45% reduction in memory access latencies.

Anti-apoptotic Activity of Heme Oxygenase-1 Up-regulated by Etoposide in Human Retinal Pigment Epithelial Cells

이상권,송주동,김강미,김종민,이상률,유영현,박영철,Lee, Sang-Kwon,Song, Ju-Dong,Kim, Kang-Mi,Kim, Jong-Min,Lee, Sang-Yull,Yoo, Young-Hyun,Park, Young-Chul Korean Society of Life Science 2007 생명과학회지 Vol.17 No.9

The topoisomerase II inhibitor etoposide causes an accumulation of DNA double strand breaks within the nuclei of cells. In this study, we investigated the effect of etoposide on the cell growth and apoptosis of human RPE cells. Etoposide evoked a significant inhibition of cell growth, and also induced DNA fragmentation in ARPE-19 cells. In addition, etoposide significantly up-regulated the expression of heme oxygenase-1 (HO-1), which is a stress-responsive protein and is known to play a protective role against the oxidative injury. And, etoposide-induced HO-1 expression was affected by the ROS scavenger N-acetyl cysteine. We also used oligonucleotides interfering with HO-1 mRNA (siRNA) for the inhibition of HO-1 expression. Interestingly, knock-down of the HO-1 gene significantly increased the level of DNA fragmentation in etoposide-treated ARPE-19 cells. In conclusion, these results suggest that up-regulated HO-1 plays as an anti-apoptotic factor in the process of apoptosis of ARPE-19 cells stimulated by etoposide. Totopoisomerase II 저해제인 etoposide는 핵안에 DNA double strand breaks를 일으키므로써 세포의 DNA에 손상을 초래한다. 본 연구에서는 인간 망막색소상피세포인 ARPE-19 세포에서의 세포성장 및 아폽토시스에서 etoposide의 역할을 살펴보았다. Etoposide는 세포의 성장을 크게 감소시켰으며 TUNEL에서 아폽토시스를 나타내는 DNA fragmentation의 증가를 유도하였다. 게다가, etoposide는 산화적 손상에 대해 세포나 조직을 보호하는 역할을 하는 것으로 알려진 세포내 항산화효소인 heme oxygenase-1 (HO-1)의 발현을 크게 증가시켰다. Etoposide에 의한 HO-1 발현증가는 항산화물질 NAC에 의해 억제되었는데, 이는 etoposide에 의한 세포내 ROS의 증가가 HO-1 발현에 중요한 역할을 한다는 것을 의미한다. 또한 HO-1 발현을 억제하기 위하여 HO-1 siRNA 방법을 사용하였다. 흥미롭게도, HO-1 유전자의 knock-down은 etoposide에 의해 유도되는 DNA fragmentation의 정도를 증가시켰다. 이들 결과를 종합해볼 때, etoposide에 의해 자극되어진 ARPE-19 세포에서 발현증가된 HO-1은 etoposide에 의한 아폽토시스 유발과정에서 세포를 보호하는 항아폽토시스의 기능을 한다는 것을 시사한다.

성인에서의 우전외측 개흉술을 이용한 개심술

이상권,김상필,송현,김종욱,송명근,이재원,Lee, Sang-Gwon,Kim, Sang-Pil,Song, Hyun,Kim, Jong-Ook,Song, Meung-Gun,Lee, Jae-Won 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.8

배경: 개심술에서 신속하고 안전한 접근과 미관상 나은 상처를 얻기 위해, 우전외측개흉으로 성인의 심방중 격결손증과 판막질환의 수술을 시행하였다. 방법: 본원에서는 1989년부터 1998년 6월까지 우전외측 개흉술 을 통하여 44예의 개심술을 시행하였고, 수술시간, 심폐우회시간, 대동맥 차단시간, 술 후 출혈량, 중환자실 재실기간, 술 후 퇴원일 등을 정중흉골절개로 수술한 경우와 비교하였다. 결과: 두 군간의 유의한 차이는 없 었고, 전예에서 사망이나 이 접근법과 관련된 이환의 증감은 찾을 수 없었다. 우전외측 개흉술로 안전하고 만족스러운 미용상의 결과를 얻었다. 결론: 우전외측개흉술은 좋은 수술시야를 제공하고 미용상 우수하고 수술의 위험을 증가시키지 않는 부분적으로 정중흉골절개를 대신할 수 있는 안전한 접근법이다. Background: To secure a rapid and safe approach which is at the same time cosmetically appealing, we employed the right anterolateral thoracotomy incision for repair of atrial septal defects and valvular heart diseases in the adult. Material and method: Between October 1989 and June 1998, 44 adult patients underwent open heart surgery through right anterolateral thoracotomy at our institution. Operative time, cardiopulmonary bypass time, aortic cross clamp time, blood loss until chest tube removal, length of ICU stay, days to discharge, and survival were compared with those that received cardiac surgery via conventional sternotomy. Result: No significant differences were observed between the two groups. There was no death and no additional morbidity directly related to this approach. Cosmetically satisfying results were obtained with safety using the right anterolateral thoracotomy approach. Conclusion: Our data show that the right anterolateral thoracotomy approach is a safe alternative to conventional median sternotomy as it offers excellent exposure and aesthetically more acceptable wounds while not adding on to the operative risks.

MZ세대의 윤리적 소비성향이 사회적 기업의 패션상품 구매의도에 미치는 영향

이상권,정인희,조윤진,Lee, Sang Kwon,Chung, Ihn Hee,Cho, Yun Jin 대한가정학회 2022 Human Ecology Research(HER) Vol.60 No.3

Generation MZ, a generic term for millennials and members of Generation Z, is an innovation-leading consumer group in the current market. This study aimed to examine the impact of the ethical consumption tendencies of millennials and Generation Z on the purchase intention of social enterprise fashion products. Data were collected from Generation MZ (15-40 years old) by quota sampling based on the demographic variables of gender, age, and region, respectively. Eight hundred responses were analyzed by descriptive statistics, factor analysis, t-test, and regressions using SPSS software. Three value factors (egoistic, altruistic, and biospheric) and three ethical consumption tendency factors (resource saving tendency, eco-friendly tendency, and consciousness of corporate responsibility) were determined by factor analyses. The results confirmed that women, who showed a higher ethical consumption tendency in all three factors, were more altruistic and biospheric than men. Furthermore, women portrayed a more favorable attitude and purchase intention towards fashion products of social enterprises. The results demonstrated that members of Generation Z were more altruistic and biospheric than millennials. Additionally, the attitude, purchase intention, and willingness to pay premium prices were higher in Generation Z members. It was confirmed that higher biospheric values correlated with greater values for the three ethical consumption tendency factors. The altruistic value affected both the resource saving tendency and eco-friendly trend, while the egoistic value had an effect on the resource saving tendency. Both attitude and purchase intention were positively influenced by all three of the ethical consumption tendency factors, and affected the willingness to pay premium prices. This was subsequently influenced by the resource saving tendency and consciousness of corporate responsibility. The results of this study contribute to understanding Generation MZ as a consumer group, and the establishment of marketing strategies for fashion companies.

비가시선 영역의 통신 단절 현상 개선과 커버리지 확장을 위한 VLC 릴레이 모듈 구현

이상권,이대희,오창헌,Lee, Sang-gwon,Lee, Dae-hee,Oh, Chang-heon 한국정보통신학회 2018 한국정보통신학회논문지 Vol.22 No.1

최근 실내조명으로 사용하는 LED(Light Emitting Diode)와 무선통신 기술을 융합한 가시광통신이 주목받고 있다. 하지만 가시광 통신은 광 신호를 측정할 수 있는 커버리지 내에서만 통신이 가능하고, 비가시선 영역에서 통신이 단절되는 현상이 발생한다. 본 논문에서는 가시광 통신의 커버리지 확장과 비가시선 영역에서 통신 단절 현상 개선을 위해 VLC(Visible Light Communication) 릴레이 모듈을 제안한다. 제안하는 VLC 릴레이 모듈은 송신기로부터 전달받은 패킷을 VLC 릴레이 모듈 및 수신기로 전송한다. 1개의 VLC 송신기와 3개의 VLC 릴레이 모듈을 설치하여 실험을 진행하였으며, VLC 릴레이 모듈의 증가에 따른 통신 커버리지 확장과 비가시선 영역에서 통신 단절 현상 개선을 확인하였다. 또한, 이중 샘플링 기법을 사용하여 광 신호 측정 성능이 2.4배 향상됨을 확인하였다. Recently, VLC(Visible Light Communication) fusing with LED(Light Emitting Diode) used in indoor lighting and wireless communication technology has attracted attention. However, the VLC can communicate only within the coverage to measure the optical signal and the communication disconnection phenomenon is occur in the NLoS(Non-Line-of-Sight) area. In this paper, we propose VLC relay module to extend the coverage of VLC and improve the communication disconnection phenomenon in NLoS area. The proposed VLC relay module transmits the packet received from the transmitter to the VLC relay module and receiver. The experiment was carried out by installing one VLC transmitter and three VLC relay modules, communication coverage expansion and the improvement of communication disconnection phenomenon in the NLoS were confirmed by the increase of the VLC relay module. Also, we confirmed that the optical signal measurement performance is improved 2.4 times by using the dual sampling method.

가스분석(5)

이상권,Lee, Sang-Gwon 한국설비기술협회 1992 설비 : 공조ㆍ냉동ㆍ위생 Vol.9 No.4

한국산 거머리로부터 항혈전단백질의 검색과 분리 , 정제

이상권,손정훈,최의성,이상기 ( Sang Kwon Lee,Jung Hoon Sohn,Eui Sung Choi,Sang Ki Rhee ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.3

Two Korean leech species, Hirudo nipponia and Whitmania sp., were examined for the presence of anticoagulant activity. Crude extracts of the leech head parts were fractionated by ethanol and the anticoagulant activity of these extracts was assessed with respect to the inhibition of thrombin, factor Xa and trypsin using the chromogenic substrate assay. While the extract from Hirudo nipponia inhibited all three serine proteases employed in the assay, that of Whitmania sp. inhibited only trypsin, but not thrombin and factor Xa. Thus, the extract from Hirudo nipponia which shows antithrombin activity was subjected to further purification. Three steps of column chromatography including gel filtration on Superose 12 column, anion exchange on Mono-Q and reverse phase HPLC on C-8 column could resolve 3 antithrombin activity peaks from anti-trypsin and anti-factor Xa activities, indicating the presence of multiple forms of thrombin-specific inhibitors in Hirudo nipponia. N-terminal amino acid sequences of the two of these forms showed a limited degree of homology with a portion of heparin cofactor Ⅱ.