의학교육연구의 질을 향상시키기 위한 '연구보고의 표준' 의 활용

유지수,Yoo, Ji-Soo 연세대학교 의과대학 2008 의학교육논단 Vol.10 No.2

Objectives: Through using of the strong research method like a Randomized Controlled Trial: RCT, we have to heighten quality of Medical Education study. I'd like to introduce "CONSORT", which stands for Consolidated Standards of Reporting Trials. Contents: Preventive Service Task Force(200l) in USA proposed Levels of evidence for enlarging evidence-based Practice: EBP. And the CONSORT was introduced, which encompasses various initiatives developed by the CONSORT Group to alleviate the problems arising from inadequate reporting of randomized controlled trials (RCTs). the CONSORT has 13 guides like these: 1. How participants were allocated to interventions 2. Scientific background and explanation of rationale 3. Eligibility criteria for participants. The settings and locations where the data were collected. 4. Precise details of the interventions intended for each group and how and when they were actually administered 5. Specific objectives and hypotheses 6. Clearly defined primary and secondary outcome measures, When applicable. any methods to enhance the quality of measurements (e.g., multiple observations, training of assessors) 7. How sample size was determined. When applicable, explanation of any interim analyses and stopping rules 8. Method used to generate the random allocation sequence, Details of any restriction [of randomization] 9. Method used to implement the random allocation sequence 10. Who generated the allocation sequence, who enrolled participants. and who assigned participants to their groups 11. Whether or not participants, those administering the interventions, and those assessing the outcomes were blinded to group assignment. If done, how the success of blinding was evaluated 12. Statistical methods used to compare groups for primary outcome(s), Methods for additional analyses, such as subgroup analyses and adjusted analyses 13. Flow of participants through each stage (a diagram is strongly recommended) Specifically, for each group report the numbers of participants randomly assigned. receiving intended treatment, completing the study protocol. and analyzed for the primary outcome. Results and Conclusion: Randomized Controlled Trial: RCT guided of CONSORT will contribute to do stronger evidence-based medical studies.

제2형 환자를 위한 운동프로그램이 당대사, 지질대사 및 심폐기능에 미치는 효과에 대한 메타분석

유지수,이숙정,Yoo Ji Soo,Lee Suk Jeong 한국간호과학회 2005 Journal of Korean Academy of Nursing Vol.35 No.3

Purpose: This study was a systematic review and meta-analysis of the effects of exercise programs in patients with type II diabetes mellitus. Method: Two investigators systematically searched and reviewed English articles from PUBMED from 1988 to 2004, selecting randomized controlled trials on structured exercise programs for DM patients. Out of 87 studies identified, a meta analysis was done for eleven studies which satisfied inclusion criteria and focused on glycemic indices, lipid indices, and cardiac function indices. Results: The means and standard deviations were compared for experimental groups that received exercise-only or exercise and diet programs and control groups that received no intervention or only diet education. The groups were considered homogeneous as the p value of the Q score in each variable group was over 0.05. The experimental groups demonstrated a moderate positive effect on HbA,c and $VO_{2max}$ (d=0.55 & 0.5), and a small positive effect on fasting blood glucose and cholesterol (d=0.38 & 0.27) compared to the control groups. HDL and LDL cholesterol levels, however, showed a very low positive effect (d=0.11 & 0.12) in the experimental groups. Aerobic exercise was more beneficial than resistance exercise on $HbA_1c$ (d=0.59 vs 0.28) in the groups. Conclusions: Regular exercise has a positive effect on $HbA_1c$, fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, and $VO_{2max}$ in Type 2 diabetic patients.

가정간호업무 전산화를 위한 가정간호관리 시스템 개발

유지수,김조자,신혜선,최희재,Yoo, Ji-Soo,Kim, Cho-Ja,Shin, Hye-Sun,Choi, Hee-Jai 한국가정간호학회 2001 가정간호학회지 Vol.8 No.1

This study was conducted to develop a home care nursing management system based on the validated and useful data base found through literature review. The contents and structure according to a development procedure for a computer system were as follows. 1. A data base on home care nursing patients was accumulated by putting data respectively in both steps and fields - from selection criteria. basic information. prescription. plan of home visits. to application of nursing process. 2. Accumulated data was classified and designed to search by basic information. drug/injection prescription. examination prescription, treatment prescription. supply. and a record of the nursing process. 3. Various forms of retrieval including graphs were elaborated in terms of diagnosis and intervention aspects.

호스피스 사이버상담 프로그램 운영에 대한 소고

유지수,이윤정,강세원,Yoo, Ji-Soo,Lee, Yoon-Jeoung,Kang, Se-Won 한국호스피스완화의료학회 2006 한국호스피스.완화의료학회지 Vol.9 No.1

목적: 본 연구는 말기 질환자 및 가족들의 삶의 질 증진 차원에서 호스피스 사이버 상담을 위한 인력 훈련 및 홍보 시행을 통하여 호스피스 사이버 상담 프로그램을 운영하여 보고자 한다. 방법: 본 연구는 호스피스 사이버 상담 제공을 위한 상담 인력 훈련, 홍보 전략 구축, 운영 및 효과 평가의 절차로 진행하였다. 결과: 2004년 10월부터 2005년 7월까지 약 9개월 동안 사이버 호스피스 홈페이지를 방문하여 회원가입을 한 대상자는 총 72명으로 20대가 17명(23.6%), 30대가 12명(16.7%), 40대가 17명(23.6%), 50대 이상이 13명(18%)를 차지하였다. 진단명 별로는 암과 관련된 질환이 90%를 차지하였으며, 상담 내용과 상담신청자와의 관계는 가족이 90%를 차지하였으며, 10%만 본인이었다. 회원 중 30명이 온라인 상담을 이용하였으며 상담 건수는 35건이었다. 상담 건수 및 상담 이용 회원수는 적었으나, 상담 이용 후 지속적인 상담원과의 연계 및 사이트 활용의 경향을 보였다. 결론: 말기 질환자 및 가족들의 삶의 질 증진, 호스피스 사업 활성화의 기초 활동으로써 호스피스에 대한사이버 상담 프로그램을 실질적으로 운영하였다. 호스피스 사이버 상담의 활성화를 위해 대중 매체 및 언론을 통한 호스피스 사업에 대한 기본적인 홍보들이 지속적으로 이루어져야 하며, 의료진을 대상으로 한 호스피스에 대한 교육도 계속되어야 할 필요가 있다. Purpose: This study is to report the operating result of the Hospice Cyber Counselling Program for improving quality of lift for terminal patients and their families. Methods: This study was performed followed by counsellor training, building strategy of public relations, management, and evaluation of the effect in order. Results: 72 subjects visited our cyber homepage and became members for approximately 9 months from Oct. 2004 to July 2005; 17 subjects in their 20s (23.6%), 12 subjects in their 30s (16.7%), 17 subjects in their 40s (23.6%), and 13 subjects above 50s (18%). Classified by diagnose related group, cancer related disease consist of 90%. As for the relationship between contents of counselling and counselling applicants, families consist of 90% and self-applicants only 10%. Only 30 members used on-line counselling and their counselling frequency was just 35 times. Although counselling frequency and the number of members who used the counselling site were not high, they tend to contact with a counsellor continuously and use the site actively after the first counselling. Conclusion: Cyber counselling program for hospice was practically managed to improve quality of life for terminal patients and their families as a basic activity for hospice business activation. Basic public relations with regard to hospice business by mass media and the press should be performed continuously and the hospice training program is required for medical personnel to be continue.

코플라 함수를 활용한 이변량 가뭄빈도해석을 통한 우리나라 가뭄 위험도 산정

유지수,유지영,이주헌,김태웅,Yu, Ji Soo,Yoo, Ji Young,Lee, Joo-Heon,Kim, Tea-Woong 한국수자원학회 2016 한국수자원학회논문집 Vol.49 No.3

가뭄은 지속기간과 심도의 두 가지 변량으로 특징지어지는 수문사상이므로 가뭄 지속기간과 심도를 동시에 고려하는 이변량 가뭄빈도해석이 요구된다. 그러나 이변량 결합 확률분포는 3차원의 분포형태를 나타내어 실무에서 분석과 활용이 불편하다는 단점이 있다. 이를 보완하기 위해 본 연구에서는 코플라 함수를 활용하여 이변량 결합 확률분포함수를 추정한 후, 지속기간별 조건부 확률분포함수를 산정하였고, 비초과확률에 따른 임계심도를 결정하였다. 과거 극심했던 가뭄사상들을 바탕으로 95% 비초과확률에 해당하는 임계심도를 갖는 극한 가뭄사상에 대하여 수문학적 위험도를 산정하였다. 10개월 지속기간을 가지는 가뭄사상의 경우, 가뭄위험도가 가장 높은 지역은 광주, 인제, 울진으로 전국 평균에 비해 1.3-2.0배 높은 가뭄발생확률을 나타내었다. 또한, 남부지역이 중부와 북부지역보다 더 높은 가뭄 취약성을 갖는다는 것을 확인하였다. The drought is generally characterized by duration and severity, thus it is required to conduct the bivariate frequency analysis simultaneously considering the drought duration and severity. However, since a bivariate joint probability distribution function (JPDF) has a 3-dimensional space, it is difficult to interpret the results in practice. In order to suggest the technical solution, this study employed copula functions to estimate an JPDF, then developed conditional JPDFs on various drought durations and estimated the critical severity corresponding to non-exceedance probability. Based on the historical severe drought events, the hydrologic risks were investigated for various extreme droughts with 95% non-exceedance probability. For the drought events with 10-month duration, the most hazardous areas were decided to Gwangju, Inje, and Uljin, which have 1.3-2.0 times higher drought occurrence probabilities compared with the national average. In addition, it was observed that southern regions were much higher drought prone areas than northern and central areas.

포도주에서 분리한 Saccharomyces cerevisiae JS59가 생성하는 Invertase의 정제 및 특성

유지수(Ji-Soo Yoo),백현동(Hyun-Dong Paik),김수영(Soo-Young Kim),이시경(Si-Kyung Lee) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.9

전화당(invert sugar)을 생산하기 위하여 포도주로부터 분리한 효모가 생산하는 invertase의 특성을 조사한 결과는 다음과 같다. 포도주로부터 분리한 효모는 지방산 분석을 통하여 Saccharomyces cerevisiae JS59로 잠정 동정되었다. 본 균주가 생성하는 invertase를 ammonium sulfate 침전, DEAE-Sephadex A-50, Sephadex G-200 column chromatography 법으로 정제하였을 때 단일성을 보였으며, specific activity가 7620.9 unit/mg, 최종 회수율은 13.9로 약 14배 정제된 효소를 얻었다. 본 효소의 K_m 값은 11.5mM이었다. SDS-PAGE로부터 분자량은 38.5 kDa으로 나타났다. 정제 된 invertase의 최적 pH는 5였고, pH 4에서도 94%의 높은 효소활성을 나타냈으며 4에서 6까지의 pH영역에서 안정하 였고, 55℃에서 최적 활성을 나타내었으며 50℃까지는 안정 하였다. Ag²⁺와 Hg²⁺에 의해서 저해를 받았고, Co²⁺, Mn²⁺에 의해서는 효소활성이 증가되었으며, 기질과 효소 반응물을 thin layer chromatography로 분석한 결과, 본 효소는 기질인 sucrose를 완전히 분해하여 환원당을 생성함이 확인되었다. The microorganism producing an invertase (E.C. 3.2.1.26) was isolated from wine and tentatively identified as Saccharomyces cerevisiae by cellular fatty acid analysis. The invertase was purified to homogeneity by ammonium sulfate precipitant, dialysis, ion-exchange chromatography on DEAE-Sephadex A-50, and gel chromatography on Sephadex G-200 from the culture supernatant of Saccharomyces cerevisiae JS59. The specific activity and the purification fold of the purified invertase were 7620.9 unit/mg protein and 13.9, respectively. The molecular weight of the purified invertase was estimated to be 38.5 kDa by SDS-PAGE. The optimum pH and temperature for the invertase activity were pH 5 and 55℃, respectively. The invertase activity was relatively stable at pH 4~6 and temperature 55℃. The activity of invertase was inhibited by Ag<SUP>2+</SUP> and Hg<SUP>2+</SUP>, but on the contrary, activated by Co<SUP>2+</SUP> and Mn<SUP>2+</SUP>. Michaelis constant (Km) for invertase reaction in sucrose solution was 11.5 mM. TLC analysis of the products produced in sucrose solution during invertase reaction showed the progressive presence of glucose and fructose in accordance with sucrose hydrolysis.

간호분야와 비간호분야의 운동관련 연구동향 분석

유지수(Yoo Ji-Soo),박지원(Park Jee Won),함옥경(Ham Ok Kyung),강세원(Kang Se Won),최은진(Choi Eun Jin) 기본간호학회 2005 기본간호학회지 Vol.12 No.3

외화선물거래의 수익에 관한 검정

유지수 ( Ji Soo Yoo ) 한국경제학회 1996 經濟學硏究 Vol.44 No.2

근거기반간호 : 국외연구 ; 동종 혈액 및 골수 이식 후의 생착실패: 근거기반간호 사례연구 고찰

유지수 ( Ji Soo Yoo ),손선영 ( Sun Young Son ) 연세대학교 김모임간호학연구소 2005 간호학탐구 Vol.13 No.2

割賦金이 부가되는 狀況에서 住宅需要에 관한 硏究

柳志洙(Ji-Soo Yoo) 영남대학교 산경연구소 2003 영상저널 Vol.11 No.-

본 논문은 割賦金이 주택수요에 어떠한 영향을 미치는가를 분석하는데 그 목적이 있다. 할부금 축적은 주택수요자가 주택소유에 대한 혜택을 포기한 금액이다. 이 대체관계로 인해서 소유가 임차보다 싸다고 하면 소비자는 주택소유보다는 임차를 선호한다. 또한 할부금이 住宅消費를 어떻게 왜곡하는가에 대해서도 분석하고 있다.