임신중 선천성 단심실 심장기형아의 초음파적 진단 2 례

최승필(SP Choi),조수용(SY hough),주갑순(KS Ju),이갑노(KN Lee) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.8

선천성 심장기형의 발생빈도가 출생아의 1%에 해당하며, 그 중 단심실 심장기형인 경우와 같이 출생후 수술이 불가능한 경우나, 출생후 수술이 가능한 질환인 경우라도 산전에 noninvasive, nonteratogenic, nontoxic procedure의 초음파적 조기발견으로 출생직후 적절한 치료 및 대책을 세울 수 있을 것이다. 저자들은 초음파를 이용한 산전 선천성 단심실 심장기형을 진단한 2례를 문헌 고찰과 함께 보고하는 바이다. Diagnostic ultrasound has been used for a number of years for assessment of the human fetus. because of the improved technology and ability to handle the mordern realtime cross-sectional ultrasound scanners, it has become possible to study cardiac anatomy during intrauterine life. Recently, two cases of single ventricular heart of fetus were detected by the long axis four-chamber plane. Accordingly we present these cases with a brief review of the literature.

냉해동 적혈구의 제조 및 동물 수혈실험의 평가

임채승 ( Cs Lim ),정현진 ( Hj Chung ),이민용 ( My Lee ),홍태의 ( Tu Hong ),김영기 ( Yk Kim ),이갑노 ( Kn Lee ),한규섭 ( Cs Han ) 국군의무사령부 1996 대한군진의학학술지 Vol.27 No.1

임신부에서 실시한 Anti-HEV 측정에 대한 연구

주갑순(KS Ju),박용균(YK Park),조수용(SY hough),서호석(HS Suh),허준용(JY Hur),이갑노(KN Lee),신재철(JC Shin),문준(J Moon) 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.3

임신부를 대상으로 실시한 본 연구에서 E형간염에 대한 항체양성율이 9.9%로 나타난 것은 우리나라에도 E형 간염이 상당히 존재하는 것을 보여주고 있으나, 임신부들의 연령별, 임신횟수 및 분만횟수별 분포에서는 각군간 유의한 차이를 볼 수 없었고, 또한 대부분에서 임상증상이 발현하지 않는 즉 무증상 감염(subclinical infection)으로 지나가는 것으로 나타났다. 그러나 간염환자에서 A형, B형 및 C형 간염이 배제된다면 반드시 E형 간염에 대한 검사는 실시해야 할 것이며, 또한 임신중 E형 간염이 발생한 경우에 그 치사율이 매우 높은 것으로 알려져 있으므로 향후 임신과 E형 간염의 관게에 대한 지속적인 연구가 필요할 것으로 사료된다. Hepatitis E was formerly called enterically-transmitted, enteric, epimemic, waterborne, or fecal-oral non-A, non-B hepatitis. Another non-A, non-B hepatitis, namely hepatitis C poses serious problems of livers to cirrhosis ans gepatocellular carcinoma in the industrialized countries. On the other hand, hepatitis E may not be endemic in these countries but is prevalent in developing countries. Hepatitis E has its highest attack rate in young to middle aged adults, with highest case-fatality rates in pregnant women. But it is not clear whether the pregnncy itself caused more severe disease, whether pregnant women were more symptomatic because of other manifestations of pregnancy, or whether pregnant women(in developing countries) were nutritionally and medically disadvantaged, thus allowing more severe impact of the infection. This study was undertaken with the objective of searching the prevalence of hepatitis E in Korea and evaluate the effect of hepatitis E on pregnancy. A total of 313 pregnant women who visited the antenatal clinic were selected during the period from May, 1994 to July, 1994 at the department of Obstetrics and Gynecology, Guro hospital, Korea University and taken the test for IgG and IgM anti-HEV with the use of ELISA kit. The positive rate of anti-HEV was 9.9%(IgG ; 5.9%, IgM ; 3.0%, IgG and IgM ; 1.0%). The discrepancy among age or parity groups was not shown, and almost all of infected women have no clinical manefestations. So we concluded that hepatitis E exists in Korea but most infected cases are probaby subclinical infections. But it is considered the patient must take the test for anti-HEV in case hepatitis A, B and C are excluded, and further study in the effect of HEV on pregnancy should be performed.

자궁근종 및 자궁근의 Estrogen수용체에 관한 연구

조수용,이갑노,박상진,박혜림 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.5

1988년 12월부터 1989년 3월까지 고려대학교부속 구로병원 산부인과로 내원하여 자궁근종으로 진단받고 자궁적출술을 받은 22명의 환자를 대상으로, 수술검체에서 ER content를 측정하여, 혈중 estradiol 및 progesteron, 환자 나이, 몸무게, 월경주기, 분만횟수, 자궁의 무게, 자궁근종의 크기 등과 조직내의 ER함량과의 관계를 비교 고찰하여 다음과 같은 결과를 얻었다. 1. 수술후의 estradiol 및 progesterone의 혈중 농도는 감소하였지만 통계적으로 유의한 차이는 없었다. 2. 환자의 연령의 증가에 따른 ER함량이, 정상 자궁근에서 증가되는 경향(r=0.2490, p=0.152)을 보여주었으나, 자궁 근종에서는 감소하는 경향(r=-0.3587, p=0.066)을 보였다. 3. 환자의 몸무게의 증가에 따른 ER함량은 정상 자궁근(r=0.0472, p=0.481)과 자궁근종(r=0.2219, p=0.196)에서 증가되는 경향을 보였다. 4. 자궁의 무게가 무거워짐에 따른 ER함량도 정상 자궁근(r=0.2038)과 자궁근종(r=0.1002)에서 증가되는 경향을 보였다. 5. 월경주기별로는 증식기보다 분비기에서 정상 자궁근 및 자궁근종의 ER함량이 높았으나 통계적으로 유의하지는 않았다. 6. 분만힛수의 증가에 따른 ER함량이, 정상 자궁근(r=0.3557, p=0.067)에서는 증가되는 경향을 보여 주었으나, 자궁근종(r=-0.4353, p=0.031)에서는 감소되는 경향을 보여주고 있다. 7. 혈중 estradiol농도와는 정상 자궁근의 ER함량 (r=-0.3824), (p=0.059) 및 자궁 근종의 ER함량(r=-0.0537, p=0.351)이 역(negative) 상관관계를 보였다. 8. 혈중 progesterone농도와는 정상 자궁근의 ER함량(r=0.5245, p=0.015) 및 자궁근종의 ER함량(r=0.1201, p=0.323)이 정(positive) 상관관계를 보였다. Uterine leiomyomas are the most common tumors of the uterus. This investigation was initiated to explore the relationship between ovarian steroid hormones and uterine leiomyomas as manifested by quantitative and qualitative changes in cytoplamic steroid receptors. The 22 women included in this study were evaluated in the Department of Obstetrics Gynecology for symptomatic uterine leiomyomas and underwent hysterectomy. Formalin-fixed and paraffin-embedded sections were stained for estrogen receptor (ER) immunohistochemically with a ER-D5 (ER related antigen) monoclonal antibody kit (Bio-Genex Lab.). The relative intensity of specific cytoplasmic staining in the ER labelled slides measured semiquantitatively with each tissue component (myometrium and leiomyomas) being scored separately. Uterine leiomyomas contain estrogen receptor in quantities comparable to those found in histologically normal uterine tissue. The changes of ER in uterine leiomyomas and myometrium were analyzed as follow: 1. In leiomyoma patients, the mean serum estradiol and progesterone levels were 59.8 ± 13.5 (S.E.) pg/ml and 2.8 ± 0.9 (S.E.) ng/ml. After hysterectomy, the mean serum estradiol and progesterone levels were 48.4 ± 23.7 (S.E.) pg/ml and 0.3 ± 0.1 (S.E.) ng/ml. 2. In myometrium, the correlation between the ER content and age alone showed the positive correlation (r=0.2490, p=0.152) but it showed the negative correlation (r=-0.3587, p=0.066) in leiomyomas. 3. Positive correlation between the ER content and patient weight ( or uterine weight) was noted, but it was not statistically significant. 4. In secretory phase, the mean ER levels of both leiomyomas and myometrium were greater than that observed in proliferative phase. 5. In myometrium, the correlation between the ER content and parity alone showed the positive correlation (r= 0.3557, p= 0.067), but it showed the negative correlation (r=-0.4353, p= 0.031) in leiomyomas. 6. Negative correlation (r= -0.3824) between the ER content and the serum estradiol alone was noted, but it was not statistically significant(p=0.323). 8. The mean ER level in leiomyomas was less than that observed in myometriym(p=0.484).

농축 적혈구에서 백혈구 제거용 필터 Bio R02plus™의 평가

서인범,마경란,조성준,장은아,임채승,김영기,이갑노 大韓輸血學會 2002 大韓輸血學會誌 Vol.13 No.2

호르몬 대체요법시 Dydrogesterone이 지질대사 및 골대사에 미치는 영향

주갑순,박용균,조수용,서호석,허준용,이재관,이갑노,임인수 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5

The addition of a monthly course of progesterone decrease the incidence of endometrial hyperplasia and endometrial carcinoma. The progesterones used in hormonal replacement therapy(HRT) differ markedly in their progesteronic, androgenic and even estrogenic activities. These characteristics may influence both symptomatic and metabolic side effects. The purpose of this study was to examine effect of bone and lipid metabolism in postmenopausal women treated with conjugated equine estrogens plus dydrogesterone. A total 131 postmenopausal women(surgical menopause=95, natural menopause=36) and not-treated postmenopausal women(control=22) were invited to participate in this study. Patients were divided into groups which had received conjugated equine estrogen(CEE) 0.625 mg/day 21-day-cycle each month(n=20), CEE 0.625 mg/day plus Dydrogesterone 10 mg/day 10-day-cycle each month(n=111), and no treatment control group(n=20). Serum lipid & lipoprotein(Triglyceride, Total cholesterol, High density lipoprotein, Low density lipoprotein) and serum osteocalcin, urinary Deoxypyridinoline were examined in all patients. There were no significant differences in bone & lipid metabolism between CEE and CEE plus Dydrogesterone groups. In conclusion, Dydrogesterone may be used safely in postmenopausal women without Metabolic side effect.

투석막 접촉후 흰쥐 메산지움 세포의 세포외기질 발현에 대한 연구

권영주,표희정,김윤희,이영기,차대룡,조원용,김형규,윤수영,이갑노 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.2

The rate of decline of residual renal function is faster in patients on hemodialyaia than in patients on peritoneal dialysis. Recent evidences show that the generation of the terminal membrane attack complex and variable cytokines during hemodialysis may be involved. Also renal fibrosis -remodeling of the mesangial matrix- is a final common pathway in all forms of chronic progressive renal diseases. As a sequelae of inflammation and injury, the humoral factors by infiltrating and resident renal cells stimulate the overproduction of the extracellular matrix, leading to end stage renal disease. We performed this study to evaluate the biocompatibility, ie. the direct effect of different dialyzer membranes on surface expression of extracellular matrix in mesangial cell. We tested the surface expression of extracellular matrix -type Ⅳ collagen, fibronectin, laminin- by flow cytometry in mouse mesangial cells(ATCC CRL-1927, SV40 MES 13, passage 27) after contact with dialyzer membranes (cuprophane : polysulphone) for 24 hours. There were no significant differeces in surface expression of extracellular matrix in mesangial cells after contact with or without dialyzer membranes. Therfore further study such as quantitative PCR, western or northern blot is needed to clarify the effect of dialyzer membranes on production of extracellular matrix in mesangial cell.