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박재봉 ( Park Jae Bong ),정일원 ( Jung Il Won ),신병길 ( Shin Byung Gil ),강보림 ( Kang Bo Rim ),이덕근 ( Lee Duk Keun ) 한국구조물진단유지관리공학회 2017 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.21 No.1
In this study, the integrated management code of damage information in bridges using the data from unmanned inspection equipment (i.e., drone with hybrid imaging equipment) was proposed. It was found that the integrated management code could be used in developing bridge management system based on 3-dimensional information model of bridge.
구내염증 치료용 구강점막 필름제의 제제설계와 약제학적 성질
이덕근,이계주,박종범,신광현 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.2
In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form, The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using Noveon^ⓡ AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, Eudragit^ⓡ RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of Noveon^ⓡ AA-1 or hydroxypropyl cellulose-M. The drug content was uniformly 1160 ±14.6 ㎍, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179 g of thickness, pH 5.7, 411 min of in vitro adhesion time and 172 g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.
구내염증 치료용 구강점막 필름제의 제제설계와 약제학적 성질
이계주,이덕근,신광현,박종범 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
In order to eliminate demerits of conventional dosage forms, dipotassium glycyrrhizate was formulated as a slim mucoadhesive film type dosage form. The mucoadhesive drug layer gel containing dipotassium glycyrrhizate was prepared using Noveon® AA-1, hydroxypropylcellulose-M, ethylcellulose N 100 and citric acid, and the protective layer gel by using ethylcellulose N 100, Dugragit® RS and castor oil. The viscosity of drug layer gel of mucoadhesive film was enhanced as the increased amount of Noveon®, AA-1 or hydroxypropyl cellulose-M. The drug content was uniformly 1160± 14.6㎍, and was varied within 3.5%. The optimum film dosage form showed a good fluidity and malleability of drug layer, with 179g of thickness. pH 5.7, 411 min of in vitro adhesion time and 172g in gravity adhesive strength. The release time of drug from the mucoadhesive film was significantly shorter but was delayed when polymers such as ethylcellulose was added. From these results, the new mucoadhesive film may be effective for the treatment of aphthous stomatitis.
트리암시놀론아세토나이드 함유 구강점막 필름제의 제제설계 및 평가
이계주,박종범,신광현,이덕근,황성주 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
To design and evaluate the double-layered mucoadhesive film preparation for the treatment of aphthous stomatitis, the film consisting of an adhesive layer containing triamcinolone acetonide and impermeable protective layer was prepared by a solvent-casting evaporation technique and subsequent drying. The polymers, Polycarbophil®, Carbopol®, CMC and gelatin, swell appoximately 2 times its volume in 30 minutes when added to water. In vitro adhesive time was longer than 8hrs and adhesive force was 177-482g/㎤. The diffusion rate of triamcinolone acetonide from film was faster than that of commercial tablet but slower than that of the film. the effect of plasticizer on the protective layer showed that the more amount of plasticizer, the greater elongation, the lesser tensile strength. The stability of drug in the film revealed that no significant reduction in the content of triamcinolone acetonide during a period of six months at room temperature and 40℃ 75% RH. Drug deposit amount permeated through hsmster cheek pouch mucosa from film was greater than that of control film and tablet. In human oral mucosa, adhesive time was between 2.38∼2.83hrs. The adhesive feeling to the human muoscal membrane of sample was better than compared with commercial film and tablet.
신규 항진균 물질 AF-011A의 생산균주 동정, 정제 및 물리 화학적 특성
김성호,현봉철,서정우,김창완,연창석,이덕근,김광표,정재경,임융호,이철훈 한국산업미생물학회 1993 한국미생물·생명공학회지 Vol.21 No.6
토양미생물 탐색을 통하여 항진균활성이 우수한 균주의 미생물을 분리하였으며 이 균주의 특성을 조사한 결과 Pseudomonas cepacia로 동정되었다. 이 균주가 생산하는 항진균 항생물질 AF-011A_1과 AF-011A_2는 효모 뿐만 아니라 mold type 진균류에도 강한 항균활성을 나타내며 넓은 온도, pH 범위에서 안정하였다. AF-011A_1/A_2는 xylose, amino acids, methylene group들로 구성된 lipopeptide 구조이다. 이 물질은 항균활성이 우수하고 안정하므로 의약품 또는 항균농약으로의 개발 가능성이 높다. AF-011A is a novel lipopeptide with potent antifungal activity isolated from Pseudomonas cepacia AF6008 deposited as KFCC 10759. The compound was isolated from the fermentation broth by extraction with 50% isopropyl alcohol. Purification was effected by chromatography on Diaion HP-20, Alumina and C_18 followed by HPTLC on silica gel. These techniques affored two closely related compounds, AF-011A_1 and AF-011A_2. The molecular weights of AF-011A_1/A_2 were determined by fast atom bombardment mass spectrometry(A_1 m/z 1,215 : A_2 m/z 1,199).
신규 항진균물질 AF-011A의 생물학적 활성 및 구조분석
서정우,임융호,김성호,현봉철,김창완,연창석,이덕근,김광표,정재경,이철훈 한국산업미생물학회 1993 한국미생물·생명공학회지 Vol.21 No.6
토양에서 분리한 Pseudomonas cepacia AF6008로부터 항진균물질 AF-011A를 분리, 정제하여 생물학적 활성을 조사한 결과 in vitro에서는 기조의 항진균물질들보다 매우 우수한 활성을 보였으나, 감염동물시험에서는 Amphotericin-B보다 역가가 열세한 상황으로 반전되었다. 그 이유는 혈청단백질과 AF-011A의 상관관계에 의한 것으로 추측된다. 반면, 농약활성은 역가 측면이나 광범위성 측면에서 매우 우수한 결과가 얻어졌다. NMR을 이용한 AF-011A의 구조분석으로 조성물이 모두 확인되었으며 1차구조를 규명하였다. AF-011A is a novel antifungal cyclic glyco-peptide isolated from Pseudomonas cepacia AF6008. AF-011A is a mixture of AF-011A_1 and AF-011A_2. Each compound contains glycine(1), serine(2), asparagines(1), 2,4-diaminobutyric acid(1). β-hydroxytyrosine(1), xylose(1) and a methylene chain amino acid(1). Additionally, A_1 contains one β-hydroxyasparagine that is replaced with an asparagines in A_2. AF-011A showed high in vitro antifungal activity against various animal and plant pathogenic fungi and caused no irritation on the skin of rabbits.