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임융호,박관하,고동수 건국대학교 농업자원개발연구소 2000 農資源開發論集 Vol.22 No.-
Although there have been several pharmacologically distinct categories of anti-allergic agents, almost all of them are known to be limited in their clinical utility due primarily to side effects and weak efficacy. This fact is encouraging many investigators to screen novel anti-allergic agents structurally different from existing compounds. In a project to search anti-allergics from natural projects, we examined a wide range of higher plants to discover that acetone-water crude extract of Geranium thunbergii is effective in suppressing the passive cutaneous anaphylaxis ( PCA) responses of rats, a standard in vivo model for anti-allergy testing, The fraction underwent four steps further in an activity-guided manner finally to separate an active principle, GT2-3. With the aid of NMR spectroscopy, COSY, HMQC and DEPT techniques, the chemical structure of GT2-3 was determined to be quercetin, a known compound. The result indicates that quercetin is not potent enough for immediate clinical application, however, quercetin can be a promising lead compound for chemical modification for anti-allergic agent.
Facial Synthesis of Versatile Chiral Norbornenes asLeukotriene D4 Antagonists from D-glucose
임융호,고동수 한국응용생명화학회 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.2
Chiral dienophile 5 was synthesized from D-glucose by consecutive diisopropylidenation, partial deprotection, diol cleavage, and Wittig reactions. Under thermal conditions, asymmetric Diels-Alder reaction between chiral dienophile and cyclopentadiene gave four possible chiral norbornenes stereoisomers whose absolute configurations were determined through CADD and NMR.
Effect of Garlic on Serum Lipids Profiles and Leptin in Rats Fed High Fat Diet
임융호,강순아,Ho Jung Shin,장기효,Sung Eun Choi,Kyung Ah Yoon,Jin Sook Kim,Hye Kyung Chun 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.2
Although garlic has been reported to have impressive effects in lowering serum lipids, there have been controversial evaluations on these effects. To find the potential fator causing the inconsistency in the previous studies, we examined the effects of two types of garlic according to the producing-area (hangihyung garlic, nangihyung garlic) on serum lipid profiles and leptin level. Thirthy six of 4 wk old Sprague Dawley male rats fed high fat diet (40% of calories as fat) for 6 wks to induce obesity, and subsequently fed 5% garlic powder supplemented (HF+H: hangihyung garlic powder, HF+N: nangihyung garlic powder) high fat diets (w/w) for further 5 wk. For the comparison, normal control group fed AIN-76A diet (11.7% of calories as fat). Supplementation with hangihyung and nangihyung garlic resulted in a significant reduction of high fat induced body weight gain, white fat (i.e., epididymal, visceral and peritoneal fat) development, adipocyte hypertrophy and the development of hyperinsulinemia and hyperliptinemia. Serum triglyceride and total cholesterol level was greatly reduced by hangihyung garlic supplementation (p<0.05). The HDL-cholesterol level was increased by dietary hangihyung and nangihyung garlic. There were slight non-significant decreases in triglyceride and total cholesterol of HF+N group as compared to those of HF group. Leptin level of HF+H group was found to be significantly lower than HF group (p<0.05). There was no significant difference among N group and HF+N group. These results suggest that hangihyung garlic may lead to the higher activity in improving lipid profiles than nangihyung garlic. Whether the hypolipidemic effect of garlic increases in a species-dependent has yet to be determined and awaits further research.
김향선,박종민,임융호 建國大學校 附設 農業資源開發硏究所 1999 農資源開發論集 Vol.21 No.-
ABSTRACTAn analytical method for the acidity measurement of grapefruits without any destruction of sample using NMR was proposed in this sutdy. 1H-NMR, 13C-NMR, COSY and HMQC experiments resulted in quantitative analysis of citric acid, glucose, fructose and sucrose. A calibration curve was obtained from the relation between pH and the ratio of proton peaks of citric acid to anomeric proton of sucrose, which was determined to be y = -0.803x + 3.45, with R2 = 0.99. The experimental values of four grapefruit samples agrees with their calculated values based on the above equation. It was conclued that the acidity of grapefruits could be analyzed using NMR without destruction.